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- Antibody Data
- Antigen structure
- References [22]
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- Product number
- 66500-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- WWTR1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated WWTR1 antibody (Cat. #66500-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, rat, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2A12A10
- Vial size
- 20ul, 150ul
Submitted references Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance.
The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling.
Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling.
Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis.
The involvement of YAP-TGFβ-SMAD-mediated fibrosis in primary inferior oblique overaction.
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.
Hippo Pathway Dysregulation in Thymic Epithelial Tumors (TETs): Associations with Clinicopathological Features and Patients' Prognosis.
The polarity protein Par3 enhances renal cell carcinoma metastasis via YAP/TAZ activation.
RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesis.
Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways.
IFT80 promotes early bone healing of tooth sockets through the activation of TAZ/RUNX2 pathway.
Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo/YAP signaling pathway.
Activating transcriptional coactivator with PDZ-binding motif by (R)-PFI-2 attenuates osteoclastogenesis and prevents ovariectomized-induced osteoporosis.
Disease-Associated Neurotoxic Astrocyte Markers in Alzheimer Disease Based on Integrative Single-Nucleus RNA Sequencing.
Hippo/YAP1 promotes osteoporotic mice bone defect repair via the activating of Wnt signaling pathway.
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.
TAZ Induces Migration of Microglia and Promotes Neurological Recovery After Spinal Cord Injury.
Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes-associated protein and transcriptional coactivator with PDZ-binding motif.
Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway.
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.
Interplay between cancer cells and M2 macrophages is necessary for miR-550a-3-5p down-regulation-mediated HPV-positive OSCC progression.
VASN promotes YAP/TAZ and EMT pathway in thyroid carcinogenesis in vitro.
Barral L, Lespinasse N, Martin Cardozo C, Jeanpierre S, Bourgeois A, Rösel K, Beillard E, Laurent D, Peyrouze P, Belhabri A, Guillermin Y, Mazurier F, Cheok M, Audry-Deschamps MC, Faivre M, Maguer-Satta V, Lefort S
Leukemia 2026 Mar 18;
Leukemia 2026 Mar 18;
The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling.
Cao H, Huang X, Jiang X, Deng J, Wang J, Wu C, Hu M, Zeng B, Hu Z, Pan H, Yang Y, Zheng K, Shen R, Zhang M, Liu B
The EMBO journal 2026 Apr;45(8):2456-2493
The EMBO journal 2026 Apr;45(8):2456-2493
Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling.
Yang Q, Chen P, He X, Jian J, He M, Lin T, Zheng S, Liu D
Frontiers in cell and developmental biology 2025;13:1693346
Frontiers in cell and developmental biology 2025;13:1693346
Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis.
Evans RC, Dar NJ, Chen L, Na R, O'Connor JC, Jiang J, Zheng S, Ran Q
Aging cell 2025 Nov;24(11):e70218
Aging cell 2025 Nov;24(11):e70218
The involvement of YAP-TGFβ-SMAD-mediated fibrosis in primary inferior oblique overaction.
Tang S, Wen C, Shen T, Zhu B, Wang X, Wang Z, Fu L, Wen Y, Han M, Kuang X, Ma W, Shen H, Yan J
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167620
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167620
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.
Yu W, Gui S, Peng L, Luo H, Xie J, Xiao J, Yilamu Y, Sun Y, Cai S, Cheng Z, Tao Z
Developmental cell 2025 Jun 23;60(12):1751-1767.e9
Developmental cell 2025 Jun 23;60(12):1751-1767.e9
Hippo Pathway Dysregulation in Thymic Epithelial Tumors (TETs): Associations with Clinicopathological Features and Patients' Prognosis.
Elm L, Gerlitz N, Hochholzer A, Papadopoulos T, Levidou G
International journal of molecular sciences 2025 Jun 20;26(13)
International journal of molecular sciences 2025 Jun 20;26(13)
The polarity protein Par3 enhances renal cell carcinoma metastasis via YAP/TAZ activation.
Lee S, Balcazar J, Davis K, Pong RC, Hsieh JT, Kapur P, Meng X
Cancer biology & medicine 2025 Jul 8;22(7):812-31
Cancer biology & medicine 2025 Jul 8;22(7):812-31
RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesis.
