Ab131386

antibody from Aladdin Scientific
Targeting: RUVBL1 ECP54, INO80H, NMP238, Pontin52, RVB1, TIH1, TIP49, TIP49a
Provider product page for Ab131386

Antibody data

Product number
Ab131386 - Provider product page
Provider
Aladdin Scientific
Product name
TIP49A Antibody
Antibody type
Polyclonal
Description
Rabbit anti Human TIP49A Antibody, Polyclonal, could be used for WB, IHC and so on.Application:WB: 1/500-1/1000IHC: 1/50-1/100 Protein FunctionPossesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 57-345
Vial size
100_l,10_l,1ml,50_l
Concentration
1,14 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
RUVBL1 protein structure - Ab131386 shown in red.