60086AZ

antibody from STEMCELL Technologies Inc

Targeting: CEACAM8 CD66b, CGM6

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60086AZ

Provider

STEMCELL Technologies Inc

Product name

Anti-Human CD66b Antibody, Clone G10F5, APC

Antibody type

Monoclonal

Description

The G10F5 antibody reacts with CD66b (previously denoted CD67), an ~95 kDa single-chain glycosylphosphatidylinositol (GPI)-linked glycoprotein expressed by neutrophilic and eosinophilic granulocytes. CD66b is a member of the carcinoembryonic antigen (CEA)-like subfamily of proteins within the immunoglobulin superfamily and possesses two Ig-like C2-type domains and one Ig-like V-type domain. In neutrophils, CD66b is localized within granules in the cytoplasm as well as being expressed on the plasma membrane. Surface expression levels increase upon granulocyte activation, an effect induced by stimulators such as phorbol myristate acetate (PMA), calcium ionophore, and N-formylmethionyl-leucyl-phenylalanine (FMLP). CD66b appears to play a role as a signaling receptor involved in cell adhesion, phagocytosis, and chemotaxis by regulating granulocyte activation and adhesion to several proteins, including CD66c, galectin-3, fibronectin, and E-selectin.

Reactivity

Human

Isotype

IgM

Vial size

100 Tests

Storage

2 - 8°C