Ye J, Wang J, Zhao J, Xia M, Wang H, Sun L, Zhang WB
Cellular signalling 2024 Sep;121:111300
Cellular signalling 2024 Sep;121:111300
Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways.
Feng S, Yu Z, Yang Y, Xiong Q, Yan X, Bi Y
Experimental cell research 2024 Sep 1;442(1):114218
Experimental cell research 2024 Sep 1;442(1):114218
IFT80 promotes early bone healing of tooth sockets through the activation of TAZ/RUNX2 pathway.
Zhao Z, Geng Y, Ni Q, Chen Y, Cao Y, Lu Y, Wang H, Wang R, Sun W
Oral diseases 2024 Oct;30(7):4558-4572
Oral diseases 2024 Oct;30(7):4558-4572
Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo/YAP signaling pathway.
Zhou Y, Wang H, Bi T, Liang P, Liu X, Shen H, Sun Q, Luo G, Liu P, Yang S, Ren W
Journal of traditional and complementary medicine 2024 Nov;14(6):656-665
Journal of traditional and complementary medicine 2024 Nov;14(6):656-665
Activating transcriptional coactivator with PDZ-binding motif by (R)-PFI-2 attenuates osteoclastogenesis and prevents ovariectomized-induced osteoporosis.
Xu R, Liu X, Zhang Y, Wang K, Chen Z, Zheng J, Zhang T, Tong P, Qian Y, Yang W
Biochemical pharmacology 2024 Jan;219:115964
Biochemical pharmacology 2024 Jan;219:115964
Disease-Associated Neurotoxic Astrocyte Markers in Alzheimer Disease Based on Integrative Single-Nucleus RNA Sequencing.
Yu W, Li Y, Zhong F, Deng Z, Wu J, Yu W, Lü Y
Cellular and molecular neurobiology 2024 Feb 12;44(1):20
Cellular and molecular neurobiology 2024 Feb 12;44(1):20
Hippo/YAP1 promotes osteoporotic mice bone defect repair via the activating of Wnt signaling pathway.
Li K, Liu L, Liu H, Liu Y, Xing J, Song J, Luo E
Cellular signalling 2024 Apr;116:111037
Cellular signalling 2024 Apr;116:111037
Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.
Cao YF, Xie L, Tong BB, Chu MY, Shi WQ, Li X, He JZ, Wang SH, Wu ZY, Deng DX, Zheng YQ, Li ZM, Xu XE, Liao LD, Cheng YW, Li LY, Xu LY, Li EM
Cell death and differentiation 2023 Feb;30(2):527-543
Cell death and differentiation 2023 Feb;30(2):527-543
TAZ Induces Migration of Microglia and Promotes Neurological Recovery After Spinal Cord Injury.
Hu X, Huang J, Li Y, Dong L, Chen Y, Ouyang F, Li J, Li Z, Jing J, Cheng L
Frontiers in pharmacology 2022;13:938416
Frontiers in pharmacology 2022;13:938416
Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes-associated protein and transcriptional coactivator with PDZ-binding motif.
Chen X, Wei X, Ma S, Xie H, Huang S, Yao M, Zhang L
Toxicology and applied pharmacology 2022 Dec 15;457:116319
Toxicology and applied pharmacology 2022 Dec 15;457:116319
Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway.
Nong S, Wei Z, Wang Z, Ma L, Guan Y, Ni J
Stem cells and development 2021 Sep 15;30(18):934-945
Stem cells and development 2021 Sep 15;30(18):934-945
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.
Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY
Nature communications 2021 Jan 28;12(1):662
Nature communications 2021 Jan 28;12(1):662
Interplay between cancer cells and M2 macrophages is necessary for miR-550a-3-5p down-regulation-mediated HPV-positive OSCC progression.
Cao MX, Zhang WL, Yu XH, Wu JS, Qiao XW, Huang MC, Wang K, Wu JB, Tang YJ, Jiang J, Liang XH, Tang YL
Journal of experimental & clinical cancer research : CR 2020 Jun 3;39(1):102
Journal of experimental & clinical cancer research : CR 2020 Jun 3;39(1):102
VASN promotes YAP/TAZ and EMT pathway in thyroid carcinogenesis in vitro.
Bhandari A, Guan Y, Xia E, Huang Q, Chen Y
American journal of translational research 2019;11(6):3589-3599
American journal of translational research 2019;11(6):3589-3599
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