HPA007415

antibody from Atlas Antibodies

Targeting: WWTR1 DKFZp586I1419, TAZ

Provider product page for HPA007415

Western blot

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [86]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: HPA007415 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA007415, RRID:AB_1080602
Product name: Anti-WWTR1
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human WWTR1, Gene description: WW domain containing transcription regulator 1, Alternative Gene Names: DKFZp586I1419, TAZ, Validated applications: ICC, IHC, WB, Uniprot ID: Q9GZV5, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

WWTR1 protein structure - HPA007415 shown in red.

Submitted references TSG-6–Mediated Extracellular Matrix Modifications Regulate Hypoxic–Ischemic Brain Injury

Srivastava T, Nguyen H, Haden G, Diba P, Sowa S, LaNguyen N, Reed-Dustin W, Zhu W, Gong X, Harris E, Baltan S, Back S
The Journal of Neuroscience 2024;44(21):e2215232024

Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation

Qin K, Wu Y, Xu Y, Rajhans S, Vo T, Lopez K, Liu J, Nipper M, Deng J, Yin X, Ramjit L, Ye Z, Luan Y, Arda H, Wang P
eLife 2024;13

Phase separation of YAP-MAML2 differentially regulates the transcriptome

Chung C, Yang J, Yang X, Liu H, Ma Z, Szulzewsky F, Holland E, Shen Y, Shu X
Proceedings of the National Academy of Sciences 2024;121(7)

External Mechanical Stability Regulates Hematoma Vascularization in Bone Healing Rather than Endothelial YAP/TAZ Mechanotransduction

Mehl J, Farahani S, Brauer E, Klaus‐Bergmann A, Thiele T, Ellinghaus A, Bartels‐Klein E, Koch K, Schmidt‐Bleek K, Petersen A, Gerhardt H, Vogel V, Duda G
Advanced Science 2024;11(13)

Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice

Yılmaz D, Marques F, Fischer Y, Zimmermann S, Hwang G, Atkins P, Mathavan N, Singh A, de Souza P, Kuhn G, Wehrle E, Müller R
Heliyon 2024;10(12):e32949

Two Hippo signaling modules orchestrate liver size and tumorigenesis

Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim D, Mao J, Zhang L, Yu F
The EMBO Journal 2023;42(11)

Hyperactivation of YAP/TAZ Drives Alterations in Mesangial Cells through Stabilization of N-Myc in Diabetic Nephropathy

Choi S, Hong S, Bae J, Suh S, Bae H, Kang K, Lee H, Koh G
Journal of the American Society of Nephrology 2023;34(5):809-828

Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers

Wang X, Moore M, Shi H, Miyata Y, Donnelly S, Radiloff D, Tabas I
Molecular Therapy - Methods & Clinical Development 2023;31

Intrinsically dysregulated cellular stress signaling genes and gene networks in postpartum depression

Rudzinskas S, Goff A, Mazzu M, Schiller C, Meltzer-Brody S, Rubinow D, Schmidt P, Goldman D
Molecular Psychiatry 2023;28(7):3023-3032

The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells

Claude-Taupin A, Isnard P, Bagattin A, Kuperwasser N, Roccio F, Ruscica B, Goudin N, Garfa-Traoré M, Regnier A, Turinsky L, Burtin M, Foretz M, Pontoglio M, Morel E, Viollet B, Terzi F, Codogno P, Dupont N
Nature Communications 2023;14(1)

The role of mechano-regulated YAP/TAZ in erectile dysfunction

Ji M, Chen D, Shu Y, Dong S, Zhang Z, Zheng H, Jin X, Zheng L, Liu Y, Zheng Y, Zhang W, Wang S, Zhou G, Li B, Ji B, Yang Y, Xu Y, Chang L
Nature Communications 2023;14(1)

Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

Teper Y, Ye L, Waldron R, Lugea A, Sun X, Sinnett-Smith J, Hines O, Pandol S, Rozengurt E, Eibl G
Scientific Reports 2023;13(1)

Antitumor Effect of Berberine Analogs in a Canine Mammary Tumor Cell Line and in Zebrafish Reporters via Wnt/β-Catenin and Hippo Pathways

Sammarco A, Beffagna G, Sacchetto R, Vettori A, Bonsembiante F, Scarin G, Gelain M, Cavicchioli L, Ferro S, Geroni C, Lombardi P, Zappulli V
Biomedicines 2023;11(12):3317

Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression

Ruan Z, Yin H, Wan T, Lin Z, Zhao S, Long H, Long C, Li Z, Liu Y, Luo H, Cheng L, Chen C, Zeng M, Lin Z, Zhao R, Chen C, Wang Z, Liu Z, Cao J, Wang Y, Jin L, Liu Y, Zhu G, Zou J, Gong J, Luo Y, Hu Y, Zhu Y, Xie H
Bone Research 2023;11(1)

Gatekeeping role of Nf2 /Merlin in vascular tip EC induction through suppression of VEGFR2 internalization

Bae J, Yang M, Jeong S, Kim J, Hong S, Kim J, Kim Y, Koh G
Science Advances 2022;8(23)

Airway secretory cell fate conversion via YAP‐mTORC1‐dependent essential amino acid metabolism

Jeon H, Choi J, Kraaier L, Kim Y, Eisenbarth D, Yi K, Kang J, Kim J, Shim H, Lee J, Lim D
The EMBO Journal 2022;41(8)

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Ong Y, Andrade J, Armbruster M, Shi C, Castro M, Costa A, Sugino T, Eelen G, Zimmermann B, Wilhelm K, Lim J, Watanabe S, Guenther S, Schneider A, Zanconato F, Kaulich M, Pan D, Braun T, Gerhardt H, Efeyan A, Carmeliet P, Piccolo S, Grosso A, Potente M
Nature Metabolism 2022;4(6):672-682

TAZ is important for maintenance of the integrity of podocytes

Chen J, Wang X, He Q, Harris R
American Journal of Physiology-Renal Physiology 2022;322(4):F419-F428

Identification and targeting of a HES1‐YAP1‐CDKN1C functional interaction in fusion‐negative rhabdomyosarcoma

Kovach A, Oristian K, Kirsch D, Bentley R, Cheng C, Chen X, Chen P, Chi J, Linardic C
Molecular Oncology 2022;16(20):3587-3605

Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration

Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, Otani Y, Tomita Y, Hattori Y, Matsumoto Y, Tsuboi N, Makino K, Hirano S, Kamiya A, Date I
Acta Neuropathologica Communications 2021;9(1)

Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

Barthet V, Brucoli M, Ladds M, Nössing C, Kiourtis C, Baudot A, O’Prey J, Zunino B, Müller M, May S, Nixon C, Long J, Bird T, Ryan K
Science Advances 2021;7(23)

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines

Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, Solberg N, Lycke M, Thorvaldsen T, Espada S, Misaghian D, Page C, Agafonov O, Nygård S, Chi N, Lin E, Tan J, Yu Y, Costa M, Krauss S, Waaler J
iScience 2021;24(7):102807

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas

Desai C, Thomason J, Kohlmeyer J, Reisetter A, Ahirwar P, Jahanseir K, Leidinger M, Ofori-Amanfo G, Fritchie K, Velu S, Breheny P, Quelle D, Tanas M
Oncotarget 2021;12(8):740-755

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

Della Chiara G, Gervasoni F, Fakiola M, Godano C, D’Oria C, Azzolin L, Bonnal R, Moreni G, Drufuca L, Rossetti G, Ranzani V, Bason R, De Simone M, Panariello F, Ferrari I, Fabbris T, Zanconato F, Forcato M, Romano O, Caroli J, Gruarin P, Sarnicola M, Cordenonsi M, Bardelli A, Zucchini N, Ceretti A, Mariani N, Cassingena A, Sartore-Bianchi A, Testa G, Gianotti L, Opocher E, Pisati F, Tripodo C, Macino G, Siena S, Bicciato S, Piccolo S, Pagani M
Nature Communications 2021;12(1)

Glucocorticoids activate Yes-associated protein in human vocal fold fibroblasts.

Nakamura R, Bing R, Doyle CP, Garabedian MJ, Branski RC
Experimental cell research 2021 Aug 15;405(2):112681

YAP/TAZ Regulate Elevation and Bone Formation of the Mouse Secondary Palate

Goodwin A, Chen C, Vo N, Bush J, Klein O
Journal of Dental Research 2020;99(12):1387-1396

TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties

Tiffon C, Giraud J, Molina-Castro S, Peru S, Seeneevassen L, Sifré E, Staedel C, Bessède E, Dubus P, Mégraud F, Lehours P, Martin O, Varon C
Cells 2020;9(6):1462

YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

Sivaraj K, Dharmalingam B, Mohanakrishnan V, Jeong H, Kato K, Schröder S, Adams S, Koh G, Adams R
eLife 2020;9

