21179-1-AP

antibody from Proteintech Group

Targeting: CBLL1 FLJ23109, HAKAI, RNF188

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

21179-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#21179-1-AP, RRID:AB_10732814

Product name

CBLL1 antibody

Antibody type

Polyclonal

Description

KD/KO validated CBLL1 antibody (Cat. #21179-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Machine Learning and Experimental Validation of m6A RNA Methylation Related Signatures for Risk Prediction, Diagnostic Biomarkers, and Immune Subtypes in Chronic Kidney Disease.

Chen J, Wang Z, Liao Y, Ding W
Journal of inflammation research 2026;19:553934

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Chromones from Saposhnikovia divaricata modulate m(6)A RNA methylation-mediated macrophage polarization by targeting CBLL1 to ameliorate RA.

Yang X, Hao Z, Xu S, Bu G, Wang M, Sun Y, Li Y, Wang Y, Chen Q, Zhang L, Kuang H, Huang L, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158172

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Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis.

Zheng W, Fu Z, Tan X, Liang X, Cao L
Biochemical genetics 2025 Feb;63(1):433-464

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Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.

George JW, Cancino RA, Griffin Miller JL, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
Endocrinology 2024 Jul 1;165(8)

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Ethoxysanguinarine Induces Apoptosis, Inhibits Metastasis and Sensitizes cells to Docetaxel in Breast Cancer Cells through Inhibition of Hakai.

Ma L, Xuan XJ, Chen XM, Fan MH, Liu J, Huang GZ, Liu Z
Chemistry & biodiversity 2023 Feb;20(2):e202200284

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Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.

George JW, Cancino RA, Miller JLG, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
bioRxiv : the preprint server for biology 2023 Aug 9;

---

Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis.

Qiao Y, Li J, Liu D, Zhang C, Liu Y, Zheng S
Frontiers in genetics 2022;13:1072948

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Celastrol inhibits the migration and invasion and enhances the anti-cancer effects of docetaxel in human triple-negative breast cancer cells.

Liu Z, Fan M, Xuan X, Xia C, Huang G, Ma L
Medical oncology (Northwood, London, England) 2022 Sep 7;39(12):189

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Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop.

Hu C, Yang L, Wang Y, Zhou S, Luo J, Gu Y
Journal of ginseng research 2021 Nov;45(6):734-743

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E3 ubiquitin ligase Hakai regulates cell growth and invasion, and increases the chemosensitivity to cisplatin in non‑small‑cell lung cancer cells.

Liu Z, Wu Y, Tao Z, Ma L
International journal of molecular medicine 2018 Aug;42(2):1145-1151

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Hakai, an E3-ligase for E-cadherin, stabilizes δ-catenin through Src kinase.

Shrestha H, Ryu T, Seo YW, Park SY, He Y, Dai W, Park E, Simkhada S, Kim H, Lee K, Kim K
Cellular signalling 2017 Feb;31:135-145

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Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions.

Sako-Kubota K, Tanaka N, Nagae S, Meng W, Takeichi M
Molecular biology of the cell 2014 Dec 1;25(24):3851-60

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

DU 145 cells were subjected to SDS PAGE followed by western blot with 21179-1-AP(CBLL1 antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using CBLL1 antibody 21179-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human breast cancer using 21179-1-AP(CBLL1 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human breast cancer using 21179-1-AP(CBLL1 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue