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antibody from Novus Biologicals
Targeting: TP53BP1
53BP1, p202, TDRD30
Western blot
Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [422]
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- Validations
- Western blot [3]
- Immunoprecipitation [1]
- Immunohistochemistry [4]
- Flow cytometry [8]
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- Product number
- NB100-304 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-304, RRID:AB_10003037
- Product name
- Rabbit Polyclonal 53BP1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Bovine, Canine, Goat, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at -20 degreesC.
Submitted references Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.
ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage.
Telomere DNA damage signaling regulates prostate cancer tumorigenesis.
Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication.
Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination.
Heterochromatin loss as a determinant of progerin-induced DNA damage in Hutchinson-Gilford Progeria.
The mTOR pathway is necessary for survival of mice with short telomeres.
CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma.
The impact of TP53BP1 and MLH1 on metastatic capability in cases of locally advanced prostate cancer and their usefulness in clinical practice.
BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.
Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity.
DNA damage invokes mitophagy through a pathway involving Spata18.
Shining light on the response to repair intermediates in DNA of living cells.
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner.
Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan.
DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia.
Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations.
EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma.
Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells.
53BP1 Accumulation in Circulating Tumor Cells Identifies Chemotherapy-Responsive Metastatic Breast Cancer Patients.
Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.
Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures.
Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway.
HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1.
Chronic Intestinal Pseudo-Obstruction and Lymphoproliferative Syndrome as a Novel Phenotype Associated With Tetratricopeptide Repeat Domain 7A Deficiency.
Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations.
Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.
Non-enzymatic roles of human RAD51 at stalled replication forks.
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage.
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL.
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.
Mice with hyper-long telomeres show less metabolic aging and longer lifespans.
Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers.
Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223.
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome.
Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.
Cytotoxicity and Genotoxicity of a New Intracanal Medicament, 2-hydroxyisocaproic Acid-An In Vitro Study.
RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci.
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2.
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase.
Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins.
Molecular and cellular basis of mammary gland fibrosis and cancer risk.
The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability.
Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells.
UFL1 promotes histone H4 ufmylation and ATM activation.
The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors.
Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.
Linear double-stranded DNAs as innovative biological parts to implement genetic circuits in mammalian cells.
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors.
Mammalian CST averts replication failure by preventing G-quadruplex accumulation.
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells.
Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.
Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP).
Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts.
LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.
Constricted migration modulates stem cell differentiation.
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.
TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.
Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest.
Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment.
Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy.
G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma.
Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.
Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury.
Formaldehyde inhibits UV-induced phosphorylation of histone H2AX.
Bcl2-Expressing Quiescent Type B Neural Stem Cells in the Ventricular-Subventricular Zone Are Resistant to Concurrent Temozolomide/X-Irradiation.
Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.
CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.
Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines.
GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival.
RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells.
DNA cross-link repair safeguards genomic stability during premeiotic germ cell development.
53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function.
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle.
Exposure to the Fungicide Captan Induces DNA Base Alterations and Replicative Stress in Mammalian Cells.
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.
The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells.
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response.
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure.
Extracorporeal Shock Wave-Supported Adipose-Derived Fresh Stromal Vascular Fraction Preserved Left Ventricular (LV) Function and Inhibited LV Remodeling in Acute Myocardial Infarction in Rat.
Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation.
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality.
2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1.
miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways.
High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair.
Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells.
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing.
Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.
CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures.
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.
An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.
Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks.
The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.
USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner.
INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
Proton irradiation orchestrates macrophage reprogramming through NFκB signaling.
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.
Long-term Persistent Organic Pollutants Exposure Induced Telomere Dysfunction and Senescence-Associated Secretary Phenotype.
Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites.
Central and Peripheral Expression of DNA Double-Strand Breaks in Human and Mouse Tissues.
Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts.
Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.
Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide.
The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage.
Impaired immune surveillance accelerates accumulation of senescent cells and aging.
Detrimental pro-senescence effects of vitamin D on lung fibrosis.
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer.
Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits.
Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1.
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.
Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib.
Plk1 overexpression induces chromosomal instability and suppresses tumor development.
Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.
53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress.
Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose.
Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells.
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress.
Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age.
Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.
Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.
ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage.
Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung.
BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.
Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.
Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of urothelial cancer and normal urothelial cells.
Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts.
CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.
Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening.
Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.
Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.
213Bi-Labeled Prostate-Specific Membrane Antigen-Targeting Agents Induce DNA Double-Strand Breaks in Prostate Cancer Xenografts.
TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9.
Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML.
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.
Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.
The telomeric DNA damage response occurs in the absence of chromatin decompaction.
53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination.
Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response.
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
DNA Damage Detection by 53BP1: Relationship to Species Longevity.
Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer.
MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer.
Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes.
DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs.
Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance.
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.
A Biallelic Mutation in the Homologous Recombination Repair Gene SPIDR Is Associated With Human Gonadal Dysgenesis.
Integrating phosphoproteomics into the clinical management of prostate cancer.
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
ATR Is a Therapeutic Target in Synovial Sarcoma.
The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.
Looping-out mechanism for resolution of replicative stress at telomeres.
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.
Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.
A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation.
DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation.
Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib.
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.
Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells.
New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity.
Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.
Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.
Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.
NOX4 downregulation leads to senescence of human vascular smooth muscle cells.
The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome.
The effect of delphinidin on the mechanical properties of keratinocytes exposed to UVB radiation.
Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number.
Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy.
Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes.
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus.
Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams.
Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis.
Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks.
A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.
Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress.
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis.
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.
Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells.
Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells.
The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells.
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.
Comparison of the Therapeutic Response to Treatment with a 177Lu-Labeled Somatostatin Receptor Agonist and Antagonist in Preclinical Models.
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.
Validation of JCountPro software for efficient assessment of ionizing radiation-induced foci in human lymphocytes.
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Is senescence-associated β-galactosidase a marker of neuronal senescence?
Roles of human POLD1 and POLD3 in genome stability.
DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner.
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model.
Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy.
Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence.
Telomeric RNAs are essential to maintain telomeres.
The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability.
RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.
DNA repair foci and late apoptosis/necrosis in peripheral blood lymphocytes of breast cancer patients undergoing radiotherapy.
Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells.
Nuclear signs of pre-neurodegeneration.
Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.
CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo.
DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma.
The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis.
Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
A prospective study on histone γ-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome.
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.
Consequence of the tumor-associated conversion to cyclin D1b.
Notch is a direct negative regulator of the DNA-damage response.
DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.
The COP9 signalosome is vital for timely repair of DNA double-strand breaks.
DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing.
Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells.
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.
Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress.
DNA damage signaling and apoptosis in preinvasive tubal lesions of ovarian carcinoma.
Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.
WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.
BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells.
Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells.
Increased FOXM1 expression can stimulate DNA repair in normal hepatocytes in vivo but also increases nuclear foci associated with senescence.
Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner.
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
NF-κB signaling mediates acquired resistance after PARP inhibition.
Imaging flow cytometry as a sensitive tool to detect low-dose-induced DNA damage by analyzing 53BP1 and γH2AX foci in human lymphocytes.
Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells.
Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.
Radiobiological response to ultra-short pulsed megavoltage electron beams of ultra-high pulse dose rate.
Dexamethasone acts as a radiosensitizer in three astrocytoma cell lines via oxidative stress.
Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.
Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation.
Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.
Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.
Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.
Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
Immunocytochemical localization of DNA double-strand breaks in human and rat brains.
DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.
TPX2 impacts acetylation of histone H4 at lysine 16: implications for DNA damage response.
Stable cellular senescence is associated with persistent DDR activation.
Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.
The role of mitochondrial function in gold nanoparticle mediated radiosensitisation.
The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation.
Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.
Generation of cell-based systems to visualize chromosome damage and translocations in living cells.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells.
TRIM28/KAP1 regulates senescence.
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
Human RECQL1 participates in telomere maintenance.
SMCHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaks.
Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination.
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.
CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice.
A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta.
The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes.
Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.
KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.
Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4.
Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.
Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.
Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.
Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53.
Human umbilical cord matrix stem cells maintain multilineage differentiation abilities and do not transform during long-term culture.
Use of the γ-H2AX assay to investigate DNA repair dynamics following multiple radiation exposures.
LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response.
ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks.
The telomere-associated homeobox-containing protein TAH1/HMBOX1 participates in telomere maintenance in ALT cells.
Engineered proteins detect spontaneous DNA breakage in human and bacterial cells.
The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.
Down-regulation of PERK enhances resistance to ionizing radiation.
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.
Inhibition of telomerase recruitment and cancer cell death.
DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells.
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia.
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.
Lamin B1 fluctuations have differential effects on cellular proliferation and senescence.
53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma.
Telomere length and telomerase activity impact the UV sensitivity syndrome xeroderma pigmentosum C.
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.
RAP1 protects from obesity through its extratelomeric role regulating gene expression.
Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells.
Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis.
BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells.
The histone methyltransferase MMSET regulates class switch recombination.
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer.
The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.
How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a.
Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations.
WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas.
53BP1 regulates DSB repair using Rif1 to control 5' end resection.
A two-step mechanism for TRF2-mediated chromosome-end protection.
Repriming of DNA synthesis at stalled replication forks by human PrimPol.
Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.
Akt regulates TPP1 homodimerization and telomere protection.
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.
Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination.
Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.
DNA damage response in microcephaly development of MCPH1 mouse model.
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.
MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1.
Radiosensitivity in breast cancer assessed by the histone γ-H2AX and 53BP1 foci.
Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment.
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
DNA damage responses following exposure to modulated radiation fields.
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.
Radiobiological effectiveness of laser accelerated electrons in comparison to electron beams from a conventional linear accelerator.
Radiobiological effectiveness of laser accelerated electrons in comparison to electron beams from a conventional linear accelerator.
A TRF1-controlled common fragile site containing interstitial telomeric sequences.
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma.
Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro.
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability.
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.
Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation.
Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells.
Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.
Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis.
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process.
The activation of DNA damage detection and repair responses in cleavage-stage rat embryos by a damaged paternal genome.
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells.
IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.
Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.
mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription.
Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by β1 integrin inhibition.
Site-specific DICER and DROSHA RNA products control the DNA-damage response.
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.
Autocrine regulation of γ-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors.
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells.
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation.
Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation.
Cerebroventricular microinjection (CVMI) into adult zebrafish brain is an efficient misexpression method for forebrain ventricular cells.
53BP1 contributes to a robust genomic stability in human fibroblasts.
Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model.
Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study.
The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency.
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta.
A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.
The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling.
Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1β and support viral replication.
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
A dual role for A-type lamins in DNA double-strand break repair.
Replication stress induces 53BP1-containing OPT domains in G1 cells.
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
Dicer is required for Sertoli cell function and survival.
H2AX post-translational modifications in the ionizing radiation response and homologous recombination.
A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion.
Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence.
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.
LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection.
Telomere protection by TPP1 is mediated by POT1a and POT1b.
Selective targeting of radiation-resistant tumor-initiating cells.
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells.
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2.
Telomeric DNA mediates de novo PML body formation.
Endocytosis is crucial for cell polarity and apical membrane recycling in the filamentous fungus Aspergillus oryzae.
The effect of photopolymerization on stem cells embedded in hydrogels.
Characterization of the p53 response to oncogene-induced senescence.
Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques.
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2.
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies.
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals.
Ramadan R, Vromans E, Anang DC, Goetschalckx I, Hoorelbeke D, Decrock E, Baatout S, Leybaert L, Aerts A
Frontiers in pharmacology 2020;11:212
Frontiers in pharmacology 2020;11:212
ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage.
Riancho J, Castanedo-Vázquez D, Gil-Bea F, Tapia O, Arozamena J, Durán-Vían C, Sedano MJ, Berciano MT, Lopez de Munain A, Lafarga M
Journal of neurology 2020 May;267(5):1291-1299
Journal of neurology 2020 May;267(5):1291-1299
Telomere DNA damage signaling regulates prostate cancer tumorigenesis.
Wu J, Crowe DL
Molecular cancer research : MCR 2020 May 28;
Molecular cancer research : MCR 2020 May 28;
Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication.
Bellelli R, Youds J, Borel V, Svendsen J, Pavicic-Kaltenbrunner V, Boulton SJ
Cell reports 2020 May 26;31(8):107675
Cell reports 2020 May 26;31(8):107675
Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination.
Kelliher JL, West KL, Gong Q, Leung JWC
Nature communications 2020 May 18;11(1):2462
Nature communications 2020 May 18;11(1):2462
Heterochromatin loss as a determinant of progerin-induced DNA damage in Hutchinson-Gilford Progeria.
Chojnowski A, Ong PF, Foo MXR, Liebl D, Hor LP, Stewart CL, Dreesen O
Aging cell 2020 Mar;19(3):e13108
Aging cell 2020 Mar;19(3):e13108
The mTOR pathway is necessary for survival of mice with short telomeres.
Ferrara-Romeo I, Martinez P, Saraswati S, Whittemore K, Graña-Castro O, Thelma Poluha L, Serrano R, Hernandez-Encinas E, Blanco-Aparicio C, Maria Flores J, Blasco MA
Nature communications 2020 Mar 3;11(1):1168
Nature communications 2020 Mar 3;11(1):1168
CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma.
Salvador-Barbero B, Álvarez-Fernández M, Zapatero-Solana E, El Bakkali A, Menéndez MDC, López-Casas PP, Di Domenico T, Xie T, VanArsdale T, Shields DJ, Hidalgo M, Malumbres M
Cancer cell 2020 Mar 16;37(3):340-353.e6
Cancer cell 2020 Mar 16;37(3):340-353.e6
The impact of TP53BP1 and MLH1 on metastatic capability in cases of locally advanced prostate cancer and their usefulness in clinical practice.
Gzil A, Jaworski D, Antosik P, Zarębska I, Durślewicz J, Dominiak J, Kasperska A, Neska-Długosz I, Grzanka D, Szylberg Ł
Urologic oncology 2020 Jun;38(6):600.e17-600.e26
Urologic oncology 2020 Jun;38(6):600.e17-600.e26
BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.
Hu Z, Mi S, Zhao T, Peng C, Peng Y, Chen L, Zhu W, Yao Y, Song Q, Li X, Li X, Jia C, Pei H
The EMBO journal 2020 Jun 17;39(12):e104133
The EMBO journal 2020 Jun 17;39(12):e104133
Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity.
Current K, Meyer C, Magyar CE, Mona CE, Almajano J, Slavik R, Stuparu AD, Cheng C, Dawson DW, Radu CG, Czernin J, Lueckerath K
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Jun 15;26(12):2946-2955
Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Jun 15;26(12):2946-2955
DNA damage invokes mitophagy through a pathway involving Spata18.
Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty JG, Croteau DL, Bohr VA
Nucleic acids research 2020 Jul 9;48(12):6611-6623
Nucleic acids research 2020 Jul 9;48(12):6611-6623
Shining light on the response to repair intermediates in DNA of living cells.
Janoshazi AK, Horton JK, Zhao ML, Prasad R, Scappini EL, Tucker CJ, Wilson SH
DNA repair 2020 Jan;85:102749
DNA repair 2020 Jan;85:102749
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner.
Zelensky AN, Schoonakker M, Brandsma I, Tijsterman M, van Gent DC, Essers J, Kanaar R
PLoS genetics 2020 Jan;16(1):e1008550
PLoS genetics 2020 Jan;16(1):e1008550
Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan.
Belmans N, Gilles L, Vermeesen R, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Lambrichts I, Jacobs R, Moreels M, DIMITRA Research Group.
Scientific reports 2020 Feb 7;10(1):2113
Scientific reports 2020 Feb 7;10(1):2113
DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia.
Popp HD, Kohl V, Naumann N, Flach J, Brendel S, Kleiner H, Weiss C, Seifarth W, Saussele S, Hofmann WK, Fabarius A
International journal of molecular sciences 2020 Feb 11;21(4)
International journal of molecular sciences 2020 Feb 11;21(4)
Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations.
Henry E, Souissi-Sahraoui I, Deynoux M, Lefèvre A, Barroca V, Campalans A, Ménard V, Calvo J, Pflumio F, Arcangeli ML
Haematologica 2020 Aug;105(8):2044-2055
Haematologica 2020 Aug;105(8):2044-2055
EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma.
