CABT-L952

antibody from Creative Diagnostics

Targeting: PML MYL, RNF71, TRIM19

No application information provided.

Antibody Data

Product number

CABT-L952

Provider

Creative Diagnostics

Product name

Mouse Anti-Human PML (aa 411-510) monoclonal antibody

Antibody type

Monoclonal

Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions