HPA027104

antibody from Atlas Antibodies

Targeting: ADPRS ADPRHL2, ARH3, FLJ20446

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA027104

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA027104, RRID:AB_10601330

Product name

Anti-ADPRHL2

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human ADPRHL2, Gene description: ADP-ribosylhydrolase like 2, Alternative Gene Names: ARH3, FLJ20446, Validated applications: IHC, ICC, Uniprot ID: Q9NX46, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.3 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions

Zentout S, Imburchia V, Chapuis C, Duma L, Schützenhofer K, Prokhorova E, Ahel I, Smith R, Huet S
Proceedings of the National Academy of Sciences 2024;121(25)

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Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J
2024

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The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome.

Hendriks IA, Buch-Larsen SC, Prokhorova E, Elsborg JD, Rebak AKLFS, Zhu K, Ahel D, Lukas C, Ahel I, Nielsen ML
Nature communications 2021 Oct 8;12(1):5893

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Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Prokhorova E, Zobel F, Smith R, Zentout S, Gibbs-Seymour I, Schützenhofer K, Peters A, Groslambert J, Zorzini V, Agnew T, Brognard J, Nielsen ML, Ahel D, Huet S, Suskiewicz MJ, Ahel I
Nature communications 2021 Jul 1;12(1):4055

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Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Hanzlikova H, Prokhorova E, Krejcikova K, Cihlarova Z, Kalasova I, Kubovciak J, Sachova J, Hailstone R, Brazina J, Ghosh S, Cirak S, Gleeson J, Ahel I, Caldecott K
Nature Communications 2020;11(1)

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Interplay of Histone Marks with Serine ADP-Ribosylation.

Bartlett E, Bonfiglio JJ, Prokhorova E, Colby T, Zobel F, Ahel I, Matic I
Cell reports 2018 Sep 25;24(13):3488-3502.e5

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Serine is the major residue for ADP-ribosylation upon DNA damage.

Palazzo L, Leidecker O, Prokhorova E, Dauben H, Matic I, Ahel I
eLife 2018 Feb 26;7

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Serine ADP-ribosylation reversal by the hydrolase ARH3.

Fontana P, Bonfiglio JJ, Palazzo L, Bartlett E, Matic I, Ahel I
eLife 2017 Jun 26;6