Struve N, Binder ZA, Stead LF, Brend T, Bagley SJ, Faulkner C, Ott L, Müller-Goebel J, Weik AS, Hoffer K, Krug L, Rieckmann T, Bußmann L, Henze M, Morrissette JJD, Kurian KM, Schüller U, Petersen C, Rothkamm K, O Rourke DM, Short SC, Kriegs M
Oncogene 2020 Apr;39(15):3041-3055
Oncogene 2020 Apr;39(15):3041-3055
Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells.
Gauthier T, Duarte-Hospital C, Vignard J, Boutet-Robinet E, Sulyok M, Snini SP, Alassane-Kpembi I, Lippi Y, Puel S, Oswald IP, Puel O
Environment international 2020 Apr;137:105568
Environment international 2020 Apr;137:105568
53BP1 Accumulation in Circulating Tumor Cells Identifies Chemotherapy-Responsive Metastatic Breast Cancer Patients.
Schochter F, Werner K, Köstler C, Faul A, Tzschaschel M, Alberter B, Müller V, Neubauer H, Fehm T, Friedl TWP, Polzer B, Janni W, Rack B, Wiesmüller L
Cancers 2020 Apr 9;12(4)
Cancers 2020 Apr 9;12(4)
Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.
Wen HJ, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC
Cellular and molecular gastroenterology and hepatology 2019;8(2):173-192
Cellular and molecular gastroenterology and hepatology 2019;8(2):173-192
Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures.
Nadeau S, Cheng A, Colmegna I, Rodier F
Methods in molecular biology (Clifton, N.J.) 2019;2045:93-105
Methods in molecular biology (Clifton, N.J.) 2019;2045:93-105
Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway.
Sekhar KR, Wang J, Freeman ML, Kirschner AN
PloS one 2019;14(4):e0214670
PloS one 2019;14(4):e0214670
HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1.
Santos-Barriopedro I, Li Y, Bahl S, Seto E
Genes & cancer 2019;10(5-6):119-133
Genes & cancer 2019;10(5-6):119-133
Chronic Intestinal Pseudo-Obstruction and Lymphoproliferative Syndrome as a Novel Phenotype Associated With Tetratricopeptide Repeat Domain 7A Deficiency.
El-Daher MT, Lemale J, Bruneau J, Leveau C, Guerin F, Lambert N, Diana JS, Neven B, Sepulveda FE, Coulomb-L'Hermine A, Molina T, Picard C, Fischer A, de Saint Basile G
Frontiers in immunology 2019;10:2592
Frontiers in immunology 2019;10:2592
Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations.
Belmans N, Gilles L, Virag P, Hedesiu M, Salmon B, Baatout S, Lucas S, Jacobs R, Lambrichts I, Moreels M
Dento maxillo facial radiology 2019 Sep;48(6):20180428
Dento maxillo facial radiology 2019 Sep;48(6):20180428
Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.
Pladevall-Morera D, Munk S, Ingham A, Garribba L, Albers E, Liu Y, Olsen JV, Lopez-Contreras AJ
Nucleic acids research 2019 Sep 5;47(15):8004-8018
Nucleic acids research 2019 Sep 5;47(15):8004-8018
Non-enzymatic roles of human RAD51 at stalled replication forks.
Mason JM, Chan YL, Weichselbaum RW, Bishop DK
Nature communications 2019 Sep 27;10(1):4410
Nature communications 2019 Sep 27;10(1):4410
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage.
Sambeat A, Ratajczak J, Joffraud M, Sanchez-Garcia JL, Giner MP, Valsesia A, Giroud-Gerbetant J, Valera-Alberni M, Cercillieux A, Boutant M, Kulkarni SS, Moco S, Canto C
Nature communications 2019 Sep 20;10(1):4291
Nature communications 2019 Sep 20;10(1):4291
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL.
Parvin S, Ramirez-Labrada A, Aumann S, Lu X, Weich N, Santiago G, Cortizas EM, Sharabi E, Zhang Y, Sanchez-Garcia I, Gentles AJ, Roberts E, Bilbao-Cortes D, Vega F, Chapman JR, Verdun RE, Lossos IS
Cancer cell 2019 Sep 16;36(3):237-249.e6
Cancer cell 2019 Sep 16;36(3):237-249.e6
Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.
Zatreanu D, Han Z, Mitter R, Tumini E, Williams H, Gregersen L, Dirac-Svejstrup AB, Roma S, Stewart A, Aguilera A, Svejstrup JQ
Molecular cell 2019 Oct 3;76(1):57-69.e9
Molecular cell 2019 Oct 3;76(1):57-69.e9
Mice with hyper-long telomeres show less metabolic aging and longer lifespans.
Muñoz-Lorente MA, Cano-Martin AC, Blasco MA
Nature communications 2019 Oct 17;10(1):4723
Nature communications 2019 Oct 17;10(1):4723
Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers.
Ge Y, Wu S, Zhang Z, Li X, Li F, Yan S, Liu H, Huang J, Zhao Y
Protein & cell 2019 Nov;10(11):808-824
Protein & cell 2019 Nov;10(11):808-824
Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223.
Scherthan H, Lee JH, Maus E, Schumann S, Muhtadi R, Chojowski R, Port M, Lassmann M, Bestvater F, Hausmann M
Cancers 2019 Nov 26;11(12)
Cancers 2019 Nov 26;11(12)
Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome.
Aguado J, Sola-Carvajal A, Cancila V, Revêchon G, Ong PF, Jones-Weinert CW, Wallén Arzt E, Lattanzi G, Dreesen O, Tripodo C, Rossiello F, Eriksson M, d'Adda di Fagagna F
Nature communications 2019 Nov 18;10(1):4990
Nature communications 2019 Nov 18;10(1):4990
Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.
Whittemore K, Martínez-Nevado E, Blasco MA
Aging 2019 Nov 15;11(21):9829-9845
Aging 2019 Nov 15;11(21):9829-9845
Cytotoxicity and Genotoxicity of a New Intracanal Medicament, 2-hydroxyisocaproic Acid-An In Vitro Study.
Selis D, Pande Y, Smoczer C, Wheater M, Alhabeil J, Paurazas S, Askar M
Journal of endodontics 2019 May;45(5):578-583
Journal of endodontics 2019 May;45(5):578-583
RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci.
Michelini F, Rossiello F, d'Adda di Fagagna F, Francia S
Nature protocols 2019 May;14(5):1489-1508
Nature protocols 2019 May;14(5):1489-1508
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, Enikolopov G, Johnson KO, Xu M, Inman C, Palmer AK, Schafer M, Weigl M, Ikeno Y, Burns TC, Passos JF, von Zglinicki T, Kirkland JL, Jurk D
Cell metabolism 2019 May 7;29(5):1061-1077.e8
Cell metabolism 2019 May 7;29(5):1061-1077.e8
Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2.
Huang J, Zhang J, Bellani MA, Pokharel D, Gichimu J, James RC, Gali H, Ling C, Yan Z, Xu D, Chen J, Meetei AR, Li L, Wang W, Seidman MM
Cell reports 2019 May 7;27(6):1794-1808.e5
Cell reports 2019 May 7;27(6):1794-1808.e5
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase.
Campillo-Marcos I, Lazo PA
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):203
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):203
Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins.
Gupta R, Li W, Yan XJ, Barrientos J, Kolitz JE, Allen SL, Rai K, Chiorazzi N, Mongini PKA
Journal of immunology (Baltimore, Md. : 1950) 2019 May 15;202(10):2924-2944
Journal of immunology (Baltimore, Md. : 1950) 2019 May 15;202(10):2924-2944
Molecular and cellular basis of mammary gland fibrosis and cancer risk.
Wu J, Crowe DL
International journal of cancer 2019 May 1;144(9):2239-2253
International journal of cancer 2019 May 1;144(9):2239-2253
The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability.
Tumini E, Herrera-Moyano E, San Martín-Alonso M, Barroso S, Galmarini CM, Aguilera A
Molecular cancer research : MCR 2019 Mar;17(3):773-782
Molecular cancer research : MCR 2019 Mar;17(3):773-782
Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells.
Gourzones C, Bellanger C, Lamure S, Gadacha OK, De Paco EG, Vincent L, Cartron G, Klein B, Moreaux J
Cancers 2019 Mar 28;11(4)
Cancers 2019 Mar 28;11(4)
UFL1 promotes histone H4 ufmylation and ATM activation.
Qin B, Yu J, Nowsheen S, Wang M, Tu X, Liu T, Li H, Wang L, Lou Z
Nature communications 2019 Mar 18;10(1):1242
Nature communications 2019 Mar 18;10(1):1242
The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors.
Peng Y, Liao Q, Tan W, Peng C, Hu Z, Chen Y, Li Z, Li J, Zhen B, Zhu W, Li X, Yao Y, Song Q, Liu C, Qi X, He F, Pei H
Nature communications 2019 Mar 15;10(1):1224
Nature communications 2019 Mar 15;10(1):1224
Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling.
Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rödel F, Seifert V, Kögel D
Cancers 2019 Mar 12;11(3)
Cancers 2019 Mar 12;11(3)
Linear double-stranded DNAs as innovative biological parts to implement genetic circuits in mammalian cells.
Li S, Su W, Zhang C
The FEBS journal 2019 Jun;286(12):2341-2354
The FEBS journal 2019 Jun;286(12):2341-2354
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors.
Efimova EV, Appelbe OK, Ricco N, Lee SS, Liu Y, Wolfgeher DJ, Collins TN, Flor AC, Ramamurthy A, Warrington S, Bindokas VP, Kron SJ
Molecular cancer research : MCR 2019 Jun;17(6):1338-1350
Molecular cancer research : MCR 2019 Jun;17(6):1338-1350
Mammalian CST averts replication failure by preventing G-quadruplex accumulation.
Zhang M, Wang B, Li T, Liu R, Xiao Y, Geng X, Li G, Liu Q, Price CM, Liu Y, Wang F
Nucleic acids research 2019 Jun 4;47(10):5243-5259
Nucleic acids research 2019 Jun 4;47(10):5243-5259
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Brandsma I, Sato K, van Rossum-Fikkert SE, van Vliet N, Sleddens E, Reuter M, Odijk H, van den Tempel N, Dekkers DHW, Bezstarosti K, Demmers JAA, Maas A, Lebbink J, Wyman C, Essers J, van Gent DC, Baarends WM, Knipscheer P, Kanaar R, Zelensky AN
Cell reports 2019 Jun 25;27(13):3790-3798.e7
Cell reports 2019 Jun 25;27(13):3790-3798.e7
Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells.
Grill S, Bisht K, Tesmer VM, Shami AN, Hammoud SS, Nandakumar J
Cell reports 2019 Jun 18;27(12):3511-3521.e7
Cell reports 2019 Jun 18;27(12):3511-3521.e7
Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.
Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE
Developmental cell 2019 Jun 17;49(6):920-935.e5
Developmental cell 2019 Jun 17;49(6):920-935.e5
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.
Caron P, Pankotai T, Wiegant WW, Tollenaere MAX, Furst A, Bonhomme C, Helfricht A, de Groot A, Pastink A, Vertegaal ACO, Luijsterburg MS, Soutoglou E, van Attikum H
Genes & development 2019 Jun 1;33(11-12):684-704
Genes & development 2019 Jun 1;33(11-12):684-704
Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP).
Lagunas AM, Francis M, Maniar NB, Nikolova G, Wu J, Crowe DL
Molecular cancer research : MCR 2019 Jul;17(7):1480-1492
Molecular cancer research : MCR 2019 Jul;17(7):1480-1492
Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts.
Prieto I, Zambrano A, Laso J, Aranda A, Samper E, Monsalve M
Free radical biology & medicine 2019 Jul;138:23-32
Free radical biology & medicine 2019 Jul;138:23-32
LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.
West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC
Nucleic acids research 2019 Jul 9;47(12):6236-6249
Nucleic acids research 2019 Jul 9;47(12):6236-6249
Constricted migration modulates stem cell differentiation.
Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE
Molecular biology of the cell 2019 Jul 22;30(16):1985-1999
Molecular biology of the cell 2019 Jul 22;30(16):1985-1999
Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.
Liu Y, Efimova EV, Ramamurthy A, Kron SJ
Journal of cell science 2019 Jul 1;132(13)
Journal of cell science 2019 Jul 1;132(13)
TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.
Lafarga V, Sung HM, Haneke K, Roessig L, Pauleau AL, Bruer M, Rodriguez-Acebes S, Lopez-Contreras AJ, Gruss OJ, Erhardt S, Mendez J, Fernandez-Capetillo O, Stoecklin G
EMBO reports 2019 Jan;20(1)
EMBO reports 2019 Jan;20(1)
Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest.
Coluzzi E, Leone S, Sgura A
Cells 2019 Jan 3;8(1)
Cells 2019 Jan 3;8(1)
Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment.
Muñoz-Galván S, Lucena-Cacace A, Perez M, Otero-Albiol D, Gomez-Cambronero J, Carnero A
Oncogene 2019 Feb;38(8):1309-1323
Oncogene 2019 Feb;38(8):1309-1323
Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy.
Fichtman B, Zagairy F, Biran N, Barsheshet Y, Chervinsky E, Ben Neriah Z, Shaag A, Assa M, Elpeleg O, Harel A, Spiegel R
Nature communications 2019 Feb 5;10(1):605
Nature communications 2019 Feb 5;10(1):605
G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma.
Wang Y, Yang J, Wild AT, Wu WH, Shah R, Danussi C, Riggins GJ, Kannan K, Sulman EP, Chan TA, Huse JT
Nature communications 2019 Feb 26;10(1):943
Nature communications 2019 Feb 26;10(1):943
Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.
Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL
Molecular cell 2019 Feb 21;73(4):684-698.e8
Molecular cell 2019 Feb 21;73(4):684-698.e8
Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury.
Bodo S, Campagne C, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z
The Journal of clinical investigation 2019 Feb 1;129(2):786-801
The Journal of clinical investigation 2019 Feb 1;129(2):786-801
Formaldehyde inhibits UV-induced phosphorylation of histone H2AX.
Yang G, Komaki Y, Yoshida I, Ibuki Y
Toxicology in vitro : an international journal published in association with BIBRA 2019 Dec;61:104687
Toxicology in vitro : an international journal published in association with BIBRA 2019 Dec;61:104687
Bcl2-Expressing Quiescent Type B Neural Stem Cells in the Ventricular-Subventricular Zone Are Resistant to Concurrent Temozolomide/X-Irradiation.
Cameron BD, Traver G, Roland JT, Brockman AA, Dean D, Johnson L, Boyd K, Ihrie RA, Freeman ML
Stem cells (Dayton, Ohio) 2019 Dec;37(12):1629-1639
Stem cells (Dayton, Ohio) 2019 Dec;37(12):1629-1639
Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.
Galindo-Campos MA, Bedora-Faure M, Farrés J, Lescale C, Moreno-Lama L, Martínez C, Martín-Caballero J, Ampurdanés C, Aparicio P, Dantzer F, Cerutti A, Deriano L, Yélamos J
Cell death and differentiation 2019 Dec;26(12):2667-2681
Cell death and differentiation 2019 Dec;26(12):2667-2681
CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.
Crochemore C, Fernández-Molina C, Montagne B, Salles A, Ricchetti M
Nature communications 2019 Dec 6;10(1):5576
Nature communications 2019 Dec 6;10(1):5576
Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines.
Köse-Vogel N, Stengel S, Gardey E, Kirchberger-Tolstik T, Reuken PA, Stallmach A, Bruns T
Cells 2019 Dec 28;9(1)
Cells 2019 Dec 28;9(1)
GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival.
Lu X, Tang M, Zhu Q, Yang Q, Li Z, Bao Y, Liu G, Hou T, Lv Y, Zhao Y, Wang H, Yang Y, Cheng Z, Wen H, Liu B, Xu X, Gu L, Zhu WG
Nucleic acids research 2019 Dec 2;47(21):10977-10993
Nucleic acids research 2019 Dec 2;47(21):10977-10993
RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells.
Peng J, Tang L, Cai M, Chen H, Wong J, Zhang P
Cancer medicine 2019 Aug;8(10):4743-4752
Cancer medicine 2019 Aug;8(10):4743-4752
DNA cross-link repair safeguards genomic stability during premeiotic germ cell development.
