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- References [37]
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- Product number
- 10473-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10473-1-AP, RRID:AB_2272754
- Product name
- USP5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP5 antibody (Cat. #10473-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.
The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1.
USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein.
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.
PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression.
The ubiquitin-specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression.
The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy.
USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.
The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.
miR-141-3p affects β-catenin signaling and apoptosis by targeting Ubtd2 in rats with anorectal malformations.
STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.
USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α.
Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1.
Ubiquitin specific peptidase 5 enhances STAT3 signaling and promotes migration and invasion in Pancreatic Cancer.
USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/β-Catenin Pathway.
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Ca(v)3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain.
Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor.
Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis.
SUMOylation regulates USP5-Cav3.2 calcium channel interactions.
Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells.
Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca(v)3.2 in mice.
Selective inhibition of Ca(V)3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain.
Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities.
Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis.
USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein.
High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Ca(v)3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells.
Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathway.
A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain.
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain.
A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.
Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks.
Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins.
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53.
Wu X, Liu H, Wang J, Zhang S, Hu Q, Wang T, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Zhao T, Wu Y, Luo J, Feng D, Guo W, Ge S, Qu Y
Cell death and differentiation 2024 Jun 20;
Cell death and differentiation 2024 Jun 20;
The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1.
Ning F, Du L, Li J, Wu T, Zhou J, Chen Z, Hu X, Zhang Y, Luan X, Xin H, Yuan C, Zhang X
Life sciences 2024 Jul 1;348:122674
Life sciences 2024 Jul 1;348:122674
USP5 facilitates bladder cancer progression by stabilizing the c-Jun protein.
Zhang HH, Zhang AQ, Peng P, Huang L, Liu CY, Nie XR, Hou DF, Zhang X, Li SZ
Cancer cell international 2024 Jan 16;24(1):32
Cancer cell international 2024 Jan 16;24(1):32
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.
Li H, Zhu X, Sun Z, Wang Q, Song S, Xu Y, He G, Mao X
ACS pharmacology & translational science 2024 Jan 12;7(1):176-185
ACS pharmacology & translational science 2024 Jan 12;7(1):176-185
PFKP deubiquitination and stabilization by USP5 activate aerobic glycolysis to promote triple-negative breast cancer progression.
Peng ZM, Han XJ, Wang T, Li JJ, Yang CX, Tou FF, Zhang Z
Breast cancer research : BCR 2024 Jan 12;26(1):10
Breast cancer research : BCR 2024 Jan 12;26(1):10
The ubiquitin-specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression.
Yan B, Guo J, Wang Z, Ning J, Wang H, Shu L, Hu K, Chen L, Shi Y, Zhang L, Liu S, Tao Y, Xiao D
MedComm 2023 Aug;4(4):e337
MedComm 2023 Aug;4(4):e337
The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy.
Pai YL, Lin YJ, Peng WH, Huang LT, Chou HY, Wang CH, Chien CT, Chen GC
Cell death & disease 2023 Aug 22;14(8):540
Cell death & disease 2023 Aug 22;14(8):540
USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.
Shi S, Pan X, Chen M, Zhang L, Zhang S, Wang X, Shi S, Chen Z, Lin W, Jiang Y
Hepatology communications 2023 Aug 1;7(8)
Hepatology communications 2023 Aug 1;7(8)
The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.
Kaokhum N, Pinto-Fernández A, Wilkinson M, Kessler BM, Ismail HM
Molecular & cellular proteomics : MCP 2022 Dec;21(12):100419
Molecular & cellular proteomics : MCP 2022 Dec;21(12):100419
miR-141-3p affects β-catenin signaling and apoptosis by targeting Ubtd2 in rats with anorectal malformations.
Wang CY, Li SY, Xiao YX, Zhen L, Wei XG, Tang XB, Yuan ZW, Bai YZ
Annals of the New York Academy of Sciences 2022 Dec;1518(1):315-327
Annals of the New York Academy of Sciences 2022 Dec;1518(1):315-327
STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.