PINK1‐Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B‐Mediated Hippo‐YAP/TAZ Pathway

Fan S, Price T, Huang W, Plue M, Warren J, Sundaramoorthy P, Paul B, Feinberg D, MacIver N, Chao N, Sipkins D, Kang Y
Advanced Science 2020;7(5)

Mechanisms of stretch-mediated skin expansion at single-cell resolution

Aragona M, Sifrim A, Malfait M, Song Y, Van Herck J, Dekoninck S, Gargouri S, Lapouge G, Swedlund B, Dubois C, Baatsen P, Vints K, Han S, Tissir F, Voet T, Simons B, Blanpain C
Nature 2020;584(7820):268-273

Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal

Chai T, Manu K, Casey P, Wang M
Oncogene 2020;39(31):5373-5389

Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras

Asahina K, Balog S, Hwang E, Moon E, Wan E, Skrypek K, Chen Y, Fernandez J, Romo J, Yang Q, Lai K, French S, Tsukamoto H
American Journal of Physiology-Gastrointestinal and Liver Physiology 2020;318(2):G265-G276

Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation

Canu V, Donzelli S, Sacconi A, Lo Sardo F, Pulito C, Bossel N, Di Benedetto A, Muti P, Botti C, Domany E, Bicciato S, Strano S, Yarden Y, Blandino G
Cell Death & Differentiation 2020;28(5):1493-1511

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

Lu Y, Wu T, Gutman O, Lu H, Zhou Q, Henis Y, Luo K
Nature Cell Biology 2020;22(4):453-464

Homeobox A4 suppresses vascular remodeling by repressing YAP / TEAD transcriptional activity

Kimura M, Horie T, Baba O, Ide Y, Tsuji S, Ruiz Rodriguez R, Watanabe T, Yamasaki T, Otani C, Xu S, Miyasaka Y, Nakashima Y, Kimura T, Ono K
EMBO reports 2020;21(4)

Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma

Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, Sladitschek H, Contessotto P, Citron A, Grilli A, Romano O, Bicciato S, Fassan M, Porcù E, Rosato A, Cordenonsi M, Piccolo S
Nature Cancer 2020;2(2):174-188

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos A, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S
Nature Materials 2020;19(7):797-806

Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity

Kronenberg N, Tilston-Lunel A, Thompson F, Chen D, Yu W, Dholakia K, Gather M, Gunn-Moore F
Frontiers in Cellular Neuroscience 2020;14

Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

Hong S, Yang M, Cho H, Park I, Bae H, Choe K, Suh S, Adams R, Alitalo K, Lim D, Koh G
Nature Communications 2020;11(1)

YAP and TAZ protect against white adipocyte cell death during obesity

Wang L, Wang S, Shi Y, Li R, Günther S, Ong Y, Potente M, Yuan Z, Liu E, Offermanns S
Nature Communications 2020;11(1)

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

Choi S, Bae H, Jeong S, Park I, Cho H, Hong S, Lee D, Lee C, Park J, Suh S, Choi J, Yang M, Jang J, Onder L, Moon J, Jeong H, Adams R, Kim J, Ludewig B, Song J, Lim D, Koh G
Nature Communications 2020;11(1)

Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway.

Vanyai HK, Prin F, Guillermin O, Marzook B, Boeing S, Howson A, Saunders RE, Snoeks T, Howell M, Mohun TJ, Thompson B
Development (Cambridge, England) 2020 Nov 12;147(21)

YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling

Cha B, Ho Y, Geng X, Mahamud M, Chen L, Kim Y, Choi D, Kim T, Randolph G, Cao X, Chen H, Srinivasan R
Development 2020

Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone

Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, Åman P, Larsson O, Ratner N, Hafner S, Simmet T, Schliemann C, Rossig C, Dirksen U, Grünewald I, Wardelmann E, Huss S, Hartmann W, Trautmann M
Scientific Reports 2019;9(1)

TAZ is required for lung alveolar epithelial cell differentiation after injury

Sun T, Huang Z, Zhang H, Posner C, Jia G, Ramalingam T, Xu M, Brightbill H, Egen J, Dey A, Arron J
JCI Insight 2019;4(14)

Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells

Kingston N, Tilston-Lunel A, Hicks-Berthet J, Varelas X
2019;1893

Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling

Volckaert T, Yuan T, Yuan J, Boateng E, Hopkins S, Zhang J, Thannickal V, Fässler R, De Langhe S
Development 2019;146(2)

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Kim Y, Choi J, Yang M, Hong S, Lee C, Kubota Y, Lim D, Koh G
Nature Communications 2019;10(1)

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

Hwang J, Kim A, Kim K, Il Park J, Oh H, Moon S, Byun M, Jeong H, Kim H, Yaffe M, Hwang E, Hong J
Nature Communications 2019;10(1)

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.