Hill RJ, Crossan GP
Nature genetics 2019 Aug;51(8):1283-1294
Nature genetics 2019 Aug;51(8):1283-1294
53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function.
Sundaravinayagam D, Rahjouei A, Andreani M, Tupiņa D, Balasubramanian S, Saha T, Delgado-Benito V, Coralluzzo V, Daumke O, Di Virgilio M
Cell reports 2019 Aug 6;28(6):1389-1399.e6
Cell reports 2019 Aug 6;28(6):1389-1399.e6
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle.
Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE
The Journal of cell biology 2019 Aug 5;218(8):2545-2563
The Journal of cell biology 2019 Aug 5;218(8):2545-2563
Exposure to the Fungicide Captan Induces DNA Base Alterations and Replicative Stress in Mammalian Cells.
Fernandez-Vidal A, Arnaud LC, Maumus M, Chevalier M, Mirey G, Salles B, Vignard J, Boutet-Robinet E
Environmental and molecular mutagenesis 2019 Apr;60(3):286-297
Environmental and molecular mutagenesis 2019 Apr;60(3):286-297
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.
Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW
Nature genetics 2019 Apr;51(4):705-715
Nature genetics 2019 Apr;51(4):705-715
The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells.
Jung HE, Shim YR, Oh JE, Oh DS, Lee HK
Immune network 2019 Apr;19(2):e12
Immune network 2019 Apr;19(2):e12
Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response.
Schiroli G, Conti A, Ferrari S, Della Volpe L, Jacob A, Albano L, Beretta S, Calabria A, Vavassori V, Gasparini P, Salataj E, Ndiaye-Lobry D, Brombin C, Chaumeil J, Montini E, Merelli I, Genovese P, Naldini L, Di Micco R
Cell stem cell 2019 Apr 4;24(4):551-565.e8
Cell stem cell 2019 Apr 4;24(4):551-565.e8
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma.
Miska J, Lee-Chang C, Rashidi A, Muroski ME, Chang AL, Lopez-Rosas A, Zhang P, Panek WK, Cordero A, Han Y, Ahmed AU, Chandel NS, Lesniak MS
Cell reports 2019 Apr 2;27(1):226-237.e4
Cell reports 2019 Apr 2;27(1):226-237.e4
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
Bhatia V, Valdés-Sánchez L, Rodriguez-Martinez D, Bhattacharya SS
F1000Research 2018;7:1233
F1000Research 2018;7:1233
Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure.
El-Daher MT, Cagnard N, Gil M, Da Cruz MC, Leveau C, Sepulveda F, Zarhrate M, Tores F, Legoix P, Baulande S, de Villartay JP, Almouzni G, Quivy JP, Fischer A, de Saint Basile G
Cell discovery 2018;4:61
Cell discovery 2018;4:61
Extracorporeal Shock Wave-Supported Adipose-Derived Fresh Stromal Vascular Fraction Preserved Left Ventricular (LV) Function and Inhibited LV Remodeling in Acute Myocardial Infarction in Rat.
Sung PH, Yin TC, Wallace CG, Chen KH, Shao PL, Lee FY, Sun CK, Sheu JJ, Chen YL, Omran MM, Chung SY, Wang CJ, Lee MS, Yip HK
Oxidative medicine and cellular longevity 2018;2018:7518920
Oxidative medicine and cellular longevity 2018;2018:7518920
Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation.
Johnson TI, Costa ASH, Ferguson AN, Frezza C
Cell death & disease 2018 Sep 6;9(9):913
Cell death & disease 2018 Sep 6;9(9):913
Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.
Chow TT, Shi X, Wei JH, Guan J, Stadler G, Huang B, Blackburn EH
Nature communications 2018 Sep 4;9(1):3583
Nature communications 2018 Sep 4;9(1):3583
Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality.
Albers E, Sbroggiò M, Pladevall-Morera D, Bizard AH, Avram A, Gonzalez P, Martin-Gonzalez J, Hickson ID, Lopez-Contreras AJ
Cell reports 2018 Sep 18;24(12):3274-3284
Cell reports 2018 Sep 18;24(12):3274-3284
2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1.
Qi Y, Toyooka T, Kashiwagi H, Yanagiba Y, Koda S, Ohta H, Wang RS
Archives of toxicology 2018 Oct;92(10):3093-3101
Archives of toxicology 2018 Oct;92(10):3093-3101
miR-30 disrupts senescence and promotes cancer by targeting both p16INK4A and DNA damage pathways.
Su W, Hong L, Xu X, Huang S, Herpai D, Li L, Xu Y, Truong L, Hu WY, Wu X, Xiao C, Zhang W, Han J, Debinski W, Xiang R, Sun P
Oncogene 2018 Oct;37(42):5618-5632
Oncogene 2018 Oct;37(42):5618-5632
High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair.
Vallabhaneni H, Lynch PJ, Chen G, Park K, Liu Y, Goehe R, Mallon BS, Boehm M, Hursh DA
Stem cells (Dayton, Ohio) 2018 Oct;36(10):1501-1513
Stem cells (Dayton, Ohio) 2018 Oct;36(10):1501-1513
Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells.
Muoio D, Berardinelli F, Leone S, Coluzzi E, di Masi A, Doria F, Freccero M, Sgura A, Folini M, Antoccia A
The FEBS journal 2018 Oct;285(20):3769-3785
The FEBS journal 2018 Oct;285(20):3769-3785
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing.
Chakraborty P, Huang JTJ, Hiom K
Nature communications 2018 Oct 19;9(1):4346
Nature communications 2018 Oct 19;9(1):4346
Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.
Evangelista FM, Maglott-Roth A, Stierle M, Brino L, Soutoglou E, Tora L
The Journal of cell biology 2018 Oct 1;217(10):3382-3397
The Journal of cell biology 2018 Oct 1;217(10):3382-3397
CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures.
Sargolzaeiaval F, Zhang J, Schleit J, Lessel D, Kubisch C, Precioso DR, Sillence D, Hisama FM, Dorschner M, Martin GM, Oshima J
Molecular genetics & genomic medicine 2018 Nov;6(6):1148-1156
Molecular genetics & genomic medicine 2018 Nov;6(6):1148-1156
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.
Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE
The Journal of cell biology 2018 Nov 5;217(11):3796-3808
The Journal of cell biology 2018 Nov 5;217(11):3796-3808
An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability.
Mitxelena J, Apraiz A, Vallejo-Rodríguez J, García-Santisteban I, Fullaondo A, Alvarez-Fernández M, Malumbres M, Zubiaga AM
Nucleic acids research 2018 May 18;46(9):4546-4559
Nucleic acids research 2018 May 18;46(9):4546-4559
Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks.
Massonneau J, Ouellet C, Lucien F, Dubois CM, Tyler J, Boissonneault G
FEBS open bio 2018 Mar;8(3):416-425
FEBS open bio 2018 Mar;8(3):416-425
The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.
Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C, Oswald E, Nougayrède JP
mBio 2018 Mar 20;9(2)
mBio 2018 Mar 20;9(2)
USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner.
Richter K, Paakkola T, Mennerich D, Kubaichuk K, Konzack A, Ali-Kippari H, Kozlova N, Koivunen P, Haapasaari KM, Jukkola-Vuorinen A, Teppo HR, Dimova EY, Bloigu R, Szabo Z, Kerkelä R, Kietzmann T
Molecular cancer research : MCR 2018 Jun;16(6):1000-1012
Molecular cancer research : MCR 2018 Jun;16(6):1000-1012
INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
Le O, Palacio L, Bernier G, Batinic-Haberle I, Hickson G, Beauséjour C
Stem cell reports 2018 Jun 5;10(6):1721-1733
Stem cell reports 2018 Jun 5;10(6):1721-1733
Proton irradiation orchestrates macrophage reprogramming through NFκB signaling.
Genard G, Wera AC, Huart C, Le Calve B, Penninckx S, Fattaccioli A, Tabarrant T, Demazy C, Ninane N, Heuskin AC, Lucas S, Michiels C
Cell death & disease 2018 Jun 27;9(7):728
Cell death & disease 2018 Jun 27;9(7):728
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.
Cánovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Pérez-Montoyo H, Serra V, González-Suárez E, Stracker TH, Nebreda AR
Cancer cell 2018 Jun 11;33(6):1094-1110.e8
Cancer cell 2018 Jun 11;33(6):1094-1110.e8
Long-term Persistent Organic Pollutants Exposure Induced Telomere Dysfunction and Senescence-Associated Secretary Phenotype.
Yuan J, Liu Y, Wang J, Zhao Y, Li K, Jing Y, Zhang X, Liu Q, Geng X, Li G, Wang F
The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Jul 9;73(8):1027-1035
The journals of gerontology. Series A, Biological sciences and medical sciences 2018 Jul 9;73(8):1027-1035
Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
Gavish-Izakson M, Velpula BB, Elkon R, Prados-Carvajal R, Barnabas GD, Ugalde AP, Agami R, Geiger T, Huertas P, Ziv Y, Shiloh Y
Nucleic acids research 2018 Jan 25;46(2):730-747
Nucleic acids research 2018 Jan 25;46(2):730-747
DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites.
Chitale S, Richly H
The Journal of cell biology 2018 Feb 5;217(2):527-540
The Journal of cell biology 2018 Feb 5;217(2):527-540
Central and Peripheral Expression of DNA Double-Strand Breaks in Human and Mouse Tissues.
Castiglione MP, Ramos RL, Leheste JR, Torres G
Anatomical record (Hoboken, N.J. : 2007) 2018 Feb 21;301(7):1251-1257
Anatomical record (Hoboken, N.J. : 2007) 2018 Feb 21;301(7):1251-1257
Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts.
Razdan N, Vasilopoulos T, Herbig U
Aging cell 2018 Dec;17(6):e12838
Aging cell 2018 Dec;17(6):e12838
Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.
Timm S, Lorat Y, Jakob B, Taucher-Scholz G, Rübe CE
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2018 Dec;129(3):600-610
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2018 Dec;129(3):600-610
Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide.
Tête A, Gallais I, Imran M, Chevanne M, Liamin M, Sparfel L, Bucher S, Burel A, Podechard N, Appenzeller BMR, Fromenty B, Grova N, Sergent O, Lagadic-Gossmann D
Free radical biology & medicine 2018 Dec;129:323-337
Free radical biology & medicine 2018 Dec;129:323-337
The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage.
Piquet S, Le Parc F, Bai SK, Chevallier O, Adam S, Polo SE
Molecular cell 2018 Dec 6;72(5):888-901.e7
Molecular cell 2018 Dec 6;72(5):888-901.e7
Impaired immune surveillance accelerates accumulation of senescent cells and aging.
Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V
Nature communications 2018 Dec 21;9(1):5435
Nature communications 2018 Dec 21;9(1):5435
Detrimental pro-senescence effects of vitamin D on lung fibrosis.
Guijarro T, Magro-Lopez E, Manso J, Garcia-Martinez R, Fernandez-Aceñero MJ, Liste I, Zambrano A
Molecular medicine (Cambridge, Mass.) 2018 Dec 19;24(1):64
Molecular medicine (Cambridge, Mass.) 2018 Dec 19;24(1):64
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity.
Becker JR, Cuella-Martin R, Barazas M, Liu R, Oliveira C, Oliver AW, Bilham K, Holt AB, Blackford AN, Heierhorst J, Jonkers J, Rottenberg S, Chapman JR
Nature communications 2018 Dec 17;9(1):5406
Nature communications 2018 Dec 17;9(1):5406
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.
Ghezraoui H, Oliveira C, Becker JR, Bilham K, Moralli D, Anzilotti C, Fischer R, Deobagkar-Lele M, Sanchiz-Calvo M, Fueyo-Marcos E, Bonham S, Kessler BM, Rottenberg S, Cornall RJ, Green CM, Chapman JR
Nature 2018 Aug;560(7716):122-127
Nature 2018 Aug;560(7716):122-127
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.
Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T
Nature 2018 Aug;560(7716):112-116
Nature 2018 Aug;560(7716):112-116
FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer.
Pecqueux C, Arslan A, Heller M, Falkenstein M, Kaczorowski A, Tolstov Y, Sültmann H, Grüllich C, Herpel E, Duensing A, Kristiansen G, Hohenfellner M, Navone NM, Duensing S
Urologic oncology 2018 Aug;36(8):365.e15-365.e26
Urologic oncology 2018 Aug;36(8):365.e15-365.e26
Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits.
La Torre M, Merigliano C, Burla R, Mottini C, Zanetti G, Del Giudice S, Carcuro M, Virdia I, Bucciarelli E, Manni I, Vinciguerra GR, Piaggio G, Riminucci M, Cumano A, Bartolazzi A, Vernì F, Soddu S, Gatti M, Saggio I
Aging cell 2018 Aug;17(4):e12730
Aging cell 2018 Aug;17(4):e12730
Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1.
Majerska J, Feretzaki M, Glousker G, Lingner J
Life science alliance 2018 Aug;1(4):e201800121
Life science alliance 2018 Aug;1(4):e201800121
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.
Petroni M, Sardina F, Infante P, Bartolazzi A, Locatelli E, Fabretti F, Di Giulio S, Capalbo C, Cardinali B, Coppa A, Tessitore A, Colicchia V, Sahùn Roncero M, Belardinilli F, Di Marcotullio L, Soddu S, Comes Franchini M, Petricci E, Gulino A, Giannini G
Cell death & disease 2018 Aug 30;9(9):895
Cell death & disease 2018 Aug 30;9(9):895
Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib.
Hehlgans S, Booms P, Güllülü Ö, Sader R, Rödel C, Balermpas P, Rödel F, Ghanaati S
International journal of molecular sciences 2018 Aug 23;19(9)
International journal of molecular sciences 2018 Aug 23;19(9)
Plk1 overexpression induces chromosomal instability and suppresses tumor development.
de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R
Nature communications 2018 Aug 1;9(1):3012
Nature communications 2018 Aug 1;9(1):3012
Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.
Biechonski S, Olender L, Zipin-Roitman A, Yassin M, Aqaqe N, Marcu-Malina V, Rall-Scharpf M, Trottier M, Meyn MS, Wiesmüller L, Beider K, Raz Y, Grisaru D, Nagler A, Milyavsky M
Scientific reports 2018 Apr 17;8(1):6071
Scientific reports 2018 Apr 17;8(1):6071
53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress.
Her J, Ray C, Altshuler J, Zheng H, Bunting SF
Molecular and cellular biology 2018 Apr 15;38(8)
Molecular and cellular biology 2018 Apr 15;38(8)
Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose.
Baselet B, Belmans N, Coninx E, Lowe D, Janssen A, Michaux A, Tabury K, Raj K, Quintens R, Benotmane MA, Baatout S, Sonveaux P, Aerts A
Frontiers in pharmacology 2017;8:213
Frontiers in pharmacology 2017;8:213
Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells.
Kim H, Li F, He Q, Deng T, Xu J, Jin F, Coarfa C, Putluri N, Liu D, Songyang Z
Cell discovery 2017;3:17034
Cell discovery 2017;3:17034
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress.
Liu R, King A, Hoch NC, Chang C, Kelly GL, Deans AJ, Heierhorst J
DNA repair 2017 Sep;57:29-34
DNA repair 2017 Sep;57:29-34
Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.
Mikuła-Pietrasik J, Uruski P, Pakuła M, Maksin K, Szubert S, Woźniak A, Naumowicz E, Szpurek D, Tykarski A, Książek K
Free radical biology & medicine 2017 Sep;110:270-279
Free radical biology & medicine 2017 Sep;110:270-279
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Viziteu E, Klein B, Basbous J, Lin YL, Hirtz C, Gourzones C, Tiers L, Bruyer A, Vincent L, Grandmougin C, Seckinger A, Goldschmidt H, Constantinou A, Pasero P, Hose D, Moreaux J
Leukemia 2017 Oct;31(10):2104-2113
Leukemia 2017 Oct;31(10):2104-2113
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age.
Hosokawa K, MacArthur BD, Ikushima YM, Toyama H, Masuhiro Y, Hanazawa S, Suda T, Arai F
Nature communications 2017 Oct 6;8(1):804
Nature communications 2017 Oct 6;8(1):804
Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1.
