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antibody from Novus Biologicals
Targeting: TLR3
CD283
Western blot
Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [78]
- Comments [0]
- Validations
- Western blot [4]
- Immunohistochemistry [3]
- Flow cytometry [5]
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- Product number
- NBP2-24875 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal TLR3 Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Canine
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum.
Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells.
Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.
Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations.
Calcium/Calmodulin-Dependent Protein Kinase IV Mediates IFN-γ-Induced Immune Behaviors in Skeletal Muscle Cells.
Substance P represents a novel first-line defense mechanism in the nose.
Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival.
Toll-like receptor 3 pathway restricts Marek's disease virus infection.
Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas.
Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury.
The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.
Early IFN-γ production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin.
Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia.
The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer.
Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice.
KAP1 promotes proliferation and metastatic progression of breast cancer cells.
Vitamin D Activation and Function in Human Corneal Epithelial Cells During TLR-Induced Inflammation.
Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome.
Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients.
Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells.
The ectodomain of TLR3 receptor is required for its plasma membrane translocation.
Regulation of Toll-like receptor expression in human conjunctival epithelial cells.
TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.
Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration.
Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells.
Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.
TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts.
Characterization of the Toll-like receptor expression profile in human multiple myeloma cells.
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2.
Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells.
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Innate immune mechanisms in Japanese encephalitis virus infection: effect on transcription of pattern recognition receptors in mouse neuronal cells and brain tissue.
Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling.
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.
Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.
Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice.
Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.
TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis.
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies.
STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines.
Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry.
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes.
Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3.
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.
Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma.
Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain.
Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells.
Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils.
Down modulation of human TLR3 function by a monoclonal antibody.
Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells.
Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.
Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis.
Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells.
High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production.
Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation.
Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages.
Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.
Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.
Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines.
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.
Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.
Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria.
Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.
The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.
Subcellular localization of Toll-like receptor 3 in human dendritic cells.
Subcellular localization of Toll-like receptor 3 in human dendritic cells.
Gao X, Gao S, Guan Y, Huang L, Huang J, Lin L, Liu Y, Zhao H, Huang B, Yuan T, Liu Y, Liang D, Zhang Y, Ma X, Li L, Li J, Zhou D, Shi D, Xu L, Chen YH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May 1;33(5):6197-6208
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May 1;33(5):6197-6208
Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells.
Igase M, Shousu K, Fujiki N, Sakurai M, Bonkobara M, Hwang CC, Coffey M, Noguchi S, Nemoto Y, Mizuno T
Veterinary and comparative oncology 2019 Jun;17(2):184-193
Veterinary and comparative oncology 2019 Jun;17(2):184-193
Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis.
Regel I, Raulefs S, Benitz S, Mihaljevic C, Rieder S, Leinenkugel G, Steiger K, Schlitter AM, Esposito I, Mayerle J, Kong B, Kleeff J, Michalski CW
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019 Jan;19(1):149-157
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2019 Jan;19(1):149-157
Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations.
Zhu J, Message SD, Mallia P, Kebadze T, Contoli M, Ward CK, Barnathan ES, Mascelli MA, Kon OM, Papi A, Stanciu LA, Edwards MR, Jeffery PK, Johnston SL
The Journal of allergy and clinical immunology 2019 Jan;143(1):114-125.e4
The Journal of allergy and clinical immunology 2019 Jan;143(1):114-125.e4
Calcium/Calmodulin-Dependent Protein Kinase IV Mediates IFN-γ-Induced Immune Behaviors in Skeletal Muscle Cells.
Gu R, Ding M, Shi D, Huang T, Guo M, Yu L, Hu J, Huang W, Liao H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(1):351-364
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(1):351-364
Substance P represents a novel first-line defense mechanism in the nose.
Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell LO
The Journal of allergy and clinical immunology 2018 Jan;141(1):128-136.e3
The Journal of allergy and clinical immunology 2018 Jan;141(1):128-136.e3
Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival.
Auger JP, Santinón A, Roy D, Mossman K, Xu J, Segura M, Gottschalk M
Frontiers in immunology 2017;8:1039
Frontiers in immunology 2017;8:1039
Toll-like receptor 3 pathway restricts Marek's disease virus infection.
