10881-1-AP

antibody from Proteintech Group

Targeting: PTGES2 C9orf15, FLJ14038

Provider product page for 10881-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 10881-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10881-1-AP, RRID:AB_2175066
Product name: PTGES2 antibody
Antibody type: Polyclonal
Description: KD/KO validated PTGES2 antibody (Cat. #10881-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PTGES2 protein structure - 10881-1-AP shown in red.

Submitted references Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease.

Zhong DD, Hu C, Zhao LL, Shen Y, Zhang RM, Liu Y, Liu BH, Su W, Yang BX, Xiong H, Guo D, Sun D, Zou YY, Sun Y
Acta pharmacologica Sinica 2026 Mar;47(3):689-700

Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2-Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging.

Zhang S, Qi J, Liu C, Zhang H, Guo B, Wu D, Liu Y, Zhen X, Zhang Y, Kang N, Zhou J, Yan G, Li C, Ding L, Sun H
Aging cell 2026 Feb;25(2):e70374

The effect of travoprost on primary human limbal epithelial cells and the siRNA-based aniridia limbal epithelial cell model, in vitro.

Li S, Stachon T, Liu S, Li Z, Hsu SL, Kundu S, Fries FN, Seitz B, Amini M, Suiwal S, Szentmáry N
PloS one 2025;20(8):e0330492

Increased sensitivity of primary aniridia limbal stromal cells to travoprost, leading to elevated migration and MMP-9 protein levels, in vitro.

Li S, Stachon T, Liu S, Li Z, Hsu SL, Kundu S, Fries FN, Seitz B, Amini M, Suiwal S, Szentmáry N
PloS one 2025;20(6):e0326967

Comprehensive analysis of metabolic patterns in renal cell carcinoma: implications for prognosis and treatment.

Wang Y, Li P, Feng T, Chen Y, Liu W, Ge Q, Zhang Q
Frontiers in immunology 2025;16:1630053

Coactosin-Like Protein Reduces Prostaglandin D(2) Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation.

Pan LL, Ren Z, Li B, Liang W, Luo Y, Yang Q, Liu H, Dong X, Tian H, Zou H, Samuelsson B, Rådmark O, Sun J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e01673

Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion.

Xu C, Luo Y, Cai Z, Ji J, Guo Z, Cai Z, You C, Zhou Y, Chen Z, Zhang W, Gong N, Wang J
Bioactive materials 2025 Oct;52:474-491

Progressively Diminished Prostaglandin E2 Signaling in Concordance with Increasing Fibrosis in Ectopic Endometrium.

Yi Y, Nie J, Liu X, Guo SW
Reproductive sciences (Thousand Oaks, Calif.) 2025 Apr;32(4):1271-1286

Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems.

Deng C, Lu C, Wang K, Chang M, Shen Y, Yang X, Sun H, Yao X, Qiu C, Xu F
Frontiers in pharmacology 2024;15:1344276

m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.

Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN
Cell metabolism 2024 Oct 1;36(10):2207-2227.e9

Inhibiting cholesterol de novo synthesis promotes hepatocellular carcinoma progression by upregulating prostaglandin E synthase 2-mediated arachidonic acid metabolism under high fatty acid conditions.

Zhao Z, Liu X, Xiang Y, Hou Z, He K, Zhong G, Hu J, Cai D, Liu Y, Ren J, Gong J, Zhao L
Cancer science 2024 Feb;115(2):477-489

Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3.

Ji Y, Lin J, Liu R, Wang K, Chang M, Gao Z, Liu B, Shen Y, Zhu J, Yao X, Qi L, Sun H
Inflammopharmacology 2024 Apr;32(2):1633-1646

Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling.

Zhong D, Chen J, Qiao R, Song C, Hao C, Zou Y, Bai M, Su W, Yang B, Sun D, Jia Z, Sun Y
Cell reports 2024 Apr 23;43(4):114075

Intracellular AGR2 transduces PGE2 stimuli to promote epithelial-mesenchymal transition and metastasis of colorectal cancer.

Zhang H, Chi J, Hu J, Ji T, Luo Z, Zhou C, Huang L, Dai Z, Li J, Wang G, Wang L, Wang Z
Cancer letters 2021 Oct 10;518:180-195

Elevated β-secretase 1 expression mediates CD4(+) T cell dysfunction via PGE2 signalling in Alzheimer's disease.

Dai L, Wang Q, Lv X, Gao F, Chen Z, Shen Y
Brain, behavior, and immunity 2021 Nov;98:337-348

Curc-mPEG454, a PEGylated curcumin derivative, as a multi-target anti-fibrotic prodrug.

Xiao S, Deng Y, Shen N, Sun Y, Tang H, Hu P, Ren H, Peng M
International immunopharmacology 2021 Dec;101(Pt A):108166

Prostaglandin E(2) increases the expression of cyclooxygenase-2 in cultured rat microglia.

Nagano T, Tsuda N, Fujimura K, Ikezawa Y, Higashi Y, Kimura SH
Journal of neuroimmunology 2021 Dec 15;361:577724

Cyclooxygenase-2 is acutely induced by CCAAT/enhancer-binding protein β to produce prostaglandin E (2) and F (2α) following gonadotropin stimulation in Leydig cells.

Yazawa T, Imamichi Y, Yuhki KI, Uwada J, Mikami D, Shimada M, Miyamoto K, Kitano T, Takahashi S, Sekiguchi T, Suzuki N, Rafiqul Islam Khan M, Ushikubi F, Umezawa A, Taniguchi T
Molecular reproduction and development 2019 Jul;86(7):786-797

Prostaglandin E2 triggers cytochrome P450 17α hydroxylase overexpression via signal transducer and activator of transcription 3 phosphorylation and promotes invasion in endometrial cancer.

Ke J, Shen Z, Li M, Peng C, Xu P, Wang M, Zhu Y, Zhang X, Wu D
Oncology letters 2018 Oct;16(4):4577-4585

Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E(2) alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field.

Sun Y, Shi Z, Wang Y, Tang C, Liao Y, Yang C, Cai P
International journal of radiation biology 2018 Dec;94(12):1159-1166

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.

Ke J, Yang Y, Che Q, Jiang F, Wang H, Chen Z, Zhu M, Tong H, Zhang H, Yan X, Wang X, Wang F, Liu Y, Dai C, Wan X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Sep;37(9):12203-12211

Effect of propofol on prostaglandin E2 production and prostaglandin synthase-2 and cyclooxygenase-2 expressions in amniotic membrane cells.

Kim JD, Ahn BM, Joo BS, Kwon JY, Chung HJ, Yu SB
Journal of anesthesia 2014 Dec;28(6):911-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 10881-1-AP( PTGES2 Antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using PTGES2 antibody 10881-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 10881-1-AP(PTGES2 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue