Antibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 14354-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14354-1-AP, RRID:AB_2257148
- Product name
- USP15 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP15 antibody (Cat. #14354-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references IL-22-Induced Ubiquitin-Specific Protease 15 Promotes Proliferation and Inflammation of Keratinocytes through Stabilization of Squamous Cell Carcinoma Antigen 2.
miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15.
K48-linked deubiquitination of VGLL4 by USP15 enhances the efficacy of tumor immunotherapy in triple-negative breast cancer.
USP8 inhibition regulates autophagy flux and controls Salmonella infection.
miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease.
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia.
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
USP15 Enhances Re-epithelialization Through Deubiquitinating EIF4A1 During Cutaneous Wound Repair.
LncRNA 2810403D21Rik/Mirf promotes ischemic myocardial injury by regulating autophagy through targeting Mir26a.
Overexpression of Ubiquitin-Specific Protease15 (USP15) Promotes Tumor Growth and Inhibits Apoptosis and Correlated With Poor Disease-Free Survival in Hepatocellular Carcinoma.
TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
Ubiquitin-Specific Protease 15 Maintains Transforming Growth Factor-β Pathway Activity by Deubiquitinating Transforming Growth Factor-β Receptor I during Wound Healing.
Use of focused ultrasonication in activity-based profiling of deubiquitinating enzymes in tissue.
USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.
Chen F, Wu S, Zhan J, Jin Y, Xuan X, Cao J, Wu T, Liang Y, Zhao X, Li Z, Wang Y, Chen L, Li Y, El Ghalbzouri A, Huang C
The Journal of investigative dermatology 2024 Jan;144(1):63-72.e4
The Journal of investigative dermatology 2024 Jan;144(1):63-72.e4
miR-26a exerts broad-spectrum antiviral effects via the enhancement of RIG-I-mediated type I interferon response by targeting USP15.
Zhang J, Li C, Hou Y, Liu D, Li Q, Wang Z, Tang R, Zheng K, Guo H, Wang W
Microbiology spectrum 2024 Jan 11;12(1):e0312423
Microbiology spectrum 2024 Jan 11;12(1):e0312423
K48-linked deubiquitination of VGLL4 by USP15 enhances the efficacy of tumor immunotherapy in triple-negative breast cancer.
Wang X, Deng X, Hu J, Zheng W, Ye D, Zhou X, Fang L
Cancer letters 2024 Apr 28;588:216764
Cancer letters 2024 Apr 28;588:216764
USP8 inhibition regulates autophagy flux and controls Salmonella infection.
Santelices J, Ou M, Maegawa GHB, Hercik K, Edelmann MJ
Frontiers in cellular and infection microbiology 2023;13:1070271
Frontiers in cellular and infection microbiology 2023;13:1070271
miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease.
Chan SC, Tung CW, Lin CW, Tung YS, Wu PM, Cheng PH, Chen CM, Yang SH
Free radical biology & medicine 2023 Nov 20;209(Pt 2):292-300
Free radical biology & medicine 2023 Nov 20;209(Pt 2):292-300
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, Lee YR, Wei W, Freeman GJ, Xie C, Zhang J
Nature communications 2023 May 19;14(1):2859
Nature communications 2023 May 19;14(1):2859
USP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion.
Tian X, Zhao Y, Yang Z, Lu Q, Zhou L, Zheng S
Cell death & disease 2022 Sep 26;13(9):823
Cell death & disease 2022 Sep 26;13(9):823
The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia.
Niederkorn M, Ishikawa C, M Hueneman K, Bartram J, Stepanchick E, R Bennett J, E Culver-Cochran A, Bolanos LC, Uible E, Choi K, Wunderlich M, Perentesis JP, M Chlon T, Filippi MD, Starczynowski DT
Leukemia 2022 Feb;36(2):438-451
Leukemia 2022 Feb;36(2):438-451
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Zhang L, Gao X, Qin Z, Shi X, Xu K, Wang S, Tang M, Wang W, Gao S, Zuo L, Zhang L, Zhang W
The Science of the total environment 2021 Aug 20;783:146898
The Science of the total environment 2021 Aug 20;783:146898
USP15 Enhances Re-epithelialization Through Deubiquitinating EIF4A1 During Cutaneous Wound Repair.
Zhao Y, Huang X, Zhang Z, Zhang Y, Zhang G, Zan T, Li Q
Frontiers in cell and developmental biology 2020;8:529
Frontiers in cell and developmental biology 2020;8:529
LncRNA 2810403D21Rik/Mirf promotes ischemic myocardial injury by regulating autophagy through targeting Mir26a.
Liang H, Su X, Wu Q, Shan H, Lv L, Yu T, Zhao X, Sun J, Yang R, Zhang L, Yan H, Zhou Y, Li X, Du Z, Shan H
Autophagy 2020 Jun;16(6):1077-1091
Autophagy 2020 Jun;16(6):1077-1091
Overexpression of Ubiquitin-Specific Protease15 (USP15) Promotes Tumor Growth and Inhibits Apoptosis and Correlated With Poor Disease-Free Survival in Hepatocellular Carcinoma.
Yao XQ, Li L, Piao LZ, Zhang GJ, Huang XZ, Wang Y, Liang ZL
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820967455
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820967455
TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.
Niederkorn M, Hueneman K, Choi K, Varney ME, Romano L, Pujato MA, Greis KD, Inoue JI, Meetei R, Starczynowski DT
Cell reports 2020 Feb 25;30(8):2776-2790.e6
Cell reports 2020 Feb 25;30(8):2776-2790.e6
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
Nordgren KKS, Wallace KB
Cardiovascular toxicology 2020 Dec;20(6):557-570
Cardiovascular toxicology 2020 Dec;20(6):557-570
Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.
Chen X, Bao G, Liu F
Cellular and molecular neurobiology 2020 Aug;40(6):999-1010
Cellular and molecular neurobiology 2020 Aug;40(6):999-1010
USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, Li Y, Balajee AS, Zhao Y
Autophagy 2020 Apr;16(4):724-734
Autophagy 2020 Apr;16(4):724-734
Ubiquitin-Specific Protease 15 Maintains Transforming Growth Factor-β Pathway Activity by Deubiquitinating Transforming Growth Factor-β Receptor I during Wound Healing.
Zhao Y, Wang Z, Ho C, Zhang G, Li Q
The American journal of pathology 2019 Jul;189(7):1351-1362
The American journal of pathology 2019 Jul;189(7):1351-1362
Use of focused ultrasonication in activity-based profiling of deubiquitinating enzymes in tissue.
Nanduri B, Shack LA, Rai AN, Epperson WB, Baumgartner W, Schmidt TB, Edelmann MJ
Analytical biochemistry 2016 Dec 15;515:9-13
Analytical biochemistry 2016 Dec 15;515:9-13
USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.
Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC
Nature immunology 2014 Jun;15(6):562-70
Nature immunology 2014 Jun;15(6):562-70
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The USP15 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP15. This antibody recognizes human,mouse,rat antigen. The USP15 antibody has been validated for the following applications: ELISA, WB analysis.