Zou H, Su R, Ruan J, Shao H, Qian K, Ye J, Qin A
Oncotarget 2017 Sep 19;8(41):70847-70853
Oncotarget 2017 Sep 19;8(41):70847-70853
Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas.
Helminen O, Huhta H, Kauppila JH, Lehenkari PP, Saarnio J, Karttunen TJ
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2017 Feb;125(2):85-92
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2017 Feb;125(2):85-92
Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury.
Brempelis KJ, Yuen SY, Schwarz N, Mohar I, Crispe IN
Hepatology (Baltimore, Md.) 2017 Apr;65(4):1336-1351
Hepatology (Baltimore, Md.) 2017 Apr;65(4):1336-1351
The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.
Yang Y, Wang SY, Huang ZF, Zou HM, Yan BR, Luo WW, Wang YY
Cell research 2016 Mar;26(3):288-303
Cell research 2016 Mar;26(3):288-303
Early IFN-γ production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin.
Evangelista MG, Castro SB, Alves CC, Dias AT, Souza VW, Reis LB, Silva LC, Castañon MC, Farias RE, Juliano MA, Ferreira AP
Autoimmunity 2016 Jun;49(4):258-67
Autoimmunity 2016 Jun;49(4):258-67
Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia.
Silva-Barrios S, Smans M, Duerr CU, Qureshi ST, Fritz JH, Descoteaux A, Stäger S
Cell reports 2016 Jun 14;15(11):2427-37
Cell reports 2016 Jun 14;15(11):2427-37
The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer.
Huhta H, Helminen O, Kauppila JH, Salo T, Porvari K, Saarnio J, Lehenkari PP, Karttunen TJ
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2016 Aug;64(8):470-82
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2016 Aug;64(8):470-82
Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice.
Chatterjee P, Chiasson VL, Seerangan G, Tobin RP, Kopriva SE, Newell-Rogers MK, Mitchell BM
American journal of hypertension 2015 Jan;28(1):135-42
American journal of hypertension 2015 Jan;28(1):135-42
KAP1 promotes proliferation and metastatic progression of breast cancer cells.
Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV
Cancer research 2015 Jan 15;75(2):344-55
Cancer research 2015 Jan 15;75(2):344-55
Vitamin D Activation and Function in Human Corneal Epithelial Cells During TLR-Induced Inflammation.
Reins RY, Baidouri H, McDermott AM
Investigative ophthalmology & visual science 2015 Dec;56(13):7715-27
Investigative ophthalmology & visual science 2015 Dec;56(13):7715-27
Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome.
Jamin A, Dehoux L, Dossier C, Fila M, Heming N, Monteiro RC, Deschênes G
Clinical and experimental immunology 2015 Dec;182(3):332-45
Clinical and experimental immunology 2015 Dec;182(3):332-45
Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients.
Tengroth L, Arebro J, Kumlien Georén S, Winqvist O, Cardell LO
PloS one 2014;9(8):e105618
PloS one 2014;9(8):e105618
Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells.
Tengroth L, Millrud CR, Kvarnhammar AM, Kumlien Georén S, Latif L, Cardell LO
PloS one 2014;9(6):e98239
PloS one 2014;9(6):e98239
The ectodomain of TLR3 receptor is required for its plasma membrane translocation.
Pohar J, Pirher N, Benčina M, Manček-Keber M, Jerala R
PloS one 2014;9(3):e92391
PloS one 2014;9(3):e92391
Regulation of Toll-like receptor expression in human conjunctival epithelial cells.
Li J, Setiawan M, Wu H, Beuerman RW, Zhao P
Mediators of inflammation 2014;2014:493596
Mediators of inflammation 2014;2014:493596
TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.
Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M
Journal of immunology (Baltimore, Md. : 1950) 2014 Jun 1;192(11):4977-88
Journal of immunology (Baltimore, Md. : 1950) 2014 Jun 1;192(11):4977-88
Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration.
Wang K, Xiao J, Peng B, Xing F, So KF, Tipoe GL, Lin B
Scientific reports 2014 Dec 23;4:7601
Scientific reports 2014 Dec 23;4:7601
Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells.
