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- Antibody Data
- Antigen structure
- References [12]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- 10881-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10881-1-AP, RRID:AB_2175066
- Product name
- PTGES2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PTGES2 antibody (Cat. #10881-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibiting cholesterol de novo synthesis promotes hepatocellular carcinoma progression by upregulating prostaglandin E synthase 2-mediated arachidonic acid metabolism under high fatty acid conditions.
Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3.
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.
Intracellular AGR2 transduces PGE2 stimuli to promote epithelial-mesenchymal transition and metastasis of colorectal cancer.
Elevated β-secretase 1 expression mediates CD4(+) T cell dysfunction via PGE2 signalling in Alzheimer's disease.
Curc-mPEG454, a PEGylated curcumin derivative, as a multi-target anti-fibrotic prodrug.
Prostaglandin E(2) increases the expression of cyclooxygenase-2 in cultured rat microglia.
Cyclooxygenase-2 is acutely induced by CCAAT/enhancer-binding protein β to produce prostaglandin E (2) and F (2α) following gonadotropin stimulation in Leydig cells.
Prostaglandin E2 triggers cytochrome P450 17α hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.
Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E(2) alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field.
Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.
Effect of propofol on prostaglandin E2 production and prostaglandin synthase-2 and cyclooxygenase-2 expressions in amniotic membrane cells.
Zhao Z, Liu X, Xiang Y, Hou Z, He K, Zhong G, Hu J, Cai D, Liu Y, Ren J, Gong J, Zhao L
Cancer science 2024 Feb;115(2):477-489
Cancer science 2024 Feb;115(2):477-489
Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3.
Ji Y, Lin J, Liu R, Wang K, Chang M, Gao Z, Liu B, Shen Y, Zhu J, Yao X, Qi L, Sun H
Inflammopharmacology 2024 Apr;32(2):1633-1646
Inflammopharmacology 2024 Apr;32(2):1633-1646
Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.
Zhong D, Chen J, Qiao R, Song C, Hao C, Zou Y, Bai M, Su W, Yang B, Sun D, Jia Z, Sun Y
Cell reports 2024 Apr 23;43(4):114075
Cell reports 2024 Apr 23;43(4):114075
Intracellular AGR2 transduces PGE2 stimuli to promote epithelial-mesenchymal transition and metastasis of colorectal cancer.
Zhang H, Chi J, Hu J, Ji T, Luo Z, Zhou C, Huang L, Dai Z, Li J, Wang G, Wang L, Wang Z
Cancer letters 2021 Oct 10;518:180-195
Cancer letters 2021 Oct 10;518:180-195
Elevated β-secretase 1 expression mediates CD4(+) T cell dysfunction via PGE2 signalling in Alzheimer's disease.
Dai L, Wang Q, Lv X, Gao F, Chen Z, Shen Y
Brain, behavior, and immunity 2021 Nov;98:337-348
Brain, behavior, and immunity 2021 Nov;98:337-348
Curc-mPEG454, a PEGylated curcumin derivative, as a multi-target anti-fibrotic prodrug.
Xiao S, Deng Y, Shen N, Sun Y, Tang H, Hu P, Ren H, Peng M
International immunopharmacology 2021 Dec;101(Pt A):108166
International immunopharmacology 2021 Dec;101(Pt A):108166
Prostaglandin E(2) increases the expression of cyclooxygenase-2 in cultured rat microglia.
Nagano T, Tsuda N, Fujimura K, Ikezawa Y, Higashi Y, Kimura SH
Journal of neuroimmunology 2021 Dec 15;361:577724
Journal of neuroimmunology 2021 Dec 15;361:577724
Cyclooxygenase-2 is acutely induced by CCAAT/enhancer-binding protein β to produce prostaglandin E (2) and F (2α) following gonadotropin stimulation in Leydig cells.
Yazawa T, Imamichi Y, Yuhki KI, Uwada J, Mikami D, Shimada M, Miyamoto K, Kitano T, Takahashi S, Sekiguchi T, Suzuki N, Rafiqul Islam Khan M, Ushikubi F, Umezawa A, Taniguchi T
Molecular reproduction and development 2019 Jul;86(7):786-797
Molecular reproduction and development 2019 Jul;86(7):786-797
Prostaglandin E2 triggers cytochrome P450 17α hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.
Ke J, Shen Z, Li M, Peng C, Xu P, Wang M, Zhu Y, Zhang X, Wu D
Oncology letters 2018 Oct;16(4):4577-4585
Oncology letters 2018 Oct;16(4):4577-4585
Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E(2) alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field.
Sun Y, Shi Z, Wang Y, Tang C, Liao Y, Yang C, Cai P
International journal of radiation biology 2018 Dec;94(12):1159-1166
International journal of radiation biology 2018 Dec;94(12):1159-1166
Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.
Ke J, Yang Y, Che Q, Jiang F, Wang H, Chen Z, Zhu M, Tong H, Zhang H, Yan X, Wang X, Wang F, Liu Y, Dai C, Wan X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Sep;37(9):12203-12211
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Sep;37(9):12203-12211
Effect of propofol on prostaglandin E2 production and prostaglandin synthase-2 and cyclooxygenase-2 expressions in amniotic membrane cells.
Kim JD, Ahn BM, Joo BS, Kwon JY, Chung HJ, Yu SB
Journal of anesthesia 2014 Dec;28(6):911-8
Journal of anesthesia 2014 Dec;28(6):911-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10881-1-AP( PTGES2 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using PTGES2 antibody 10881-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10881-1-AP(PTGES2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