Garzón J, Rodríguez R, Kong Z, Chabes A, Rodríguez-Acebes S, Méndez J, Moreno S, García-Higuera I
Oncogene 2017 Oct 19;36(42):5808-5818
Oncogene 2017 Oct 19;36(42):5808-5818
Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.
Jongen JMJ, van der Waals LM, Trumpi K, Laoukili J, Peters NA, Schenning-van Schelven SJ, Govaert KM, Borel Rinkes IHM, Kranenburg O
Oncotarget 2017 Oct 17;8(49):86296-86311
Oncotarget 2017 Oct 17;8(49):86296-86311
ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage.
Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, Hessmann E, Russell R, Lechel A, Azoitei N, Lin Q, Liebau S, Hohwieler M, Bohnenberger H, Lesina M, Algül H, Gieldon L, Schröck E, Gaedcke J, Wagner M, Wiesmüller L, Sipos B, Seufferlein T, Reinhardt HC, Frappart PO, Kleger A
Cancer research 2017 Oct 15;77(20):5576-5590
Cancer research 2017 Oct 15;77(20):5576-5590
Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung.
Traver G, Mont S, Gius D, Lawson WE, Ding GX, Sekhar KR, Freeman ML
Free radical biology & medicine 2017 Nov;112:578-586
Free radical biology & medicine 2017 Nov;112:578-586
BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.
Patel DS, Misenko SM, Her J, Bunting SF
The Journal of cell biology 2017 Nov 6;216(11):3521-3534
The Journal of cell biology 2017 Nov 6;216(11):3521-3534
Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.
Fujita K, Mao Y, Uchida S, Chen X, Shiwaku H, Tamura T, Ito H, Watase K, Homma H, Tagawa K, Sudol M, Okazawa H
Nature communications 2017 Nov 30;8(1):1864
Nature communications 2017 Nov 30;8(1):1864
Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.
Schuhwerk H, Bruhn C, Siniuk K, Min W, Erener S, Grigaravicius P, Krüger A, Ferrari E, Zubel T, Lazaro D, Monajembashi S, Kiesow K, Kroll T, Bürkle A, Mangerich A, Hottiger M, Wang ZQ
Nucleic acids research 2017 Nov 2;45(19):11174-11192
Nucleic acids research 2017 Nov 2;45(19):11174-11192
Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of urothelial cancer and normal urothelial cells.
Bill MA, Srivastava K, Breen C, Butterworth KT, McMahon SJ, Prise KM, McCloskey KD
Oncotarget 2017 Nov 14;8(57):97331-97343
Oncotarget 2017 Nov 14;8(57):97331-97343
Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts.
Bejarano L, Schuhmacher AJ, Méndez M, Megías D, Blanco-Aparicio C, Martínez S, Pastor J, Squatrito M, Blasco MA
Cancer cell 2017 Nov 13;32(5):590-607.e4
Cancer cell 2017 Nov 13;32(5):590-607.e4
CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.
Hilmi K, Jangal M, Marques M, Zhao T, Saad A, Zhang C, Luo VM, Syme A, Rejon C, Yu Z, Krum A, Fabian MR, Richard S, Alaoui-Jamali M, Orthwein A, McCaffrey L, Witcher M
Science advances 2017 May;3(5):e1601898
Science advances 2017 May;3(5):e1601898
Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening.
Ji S, Zhu L, Gao Y, Zhang X, Yan Y, Cen J, Li R, Zeng R, Liao L, Hou C, Gao Y, Gao S, Wei G, Hui L
Cell research 2017 May;27(5):642-656
Cell research 2017 May;27(5):642-656
Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae.
Kalimutho M, Bain AL, Mukherjee B, Nag P, Nanayakkara DM, Harten SK, Harris JL, Subramanian GN, Sinha D, Shirasawa S, Srihari S, Burma S, Khanna KK
Molecular oncology 2017 May;11(5):470-490
Molecular oncology 2017 May;11(5):470-490
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.
Contrepois K, Coudereau C, Benayoun BA, Schuler N, Roux PF, Bischof O, Courbeyrette R, Carvalho C, Thuret JY, Ma Z, Derbois C, Nevers MC, Volland H, Redon CE, Bonner WM, Deleuze JF, Wiel C, Bernard D, Snyder MP, Rübe CE, Olaso R, Fenaille F, Mann C
Nature communications 2017 May 10;8:14995
Nature communications 2017 May 10;8:14995
Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency.
Cottineau J, Kottemann MC, Lach FP, Kang YH, Vély F, Deenick EK, Lazarov T, Gineau L, Wang Y, Farina A, Chansel M, Lorenzo L, Piperoglou C, Ma CS, Nitschke P, Belkadi A, Itan Y, Boisson B, Jabot-Hanin F, Picard C, Bustamante J, Eidenschenk C, Boucherit S, Aladjidi N, Lacombe D, Barat P, Qasim W, Hurst JA, Pollard AJ, Uhlig HH, Fieschi C, Michon J, Bermudez VP, Abel L, de Villartay JP, Geissmann F, Tangye SG, Hurwitz J, Vivier E, Casanova JL, Smogorzewska A, Jouanguy E
The Journal of clinical investigation 2017 May 1;127(5):1991-2006
The Journal of clinical investigation 2017 May 1;127(5):1991-2006
213Bi-Labeled Prostate-Specific Membrane Antigen-Targeting Agents Induce DNA Double-Strand Breaks in Prostate Cancer Xenografts.
Nonnekens J, Chatalic KL, Molkenboer-Kuenen JD, Beerens CE, Bruchertseifer F, Morgenstern A, Veldhoven-Zweistra J, Schottelius M, Wester HJ, van Gent DC, van Weerden WM, Boerman OC, de Jong M, Heskamp S
Cancer biotherapy & radiopharmaceuticals 2017 Mar;32(2):67-73
Cancer biotherapy & radiopharmaceuticals 2017 Mar;32(2):67-73
TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9.
Liu Y, Cussiol JR, Dibitetto D, Sims JR, Twayana S, Weiss RS, Freire R, Marini F, Pellicioli A, Smolka MB
The Journal of cell biology 2017 Mar 6;216(3):623-639
The Journal of cell biology 2017 Mar 6;216(3):623-639
Microinjection of Antibodies Targeting the Lamin A/C Histone-Binding Site Blocks Mitotic Entry and Reveals Separate Chromatin Interactions with HP1, CenpB and PML.
Dixon CR, Platani M, Makarov AA, Schirmer EC
Cells 2017 Mar 25;6(2)
Cells 2017 Mar 25;6(2)
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.
Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X, Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B, Lan L
Molecular cell 2017 Mar 2;65(5):818-831.e5
Molecular cell 2017 Mar 2;65(5):818-831.e5
Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche.
Yang TB, Chen Q, Deng JT, Jagannathan G, Tobias JW, Schultz DC, Wang S, Lengner CJ, Rustgi AK, Lynch JP, Johnson FB
Nature communications 2017 Mar 17;8:14766
Nature communications 2017 Mar 17;8:14766
The telomeric DNA damage response occurs in the absence of chromatin decompaction.
Vancevska A, Douglass KM, Pfeiffer V, Manley S, Lingner J
Genes & development 2017 Mar 15;31(6):567-577
Genes & development 2017 Mar 15;31(6):567-577
53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination.
Feldman S, Wuerffel R, Achour I, Wang L, Carpenter PB, Kenter AL
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2434-2444
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2434-2444
Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response.
Coucoravas C, Dhanjal S, Henriksson S, Böhm S, Farnebo M
RNA biology 2017 Jun 3;14(6):804-813
RNA biology 2017 Jun 3;14(6):804-813
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li JM, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P
Nature communications 2017 Jun 12;8:15751
Nature communications 2017 Jun 12;8:15751
DNA Damage Detection by 53BP1: Relationship to Species Longevity.
Croco E, Marchionni S, Bocchini M, Angeloni C, Stamato T, Stefanelli C, Hrelia S, Sell C, Lorenzini A
The journals of gerontology. Series A, Biological sciences and medical sciences 2017 Jun 1;72(6):763-770
The journals of gerontology. Series A, Biological sciences and medical sciences 2017 Jun 1;72(6):763-770
Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer.
Huang D, Lu W, Zou S, Wang H, Jiang Y, Zhang X, Li P, Songyang Z, Wang L, Wang J, Huang J, Fang L
Cancer science 2017 Jul;108(7):1293-1302
Cancer science 2017 Jul;108(7):1293-1302
MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells.
Lai X, Broderick R, Bergoglio V, Zimmer J, Badie S, Niedzwiedz W, Hoffmann JS, Tarsounas M
Nature communications 2017 Jul 17;8:15983
Nature communications 2017 Jul 17;8:15983
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Jaiswal H, Benada J, Müllers E, Akopyan K, Burdova K, Koolmeister T, Helleday T, Medema RH, Macurek L, Lindqvist A
The EMBO journal 2017 Jul 14;36(14):2161-2176
The EMBO journal 2017 Jul 14;36(14):2161-2176
Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer.
Li M, Chen Q, Yu X
Cancer research 2017 Jan 15;77(2):448-458
Cancer research 2017 Jan 15;77(2):448-458
Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes.
Mytych J, Wos I, Solek P, Koziorowski M
Experimental cell research 2017 Jan 15;350(2):358-367
Experimental cell research 2017 Jan 15;350(2):358-367
DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs.
Rossiello F, Aguado J, Sepe S, Iannelli F, Nguyen Q, Pitchiaya S, Carninci P, d'Adda di Fagagna F
Nature communications 2017 Feb 27;8:13980
Nature communications 2017 Feb 27;8:13980
Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance.
Hess J, Unger K, Orth M, Schötz U, Schüttrumpf L, Zangen V, Gimenez-Aznar I, Michna A, Schneider L, Stamp R, Selmansberger M, Braselmann H, Hieber L, Drexler GA, Kuger S, Klein D, Jendrossek V, Friedl AA, Belka C, Zitzelsberger H, Lauber K
Cancer letters 2017 Feb 1;386:87-99
Cancer letters 2017 Feb 1;386:87-99
ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.
Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM
Genes & development 2017 Feb 1;31(3):260-274
Genes & development 2017 Feb 1;31(3):260-274
A Biallelic Mutation in the Homologous Recombination Repair Gene SPIDR Is Associated With Human Gonadal Dysgenesis.
Smirin-Yosef P, Zuckerman-Levin N, Tzur S, Granot Y, Cohen L, Sachsenweger J, Borck G, Lagovsky I, Salmon-Divon M, Wiesmüller L, Basel-Vanagaite L
The Journal of clinical endocrinology and metabolism 2017 Feb 1;102(2):681-688
The Journal of clinical endocrinology and metabolism 2017 Feb 1;102(2):681-688
Integrating phosphoproteomics into the clinical management of prostate cancer.
Cheng LC, Tan VM, Ganesan S, Drake JM
Clinical and translational medicine 2017 Dec;6(1):9
Clinical and translational medicine 2017 Dec;6(1):9
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, Cabrini M, Wang Y, Capozzo I, Iannelli F, Matti V, Francia S, Shivashankar GV, Walter NG, d'Adda di Fagagna F
Nature cell biology 2017 Dec;19(12):1400-1411
Nature cell biology 2017 Dec;19(12):1400-1411
ATR Is a Therapeutic Target in Synovial Sarcoma.
Jones SE, Fleuren EDG, Frankum J, Konde A, Williamson CT, Krastev DB, Pemberton HN, Campbell J, Gulati A, Elliott R, Menon M, Selfe JL, Brough R, Pettitt SJ, Niedzwiedz W, van der Graaf WTA, Shipley J, Ashworth A, Lord CJ
Cancer research 2017 Dec 15;77(24):7014-7026
Cancer research 2017 Dec 15;77(24):7014-7026
The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.
Vohhodina J, Barros EM, Savage AL, Liberante FG, Manti L, Bankhead P, Cosgrove N, Madden AF, Harkin DP, Savage KI
Nucleic acids research 2017 Dec 15;45(22):12816-12833
Nucleic acids research 2017 Dec 15;45(22):12816-12833
Looping-out mechanism for resolution of replicative stress at telomeres.
Zhang T, Zhang Z, Li F, Hu Q, Liu H, Tang M, Ma W, Huang J, Songyang Z, Rong Y, Zhang S, Chen BP, Zhao Y
EMBO reports 2017 Aug;18(8):1412-1428
EMBO reports 2017 Aug;18(8):1412-1428
p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.
Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, Miller S, Porat Z, Ben-Dor S, Krizhanovsky V
The EMBO journal 2017 Aug 1;36(15):2280-2295
The EMBO journal 2017 Aug 1;36(15):2280-2295
Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.
Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaitė Ž, Wessel SR, Zlatanou A, Vernet A, von Kriegsheim A, Mottram RM, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Al Tala S, Alswaid A, Ahmed S, Al-Aama JY, Altmüller J, Al Balwi M, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, Nürnberg P, Percin EF, Peron A, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, Tomancak P, Yigit G, Taylor AM, Reijns MA, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS
Nature genetics 2017 Apr;49(4):537-549
Nature genetics 2017 Apr;49(4):537-549
A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation.
Liu X, Liu F, Gao S, Reske J, Li A, Wu CL, Yang C, Chen F, Luo R, Xiao H
Cancer letters 2017 Apr 10;391:152-161
Cancer letters 2017 Apr 10;391:152-161
DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation.
Latella L, Dall'Agnese A, Boscolo FS, Nardoni C, Cosentino M, Lahm A, Sacco A, Puri PL
Genes & development 2017 Apr 1;31(7):648-659
Genes & development 2017 Apr 1;31(7):648-659
Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib.
Nonnekens J, van Kranenburg M, Beerens CE, Suker M, Doukas M, van Eijck CH, de Jong M, van Gent DC
Theranostics 2016;6(11):1821-32
Theranostics 2016;6(11):1821-32
In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.
Chatalic KL, Konijnenberg M, Nonnekens J, de Blois E, Hoeben S, de Ridder C, Brunel L, Fehrentz JA, Martinez J, van Gent DC, Nock BA, Maina T, van Weerden WM, de Jong M
Theranostics 2016;6(1):104-17
Theranostics 2016;6(1):104-17
Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells.
Bhatt N, Ghosh R, Roy S, Gao Y, Armanios M, Cheng L, Franco S
Stem cell research 2016 Sep;17(2):296-305
Stem cell research 2016 Sep;17(2):296-305
New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity.
Henry A, Nokin MJ, Leroi N, Lallemand F, Lambert J, Goffart N, Roncarati P, Bianchi E, Peixoto P, Blomme A, Turtoi A, Peulen O, Habraken Y, Scholtes F, Martinive P, Delvenne P, Rogister B, Castronovo V, Bellahcène A
Oncotarget 2016 Sep 27;7(39):63708-63721
Oncotarget 2016 Sep 27;7(39):63708-63721
Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.
Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H
Scientific reports 2016 Sep 22;6:33861
Scientific reports 2016 Sep 22;6:33861
Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.
Lescale C, Lenden Hasse H, Blackford AN, Balmus G, Bianchi JJ, Yu W, Bacoccina L, Jarade A, Clouin C, Sivapalan R, Reina-San-Martin B, Jackson SP, Deriano L
Cell reports 2016 Sep 13;16(11):2967-2979
Cell reports 2016 Sep 13;16(11):2967-2979
Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.
Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet-Robinet E, Salles B, Mirey G, Vignard J
Scientific reports 2016 Oct 24;6:36022
Scientific reports 2016 Oct 24;6:36022
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.
Toonen LJ, Schmidt I, Luijsterburg MS, van Attikum H, van Roon-Mom WM
Scientific reports 2016 Oct 12;6:35200
Scientific reports 2016 Oct 12;6:35200
NOX4 downregulation leads to senescence of human vascular smooth muscle cells.
Przybylska D, Janiszewska D, Goździk A, Bielak-Zmijewska A, Sunderland P, Sikora E, Mosieniak G
Oncotarget 2016 Oct 11;7(41):66429-66443
Oncotarget 2016 Oct 11;7(41):66429-66443
The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome.
Chua S, Lee FY, Chiang HJ, Chen KH, Lu HI, Chen YT, Yang CC, Lin KC, Chen YL, Kao GS, Chen CH, Chang HW, Yip HK
Journal of pineal research 2016 Nov;61(4):438-456
Journal of pineal research 2016 Nov;61(4):438-456
The effect of delphinidin on the mechanical properties of keratinocytes exposed to UVB radiation.
