orb386105

antibody from Biorbyt

Targeting: TP63 EEC3, KET, NBP, OFC8, p51, p53CP, p63, p73H, p73L, SHFM4, TP53CP, TP53L, TP73L

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb386105

Provider

Biorbyt

Product name

p63 Antibody / Tumor protein 63

Antibody type

Polyclonal

Description

p63 is a homolog of the tumor suppressor p53. It is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63 was detected in nuclei of the basal epithelium in normal prostate glands; however, it was not expressed in malignant tumors of the prostate. As a result, p63 has been reported as a useful marker for differentiating benign from malignant lesions in the prostate, particularly when used in combination with markers of high molecular weight cytokeratins and the prostate-specific marker AMACR (P504S). p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90%. Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80%. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

20 ug

Storage

Store the p63 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).