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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [12]
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- Product number
- 14963-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SLC25A39 antibody
- Antibody type
- Polyclonal
- Description
- SLC25A39 antibody (Cat. #14963-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis.
FGF21 maintains redox homeostasis and promotes neuronal survival after traumatic brain injury by targeting SLC25A39-mediated mitochondrial GSH transport.
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.
Chronic Exposure to Arsenic and Fluoride Starting at Gestation Alters Liver Mitochondrial Protein Expression and Induces Early Onset of Liver Fibrosis in Male Mouse Offspring.
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism.
S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease.
Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis.
Autoregulatory control of mitochondrial glutathione homeostasis.
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Alves F, Lane D, Wahida A, Jakaria M, Kalinowski P, Southon A, Belaidi AA, Samperi-Esteve T, Nguyen TPM, Lei P, Krueger M, Mueller S, Conrad M, Agarwal P, Leurgans SE, Schneider J, Bush AI, Ayton S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e04175
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e04175
FGF21 maintains redox homeostasis and promotes neuronal survival after traumatic brain injury by targeting SLC25A39-mediated mitochondrial GSH transport.
Wang L, Li W, Wu X, Ouyang Q, Sun B, Luo J, Guo H, Yang T, Ma Y
Journal of translational medicine 2025 Oct 2;23(1):1044
Journal of translational medicine 2025 Oct 2;23(1):1044
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
Cancer cell 2025 Jun 9;43(6):1076-1092.e5
SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation.
Pena IA, Shi JS, Chang SM, Yang J, Block S, Adelmann CH, Keys HR, Ge P, Bathla S, Witham IH, Sienski G, Nairn AC, Sabatini DM, Lewis CA, Kory N, Vander Heiden MG, Heiman M
Nature communications 2025 Jan 24;16(1):978
Nature communications 2025 Jan 24;16(1):978
Chronic Exposure to Arsenic and Fluoride Starting at Gestation Alters Liver Mitochondrial Protein Expression and Induces Early Onset of Liver Fibrosis in Male Mouse Offspring.
González-Alfonso WL, Petrosyan P, Del Razo LM, Sánchez-Peña LC, Tapia-Rodríguez M, Hernández-Muñoz R, Gonsebatt ME
Biological trace element research 2025 Feb;203(2):930-943
Biological trace element research 2025 Feb;203(2):930-943
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
Bischoff ME, Shamsaei B, Yang J, Secic D, Vemuri B, Reisz JA, D'Alessandro A, Bartolacci C, Adamczak R, Schmidt L, Wang J, Martines A, Venkat J, Tcheuyap VT, Biesiada J, Behrmann CA, Vest KE, Brugarolas J, Scaglioni PP, Plas DR, Patra KC, Gulati S, Landero Figueroa JA, Meller J, Cunningham JT, Czyzyk-Krzeska MF
Cancer discovery 2025 Feb 7;15(2):401-426
Cancer discovery 2025 Feb 7;15(2):401-426
NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism.
Liu J, Tang H, Chen F, Li C, Xie Y, Kang R, Tang D
Scientific reports 2024 Nov 28;14(1):29579
Scientific reports 2024 Nov 28;14(1):29579
S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease.
Goicoechea L, Torres S, Fàbrega L, Barrios M, Núñez S, Casas J, Fabrias G, García-Ruiz C, Fernández-Checa JC
Redox biology 2024 Jun;72:103150
Redox biology 2024 Jun;72:103150
Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis.
Shi X, DeCiucis M, Grabinska KA, Kanyo J, Liu A, Lam TT, Shen H
Molecular cell 2024 Feb 15;84(4):802-810.e6
Molecular cell 2024 Feb 15;84(4):802-810.e6
Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.
Shi X, Reinstadler B, Shah H, To TL, Byrne K, Summer L, Calvo SE, Goldberger O, Doench JG, Mootha VK, Shen H
Nature communications 2022 May 5;13(1):2483
Nature communications 2022 May 5;13(1):2483
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
Nature 2021 Nov;599(7883):136-140
Nature 2021 Nov;599(7883):136-140
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