Sobiepanek A, Milner-Krawczyk M, Bobecka-Wesołowska K, Kobiela T
Journal of photochemistry and photobiology. B, Biology 2016 Nov;164:264-270
Journal of photochemistry and photobiology. B, Biology 2016 Nov;164:264-270
Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number.
Graciotti M, Fang Z, Johnsson K, Gönczy P
Chembiochem : a European journal of chemical biology 2016 Nov 3;17(21):2063-2074
Chembiochem : a European journal of chemical biology 2016 Nov 3;17(21):2063-2074
Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy.
Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 15;113(46):13120-13125
Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 15;113(46):13120-13125
Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes.
Kreienkamp R, Croke M, Neumann MA, Bedia-Diaz G, Graziano S, Dusso A, Dorsett D, Carlberg C, Gonzalo S
Oncotarget 2016 May 24;7(21):30018-31
Oncotarget 2016 May 24;7(21):30018-31
Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus.
Martínez I, García-Carpizo V, Guijarro T, García-Gomez A, Navarro D, Aranda A, Zambrano A
Virulence 2016 May 18;7(4):427-42
Virulence 2016 May 18;7(4):427-42
Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams.
Chaudhary P, Marshall TI, Currell FJ, Kacperek A, Schettino G, Prise KM
International journal of radiation oncology, biology, physics 2016 May 1;95(1):86-94
International journal of radiation oncology, biology, physics 2016 May 1;95(1):86-94
Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis.
O'Hagan-Wong K, Nadeau S, Carrier-Leclerc A, Apablaza F, Hamdy R, Shum-Tim D, Rodier F, Colmegna I
Oncotarget 2016 Mar 22;7(12):13285-96
Oncotarget 2016 Mar 22;7(12):13285-96
Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks.
Pauty J, Côté MF, Rodrigue A, Velic D, Masson JY, Fortin S
Scientific reports 2016 Mar 22;6:23302
Scientific reports 2016 Mar 22;6:23302
A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds.
Kubben N, Brimacombe KR, Donegan M, Li Z, Misteli T
Methods (San Diego, Calif.) 2016 Mar 1;96:46-58
Methods (San Diego, Calif.) 2016 Mar 1;96:46-58
Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress.
Stankovic-Valentin N, Drzewicka K, König C, Schiebel E, Melchior F
The EMBO journal 2016 Jun 15;35(12):1312-29
The EMBO journal 2016 Jun 15;35(12):1312-29
Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.
Obermeier K, Sachsenweger J, Friedl TW, Pospiech H, Winqvist R, Wiesmüller L
Oncogene 2016 Jul 21;35(29):3796-806
Oncogene 2016 Jul 21;35(29):3796-806
53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis.
Fong CS, Mazo G, Das T, Goodman J, Kim M, O'Rourke BP, Izquierdo D, Tsou MF
eLife 2016 Jul 2;5
eLife 2016 Jul 2;5
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
Picco V, Coste I, Giraud-Panis MJ, Renno T, Gilson E, Pagès G
Oncotarget 2016 Jul 19;7(29):46615-46627
Oncotarget 2016 Jul 19;7(29):46615-46627
A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.
Lambrus BG, Daggubati V, Uetake Y, Scott PM, Clutario KM, Sluder G, Holland AJ
The Journal of cell biology 2016 Jul 18;214(2):143-53
The Journal of cell biology 2016 Jul 18;214(2):143-53
Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells.
Mao P, Liu J, Zhang Z, Zhang H, Liu H, Gao S, Rong YS, Zhao Y
Nature communications 2016 Jul 11;7:12154
Nature communications 2016 Jul 11;7:12154
Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells.
Jullien D, Vignard J, Fedor Y, Béry N, Olichon A, Crozatier M, Erard M, Cassard H, Ducommun B, Salles B, Mirey G
Journal of cell science 2016 Jul 1;129(13):2673-83
Journal of cell science 2016 Jul 1;129(13):2673-83
The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells.
Storch K, Cordes N
International journal of oncology 2016 Jan;48(1):191-8
International journal of oncology 2016 Jan;48(1):191-8
A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.
Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, Deng M, Qin B, Correia C, Lee S, Kim J, Sparks M, Nair AA, Evans DL, Kalari KR, Zhang P, Wang L, You Z, Kaufmann SH, Lou Z, Pei H
Nature communications 2016 Jan 5;7:10201
Nature communications 2016 Jan 5;7:10201
Comparison of the Therapeutic Response to Treatment with a 177Lu-Labeled Somatostatin Receptor Agonist and Antagonist in Preclinical Models.
Dalm SU, Nonnekens J, Doeswijk GN, de Blois E, van Gent DC, Konijnenberg MW, de Jong M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016 Feb;57(2):260-5
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016 Feb;57(2):260-5
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress.
Petroni M, Sardina F, Heil C, Sahún-Roncero M, Colicchia V, Veschi V, Albini S, Fruci D, Ricci B, Soriani A, Di Marcotullio L, Screpanti I, Gulino A, Giannini G
Cell death and differentiation 2016 Feb;23(2):197-206
Cell death and differentiation 2016 Feb;23(2):197-206
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.
Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E
PLoS genetics 2016 Feb;12(2):e1005791
PLoS genetics 2016 Feb;12(2):e1005791
RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.
Lescale C, Abramowski V, Bedora-Faure M, Murigneux V, Vera G, Roth DB, Revy P, de Villartay JP, Deriano L
Nature communications 2016 Feb 2;7:10529
Nature communications 2016 Feb 2;7:10529
Validation of JCountPro software for efficient assessment of ionizing radiation-induced foci in human lymphocytes.
Jakl L, Lobachevsky P, Vokálová L, Durdík M, Marková E, Belyaev I
International journal of radiation biology 2016 Dec;92(12):766-773
International journal of radiation biology 2016 Dec;92(12):766-773
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S
Nature cell biology 2016 Dec;18(12):1357-1366
Nature cell biology 2016 Dec;18(12):1357-1366
Is senescence-associated β-galactosidase a marker of neuronal senescence?
Piechota M, Sunderland P, Wysocka A, Nalberczak M, Sliwinska MA, Radwanska K, Sikora E
Oncotarget 2016 Dec 6;7(49):81099-81109
Oncotarget 2016 Dec 6;7(49):81099-81109
Roles of human POLD1 and POLD3 in genome stability.
Tumini E, Barroso S, -Calero CP, Aguilera A
Scientific reports 2016 Dec 15;6:38873
Scientific reports 2016 Dec 15;6:38873
DNA Replication Origins in Immunoglobulin Switch Regions Regulate Class Switch Recombination in an R-Loop-Dependent Manner.
Wiedemann EM, Peycheva M, Pavri R
Cell reports 2016 Dec 13;17(11):2927-2942
Cell reports 2016 Dec 13;17(11):2927-2942
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Luo K, Li L, Li Y, Wu C, Yin Y, Chen Y, Deng M, Nowsheen S, Yuan J, Lou Z
Genes & development 2016 Dec 1;30(23):2581-2595
Genes & development 2016 Dec 1;30(23):2581-2595
Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model.
Parekh PR, Choudhuri R, Weyemi U, Martin OA, Bonner WM, Redon CE
Cancer medicine 2016 Aug;5(8):1731-41
Cancer medicine 2016 Aug;5(8):1731-41
Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy.
Butterworth KT, Nicol JR, Ghita M, Rosa S, Chaudhary P, McGarry CK, McCarthy HO, Jimenez-Sanchez G, Bazzi R, Roux S, Tillement O, Coulter JA, Prise KM
Nanomedicine (London, England) 2016 Aug;11(16):2035-47
Nanomedicine (London, England) 2016 Aug;11(16):2035-47
Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Schmidt JC, Zaug AJ, Cech TR
Cell 2016 Aug 25;166(5):1188-1197.e9
Cell 2016 Aug 25;166(5):1188-1197.e9
Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence.
Patel PL, Suram A, Mirani N, Bischof O, Herbig U
Proceedings of the National Academy of Sciences of the United States of America 2016 Aug 23;113(34):E5024-33
Proceedings of the National Academy of Sciences of the United States of America 2016 Aug 23;113(34):E5024-33
Telomeric RNAs are essential to maintain telomeres.
Montero JJ, López de Silanes I, Graña O, Blasco MA
Nature communications 2016 Aug 17;7:12534
Nature communications 2016 Aug 17;7:12534
The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability.
Ho TLF, Guilbaud G, Blow JJ, Sale JE, Watson CJ
Cell reports 2016 Apr 26;15(4):724-734
Cell reports 2016 Apr 26;15(4):724-734
RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen JQ, Herrmann MA, Kumar S, Kalab P
Molecular biology of the cell 2016 Apr 15;27(8):1346-57
Molecular biology of the cell 2016 Apr 15;27(8):1346-57
DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors.
Francia S, Cabrini M, Matti V, Oldani A, d'Adda di Fagagna F
Journal of cell science 2016 Apr 1;129(7):1468-76
Journal of cell science 2016 Apr 1;129(7):1468-76
DNA repair foci and late apoptosis/necrosis in peripheral blood lymphocytes of breast cancer patients undergoing radiotherapy.
Marková E, Somsedíková A, Vasilyev S, Pobijaková M, Lacková A, Lukačko P, Belyaev I
International journal of radiation biology 2015;91(12):934-45
International journal of radiation biology 2015;91(12):934-45
Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells.
Rall M, Kraft D, Volcic M, Cucu A, Nasonova E, Taucher-Scholz G, Bönig H, Wiesmüller L, Fournier C
Frontiers in oncology 2015;5:250
Frontiers in oncology 2015;5:250
Nuclear signs of pre-neurodegeneration.
Baltanás FC, Valero J, Alonso JR, Berciano MT, Lafarga M
Methods in molecular biology (Clifton, N.J.) 2015;1254:43-54
Methods in molecular biology (Clifton, N.J.) 2015;1254:43-54
Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction.
Mar FA, Debnath J, Stohr BA
Autophagy 2015;11(3):527-37
Autophagy 2015;11(3):527-37
CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo.
Li M, Huang R, Jiang X, Chen Y, Zhang Z, Zhang X, Liang P, Zhan S, Cao S, Songyang Z, Huang J
PloS one 2015;10(11):e0143148
PloS one 2015;10(11):e0143148
DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma.
Weaver AN, Cooper TS, Rodriguez M, Trummell HQ, Bonner JA, Rosenthal EL, Yang ES
Oncotarget 2015 Sep 29;6(29):26995-7007
Oncotarget 2015 Sep 29;6(29):26995-7007
The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis.
Hehlgans S, Oppermann J, Reichert S, Fulda S, Rödel C, Rödel F
Radiation oncology (London, England) 2015 Sep 17;10:198
Radiation oncology (London, England) 2015 Sep 17;10:198
Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
Lin H, Ha K, Lu G, Fang X, Cheng R, Zuo Q, Zhang P
Molecular and cellular biology 2015 Nov;35(21):3657-68
Molecular and cellular biology 2015 Nov;35(21):3657-68
A prospective study on histone γ-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome.
Djuzenova CS, Zimmermann M, Katzer A, Fiedler V, Distel LV, Gasser M, Waaga-Gasser AM, Flentje M, Polat B
BMC cancer 2015 Nov 6;15:856
BMC cancer 2015 Nov 6;15:856
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.
Bol GM, Vesuna F, Xie M, Zeng J, Aziz K, Gandhi N, Levine A, Irving A, Korz D, Tantravedi S, Heerma van Voss MR, Gabrielson K, Bordt EA, Polster BM, Cope L, van der Groep P, Kondaskar A, Rudek MA, Hosmane RS, van der Wall E, van Diest PJ, Tran PT, Raman V
EMBO molecular medicine 2015 May;7(5):648-69
EMBO molecular medicine 2015 May;7(5):648-69
Consequence of the tumor-associated conversion to cyclin D1b.
Augello MA, Berman-Booty LD, Carr R 3rd, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE
EMBO molecular medicine 2015 May;7(5):628-47
EMBO molecular medicine 2015 May;7(5):628-47
Notch is a direct negative regulator of the DNA-damage response.
Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F
Nature structural & molecular biology 2015 May;22(5):417-24
Nature structural & molecular biology 2015 May;22(5):417-24
DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.
Yu Q, Katlinskaya YV, Carbone CJ, Zhao B, Katlinski KV, Zheng H, Guha M, Li N, Chen Q, Yang T, Lengner CJ, Greenberg RA, Johnson FB, Fuchs SY
Cell reports 2015 May 5;11(5):785-797
Cell reports 2015 May 5;11(5):785-797
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Xu G, Chapman JR, Brandsma I, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers JE, Watanabe K, Pieterse M, Kersbergen A, Sol W, Celie PHN, Schouten PC, van den Broek B, Salman A, Nieuwland M, de Rink I, de Ronde J, Jalink K, Boulton SJ, Chen J, van Gent DC, Bartek J, Jonkers J, Borst P, Rottenberg S
Nature 2015 May 28;521(7553):541-544
Nature 2015 May 28;521(7553):541-544
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.
Zong D, Callén E, Pegoraro G, Lukas C, Lukas J, Nussenzweig A
Nucleic acids research 2015 May 26;43(10):4950-61
Nucleic acids research 2015 May 26;43(10):4950-61
The COP9 signalosome is vital for timely repair of DNA double-strand breaks.
Meir M, Galanty Y, Kashani L, Blank M, Khosravi R, Fernández-Ávila MJ, Cruz-García A, Star A, Shochot L, Thomas Y, Garrett LJ, Chamovitz DA, Bodine DM, Kurz T, Huertas P, Ziv Y, Shiloh Y
Nucleic acids research 2015 May 19;43(9):4517-30
Nucleic acids research 2015 May 19;43(9):4517-30
DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing.
Diotti R, Kalan S, Matveyenko A, Loayza D
Molecular cancer research : MCR 2015 Mar;13(3):402-10
Molecular cancer research : MCR 2015 Mar;13(3):402-10
Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells.
Lewinska A, Wnuk M, Grabowska W, Zabek T, Semik E, Sikora E, Bielak-Zmijewska A
Toxicology letters 2015 Mar 18;233(3):227-38
Toxicology letters 2015 Mar 18;233(3):227-38
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.
Papp SJ, Huber AL, Jordan SD, Kriebs A, Nguyen M, Moresco JJ, Yates JR, Lamia KA
eLife 2015 Mar 10;4
eLife 2015 Mar 10;4
Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress.
Gole B, Baumann C, Mian E, Ireno CI, Wiesmüller L
Oncogene 2015 Jun;34(26):3391-401
Oncogene 2015 Jun;34(26):3391-401
DNA damage signaling and apoptosis in preinvasive tubal lesions of ovarian carcinoma.
Chene G, Ouellet V, Rahimi K, Barres V, Caceres K, Meunier L, Cyr L, De Ladurantaye M, Provencher D, Mes Masson AM
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2015 Jun;25(5):761-9
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2015 Jun;25(5):761-9
Stn1 is critical for telomere maintenance and long-term viability of somatic human cells.
Boccardi V, Razdan N, Kaplunov J, Mundra JJ, Kimura M, Aviv A, Herbig U
Aging cell 2015 Jun;14(3):372-81
Aging cell 2015 Jun;14(3):372-81
WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis.
Vassilopoulos A, Tominaga Y, Kim HS, Lahusen T, Li B, Yu H, Gius D, Deng CX
Oncogene 2015 Jun 4;34(23):3023-35
Oncogene 2015 Jun 4;34(23):3023-35
HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.
Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S, Okazawa H
EMBO molecular medicine 2015 Jan;7(1):78-101
EMBO molecular medicine 2015 Jan;7(1):78-101
Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.
Mender I, Gryaznov S, Dikmen ZG, Wright WE, Shay JW
Cancer discovery 2015 Jan;5(1):82-95
Cancer discovery 2015 Jan;5(1):82-95
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Sykora P, Misiak M, Wang Y, Ghosh S, Leandro GS, Liu D, Tian J, Baptiste BA, Cong WN, Brenerman BM, Fang E, Becker KG, Hamilton RJ, Chigurupati S, Zhang Y, Egan JM, Croteau DL, Wilson DM 3rd, Mattson MP, Bohr VA
Nucleic acids research 2015 Jan;43(2):943-59
Nucleic acids research 2015 Jan;43(2):943-59
A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.