Lodge EJ, Santambrogio A, Russell JP, Xekouki P, Jacques TS, Johnson RL, Thavaraj S, Bornstein SR, Andoniadou CL
eLife 2019 Mar 26;8

Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ.

Xekouki P, Lodge EJ, Matschke J, Santambrogio A, Apps JR, Sharif A, Jacques TS, Aylwin S, Prevot V, Li R, Flitsch J, Bornstein SR, Theodoropoulou M, Andoniadou CL
Endocrine-related cancer 2019 Jan 1;26(1):215-225

A comprehensive evaluation of Hippo pathway silencing in sarcomas

Merritt N, Fullenkamp C, Hall S, Qian Q, Desai C, Thomason J, Lambertz A, Dupuy A, Darbro B, Tanas M
Oncotarget 2018;9(60):31620-31636

Pulmonary pericytes regulate lung morphogenesis

Kato K, Diéguez-Hurtado R, Park D, Hong S, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana J, Koh G, Adams R
Nature Communications 2018;9(1)

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Mohamed A, Shah N, Hettmer S, Vargesson N, Wackerhage H
Scientific Reports 2018;8(1)

Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation

LeBlanc L, Lee B, Yu A, Kim M, Kambhampati A, Dupont S, Seruggia D, Ryu B, Orkin S, Kim J
eLife 2018;7

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Neto F, Klaus-Bergmann A, Ong Y, Alt S, Vion A, Szymborska A, Carvalho J, Hollfinger I, Bartels-Klein E, Franco C, Potente M, Gerhardt H
eLife 2018;7

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S
Nature 2018;563(7730):265-269

Hippo signaling dysfunction induces cancer cell addiction to YAP

Han H, Yang B, Nakaoka H, Yang J, Zhao Y, Le Nguyen K, Bishara A, Mandalia T, Wang W
Oncogene 2018;37(50):6414-6424

Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway

Li N, Feng Y, Hu Y, He C, Xie C, Ouyang Y, Artim S, Huang D, Zhu Y, Luo Z, Ge Z, Lu N
Journal of Experimental & Clinical Cancer Research 2018;37(1)

Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury

Konishi T, Schuster R, Lentsch A
American Journal of Physiology-Gastrointestinal and Liver Physiology 2018;314(4):G471-G482

The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis

Deel M, Slemmons K, Hinson A, Genadry K, Burgess B, Crose L, Kuprasertkul N, Oristian K, Bentley R, Linardic C
Clinical Cancer Research 2018;24(11):2616-2630

RETRACTED: Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability

Lu Y, Maruyama J, Kuwata K, Fukuda H, Iwasa H, Arimoto-Matsuzaki K, Sugimura H, Hata Y
Biochemistry and Biophysics Reports 2018;16

An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression

Luu A, Schott C, Jones R, Poon A, Golding B, Hamed R, Deheshi B, Mutsaers A, Wood G, Viloria-Petit A
BMC Veterinary Research 2018;14(1)

Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer

Jeong S, Kim H, Kim M, Lee J, Lee J, Kim J, Kim J, Park W, Kim S, Kim J, Kim H, Kim J, Choi H, Lim D
Journal of Clinical Investigation 2018;128(3):1010-1025

Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.

Eales KL, Wilkinson EA, Cruickshank G, Tucker JHR, Tennant DA
Scientific reports 2018 Sep 25;8(1):14358

A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination

Deng Y, Wu L, Bai S, Zhao C, Wang H, Wang J, Xu L, Sakabe M, Zhou W, Xin M, Lu Q
Nature Communications 2017;8(1)

Glucocorticoid receptor signalling activates YAP in breast cancer

Sorrentino G, Ruggeri N, Zannini A, Ingallina E, Bertolio R, Marotta C, Neri C, Cappuzzello E, Forcato M, Rosato A, Mano M, Bicciato S, Del Sal G
Nature Communications 2017;8(1)

Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association with Cell Shape and Cytoskeletal Modifications

