BS8521

antibody from Bioworld Technology, Inc
Targeting: GRK6 GPRK6
Provider product page for BS8521
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8521 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GRK6 polyclonal antibody
Antibody type
Polyclonal
Antigen
G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; GRK6; GPRK6;
Description
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of ÉÇ-adrenergic receptor kinase, GRK 2 (ÉÇARK, ÉÇARK1) and GRK 3 (ÉÇARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GRK6 protein structure - BS8521 shown in red.