Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations [0]
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- Product number
- 612301 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#612301, RRID:AB_315774
- Product name
- Purified anti-Cytochrome c
- Antibody type
- Monoclonal
- Antigen
- Rat cyt c-OVA
- Description
- Cytochrome c is a 15 kD protein found in the mitochondrial intermembrane space with a heme-binding domain. Cytochrome c is a component of the electron transport chain; the heme group transfers electrons from cytochrome b-c1 complex to cytochrome oxidase complex. Cytochrome c initiates apoptosis by release to cytoplasm and binding Apaf-1 which activates procaspase 9. Cytochrome c interacts with the cytochrome b-c1 complex, cytochrome oxidase complex, heme, Apaf-1, and Caspase 9 proteins. The 6H2.B4 monoclonal antibody recognizes human, mouse, and rat cytochrome-c and has been shown to be useful for intracellular flow cytometric staining, Western blotting, immunoprecipitation, and immunofluorescence staining.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store at 4° C.
Submitted references Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species.
Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease.
McGuire KA, Barlan AU, Griffin TM, Wiethoff CM
Journal of virology 2011 Oct;85(20):10806-13
Journal of virology 2011 Oct;85(20):10806-13
Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease.
She P, Zhang Z, Marchionini D, Diaz WC, Jetton TJ, Kimball SR, Vary TC, Lang CH, Lynch CJ
American journal of physiology. Endocrinology and metabolism 2011 Jul;301(1):E49-61
American journal of physiology. Endocrinology and metabolism 2011 Jul;301(1):E49-61
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