Hagiyama M, Yabuta N, Okuzaki D, Inoue T, Takashima Y, Kimura R, Ri A, Ito A
Frontiers in Physiology 2017;8

Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ

Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun Y, Xiong Y, Yuan H, Guan K
Cancer Research 2017;77(9):2413-2423

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

Noguchi S, Saito A, Mikami Y, Urushiyama H, Horie M, Matsuzaki H, Takeshima H, Makita K, Miyashita N, Mitani A, Jo T, Yamauchi Y, Terasaki Y, Nagase T
Scientific Reports 2017;7(1)

MCM7and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer

Lo Sardo F, Forcato M, Sacconi A, Capaci V, Zanconato F, Di Agostino S, Del Sal G, Pandolfi P, Strano S, Bicciato S, Blandino G
Carcinogenesis 2017;38(1):64-75

Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

Sun C, De Mello V, Mohamed A, Ortuste Quiroga H, Garcia-Munoz A, Al Bloshi A, Tremblay A, von Kriegsheim A, Collie-Duguid E, Vargesson N, Matallanas D, Wackerhage H, Zammit P
Stem Cells 2017;35(8):1958-1972

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie G, Kouskoff V, Lacaud G, Murray G, Sansom O, Hurlstone A, Malliri A
Cancer Cell 2017;31(5):621-634.e6

ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer

Liu C, Yu T, Huang Y, Cui L, Hong W
Journal of Biological Chemistry 2017;292(22):9420-9430

Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis

Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, Severino L, Scaini D, Mano M, Mantovani F, Rosato A, Bicciato S, Piccolo S, Del Sal G
Nature Cell Biology 2017;20(1):28-35

Targeted Disruption of YAP and TAZ Impairs the Maintenance of the Adrenal Cortex

Levasseur A, St-Jean G, Paquet M, Boerboom D, Boyer A
Endocrinology 2017;158(11):3738-3753

miR205 inhibits stem cell renewal in SUM159PT breast cancer cells

Ahmad A, Mayoral-Varo V, Calcabrini A, Sánchez-Bailón M, Martín-Pérez J
PLOS ONE 2017;12(11):e0188637

TAZ and YAP are frequently activated oncoproteins in sarcomas

Fullenkamp C, Hall S, Jaber O, Pakalniskis B, Savage E, Savage J, Ofori-Amanfo G, Lambertz A, Ivins S, Stipp C, Miller B, Milhem M, Tanas M
Oncotarget 2016;7(21):30094-30108

Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development

Lodge E, Russell J, Patist A, Francis-West P, Andoniadou C
Frontiers in Physiology 2016;7

Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration

Feng X, Liu P, Zhou X, Li M, Li F, Wang Z, Meng Z, Sun Y, Yu Y, Xiong Y, Yuan H, Guan K
Journal of Biological Chemistry 2016;291(36):18947-18958

The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

Mohamed A, Sun C, De Mello V, Selfe J, Missiaglia E, Shipley J, Murray G, Zammit P, Wackerhage H
The Journal of Pathology 2016;240(1):3-14

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

Gruber R, Panayiotou R, Nye E, Spencer-Dene B, Stamp G, Behrens A
Gastroenterology 2016;151(3):526-539

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu F, Lagares D, Choi K, Stopfer L, Marinković A, Vrbanac V, Probst C, Hiemer S, Sisson T, Horowitz J, Rosas I, Fredenburgh L, Feghali-Bostwick C, Varelas X, Tager A, Tschumperlin D
American Journal of Physiology-Lung Cellular and Molecular Physiology 2015;308(4):L344-L357

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

Di Agostino S, Sorrentino G, Ingallina E, Valenti F, Ferraiuolo M, Bicciato S, Piazza S, Strano S, Del Sal G, Blandino G
EMBO reports 2015;17(2):188-201

Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma

Wanjin H, Slemmons K, Crose L, Rudzinski E, Bentley R, Linardic C
PLOS ONE 2015;10(10):e0140781

Metabolic control of YAP and TAZ by the mevalonate pathway

Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, Rosato A, Piccolo S, Del Sal G
Nature Cell Biology 2014;16(4):357-366

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Enhanced validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Genetic validation
Main image
Experimental details: Western blot analysis in EFO-21 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-WWTR1 antibody. Remaining relative intensity is presented. Loading control: Anti-PPIB.
Sample type: Human
Protocol: Protocol

Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human placenta and skeletal muscle tissues using HPA007415 antibody. Corresponding WWTR1 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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