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- References [22]
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- Product number
- 23066-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- FOXC2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FOXC2 antibody (Cat. #23066-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Modeling of Capicua Family Fusion Oncoprotein-Driven Cancers Reveals Gene-Specific Functionality.
FOXC2 regulates CYP1B1 transcription and activates the TGF-β/Smad pathway to promote pulmonary fibrosis.
GLI2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating WNT and Prostaglandin Signaling.
First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers.
DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma.
Aloe-Emodin Targeting FOXC2 Disrupts NETs Formation and EMT-Driven Postoperative Peritoneal Adhesion Through TGF-β1-Smad2/3 Pathway.
ADAM12 Silencing Mediated by FOXC2 Represses Meningioma Progression Through Inactivating the JAK1/STAT3/VEGFA Pathway.
Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway.
APOE-NOTCH axis governs elastogenesis during human cardiac valve remodeling.
Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling.
An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves.
Three-dimensional morphologic and molecular atlases of nasal vasculature.
Improving the Function of Meningeal Lymphatic Vessels to Promote Brain Edema Absorption after Traumatic Brain Injury.
Differential Gene Expression Profiling in Alveolar Echinococcosis Identifies Potential Biomarkers Associated With Angiogenesis.
Exogenous interleukin 33 enhances the brain's lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice.
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
VEGF-C/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis.
Long non-coding RNA GClnc1 knockdown suppresses progression of epithelial ovarian cancer by recruiting FOXC2 to disrupt the NOTCH1/NF-κB/Snail pathway.
Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma.
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Naringin promotes osteogenic differentiation of bone marrow stromal cells by up-regulating Foxc2 expression via the IHH signaling pathway.
STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
Luck C, Luo Y, Vasileva E, Jacobs KA, Riad J, Macaraig CD, Ponce RKM, Amatruda JF, Okimoto RA
Molecular cancer research : MCR 2026 May 4;24(5):337-355
Molecular cancer research : MCR 2026 May 4;24(5):337-355
FOXC2 regulates CYP1B1 transcription and activates the TGF-β/Smad pathway to promote pulmonary fibrosis.
Chen W, Peng J, Tang X, Xiao Y, Chen Y, Tang L, Ouyang S
Cellular signalling 2026 Jul;143:112445
Cellular signalling 2026 Jul;143:112445
GLI2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating WNT and Prostaglandin Signaling.
DeVito NC, Nguyen YV, Sturdivant M, Plebanek MP, Villarreal KA, Yarla N, Jain V, Aksu M, Beasley GM, Theivanthiran B, Hanks BA
Cancer research 2025 May 2;85(9):1644-1662
Cancer research 2025 May 2;85(9):1644-1662
First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers.
Luck C, Jacobs KA, Riad J, Macaraig CD, Ponce RKM, Okimoto RA
bioRxiv : the preprint server for biology 2025 May 14;
bioRxiv : the preprint server for biology 2025 May 14;
DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma.
Chen X, Liu Q, Wu J, Zhou P, Zhao M, Song J
Nature communications 2025 Jul 23;16(1):6769
Nature communications 2025 Jul 23;16(1):6769
Aloe-Emodin Targeting FOXC2 Disrupts NETs Formation and EMT-Driven Postoperative Peritoneal Adhesion Through TGF-β1-Smad2/3 Pathway.
Yang L, Fang Y, Lian Y, Kong Z, Miao J, Chen Y, Li W, Chen F, Zhang B, Chen Y, Bian Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e11013
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e11013
ADAM12 Silencing Mediated by FOXC2 Represses Meningioma Progression Through Inactivating the JAK1/STAT3/VEGFA Pathway.
Zhang H, Yang B
Biochemical genetics 2025 Aug;63(4):3640-3655
Biochemical genetics 2025 Aug;63(4):3640-3655
Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway.
Wang H, Chen S, Tang Y, Nie K, Gao Y, Wang Z, Su H, Wu F, Gong J, Fang K, Dong H, Hu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155268
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155268
APOE-NOTCH axis governs elastogenesis during human cardiac valve remodeling.
Liu Z, Liu Y, Yu Z, Tan C, Pek N, O'Donnell A, Wu A, Glass I, Winlaw DS, Guo M, Spence JR, Chen YW, Yutzey KE, Miao Y, Gu M
Nature cardiovascular research 2024 Aug;3(8):933-950
Nature cardiovascular research 2024 Aug;3(8):933-950
Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling.
