23306-1-AP

antibody from Proteintech Group

Targeting: WWTR1 DKFZp586I1419, TAZ

Provider product page for 23306-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [49]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 23306-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#23306-1-AP, RRID:AB_2721185
Product name: WWTR1 antibody
Antibody type: Polyclonal
Description: KD/KO validated WWTR1 antibody (Cat. #23306-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

WWTR1 protein structure - 23306-1-AP shown in red.

Submitted references Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling.

Liang P, Xie W, Wang X, Du Z, Zheng C, Zhao H, Wang Z, Ji Z
International immunopharmacology 2024 May 10;132:111900

NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization.

Zou S, Huang Y, Yang Z, Zhang J, Meng M, Zhang Y, Feng J, Sun R, Li W, Wang W, López JG, Fang L
Clinical and translational medicine 2024 Mar;14(3):e1621

LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway.

Zhang R, Zhan Y, Lang Z, Li Y, Zhang W, Zheng J
Communications biology 2024 Mar 4;7(1):266

Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation.

Yang F, Wang P, Dong X, Dai W, Chen W, Yuan G, Bai D, Xu H
Oral diseases 2024 Jul;30(5):3308-3320

YAP and TAZ regulate remyelination in the central nervous system.

Hong J, Kirkland JM, Acheta J, Marziali LN, Beck B, Jeanette H, Bhatia U, Davis G, Herron J, Roué C, Abi-Ghanem C, Feltri ML, Zuloaga KL, Bechler ME, Poitelon Y, Belin S
Glia 2024 Jan;72(1):156-166

Activating transcriptional coactivator with PDZ-binding motif by (R)-PFI-2 attenuates osteoclastogenesis and prevents ovariectomized-induced osteoporosis.

Xu R, Liu X, Zhang Y, Wang K, Chen Z, Zheng J, Zhang T, Tong P, Qian Y, Yang W
Biochemical pharmacology 2024 Jan;219:115964

TGFβ and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas.

Nipper M, Xu Y, Liu J, Yin X, Liu Z, Ye Z, Zhang J, Chen Y, Wang P
Cells 2024 Jan 18;13(2)

Transcriptomics analysis revealed that TAZ regulates the proliferation of KIRC cells through mitophagy.

He Z, Shi J, Zhu B, Tian Z, Zhang Z
BMC cancer 2024 Feb 19;24(1):229

DNMT3A Cooperates with YAP/TAZ to Drive Gallbladder Cancer Metastasis.

Xu S, Yuan Z, Jiang C, Chen W, Li Q, Chen T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(16):e2308531

LncRNA PVT1 promotes strong stemness and endothelial progenitor cell characteristics in renal carcinoma stem cells.

Wang L, Yang G, Guo P, Lv Y, Fu B, Bai Y, Xiong F, Zhao D, Li C, Zhang J, Bai S, Zeng F, Xu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23118

Identification of ALG3 as a potential prognostic biomarker in lung adenocarcinoma.

Yuan Y, Xie B, Guo D, Liu C, Jiang G, Lai G, Zhang Y, Hu X, Wu Z, Zheng R, Huang L
Heliyon 2023 Jul;9(7):e18065

Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis.

Yang X, Ou Y, Yang Y, Wang L, Zhang Y, Zhao F, Shui P, Qing J
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(14):1242-1253

PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling.

Chen H, Yang W, Li Y, Ji Z
Cell death & disease 2023 Jul 15;14(7):433

USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner.

Wu Z, Zhu L, Nie X, Wei L, Qi Y
Experimental & molecular medicine 2023 Jan;55(1):183-195

TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma.

Wang YQ, Wu DH, Wei D, Shen JY, Huang ZW, Liang XY, Cho WCS, Ma J, Lv J, Chen YP
Science advances 2023 Jan 6;9(1):eadd0960

Proteomic analysis reveals the aging-related pathways contribute to pulmonary fibrogenesis.

Zhang T, Yuan X, Jiang M, Liu B, Zhai N, Zhang Q, Song X, Lv C, Zhang J, Li H
Aging 2023 Dec 22;15(24):15382-15401

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA).