Uringa EJ, Baldeyron C, Odijk H, Wassenaar E, van Cappellen WA, Maas A, Hoeijmakers JH, Baarends WM, Kanaar R, Essers J
DNA repair 2015 Jan;25:27-40
DNA repair 2015 Jan;25:27-40
BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells.
Burdak-Rothkamm S, Rothkamm K, McClelland K, Al Rashid ST, Prise KM
Cancer letters 2015 Jan 28;356(2 Pt B):454-61
Cancer letters 2015 Jan 28;356(2 Pt B):454-61
Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells.
Lewinska A, Jarosz P, Czech J, Rzeszutek I, Bielak-Zmijewska A, Grabowska W, Wnuk M
Mutation research. Genetic toxicology and environmental mutagenesis 2015 Feb;779:23-34
Mutation research. Genetic toxicology and environmental mutagenesis 2015 Feb;779:23-34
Increased FOXM1 expression can stimulate DNA repair in normal hepatocytes in vivo but also increases nuclear foci associated with senescence.
Baranski OA, Kalinichenko VV, Adami GR
Cell proliferation 2015 Feb;48(1):105-15
Cell proliferation 2015 Feb;48(1):105-15
Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner.
Grabowska W, Kucharewicz K, Wnuk M, Lewinska A, Suszek M, Przybylska D, Mosieniak G, Sikora E, Bielak-Zmijewska A
Age (Dordrecht, Netherlands) 2015 Feb;37(1):9744
Age (Dordrecht, Netherlands) 2015 Feb;37(1):9744
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M
The EMBO journal 2015 Feb 3;34(3):410-24
The EMBO journal 2015 Feb 3;34(3):410-24
NF-κB signaling mediates acquired resistance after PARP inhibition.
Nakagawa Y, Sedukhina AS, Okamoto N, Nagasawa S, Suzuki N, Ohta T, Hattori H, Roche-Molina M, Narváez AJ, Jeyasekharan AD, Bernal JA, Sato K
Oncotarget 2015 Feb 28;6(6):3825-39
Oncotarget 2015 Feb 28;6(6):3825-39
Imaging flow cytometry as a sensitive tool to detect low-dose-induced DNA damage by analyzing 53BP1 and γH2AX foci in human lymphocytes.
Durdik M, Kosik P, Gursky J, Vokalova L, Markova E, Belyaev I
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2015 Dec;87(12):1070-8
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2015 Dec;87(12):1070-8
Role of Pro-inflammatory Cytokines in Radiation-Induced Genomic Instability in Human Bronchial Epithelial Cells.
Werner E, Wang H, Doetsch PW
Radiation research 2015 Dec;184(6):621-9
Radiation research 2015 Dec;184(6):621-9
Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.
Perez M, Muñoz-Galván S, Jiménez-García MP, Marín JJ, Carnero A
Oncotarget 2015 Dec 1;6(38):40557-74
Oncotarget 2015 Dec 1;6(38):40557-74
Radiobiological response to ultra-short pulsed megavoltage electron beams of ultra-high pulse dose rate.
Beyreuther E, Karsch L, Laschinsky L, Leßmann E, Naumburger D, Oppelt M, Richter C, Schürer M, Woithe J, Pawelke J
International journal of radiation biology 2015 Aug;91(8):643-52
International journal of radiation biology 2015 Aug;91(8):643-52
Dexamethasone acts as a radiosensitizer in three astrocytoma cell lines via oxidative stress.
Ortega-Martínez S
Redox biology 2015 Aug;5:388-397
Redox biology 2015 Aug;5:388-397
Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.
Boucher D, Vu T, Bain AL, Tagliaro-Jahns M, Shi W, Lane SW, Khanna KK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Aug;29(8):3326-34
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Aug;29(8):3326-34
Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage.
Fukuda T, Wu W, Okada M, Maeda I, Kojima Y, Hayami R, Miyoshi Y, Tsugawa K, Ohta T
Cancer science 2015 Aug;106(8):1050-6
Cancer science 2015 Aug;106(8):1050-6
CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation.
Han X, Liu Z, Jo MC, Zhang K, Li Y, Zeng Z, Li N, Zu Y, Qin L
Science advances 2015 Aug;1(7):e1500454
Science advances 2015 Aug;1(7):e1500454
Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.
Chojnowski A, Ong PF, Wong ES, Lim JS, Mutalif RA, Navasankari R, Dutta B, Yang H, Liow YY, Sze SK, Boudier T, Wright GD, Colman A, Burke B, Stewart CL, Dreesen O
eLife 2015 Aug 27;4
eLife 2015 Aug 27;4
Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.
Markiewicz E, Barnard S, Haines J, Coster M, van Geel O, Wu W, Richards S, Ainsbury E, Rothkamm K, Bouffler S, Quinlan RA
Open biology 2015 Apr;5(4):150011
Open biology 2015 Apr;5(4):150011
Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.
Aarts M, Bajrami I, Herrera-Abreu MT, Elliott R, Brough R, Ashworth A, Lord CJ, Turner NC
Molecular cancer therapeutics 2015 Apr;14(4):865-76
Molecular cancer therapeutics 2015 Apr;14(4):865-76
Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
Gibbs-Seymour I, Markiewicz E, Bekker-Jensen S, Mailand N, Hutchison CJ
Aging cell 2015 Apr;14(2):162-9
Aging cell 2015 Apr;14(2):162-9
Immunocytochemical localization of DNA double-strand breaks in human and rat brains.
Torres G, Leheste JR, Ramos RL
Neuroscience 2015 Apr 2;290:196-203
Neuroscience 2015 Apr 2;290:196-203
DNA damage focus analysis in blood samples of minipigs reveals acute partial body irradiation.
Lamkowski A, Forcheron F, Agay D, Ahmed EA, Drouet M, Meineke V, Scherthan H
PloS one 2014;9(2):e87458
PloS one 2014;9(2):e87458
TPX2 impacts acetylation of histone H4 at lysine 16: implications for DNA damage response.
Neumayer G, Nguyen MD
PloS one 2014;9(11):e110994
PloS one 2014;9(11):e110994
Stable cellular senescence is associated with persistent DDR activation.
Fumagalli M, Rossiello F, Mondello C, d'Adda di Fagagna F
PloS one 2014;9(10):e110969
PloS one 2014;9(10):e110969
Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.
Werner E, Wang H, Doetsch PW
PloS one 2014;9(10):e108234
PloS one 2014;9(10):e108234
The role of mitochondrial function in gold nanoparticle mediated radiosensitisation.
Taggart LE, McMahon SJ, Currell FJ, Prise KM, Butterworth KT
Cancer nanotechnology 2014;5(1):5
Cancer nanotechnology 2014;5(1):5
The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation.
Houlihan SL, Feng Y
eLife 2014 Sep 23;3:e03297
eLife 2014 Sep 23;3:e03297
Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.
Naipal KA, Verkaik NS, Ameziane N, van Deurzen CH, Ter Brugge P, Meijers M, Sieuwerts AM, Martens JW, O'Connor MJ, Vrieling H, Hoeijmakers JH, Jonkers J, Kanaar R, de Winter JP, Vreeswijk MP, Jager A, van Gent DC
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Sep 15;20(18):4816-26
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Sep 15;20(18):4816-26
Generation of cell-based systems to visualize chromosome damage and translocations in living cells.
Roukos V, Burgess RC, Misteli T
Nature protocols 2014 Oct;9(10):2476-92
Nature protocols 2014 Oct;9(10):2476-92
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Pefani DE, Latusek R, Pires I, Grawenda AM, Yee KS, Hamilton G, van der Weyden L, Esashi F, Hammond EM, O'Neill E
Nature cell biology 2014 Oct;16(10):962-71, 1-8
Nature cell biology 2014 Oct;16(10):962-71, 1-8
Effect of radiation quality on mutagenic joining of enzymatically-induced DNA double-strand breaks in previously irradiated human cells.
Li Z, Wang H, Wang Y, Murnane JP, Dynan WS
Radiation research 2014 Nov;182(5):573-9
Radiation research 2014 Nov;182(5):573-9
TRIM28/KAP1 regulates senescence.
Santos J, Gil J
Immunology letters 2014 Nov;162(1 Pt B):281-9
Immunology letters 2014 Nov;162(1 Pt B):281-9
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Chitnis MM, Lodhia KA, Aleksic T, Gao S, Protheroe AS, Macaulay VM
Oncogene 2014 Nov 6;33(45):5262-73
Oncogene 2014 Nov 6;33(45):5262-73
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.
Zimmermann M, Kibe T, Kabir S, de Lange T
Genes & development 2014 Nov 15;28(22):2477-91
Genes & development 2014 Nov 15;28(22):2477-91
Human RECQL1 participates in telomere maintenance.
Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau DL, Bohr VA
Nucleic acids research 2014 May;42(9):5671-88
Nucleic acids research 2014 May;42(9):5671-88
SMCHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaks.
Coker H, Brockdorff N
Journal of cell science 2014 May 1;127(Pt 9):1869-74
Journal of cell science 2014 May 1;127(Pt 9):1869-74
Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.
Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM
PLoS genetics 2014 Mar;10(3):e1004178
PLoS genetics 2014 Mar;10(3):e1004178
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination.
Zahn A, Eranki AK, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM
Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 18;111(11):E988-97
Proceedings of the National Academy of Sciences of the United States of America 2014 Mar 18;111(11):E988-97
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.
Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH
The Journal of cell biology 2014 Jun 9;205(5):663-75
The Journal of cell biology 2014 Jun 9;205(5):663-75
CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A
The Journal of experimental medicine 2014 Jun 2;211(6):1027-36
The Journal of experimental medicine 2014 Jun 2;211(6):1027-36
Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency.
Carlessi L, Fusar Poli E, Bechi G, Mantegazza M, Pascucci B, Narciso L, Dogliotti E, Sala C, Verpelli C, Lecis D, Delia D
Cell death & disease 2014 Jul 17;5:e1342
Cell death & disease 2014 Jul 17;5:e1342
A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice.
Frescas D, de Lange T
Genes & development 2014 Jan 15;28(2):153-66
Genes & development 2014 Jan 15;28(2):153-66
A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta.
Bielak-Zmijewska A, Wnuk M, Przybylska D, Grabowska W, Lewinska A, Alster O, Korwek Z, Cmoch A, Myszka A, Pikula S, Mosieniak G, Sikora E
Biogerontology 2014 Feb;15(1):47-64
Biogerontology 2014 Feb;15(1):47-64
The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes.
Herrera-Moyano E, Moriel-Carretero M, Montelone BA, Aguilera A
PLoS genetics 2014 Dec;10(12):e1004859
PLoS genetics 2014 Dec;10(12):e1004859
Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.
Tang M, Li Y, Zhang X, Deng T, Zhou Z, Ma W, Songyang Z
The Journal of biological chemistry 2014 Dec 5;289(49):34024-32
The Journal of biological chemistry 2014 Dec 5;289(49):34024-32
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity.
Gazzaniga FS, Blackburn EH
Blood 2014 Dec 11;124(25):3675-84
Blood 2014 Dec 11;124(25):3675-84
KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes.
Tubbs AT, Dorsett Y, Chan E, Helmink B, Lee BS, Hung P, George R, Bredemeyer AL, Mittal A, Pappu RV, Chowdhury D, Mosammaparast N, Krangel MS, Sleckman BP
Molecular and cellular biology 2014 Aug;34(15):2811-21
Molecular and cellular biology 2014 Aug;34(15):2811-21
Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4.
Terasawa M, Shinohara A, Shinohara M
PLoS genetics 2014 Aug;10(8):e1004563
PLoS genetics 2014 Aug;10(8):e1004563
Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.
Frescas D, de Lange T
The Journal of biological chemistry 2014 Aug 29;289(35):24180-7
The Journal of biological chemistry 2014 Aug 29;289(35):24180-7
Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
Peng M, Xie J, Ucher A, Stavnezer J, Cantor SB
The EMBO journal 2014 Aug 1;33(15):1698-712
The EMBO journal 2014 Aug 1;33(15):1698-712
TRF2-tethered TIN2 can mediate telomere protection by TPP1/POT1.
Frescas D, de Lange T
Molecular and cellular biology 2014 Apr;34(7):1349-62
Molecular and cellular biology 2014 Apr;34(7):1349-62
Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.
Bazzi H, Anderson KV
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 15;111(15):E1491-500
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 15;111(15):E1491-500
Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53.
Despars G, Carbonneau CL, Bardeau P, Coutu DL, Beauséjour CM
PloS one 2013;8(8):e73206
PloS one 2013;8(8):e73206
Human umbilical cord matrix stem cells maintain multilineage differentiation abilities and do not transform during long-term culture.
Scheers I, Lombard C, Paganelli M, Campard D, Najimi M, Gala JL, Decottignies A, Sokal E
PloS one 2013;8(8):e71374
PloS one 2013;8(8):e71374
Use of the γ-H2AX assay to investigate DNA repair dynamics following multiple radiation exposures.
Mariotti LG, Pirovano G, Savage KI, Ghita M, Ottolenghi A, Prise KM, Schettino G
PloS one 2013;8(11):e79541
PloS one 2013;8(11):e79541
LIM Protein Ajuba Participates in the Repression of the ATR-Mediated DNA Damage Response.
Kalan S, Matveyenko A, Loayza D
Frontiers in genetics 2013;4:95
Frontiers in genetics 2013;4:95
ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks.
Köcher S, Spies-Naumann A, Kriegs M, Dahm-Daphi J, Dornreiter I
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):409-14
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):409-14
The telomere-associated homeobox-containing protein TAH1/HMBOX1 participates in telomere maintenance in ALT cells.
Feng X, Luo Z, Jiang S, Li F, Han X, Hu Y, Wang D, Zhao Y, Ma W, Liu D, Huang J, Songyang Z
Journal of cell science 2013 Sep 1;126(Pt 17):3982-9
Journal of cell science 2013 Sep 1;126(Pt 17):3982-9
Engineered proteins detect spontaneous DNA breakage in human and bacterial cells.
Shee C, Cox BD, Gu F, Luengas EM, Joshi MC, Chiu LY, Magnan D, Halliday JA, Frisch RL, Gibson JL, Nehring RB, Do HG, Hernandez M, Li L, Herman C, Hastings PJ, Bates D, Harris RS, Miller KM, Rosenberg SM
eLife 2013 Oct 29;2:e01222
eLife 2013 Oct 29;2:e01222
The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.
Elsen S, Collin-Faure V, Gidrol X, Lemercier C
Cellular and molecular life sciences : CMLS 2013 Nov;70(22):4385-97
Cellular and molecular life sciences : CMLS 2013 Nov;70(22):4385-97
Down-regulation of PERK enhances resistance to ionizing radiation.
Oommen D, Prise KM
Biochemical and biophysical research communications 2013 Nov 8;441(1):31-5
Biochemical and biophysical research communications 2013 Nov 8;441(1):31-5
siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.
Böhringer M, Obermeier K, Griner N, Waldraff D, Dickinson E, Eirich K, Schindler D, Hagen M, Jerry DJ, Wiesmüller L
Oncogene 2013 Nov 28;32(48):5458-70
Oncogene 2013 Nov 28;32(48):5458-70
Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.
Chan EA, Teng G, Corbett E, Choudhury KR, Bassing CH, Schatz DG, Krangel MS
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 26;110(48):E4628-37
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 26;110(48):E4628-37
Inhibition of telomerase recruitment and cancer cell death.
Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR
The Journal of biological chemistry 2013 Nov 15;288(46):33171-80
The Journal of biological chemistry 2013 Nov 15;288(46):33171-80
DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells.
Békés M, Okamoto K, Crist SB, Jones MJ, Chapman JR, Brasher BB, Melandri FD, Ueberheide BM, Denchi EL, Huang TT
Cell reports 2013 Nov 14;5(3):826-38
Cell reports 2013 Nov 14;5(3):826-38
POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia.
Ramsay AJ, Quesada V, Foronda M, Conde L, Martínez-Trillos A, Villamor N, Rodríguez D, Kwarciak A, Garabaya C, Gallardo M, López-Guerra M, López-Guillermo A, Puente XS, Blasco MA, Campo E, López-Otín C
Nature genetics 2013 May;45(5):526-30
Nature genetics 2013 May;45(5):526-30
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.
Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L
Nature neuroscience 2013 May;16(5):613-21
Nature neuroscience 2013 May;16(5):613-21
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.
Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, Odreman F, Glatter T, Graziano S, Mendoza-Maldonado R, Marino F, Lucic B, Biasin V, Gstaiger M, Aebersold R, Sidorova JM, Monnat RJ Jr, Lopes M, Vindigni A
Nature structural & molecular biology 2013 Mar;20(3):347-54
Nature structural & molecular biology 2013 Mar;20(3):347-54
Lamin B1 fluctuations have differential effects on cellular proliferation and senescence.
Dreesen O, Chojnowski A, Ong PF, Zhao TY, Common JE, Lunny D, Lane EB, Lee SJ, Vardy LA, Stewart CL, Colman A
The Journal of cell biology 2013 Mar 4;200(5):605-17
The Journal of cell biology 2013 Mar 4;200(5):605-17
53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma.
Ausborn NL, Wang T, Wentz SC, Washington MK, Merchant NB, Zhao Z, Shyr Y, Chakravarthy AB, Xia F
BMC cancer 2013 Mar 26;13:155
BMC cancer 2013 Mar 26;13:155
Telomere length and telomerase activity impact the UV sensitivity syndrome xeroderma pigmentosum C.
Stout GJ, Blasco MA
Cancer research 2013 Mar 15;73(6):1844-54
Cancer research 2013 Mar 15;73(6):1844-54
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines.
Grosso S, Doyen J, Parks SK, Bertero T, Paye A, Cardinaud B, Gounon P, Lacas-Gervais S, Noël A, Pouysségur J, Barbry P, Mazure NM, Mari B
Cell death & disease 2013 Mar 14;4:e544
Cell death & disease 2013 Mar 14;4:e544
RAP1 protects from obesity through its extratelomeric role regulating gene expression.
Martínez P, Gómez-López G, García F, Mercken E, Mitchell S, Flores JM, de Cabo R, Blasco MA
Cell reports 2013 Jun 27;3(6):2059-74
Cell reports 2013 Jun 27;3(6):2059-74
Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.
Yeung F, Ramírez CM, Mateos-Gomez PA, Pinzaru A, Ceccarini G, Kabir S, Fernández-Hernando C, Sfeir A
Cell reports 2013 Jun 27;3(6):1847-56
Cell reports 2013 Jun 27;3(6):1847-56
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB
Nature 2013 Jun 13;498(7453):246-50
Nature 2013 Jun 13;498(7453):246-50
DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells.
Korwek Z, Bielak-Zmijewska A, Mosieniak G, Alster O, Moreno-Villanueva M, Burkle A, Sikora E
Mutagenesis 2013 Jul;28(4):411-6
Mutagenesis 2013 Jul;28(4):411-6
Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis.
Gascoigne KE, Cheeseman IM
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2013 Jul;21(4):407-18
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2013 Jul;21(4):407-18
BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells.
Grotsky DA, Gonzalez-Suarez I, Novell A, Neumann MA, Yaddanapudi SC, Croke M, Martinez-Alonso M, Redwood AB, Ortega-Martinez S, Feng Z, Lerma E, Ramon y Cajal T, Zhang J, Matias-Guiu X, Dusso A, Gonzalo S
The Journal of cell biology 2013 Jan 21;200(2):187-202
The Journal of cell biology 2013 Jan 21;200(2):187-202
The histone methyltransferase MMSET regulates class switch recombination.
Pei H, Wu X, Liu T, Yu K, Jelinek DF, Lou Z
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 15;190(2):756-63
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 15;190(2):756-63
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C
Genes & development 2013 Jan 1;27(1):39-51
Genes & development 2013 Jan 1;27(1):39-51
Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer.
Ziebarth AJ, Nowsheen S, Steg AD, Shah MM, Katre AA, Dobbin ZC, Han HD, Lopez-Berestein G, Sood AK, Conner M, Yang ES, Landen CN
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jan 1;19(1):170-82
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jan 1;19(1):170-82
The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.
Rodrigue A, Coulombe Y, Jacquet K, Gagné JP, Roques C, Gobeil S, Poirier G, Masson JY
Journal of cell science 2013 Jan 1;126(Pt 1):348-59
Journal of cell science 2013 Jan 1;126(Pt 1):348-59
How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a.
Jeyapalan JC, Sedivy JM
Aging 2013 Feb;5(2):120-9
Aging 2013 Feb;5(2):120-9
Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations.
Mokrani-Benhelli H, Gaillard L, Biasutto P, Le Guen T, Touzot F, Vasquez N, Komatsu J, Conseiller E, Pïcard C, Gluckman E, Francannet C, Fischer A, Durandy A, Soulier J, de Villartay JP, Cavazzana-Calvo M, Revy P
Human mutation 2013 Feb;34(2):374-84
Human mutation 2013 Feb;34(2):374-84
WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas.
Caretti V, Hiddingh L, Lagerweij T, Schellen P, Koken PW, Hulleman E, van Vuurden DG, Vandertop WP, Kaspers GJ, Noske DP, Wurdinger T
Molecular cancer therapeutics 2013 Feb;12(2):141-50
Molecular cancer therapeutics 2013 Feb;12(2):141-50
53BP1 regulates DSB repair using Rif1 to control 5' end resection.
Zimmermann M, Lottersberger F, Buonomo SB, Sfeir A, de Lange T
Science (New York, N.Y.) 2013 Feb 8;339(6120):700-4
Science (New York, N.Y.) 2013 Feb 8;339(6120):700-4
A two-step mechanism for TRF2-mediated chromosome-end protection.
Okamoto K, Bartocci C, Ouzounov I, Diedrich JK, Yates JR 3rd, Denchi EL
Nature 2013 Feb 28;494(7438):502-5
Nature 2013 Feb 28;494(7438):502-5
Repriming of DNA synthesis at stalled replication forks by human PrimPol.
Mourón S, Rodriguez-Acebes S, Martínez-Jiménez MI, García-Gómez S, Chocrón S, Blanco L, Méndez J
Nature structural & molecular biology 2013 Dec;20(12):1383-9
Nature structural & molecular biology 2013 Dec;20(12):1383-9
Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.
Remeseiro S, Cuadrado A, Kawauchi S, Calof AL, Lander AD, Losada A
Biochimica et biophysica acta 2013 Dec;1832(12):2097-102
Biochimica et biophysica acta 2013 Dec;1832(12):2097-102
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.
Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D, Toellner KM, Su IH, Casola S
The Journal of clinical investigation 2013 Dec;123(12):5009-22
The Journal of clinical investigation 2013 Dec;123(12):5009-22
Akt regulates TPP1 homodimerization and telomere protection.
Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z
Aging cell 2013 Dec;12(6):1091-9
Aging cell 2013 Dec;12(6):1091-9
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.
Chen B, Gilbert LA, Cimini BA, Schnitzbauer J, Zhang W, Li GW, Park J, Blackburn EH, Weissman JS, Qi LS, Huang B
Cell 2013 Dec 19;155(7):1479-91
Cell 2013 Dec 19;155(7):1479-91
Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination.
Cortizas EM, Zahn A, Hajjar ME, Patenaude AM, Di Noia JM, Verdun RE
Journal of immunology (Baltimore, Md. : 1950) 2013 Dec 1;191(11):5751-63
Journal of immunology (Baltimore, Md. : 1950) 2013 Dec 1;191(11):5751-63
Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.
Croke M, Neumann MA, Grotsky DA, Kreienkamp R, Yaddanapudi SC, Gonzalo S
Cell cycle (Georgetown, Tex.) 2013 Dec 1;12(23):3629-39
Cell cycle (Georgetown, Tex.) 2013 Dec 1;12(23):3629-39
DNA damage response in microcephaly development of MCPH1 mouse model.
Zhou ZW, Tapias A, Bruhn C, Gruber R, Sukchev M, Wang ZQ
DNA repair 2013 Aug;12(8):645-55
DNA repair 2013 Aug;12(8):645-55
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair.
Britton S, Coates J, Jackson SP
The Journal of cell biology 2013 Aug 5;202(3):579-95
The Journal of cell biology 2013 Aug 5;202(3):579-95
Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair.
Wei D, Parsels LA, Karnak D, Davis MA, Parsels JD, Marsh AC, Zhao L, Maybaum J, Lawrence TS, Sun Y, Morgan MA
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4422-32
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 15;19(16):4422-32
MicroRNA 223 is upregulated in the multistep progression of Barrett's esophagus and modulates sensitivity to chemotherapy by targeting PARP1.
Streppel MM, Pai S, Campbell NR, Hu C, Yabuuchi S, Canto MI, Wang JS, Montgomery EA, Maitra A
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 1;19(15):4067-78
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Aug 1;19(15):4067-78
Radiosensitivity in breast cancer assessed by the histone γ-H2AX and 53BP1 foci.
Djuzenova CS, Elsner I, Katzer A, Worschech E, Distel LV, Flentje M, Polat B
Radiation oncology (London, England) 2013 Apr 24;8:98
Radiation oncology (London, England) 2013 Apr 24;8:98
Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment.
Zhang Y, Chen LY, Han X, Xie W, Kim H, Yang D, Liu D, Songyang Z
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 2;110(14):5457-62
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 2;110(14):5457-62
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.
Taylor BJ, Nik-Zainal S, Wu YL, Stebbings LA, Raine K, Campbell PJ, Rada C, Stratton MR, Neuberger MS
eLife 2013 Apr 16;2:e00534
eLife 2013 Apr 16;2:e00534
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK, ALT Starr Cancer Consortium.
PLoS genetics 2012;8(7):e1002772
PLoS genetics 2012;8(7):e1002772
DNA damage responses following exposure to modulated radiation fields.
Trainor C, Butterworth KT, McGarry CK, McMahon SJ, O'Sullivan JM, Hounsell AR, Prise KM
PloS one 2012;7(8):e43326
PloS one 2012;7(8):e43326
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.
Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R
PloS one 2012;7(11):e49211
PloS one 2012;7(11):e49211
Radiobiological effectiveness of laser accelerated electrons in comparison to electron beams from a conventional linear accelerator.
Laschinsky L, Baumann M, Beyreuther E, Enghardt W, Kaluza M, Karsch L, Lessmann E, Naumburger D, Nicolai M, Richter C, Sauerbrey R, Schlenvoigt HP, Pawelke J
Journal of radiation research 2012;53(3):395-403
Journal of radiation research 2012;53(3):395-403
Radiobiological effectiveness of laser accelerated electrons in comparison to electron beams from a conventional linear accelerator.
Laschinsky L, Baumann M, Beyreuther E, Enghardt W, Kaluza M, Karsch L, Lessmann E, Naumburger D, Nicolai M, Richter C, Sauerbrey R, Schlenvoigt HP, Pawelke J
Journal of radiation research 2012;53(3):395-403
Journal of radiation research 2012;53(3):395-403
A TRF1-controlled common fragile site containing interstitial telomeric sequences.
Bosco N, de Lange T
Chromosoma 2012 Oct;121(5):465-74
Chromosoma 2012 Oct;121(5):465-74
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma.
Squatrito M, Vanoli F, Schultz N, Jasin M, Holland EC
Cancer research 2012 Oct 15;72(20):5250-60
Cancer research 2012 Oct 15;72(20):5250-60
Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro.
Eke I, Storch K, Kästner I, Vehlow A, Faethe C, Mueller-Klieser W, Taucher-Scholz G, Temme A, Schackert G, Cordes N
International journal of radiation oncology, biology, physics 2012 Nov 15;84(4):e515-23
International journal of radiation oncology, biology, physics 2012 Nov 15;84(4):e515-23
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability.
Mirza S, Katafiasz BJ, Kumar R, Wang J, Mohibi S, Jain S, Gurumurthy CB, Pandita TK, Dave BJ, Band H, Band V
Cell cycle (Georgetown, Tex.) 2012 Nov 15;11(22):4266-74
Cell cycle (Georgetown, Tex.) 2012 Nov 15;11(22):4266-74
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.
Popuri V, Croteau DL, Brosh RM Jr, Bohr VA
Cell cycle (Georgetown, Tex.) 2012 Nov 15;11(22):4252-65
Cell cycle (Georgetown, Tex.) 2012 Nov 15;11(22):4252-65
Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation.
Popova T, Manié E, Rieunier G, Caux-Moncoutier V, Tirapo C, Dubois T, Delattre O, Sigal-Zafrani B, Bollet M, Longy M, Houdayer C, Sastre-Garau X, Vincent-Salomon A, Stoppa-Lyonnet D, Stern MH
Cancer research 2012 Nov 1;72(21):5454-62
Cancer research 2012 Nov 1;72(21):5454-62
Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells.
Korwek Z, Sewastianik T, Bielak-Zmijewska A, Mosieniak G, Alster O, Moreno-Villanueva M, Burkle A, Sikora E
DNA repair 2012 Nov 1;11(11):864-73
DNA repair 2012 Nov 1;11(11):864-73
Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.
Meng Y, Efimova EV, Hamzeh KW, Darga TE, Mauceri HJ, Fu YX, Kron SJ, Weichselbaum RR
Molecular therapy : the journal of the American Society of Gene Therapy 2012 May;20(5):1046-55
Molecular therapy : the journal of the American Society of Gene Therapy 2012 May;20(5):1046-55
A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.
Luijsterburg MS, Acs K, Ackermann L, Wiegant WW, Bekker-Jensen S, Larsen DH, Khanna KK, van Attikum H, Mailand N, Dantuma NP
The EMBO journal 2012 May 30;31(11):2511-27
The EMBO journal 2012 May 30;31(11):2511-27
Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis.
Gomes J, Magalhães A, Michel V, Amado IF, Aranha P, Ovesen RG, Hansen HC, Gärtner F, Reis CA, Touati E
Toxicological sciences : an official journal of the Society of Toxicology 2012 Mar;126(1):60-71
Toxicological sciences : an official journal of the Society of Toxicology 2012 Mar;126(1):60-71
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F
Nature cell biology 2012 Mar 18;14(4):355-65
Nature cell biology 2012 Mar 18;14(4):355-65
Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process.
Wong V, Armknecht S, Zhitkovich A
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2012 Jun;26(2-3):192-6
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2012 Jun;26(2-3):192-6
The activation of DNA damage detection and repair responses in cleavage-stage rat embryos by a damaged paternal genome.
Grenier L, Robaire B, Hales BF
Toxicological sciences : an official journal of the Society of Toxicology 2012 Jun;127(2):555-66
Toxicological sciences : an official journal of the Society of Toxicology 2012 Jun;127(2):555-66
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.
Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U
The EMBO journal 2012 Jun 29;31(13):2839-51
The EMBO journal 2012 Jun 29;31(13):2839-51
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells.
Davoli T, de Lange T
Cancer cell 2012 Jun 12;21(6):765-76
Cancer cell 2012 Jun 12;21(6):765-76
IL-7Rα deficiency in p53null mice exacerbates thymocyte telomere erosion and lymphomagenesis.
Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y
Cell death and differentiation 2012 Jul;19(7):1139-51
Cell death and differentiation 2012 Jul;19(7):1139-51
Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.
Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S, Fukai S
The Journal of biological chemistry 2012 Jul 27;287(31):25860-8
The Journal of biological chemistry 2012 Jul 27;287(31):25860-8
mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription.
Pont AR, Sadri N, Hsiao SJ, Smith S, Schneider RJ
Molecular cell 2012 Jul 13;47(1):5-15
Molecular cell 2012 Jul 13;47(1):5-15
Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.
Pires IM, Olcina MM, Anbalagan S, Pollard JR, Reaper PM, Charlton PA, McKenna WG, Hammond EM
British journal of cancer 2012 Jul 10;107(2):291-9
British journal of cancer 2012 Jul 10;107(2):291-9
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
Polo SE, Blackford AN, Chapman JR, Baskcomb L, Gravel S, Rusch A, Thomas A, Blundred R, Smith P, Kzhyshkowska J, Dobner T, Taylor AM, Turnell AS, Stewart GS, Grand RJ, Jackson SP
Molecular cell 2012 Feb 24;45(4):505-16
Molecular cell 2012 Feb 24;45(4):505-16
SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, Fritsch L, Battisti V, Ait-Si-Ali S, Hoffbeck AS, Soutoglou E, Will H
Nucleic acids research 2012 Dec;40(22):11363-79
Nucleic acids research 2012 Dec;40(22):11363-79
The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.