Green TL, Santos MF, Ejaeidi AA, Craft BS, Lewis RE, Cruse JM
Experimental and molecular pathology 2014 Aug;97(1):44-8
Experimental and molecular pathology 2014 Aug;97(1):44-8
Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G
Journal of medical virology 2014 Aug;86(8):1402-11
Journal of medical virology 2014 Aug;86(8):1402-11
TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts.
Hamidi S, Schäfer-Korting M, Weindl G
Biochimica et biophysica acta 2014 Apr 4;1841(4):484-94
Biochimica et biophysica acta 2014 Apr 4;1841(4):484-94
Characterization of the Toll-like receptor expression profile in human multiple myeloma cells.
Abdi J, Mutis T, Garssen J, Redegeld F
PloS one 2013;8(4):e60671
PloS one 2013;8(4):e60671
Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2.
Østvik AE, Granlund AV, Torp SH, Flatberg A, Beisvåg V, Waldum HL, Flo TH, Espevik T, Damås JK, Sandvik AK
Clinical and experimental immunology 2013 Sep;173(3):502-11
Clinical and experimental immunology 2013 Sep;173(3):502-11
Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells.
Yan K, Zhu W, Yu L, Li N, Zhang X, Liu P, Chen Q, Chen Y, Han D
Molecular and cellular endocrinology 2013 Jun 15;372(1-2):73-85
Molecular and cellular endocrinology 2013 Jun 15;372(1-2):73-85
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Pohar J, Pirher N, Benčina M, Manček-Keber M, Jerala R
The Journal of biological chemistry 2013 Jan 4;288(1):442-54
The Journal of biological chemistry 2013 Jan 4;288(1):442-54
Innate immune mechanisms in Japanese encephalitis virus infection: effect on transcription of pattern recognition receptors in mouse neuronal cells and brain tissue.
Fadnis PR, Ravi V, Desai A, Turtle L, Solomon T
Viral immunology 2013 Dec;26(6):366-77
Viral immunology 2013 Dec;26(6):366-77
Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling.
Yamashita M, Chattopadhyay S, Fensterl V, Saikia P, Wetzel JL, Sen GC
Science signaling 2012 Jul 17;5(233):ra50
Science signaling 2012 Jul 17;5(233):ra50
Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.
Kleinman ME, Kaneko H, Cho WG, Dridi S, Fowler BJ, Blandford AD, Albuquerque RJ, Hirano Y, Terasaki H, Kondo M, Fujita T, Ambati BK, Tarallo V, Gelfand BD, Bogdanovich S, Baffi JZ, Ambati J
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jan;20(1):101-8
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jan;20(1):101-8
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
Dasgupta G, Chentoufi AA, You S, Falatoonzadeh P, Urbano LA, Akhtarmalik A, Nguyen K, Ablabutyan L, Nesburn AB, BenMohamed L
Investigative ophthalmology & visual science 2011 May 17;52(6):3321-33
Investigative ophthalmology & visual science 2011 May 17;52(6):3321-33
The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.
Menendez D, Shatz M, Azzam K, Garantziotis S, Fessler MB, Resnick MA
PLoS genetics 2011 Mar;7(3):e1001360
PLoS genetics 2011 Mar;7(3):e1001360
Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.
Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4794-804
Journal of immunology (Baltimore, Md. : 1950) 2011 Apr 15;186(8):4794-804
Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice.
Johnston MJ, Wang A, Catarino ME, Ball L, Phan VC, MacDonald JA, McKay DM
Infection and immunity 2010 Mar;78(3):1364-75
Infection and immunity 2010 Mar;78(3):1364-75
Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.
Peltier DC, Simms A, Farmer JR, Miller DJ
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):7010-21
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 15;184(12):7010-21
TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis.
Taura M, Fukuda R, Suico MA, Eguma A, Koga T, Shuto T, Sato T, Morino-Koga S, Kai H
Cancer science 2010 Jul;101(7):1610-7
Cancer science 2010 Jul;101(7):1610-7
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies.
