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- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Immunohistochemistry [1]
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- Product number
- HPA006753 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA006753, RRID:AB_1079624
- Product name
- Anti-PITRM1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human PITRM1, Gene description: pitrilysin metallopeptidase 1, Alternative Gene Names: hMP1, KIAA1104, MP1, PreP, Validated applications: WB, IHC, ICC, Uniprot ID: Q5JRX3, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.05 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients.
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Di Donfrancesco A, Berlingieri C, Giacomello M, Frascarelli C, Magalhaes Rebelo AP, Bindoff LA, Reeval S, Renbaum P, Santorelli FM, Massaro G, Viscomi C, Zeviani M, Ghezzi D, Bottani E, Brunetti D
Frontiers in pharmacology 2023;14:1220620
Frontiers in pharmacology 2023;14:1220620
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Pérez MJ, Ivanyuk D, Panagiotakopoulou V, Di Napoli G, Kalb S, Brunetti D, Al-Shaana R, Kaeser SA, Fraschka SA, Jucker M, Zeviani M, Viscomi C, Deleidi M
Molecular psychiatry 2021 Oct;26(10):5733-5750
Molecular psychiatry 2021 Oct;26(10):5733-5750
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human testis and salivary gland tissues using Anti-PITRM1 antibody. Corresponding PITRM1 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