Ohishi H, Shimada S, Uchino S, Li J, Sato Y, Shintani M, Owada H, Ohkawa Y, Pertsinidis A, Yamamoto T, Kimura H, Ochiai H
Nature communications 2022 Dec 20;13(1):7672
Nature communications 2022 Dec 20;13(1):7672
USP5 promotes breast cancer cell proliferation and metastasis by stabilizing HIF2α.
Huang W, Liu X, Zhang Y, Deng M, Li G, Chen G, Yu L, Jin L, Liu T, Wang Y, Chen Y
Journal of cellular physiology 2022 Apr;237(4):2211-2219
Journal of cellular physiology 2022 Apr;237(4):2211-2219
Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1.
Zhang Z, Cui Z, Xie Z, Li C, Xu C, Guo X, Yu J, Chen T, Facchinetti F, Bohnenberger H, Leong TL, Xie Y, Mao X, Zhao J
Translational lung cancer research 2021 Oct;10(10):3995-4011
Translational lung cancer research 2021 Oct;10(10):3995-4011
Ubiquitin specific peptidase 5 enhances STAT3 signaling and promotes migration and invasion in Pancreatic Cancer.
Lian J, Liu C, Guan X, Wang B, Yao Y, Su D, Ma Y, Fang L, Zhang Y
Journal of Cancer 2020;11(23):6802-6811
Journal of Cancer 2020;11(23):6802-6811
USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/β-Catenin Pathway.
Xue S, Wu W, Wang Z, Lu G, Sun J, Jin X, Xie L, Wang X, Tan C, Wang Z, Wang W, Ding X
Frontiers in pharmacology 2020;11:668
Frontiers in pharmacology 2020;11:668
MAFG-AS1 promotes tumor progression via regulation of the HuR/PTBP1 axis in bladder urothelial carcinoma.
Xiao M, Liu J, Xiang L, Zhao K, He D, Zeng Q, Zhang Q, Xie D, Deng M, Zhu Y, Zhang Y, Liu Y, Bo H, Liu X, Chen X, Gong L, Bao Y, Hu Y, Cheng Y, Deng L, Zhu R, Xing X, Zhou M, Xiong W, Zhou Y, Zhou J, Li X, Cao K
Clinical and translational medicine 2020 Dec;10(8):e241
Clinical and translational medicine 2020 Dec;10(8):e241
Ca(v)3.2 overexpression in L4 dorsal root ganglion neurons after L5 spinal nerve cutting involves Egr-1, USP5 and HMGB1 in rats: An emerging signaling pathway for neuropathic pain.
Tomita S, Sekiguchi F, Kasanami Y, Naoe K, Tsubota M, Wake H, Nishibori M, Kawabata A
European journal of pharmacology 2020 Dec 5;888:173587
European journal of pharmacology 2020 Dec 5;888:173587
Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor.
Xu X, Huang A, Cui X, Han K, Hou X, Wang Q, Cui L, Yang Y
Theranostics 2019;9(14):4208-4220
Theranostics 2019;9(14):4208-4220
Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis.
Chen XH, Xu YJ, Wang XG, Lin P, Cao BY, Zeng YY, Wang Q, Zhang ZB, Mao XL, Zhang T
Acta pharmacologica Sinica 2019 Dec;40(12):1568-1577
Acta pharmacologica Sinica 2019 Dec;40(12):1568-1577
SUMOylation regulates USP5-Cav3.2 calcium channel interactions.
Garcia-Caballero A, Zhang FX, Chen L, M'Dahoma S, Huang J, Zamponi GW
Molecular brain 2019 Aug 27;12(1):73
Molecular brain 2019 Aug 27;12(1):73
Ubiquitin-specific peptidase 5 and ovarian tumor deubiquitinase 6A are differentially expressed in p53+/+ and p53-/- HCT116 cells.
Kim SY, Kwon SK, Lee SY, Baek KH
International journal of oncology 2018 May;52(5):1705-1714
International journal of oncology 2018 May;52(5):1705-1714
Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Ca(v)3.2 in mice.
