orb150857

antibody from Biorbyt
Targeting: NRCAM Bravo, KIAA0343
Provider product page for orb150857
Western blot
Immunocytochemistry

Antibody data

Product number
orb150857 - Provider product page
Provider
Biorbyt
Product name
NrCAM antibody
Antibody type
Monoclonal
Description
Mouse monoclonal to NrCAM (ATTO-390). Neuronal cell adhesion molecule (NrCAM) is a cell surface protein of the immunoglobulin (Ig) superfamily. NrCAM (also known as Bravo) contains six Ig domains, five fibronectin repeats, a transmembrane region and an intracellular domain. NrCAM is expressed in brain, spinal cord, peripheral nervous system and pancreas. In the spinal cord, NrCAM acts as a ligand for axonin-1 to guide commissural axons across the floor plate. NrCAM also acts as a ligand for F3 to control actin-dependent growth cone motility. NrCAM interacts with neurofascin and may facilitate the clustering of the cystoskeletal protein ankyrin G and the voltage-dependent sodium channel proteins at the node of Ranvier. NrCAM expression may play a role in the severity of certain types of tumors. NrCAM is overexpressed in high-grade astrocytomas, gliomas and glioblastoma tumor tissues. In the pancreas, NrCAM expression is upregulated in intraductal hyperplasia. Antisense NrCAM reduces the tumorigenic properties of human glioblastoma cells in vitro and slowed tumor growth in vivo. The gene encoding human NrCAM maps to chromosome 7q31. 1-q31. 2.
Reactivity
Human, Mouse, Rat
Host
Mouse
Isotype
IgG
Antibody clone number
S364-51
Vial size
100 ug
Concentration
1 mg/ml
Storage
Conjugated antibodies should be stored at 4°C
NRCAM protein structure - orb150857 shown in red.