Sveiven SN, Anesko K, Morgan J, Nair MG, Nordgren TM
International journal of molecular sciences 2023 Apr 11;24(8)

The Hippo Pathway Effector Transcriptional Co-activator With PDZ-Binding Motif Correlates With Clinical Prognosis and Immune Infiltration in Colorectal Cancer.

Wang Y, Nie H, Li H, Liao Z, Yang X, He X, Ma J, Zhou J, Ou C
Frontiers in medicine 2022;9:888093

A positive feedback loop of the TAZ/β-catenin axis promotes Helicobacter pylori-associated gastric carcinogenesis.

Xu X, Shu C, Wu X, Ouyang Y, Cheng H, Zhou Y, Wang H, He C, Xie C, He X, Hong J, Lu N, Ge Z, Zhu Y, Li N
Frontiers in microbiology 2022;13:1065462

Mesenchymal Stem Cells Inhibits Migration and Vasculogenic Mimicry in Nasopharyngeal Carcinoma Via Exosomal MiR-125a.

Wan F, Zhang H, Hu J, Chen L, Geng S, Kong L, Lu JJ
Frontiers in oncology 2022;12:781979

Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway.

Ning S, Chen Y, Wang G, Liu Y, Yang Y, Zhang Z
Frontiers in oncology 2022;12:1031160

Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis.

Wang L, Zhang Y, Ren Y, Yang X, Ben H, Zhao F, Yang S, Wang L, Qing J
European journal of pharmacology 2022 Oct 15;932:175241

PSMA1 mediates tumor progression and poor prognosis of gastric carcinoma by deubiquitinating and stabilizing TAZ.

Yang Q, Lu Y, Shangguan J, Shu X
Cell death & disease 2022 Nov 23;13(11):989

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Ferrand N, Fert A, Morichon R, Radosevic-Robin N, Zaoui M, Sabbah M
Cancers 2022 Mar 14;14(6)

The proteasome-dependent degradation of ALKBH5 regulates ECM deposition in PM(2.5) exposure-induced pulmonary fibrosis of mice.

Zhang Y, Liu Q, Ning J, Jiang T, Kang A, Li L, Pang Y, Zhang B, Huang X, Wang Q, Bao L, Niu Y, Zhang R
Journal of hazardous materials 2022 Jun 15;432:128655

DEPTOR exacerbates bone-fat imbalance in osteoporosis by transcriptionally modulating BMSC differentiation.

Ouyang Z, Kang D, Li K, Liang G, Liu Z, Mai Q, Chen Q, Yao C, Wei R, Tan X, Bai X, Huang B, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113164

Piezo channels contribute to the regulation of myelination in Schwann cells.

Acheta J, Bhatia U, Haley J, Hong J, Rich K, Close R, Bechler ME, Belin S, Poitelon Y
Glia 2022 Dec;70(12):2276-2289

Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway.

Liu H, Zhang S, Liu Y, Ma J, Chen W, Yin T, Li T, Liang B, Tao L
Respiratory research 2022 Aug 19;23(1):209

USP26 promotes anaplastic thyroid cancer progression by stabilizing TAZ.

Tang J, Luo Y, Xiao L
Cell death & disease 2022 Apr 9;13(4):326

Traditional Chinese medicine Yiqi Huoxue recipe attenuates hepatic fibrosis via YAP/TAZ signaling.

Zhao W, Zhang X, Hou M, Zhang Y, Tang Y, Li L, Dong S, Liu L, Zhao D, Li W, Nan Y
Histology and histopathology 2021 Sep;36(9):967-979

YAP drives fate conversion and chemoresistance of small cell lung cancer.

Wu Q, Guo J, Liu Y, Zheng Q, Li X, Wu C, Fang D, Chen X, Ma L, Xu P, Xu X, Liao C, Wu M, Shen L, Song H
Science advances 2021 Oct;7(40):eabg1850

CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.

Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y
The Journal of biological chemistry 2021 Jul;297(1):100803

TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling.

Yang W, Lu X, Zhang T, Han W, Li J, He W, Jia Y, Zhao K, Qin A, Qian Y
Bone research 2021 Jul 12;9(1):33

Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.

Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022

The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.

Liu T, Yang Y, Xie Z, Luo Q, Yang D, Liu X, Zhao H, Wei Q, Liu Y, Li L, Wang Y, Wang F, Yu J, Xu J, Yu J, Yi P
Molecular therapy. Nucleic acids 2021 Dec 3;26:388-400

YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration.