DeVito NC, Nguyen YV, Sturdivant M, Plebanek MP, Howell K, Yarla N, Jain V, Aksu M, Beasley G, Theivanthiran B, Hanks BA
bioRxiv : the preprint server for biology 2024 Apr 1;
bioRxiv : the preprint server for biology 2024 Apr 1;
An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves.
Chen D, Wiggins D, Sevick EM, Davis MJ, King PD
bioRxiv : the preprint server for biology 2023 Nov 23;
bioRxiv : the preprint server for biology 2023 Nov 23;
Three-dimensional morphologic and molecular atlases of nasal vasculature.
Hong SP, Yang MJ, Bae JH, Choi DR, Kim YC, Yang MS, Oh B, Kang KW, Lee SM, Kim B, Kim YD, Ahn JH, Koh GY
Nature cardiovascular research 2023 May;2(5):449-466
Nature cardiovascular research 2023 May;2(5):449-466
Improving the Function of Meningeal Lymphatic Vessels to Promote Brain Edema Absorption after Traumatic Brain Injury.
Liao J, Zhang M, Shi Z, Lu H, Wang L, Fan W, Tong X, Yan H
Journal of neurotrauma 2023 Feb;40(3-4):383-394
Journal of neurotrauma 2023 Feb;40(3-4):383-394
Differential Gene Expression Profiling in Alveolar Echinococcosis Identifies Potential Biomarkers Associated With Angiogenesis.
Yimingjiang M, Aini A, Tuergan T, Zhang W
Open forum infectious diseases 2023 Feb;10(2):ofad031
Open forum infectious diseases 2023 Feb;10(2):ofad031
Exogenous interleukin 33 enhances the brain's lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice.
Liu M, Huang J, Liu T, Yuan J, Lv C, Sha Z, Wu C, Jiang W, Liu X, Nie M, Chen Y, Dong S, Qian Y, Gao C, Fan Y, Wu D, Jiang R
Acta neuropathologica communications 2023 Apr 7;11(1):61
Acta neuropathologica communications 2023 Apr 7;11(1):61
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Lin F, Li X, Wang X, Sun H, Wang Z, Wang X
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
Journal of experimental & clinical cancer research : CR 2022 Apr 7;41(1):129
VEGF-C/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis.
Lin QY, Zhang YL, Bai J, Liu JQ, Li HH
Clinical and translational medicine 2021 Mar;11(3):e374
Clinical and translational medicine 2021 Mar;11(3):e374
Long non-coding RNA GClnc1 knockdown suppresses progression of epithelial ovarian cancer by recruiting FOXC2 to disrupt the NOTCH1/NF-κB/Snail pathway.
Wu D, Ke Y, Xiao R, Liu J, Li Q, Wang Y
Experimental cell research 2021 Feb 1;399(1):112422
Experimental cell research 2021 Feb 1;399(1):112422
Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma.
Bi Y, Guo S, Xu X, Kong P, Cui H, Yan T, Ma Y, Cheng Y, Chen Y, Liu X, Zhang L, Cheng C, Xu E, Qian Y, Yang J, Song B, Li H, Wang F, Hu X, Liu X, Niu X, Zhai Y, Liu J, Li Y, Cheng X, Cui Y
Cell death & disease 2020 Apr 27;11(4):296
Cell death & disease 2020 Apr 27;11(4):296
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, Chen H, Xu F, Li Q, Zhao G
Theranostics 2019;9(16):4795-4810
Theranostics 2019;9(16):4795-4810
Naringin promotes osteogenic differentiation of bone marrow stromal cells by up-regulating Foxc2 expression via the IHH signaling pathway.
Lin FX, Du SX, Liu DZ, Hu QX, Yu GY, Wu CC, Zheng GZ, Xie D, Li XD, Chang B
American journal of translational research 2016;8(11):5098-5107
American journal of translational research 2016;8(11):5098-5107
STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential.
Wang P, Cheng H, Wu J, Yan A, Zhang L
Acta biochimica et biophysica Sinica 2015 Mar;47(3):214-23
Acta biochimica et biophysica Sinica 2015 Mar;47(3):214-23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FOXC2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human FOXC2. This antibody recognizes human antigen. The FOXC2 antibody has been validated for the following applications: ELISA, WB analysis.
