orb534114

antibody from Biorbyt

Targeting: TP63 EEC3, KET, NBP, OFC8, p51, p53CP, p63, p73H, p73L, SHFM4, TP53CP, TP53L, TP73L

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb534114

Provider

Biorbyt

Product name

p63 Antibody / Tumor protein 63

Antibody type

Recombinant

Description

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. [UniProt]

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antibody clone number

TMPR63-1R

Vial size

20 ug

Storage

Store the recombinant p63 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).