Ozaki T, Matsuoka J, Tsubota M, Tomita S, Sekiguchi F, Minami T, Kawabata A
Toxicology 2018 Jan 15;393:102-112
Toxicology 2018 Jan 15;393:102-112
Selective inhibition of Ca(V)3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain.
Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM
Science signaling 2018 Aug 28;11(545)
Science signaling 2018 Aug 28;11(545)
Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities.
Xie X, Matsumoto S, Endo A, Fukushima T, Kawahara H, Saeki Y, Komada M
Journal of cell science 2018 Apr 12;131(8)
Journal of cell science 2018 Apr 12;131(8)
Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis.
Wang S, Juan J, Zhang Z, Du Y, Xu Y, Tong J, Cao B, Moran MF, Zeng Y, Mao X
Cell death & disease 2017 Sep 21;8(9):e3058
Cell death & disease 2017 Sep 21;8(9):e3058
USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein.
Li XY, Wu HY, Mao XF, Jiang LX, Wang YX
Biochemical and biophysical research communications 2017 Oct 7;492(1):48-54
Biochemical and biophysical research communications 2017 Oct 7;492(1):48-54
High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Ca(v)3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells.
Fukami K, Asano E, Ueda M, Sekiguchi F, Yoshida S, Kawabata A
Journal of pharmacological sciences 2017 Jan;133(1):57-60
Journal of pharmacological sciences 2017 Jan;133(1):57-60
Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathway.
Stemkowski PL, Garcia-Caballero A, Gadotti VM, M'Dahoma S, Chen L, Souza IA, Zamponi GW
Molecular pain 2017 Jan-Dec;13:1744806917724698
Molecular pain 2017 Jan-Dec;13:1744806917724698
A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain.
Garcia-Caballero A, Gadotti VM, Chen L, Zamponi GW
Molecular pain 2016;12
Molecular pain 2016;12
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
Zhang Z, Tong J, Tang X, Juan J, Cao B, Hurren R, Chen G, Taylor P, Xu X, Shi CX, Du J, Hou J, Wang G, Wu D, Stewart AK, Schimmer AD, Moran MF, Mao X
Blood 2016 Mar 31;127(13):1676-86
Blood 2016 Mar 31;127(13):1676-86
Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.
Qian G, Ren Y, Zuo Y, Yuan Y, Zhao P, Wang X, Cheng Q, Liu J, Zhang L, Guo T, Liu C, Zheng H
Biochemical and biophysical research communications 2016 Jun 3;474(3):491-496
Biochemical and biophysical research communications 2016 Jun 3;474(3):491-496
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain.
Gadotti VM, Caballero AG, Berger ND, Gladding CM, Chen L, Pfeifer TA, Zamponi GW
Molecular pain 2015 Mar 14;11:12
Molecular pain 2015 Mar 14;11:12
A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.
Song AX, Yang H, Gao YG, Zhou CJ, Zhang YH, Hu HY
PloS one 2014;9(9):e107509
PloS one 2014;9(9):e107509
Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks.
Nakajima S, Lan L, Wei L, Hsieh CL, Rapić-Otrin V, Yasui A, Levine AS
PloS one 2014;9(1):e84899
PloS one 2014;9(1):e84899
Selenoprotein S is involved in maintenance and transport of multiprotein complexes.
Turanov AA, Shchedrina VA, Everley RA, Lobanov AV, Yim SH, Marino SM, Gygi SP, Hatfield DL, Gladyshev VN
The Biochemical journal 2014 Sep 15;462(3):555-65
The Biochemical journal 2014 Sep 15;462(3):555-65
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins.
Besche HC, Haas W, Gygi SP, Goldberg AL
Biochemistry 2009 Mar 24;48(11):2538-49
Biochemistry 2009 Mar 24;48(11):2538-49
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53.
Dayal S, Sparks A, Jacob J, Allende-Vega N, Lane DP, Saville MK
The Journal of biological chemistry 2009 Feb 20;284(8):5030-41
The Journal of biological chemistry 2009 Feb 20;284(8):5030-41
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP5. This antibody recognizes human, mouse, rat antigen. The USP5 antibody has been validated for the following applications: ELISA, WB analysis.