Jeanette H, Marziali LN, Bhatia U, Hellman A, Herron J, Kopec AM, Feltri ML, Poitelon Y, Belin S
Glia 2021 Apr;69(4):1061-1074

The lncRNA BCYRN1 Functions as an Oncogene in Human Glioma by Downregulating miR-125a-5p in vitro.

Yu W, Xiang D, Jia H, He X, Sheng J, Long Y, Zhu S, Wang K, Liu Q
Cancer management and research 2020;12:1151-1161

MiR-34a-5p Inhibits Proliferation, Migration, Invasion and Epithelial-mesenchymal Transition in Esophageal Squamous Cell Carcinoma by Targeting LEF1 and Inactivation of the Hippo-YAP1/TAZ Signaling Pathway.

Wang X, Zhao Y, Lu Q, Fei X, Lu C, Li C, Chen H
Journal of Cancer 2020;11(10):3072-3081

YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.

Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J
Cell reports 2020 Sep 8;32(10):108120

A Division of Labor between YAP and TAZ in Non-Small Cell Lung Cancer.

Shreberk-Shaked M, Dassa B, Sinha S, Di Agostino S, Azuri I, Mukherjee S, Aylon Y, Blandino G, Ruppin E, Oren M
Cancer research 2020 Oct 1;80(19):4145-4157

Eva-1 homolog A promotes papillary thyroid cancer progression and epithelial-mesenchymal transition via the Hippo signalling pathway.

Lin BY, Wen JL, Zheng C, Lin LZ, Chen CZ, Qu JM
Journal of cellular and molecular medicine 2020 Nov;24(22):13070-13080

Vitamin D3 analogue facilitates epithelial wound healing through promoting epithelial-mesenchymal transition via the Hippo pathway.

Wang D, Lin L, Lei K, Zeng J, Luo J, Yin Y, Li Y, Zhang L, Nie X, Zuo D, Sun L
Journal of dermatological science 2020 Nov;100(2):120-128

TRIB3 confers radiotherapy resistance in esophageal squamous cell carcinoma by stabilizing TAZ.

Zhou S, Liu S, Lin C, Li Y, Ye L, Wu X, Jian Y, Dai Y, Ouyang Y, Zhao L, Liu M, Song L, Xi M
Oncogene 2020 Apr;39(18):3710-3725

Jiedu Sangen Decoction Inhibits the Invasion and Metastasis of Colorectal Cancer Cells by Regulating EMT through the Hippo Signaling Pathway.

Yuan L, Zhou M, Wasan HS, Zhang K, Li Z, Guo K, Shen F, Shen M, Ruan S
Evidence-based complementary and alternative medicine : eCAM 2019;2019:1431726

miR-125 inhibits colorectal cancer proliferation and invasion by targeting TAZ.

Yang M, Tang X, Wang Z, Wu X, Tang D, Wang D
Bioscience reports 2019 Dec 20;39(12)

MicroRNA-144 inhibits proliferation by targeting WW domain-containing transcription regulator protein 1 in papillary thyroid cancer.

Sun W, Lan X, Wang Z, Dong W, He L, Zhang T, Zhang P, Zhang H
Oncology letters 2018 Jan;15(1):1007-1013

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Wu LMN, Deng Y, Wang J, Zhao C, Wang J, Rao R, Xu L, Zhou W, Choi K, Rizvi TA, Remke M, Rubin JB, Johnson RL, Carroll TJ, Stemmer-Rachamimov AO, Wu J, Zheng Y, Xin M, Ratner N, Lu QR
Cancer cell 2018 Feb 12;33(2):292-308.e7

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells.

Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C, Ameroso D, Abiko K, Hwang Y, Gregorieff A, Wrana JL, Asmani M, Zhao R, Sim FJ, Wrabetz L, Svaren J, Feltri ML
Nature neuroscience 2016 Jul;19(7):879-87

Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth.

Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X, Ye L
Oncogene 2016 Aug 4;35(31):4048-57

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with 23306-1-AP( WWTR1,TAZ Antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TAZ antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TAZ. This antibody recognizes human antigen. The TAZ antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 23306-1-AP.pdf

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