Courilleau C, Chailleux C, Jauneau A, Grimal F, Briois S, Boutet-Robinet E, Boudsocq F, Trouche D, Canitrot Y
The Journal of cell biology 2012 Dec 24;199(7):1067-81
The Journal of cell biology 2012 Dec 24;199(7):1067-81
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR
Nature 2012 Dec 13;492(7428):285-9
Nature 2012 Dec 13;492(7428):285-9
Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by β1 integrin inhibition.
Eke I, Dickreuter E, Cordes N
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2012 Aug;104(2):235-42
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2012 Aug;104(2):235-42
Site-specific DICER and DROSHA RNA products control the DNA-damage response.
Francia S, Michelini F, Saxena A, Tang D, de Hoon M, Anelli V, Mione M, Carninci P, d'Adda di Fagagna F
Nature 2012 Aug 9;488(7410):231-5
Nature 2012 Aug 9;488(7410):231-5
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.
Bolderson E, Savage KI, Mahen R, Pisupati V, Graham ME, Richard DJ, Robinson PJ, Venkitaraman AR, Khanna KK
The Journal of biological chemistry 2012 Aug 10;287(33):28122-31
The Journal of biological chemistry 2012 Aug 10;287(33):28122-31
Autocrine regulation of γ-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors.
Nishimaki N, Tsukimoto M, Kitami A, Kojima S
DNA repair 2012 Aug 1;11(8):657-65
DNA repair 2012 Aug 1;11(8):657-65
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S
The EMBO journal 2012 Apr 18;31(8):1865-78
The EMBO journal 2012 Apr 18;31(8):1865-78
Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells.
Wilsker D, Chung JH, Bunz F
Cell cycle (Georgetown, Tex.) 2012 Apr 15;11(8):1564-72
Cell cycle (Georgetown, Tex.) 2012 Apr 15;11(8):1564-72
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation.
Fernandez-L A, Squatrito M, Northcott P, Awan A, Holland EC, Taylor MD, Nahlé Z, Kenney AM
Oncogene 2012 Apr 12;31(15):1923-37
Oncogene 2012 Apr 12;31(15):1923-37
Microsatellite instability in pediatric high grade glioma is associated with genomic profile and differential target gene inactivation.
Viana-Pereira M, Lee A, Popov S, Bax DA, Al-Sarraj S, Bridges LR, Stávale JN, Hargrave D, Jones C, Reis RM
PloS one 2011;6(5):e20588
PloS one 2011;6(5):e20588
Cerebroventricular microinjection (CVMI) into adult zebrafish brain is an efficient misexpression method for forebrain ventricular cells.
Kizil C, Brand M
PloS one 2011;6(11):e27395
PloS one 2011;6(11):e27395
53BP1 contributes to a robust genomic stability in human fibroblasts.
Fink LS, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia S, Lorenzini A, Sell C
Aging 2011 Sep;3(9):836-45
Aging 2011 Sep;3(9):836-45
Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model.
Galron R, Gruber R, Lifshitz V, Lu H, Kirshner M, Ziv N, Wang ZQ, Shiloh Y, Barzilai A, Frenkel D
Journal of molecular neuroscience : MN 2011 Oct;45(2):202-11
Journal of molecular neuroscience : MN 2011 Oct;45(2):202-11
Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.
Reichert S, Rödel C, Mirsch J, Harter PN, Tomicic MT, Mittelbronn M, Kaina B, Rödel F
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Oct;101(1):51-8
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Oct;101(1):51-8
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Zhang W, Peng G, Lin SY, Zhang P
The Journal of biological chemistry 2011 Oct 14;286(41):35899-35905
The Journal of biological chemistry 2011 Oct 14;286(41):35899-35905
Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study.
Ben Abdelali R, Asnafi V, Leguay T, Boissel N, Buzyn A, Chevallier P, Thomas X, Lepretre S, Huguet F, Vey N, Escoffre-Barbe M, Tavernier E, Reman O, Fegueux N, Turlure P, Rousselot P, Cahn JY, Lheritier V, Chalandon Y, Béné MC, Macintyre E, Dombret H, Ifrah N, Group for Research on Adult Acute Lymphoblastic Leukemia.
Blood 2011 Nov 10;118(19):5099-107
Blood 2011 Nov 10;118(19):5099-107
The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency.
Westin ER, Aykin-Burns N, Buckingham EM, Spitz DR, Goldman FD, Klingelhutz AJ
Antioxidants & redox signaling 2011 Mar 15;14(6):985-97
Antioxidants & redox signaling 2011 Mar 15;14(6):985-97
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J, Knight S, Jacobsen SE, Kranc KR, Simon AK
The Journal of experimental medicine 2011 Mar 14;208(3):455-67
The Journal of experimental medicine 2011 Mar 14;208(3):455-67
Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta.
Singh M, Kindelberger D, Nagymanyoki Z, Ng SW, Quick CM, Elias KM, Yamamoto H, Fichorova R, Fulop V, Berkowitz RS
Gynecologic oncology 2011 Jul;122(1):178-82
Gynecologic oncology 2011 Jul;122(1):178-82
A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.
Gonzalez-Suarez I, Redwood AB, Grotsky DA, Neumann MA, Cheng EH, Stewart CL, Dusso A, Gonzalo S
The EMBO journal 2011 Jul 12;30(16):3383-96
The EMBO journal 2011 Jul 12;30(16):3383-96
The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb'-encoded modulation of TNF-α signaling.
Le VT, Trilling M, Hengel H
Journal of virology 2011 Dec;85(24):13260-70
Journal of virology 2011 Dec;85(24):13260-70
Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1β and support viral replication.
Beura LK, Dinh PX, Osorio FA, Pattnaik AK
Journal of virology 2011 Dec;85(24):12939-49
Journal of virology 2011 Dec;85(24):12939-49
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.
Domínguez-Sánchez MS, Barroso S, Gómez-González B, Luna R, Aguilera A
PLoS genetics 2011 Dec;7(12):e1002386
PLoS genetics 2011 Dec;7(12):e1002386
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ
Nature 2011 Aug 21;477(7364):349-53
Nature 2011 Aug 21;477(7364):349-53
A dual role for A-type lamins in DNA double-strand break repair.
Redwood AB, Perkins SM, Vanderwaal RP, Feng Z, Biehl KJ, Gonzalez-Suarez I, Morgado-Palacin L, Shi W, Sage J, Roti-Roti JL, Stewart CL, Zhang J, Gonzalo S
Cell cycle (Georgetown, Tex.) 2011 Aug 1;10(15):2549-60
Cell cycle (Georgetown, Tex.) 2011 Aug 1;10(15):2549-60
Replication stress induces 53BP1-containing OPT domains in G1 cells.
Harrigan JA, Belotserkovskaya R, Coates J, Dimitrova DS, Polo SE, Bradshaw CR, Fraser P, Jackson SP
The Journal of cell biology 2011 Apr 4;193(1):97-108
The Journal of cell biology 2011 Apr 4;193(1):97-108
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
Baldeyron C, Soria G, Roche D, Cook AJ, Almouzni G
The Journal of cell biology 2011 Apr 4;193(1):81-95
The Journal of cell biology 2011 Apr 4;193(1):81-95
Dicer is required for Sertoli cell function and survival.
Kim GJ, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, Barrionuevo F
The International journal of developmental biology 2010;54(5):867-75
The International journal of developmental biology 2010;54(5):867-75
H2AX post-translational modifications in the ionizing radiation response and homologous recombination.
Xie A, Odate S, Chandramouly G, Scully R
Cell cycle (Georgetown, Tex.) 2010 Sep 1;9(17):3602-10
Cell cycle (Georgetown, Tex.) 2010 Sep 1;9(17):3602-10
A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion.
Gong Y, de Lange T
Molecular cell 2010 Nov 12;40(3):377-87
Molecular cell 2010 Nov 12;40(3):377-87
Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence.
Chayot R, Danckaert A, Montagne B, Ricchetti M
DNA repair 2010 Nov 10;9(11):1187-99
DNA repair 2010 Nov 10;9(11):1187-99
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Orsburn B, Escudero B, Prakash M, Gesheva S, Liu G, Huso DL, Franco S
Molecular and cellular biology 2010 May;30(10):2341-52
Molecular and cellular biology 2010 May;30(10):2341-52
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.
Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM
Aging cell 2010 Jun;9(3):398-409
Aging cell 2010 Jun;9(3):398-409
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.
Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J
Nature structural & molecular biology 2010 Jun;17(6):688-95
Nature structural & molecular biology 2010 Jun;17(6):688-95
LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection.
Sheppard SA, Loayza D
Aging 2010 Jul;2(7):432-44
Aging 2010 Jul;2(7):432-44
Telomere protection by TPP1 is mediated by POT1a and POT1b.
Kibe T, Osawa GA, Keegan CE, de Lange T
Molecular and cellular biology 2010 Feb;30(4):1059-66
Molecular and cellular biology 2010 Feb;30(4):1059-66
Selective targeting of radiation-resistant tumor-initiating cells.
Zhang M, Atkinson RL, Rosen JM
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 23;107(8):3522-7
Proceedings of the National Academy of Sciences of the United States of America 2010 Feb 23;107(8):3522-7
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.
Squatrito M, Brennan CW, Helmy K, Huse JT, Petrini JH, Holland EC
Cancer cell 2010 Dec 14;18(6):619-29
Cancer cell 2010 Dec 14;18(6):619-29
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA
The Journal of biological chemistry 2010 Apr 23;285(17):12935-47
The Journal of biological chemistry 2010 Apr 23;285(17):12935-47
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
Herranz D, Muñoz-Martin M, Cañamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M
Nature communications 2010 Apr 12;1:3
Nature communications 2010 Apr 12;1:3
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells.
Watrin E, Peters JM
The EMBO journal 2009 Sep 2;28(17):2625-35
The EMBO journal 2009 Sep 2;28(17):2625-35
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2.
Dimitrova N, de Lange T
Molecular and cellular biology 2009 Oct;29(20):5552-63
Molecular and cellular biology 2009 Oct;29(20):5552-63
Telomeric DNA mediates de novo PML body formation.
Brouwer AK, Schimmel J, Wiegant JC, Vertegaal AC, Tanke HJ, Dirks RW
Molecular biology of the cell 2009 Nov;20(22):4804-15
Molecular biology of the cell 2009 Nov;20(22):4804-15
Endocytosis is crucial for cell polarity and apical membrane recycling in the filamentous fungus Aspergillus oryzae.
Higuchi Y, Shoji JY, Arioka M, Kitamoto K
Eukaryotic cell 2009 Jan;8(1):37-46
Eukaryotic cell 2009 Jan;8(1):37-46
The effect of photopolymerization on stem cells embedded in hydrogels.
Fedorovich NE, Oudshoorn MH, van Geemen D, Hennink WE, Alblas J, Dhert WJ
Biomaterials 2009 Jan;30(3):344-53
Biomaterials 2009 Jan;30(3):344-53
Characterization of the p53 response to oncogene-induced senescence.
Ruiz L, Traskine M, Ferrer I, Castro E, Leal JF, Kaufman M, Carnero A
PloS one 2008 Sep 18;3(9):e3230
PloS one 2008 Sep 18;3(9):e3230
Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques.
Hokey DA, Johnson FB, Smith J, Weber JL, Yan J, Hirao L, Boyer JD, Lewis MG, Makedonas G, Betts MR, Weiner DB
European journal of immunology 2008 May;38(5):1435-45
European journal of immunology 2008 May;38(5):1435-45
Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2.
Konishi A, de Lange T
Genes & development 2008 May 1;22(9):1221-30
Genes & development 2008 May 1;22(9):1221-30
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.
Denchi EL, de Lange T
Nature 2007 Aug 30;448(7157):1068-71
Nature 2007 Aug 30;448(7157):1068-71
Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies.
Valero J, Berciano MT, Weruaga E, Lafarga M, Alonso JR
Molecular and cellular neurosciences 2006 Nov;33(3):283-95
Molecular and cellular neurosciences 2006 Nov;33(3):283-95
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
Hockemeyer D, Daniels JP, Takai H, de Lange T
Cell 2006 Jul 14;126(1):63-77
Cell 2006 Jul 14;126(1):63-77
Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals.
Patton KM, McGuire TC, Hines MT, Mealey RH, Hines SA
Infection and immunity 2005 Apr;73(4):2083-93
Infection and immunity 2005 Apr;73(4):2083-93
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Supportive validation
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- Western Blot: 53BP1 Antibody [NB100-304] - Whole cell lysate from U2OS or 293T cells. Bands indicate an observed molecular weight of ~220 kDa and the theoretical molecular weight is 214 kDa.
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- Western Blot: 53BP1 Antibody [NB100-304] - Total protein from HeLa, A431, Neuro2A, and PC12 was separated on a 12% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 1.0 ug/mL in 5% block buffer and detected with an anti-rabbit HRP secondary antibody using chemiluminescence. The observed molecular weight for these samples are ~250 kDa and the theoretical molecular weight is 214 kDa.
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- Western Blot: 53BP1 Antibody [NB100-304] - Lamin A/C-53BP1 interaction is regulated in a DNA damage-dependent manner. U2OS/GFP-lamin A ceels were pretreated with 10 um ATMi f for 1 h before exposure to IR (10 Gy, 1 h recovery). Cell extracts were then subjected to immunoprecipitation using GFP-Trap beads, and bound complexes were then analyzed by immunoblotting using 53BP1 and GFP antibodies. WCE represents 1% input. Image collected and cropped by CiteAb from the following publication (http://doi.wiley.com/10.1111/acel.12258), licensed under a CC-BY licence.
Supportive validation
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- Immunoprecipitation: 53BP1 Antibody [NB100-304] - Lysates from HCC44 cells in 1% NP40. Image from verified customer review.
Supportive validation
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- Immunohistochemistry-Paraffin: 53BP1 Antibody [NB100-304] - Detection of Human and Mouse 53BP1 by IHC. Sample: FFPE sections of human ovarian carcinoma (left) and mouse teratoma (right). Antibody: 53BP1 Antibody (Catalog #NB100-304) used at a dilution of 1:1000 (1ug/mL). Detection: DAB.
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- Immunohistochemistry-Paraffin: 53BP1 Antibody [NB100-304] - Staining of 53BP1 in human colon cancer using DAB with hematoxylin counterstain.
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- Immunohistochemistry-Frozen: 53BP1 Antibody [NB100-304] - Irradiated cochlear spiral ganglion cells, mouse, frozen section of fixed material. Image from verified customer review.
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- Immunohistochemistry-Paraffin: 53BP1 Antibody [NB100-304] - Human breast tumors stained with 53BP1 antibody. Image from verified customer review.
Supportive validation
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- Flow Cytometry: 53BP1 Antibody [NB100-304] - 1 million Jurkat cells were fixed, permeabilized, and stained with 1.5 ug/mL anti-53BP1 NB100-304 in a 150 uL reaction. Isotype control (black), anti-53BP1 (red).
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- Flow Cytometry: 53BP1 Antibody [NB100-304] - An intracellular stain was performed on HeLa cells with NB100-304AF647 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 647.
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- Flow (Intracellular): 53BP1 Antibody [NB100-304] - An intracellular stain was performed on Neuro2A cells with NB100-304F (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 10 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to FITC.
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- Flow (Intracellular): 53BP1 Antibody [NB100-304] - An intracellular stain was performed on Neuro2A cells with NB100-304G (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to DyLight 488.
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- Flow Cytometry: 53BP1 Antibody [NB100-304] - An intracellular stain was performed on NIH3T3 cells with 53BP1 Antibody NB100-304AF488 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 488.
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- Flow Cytometry: 53BP1 Antibody [NB100-304] - An intracellular stain was performed on RH-30 cells with 53BP1 Antibody (Catalog #NB100-304AF647) (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 647.
- Submitted by
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- Main image
- Experimental details
- Flow Cytometry: 53BP1 Antibody [NB100-304] - An intracellular stain was performed on HeLa cells with 53BP1 Antibody NB100-304AF488 (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 488.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: 53BP1 Antibody [NB100-304] - An intracellular stain was performed on A431 cells with 53BP1 Antibody (Catalog #NB100-304AF647) (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Alexa Fluor 647.
