Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 13502-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13502-1-AP, RRID:AB_10642951
- Product name
- USP46 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP46 antibody (Cat. #13502-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain.
The Deubiquitinating Enzyme USP46 Abolishes Cell Survival of Prostate Cancer via Enhancing BECN1-Dependent Autophagy.
Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins.
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Integrated quantitative proteomics and phosphoproteomics analysis reveals USP46-POU4F1-HPSE signaling axis in the pathogenesis of Hirschsprung disease.
Ceftriaxone Modulates Ubiquitination of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptors to Improve Long-Term Potentiation Impairment Induced by Exogenous β-Amyloid in a Glutamate Transporter-1 Dependent Manner.
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma.
USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis.
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis.
Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma.
USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Murata K, Haneishi N, Nakagawa R, Daitoku Y, Mizuno S
Experimental animals 2026 Jan 1;75(1):63-72
Experimental animals 2026 Jan 1;75(1):63-72
The Deubiquitinating Enzyme USP46 Abolishes Cell Survival of Prostate Cancer via Enhancing BECN1-Dependent Autophagy.
Yang Y, Cao H, Sun P, Feng Y, Chen L, Gao R
Biotechnology and applied biochemistry 2026 Feb;73(1):231-238
Biotechnology and applied biochemistry 2026 Feb;73(1):231-238
Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins.
Yoshioka K, Nakagawa R, Nguyen CLK, Suzuki H, Ishigaki K, Mizuno S, Okiyoneda T, Ebihara S, Murata K
FEBS open bio 2025 Jan;15(1):151-164
FEBS open bio 2025 Jan;15(1):151-164
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Yang H, Wang Z, Xiong W, Zhou L, Yu S
Experimental neurology 2025 Apr;386:115175
Experimental neurology 2025 Apr;386:115175
Integrated quantitative proteomics and phosphoproteomics analysis reveals USP46-POU4F1-HPSE signaling axis in the pathogenesis of Hirschsprung disease.
Li G, Sun F, Chen J, Xu Q, Zhang X, Chen L, Hou P, Li A
Acta biochimica et biophysica Sinica 2025 Apr 18;58(2):406-420
Acta biochimica et biophysica Sinica 2025 Apr 18;58(2):406-420
Ceftriaxone Modulates Ubiquitination of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptors to Improve Long-Term Potentiation Impairment Induced by Exogenous β-Amyloid in a Glutamate Transporter-1 Dependent Manner.
Jiang R, Li L, Wang B, Liu L, Liu L, Xian X, Li W
Molecular neurobiology 2024 Sep;61(9):7181-7194
Molecular neurobiology 2024 Sep;61(9):7181-7194
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma.
Wen Y, Wang H, Yang X, Zhu Y, Li M, Ma X, Huang L, Wan R, Zhang C, Li S, Jia H, Guo Q, Lu X, Li Z, Shen X, Zhang Q, Si L, Yin C, Liu T
Nature communications 2024 Nov 21;15(1):10088
Nature communications 2024 Nov 21;15(1):10088
USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis.
Gao S, Wang Y, Xu Y, Liu L, Liu S
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167011
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167011
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E
Nature communications 2023 Oct 5;14(1):6173
Nature communications 2023 Oct 5;14(1):6173
Ubiquitin specific protease 46 potentiates triple negative breast cancer development by stabilizing PGAM1-mediated glycolysis.
Ke L, Jia Z, Gao W, Luo L
Cell biology international 2023 Jan;47(1):41-51
Cell biology international 2023 Jan;47(1):41-51
Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma.
Tian M, Zhu R, Ding F, Liu Z
Experimental cell research 2020 Oct 1;395(1):112188
Experimental cell research 2020 Oct 1;395(1):112188
USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Yu Z, Song H, Jia M, Zhang J, Wang W, Li Q, Zhang L, Zhao W
The Journal of experimental medicine 2017 Dec 4;214(12):3553-3563
The Journal of experimental medicine 2017 Dec 4;214(12):3553-3563
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human kidney tissue were subjected to SDS PAGE followed by western blot with 13502-1-AP(USP46 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP46 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP46. This antibody recognizes human,mouse,rat antigen. The USP46 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