Ménager P, Roux P, Mégret F, Bourgeois JP, Le Sourd AM, Danckaert A, Lafage M, Préhaud C, Lafon M
PLoS pathogens 2009 Feb;5(2):e1000315
PLoS pathogens 2009 Feb;5(2):e1000315
STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
Cohen PA, Koski GK, Czerniecki BJ, Bunting KD, Fu XY, Wang Z, Zhang WJ, Carter CS, Awad M, Distel CA, Nagem H, Paustian CC, Johnson TD, Tisdale JF, Shu S
Blood 2008 Sep 1;112(5):1832-43
Blood 2008 Sep 1;112(5):1832-43
p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines.
Taura M, Eguma A, Suico MA, Shuto T, Koga T, Komatsu K, Komune T, Sato T, Saya H, Li JD, Kai H
Molecular and cellular biology 2008 Nov;28(21):6557-67
Molecular and cellular biology 2008 Nov;28(21):6557-67
Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry.
Burgener IA, Jungi TW
Veterinary immunology and immunopathology 2008 Jul 15;124(1-2):184-91
Veterinary immunology and immunopathology 2008 Jul 15;124(1-2):184-91
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Sacre SM, Lo A, Gregory B, Simmonds RE, Williams L, Feldmann M, Brennan FM, Foxwell BM
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Sacre SM, Lo A, Gregory B, Simmonds RE, Williams L, Feldmann M, Brennan FM, Foxwell BM
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 1;181(11):8002-9
Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes.
Kim H, Yang E, Lee J, Kim SH, Shin JS, Park JY, Choi SJ, Kim SJ, Choi IH
Immunology 2008 Aug;124(4):480-8
Immunology 2008 Aug;124(4):480-8
Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3.
Fukuda K, Watanabe T, Tokisue T, Tsujita T, Nishikawa S, Hasegawa T, Seya T, Matsumoto M
The Journal of biological chemistry 2008 Aug 15;283(33):22787-94
The Journal of biological chemistry 2008 Aug 15;283(33):22787-94
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.
Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi JZ, Albuquerque RJ, Yamasaki S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Karikó K, Ambati BK, Wilgus TA, DiPietro LA, Sakurai E, Zhang K, Smith JR, Taylor EW, Ambati J
Nature 2008 Apr 3;452(7187):591-7
Nature 2008 Apr 3;452(7187):591-7
Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma.
Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Oct 1;13(19):5703-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 Oct 1;13(19):5703-9
Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.
Lundberg AM, Drexler SK, Monaco C, Williams LM, Sacre SM, Feldmann M, Foxwell BM
Blood 2007 Nov 1;110(9):3245-52
Blood 2007 Nov 1;110(9):3245-52
Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain.
Ranjith-Kumar CT, Miller W, Xiong J, Russell WK, Lamb R, Santos J, Duffy KE, Cleveland L, Park M, Bhardwaj K, Wu Z, Russell DH, Sarisky RT, Mbow ML, Kao CC
The Journal of biological chemistry 2007 Mar 9;282(10):7668-78
The Journal of biological chemistry 2007 Mar 9;282(10):7668-78
Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells.
Ranjith-Kumar CT, Miller W, Sun J, Xiong J, Santos J, Yarbrough I, Lamb RJ, Mills J, Duffy KE, Hoose S, Cunningham M, Holzenburg A, Mbow ML, Sarisky RT, Kao CC
The Journal of biological chemistry 2007 Jun 15;282(24):17696-705
The Journal of biological chemistry 2007 Jun 15;282(24):17696-705
Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils.
Wong CK, Cheung PF, Ip WK, Lam CW
American journal of respiratory cell and molecular biology 2007 Jul;37(1):85-96
American journal of respiratory cell and molecular biology 2007 Jul;37(1):85-96
Down modulation of human TLR3 function by a monoclonal antibody.
Duffy KE, Lamb RJ, San Mateo LR, Jordan JL, Canziani G, Brigham-Burke M, Korteweg J, Cunningham M, Beck HS, Carton J, Giles-Komar J, Duchala C, Sarisky RT, Mbow ML
Cellular immunology 2007 Aug;248(2):103-14
Cellular immunology 2007 Aug;248(2):103-14
Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells.
Yang X, Murthy V, Schultz K, Tatro JB, Fitzgerald KA, Beasley D
American journal of physiology. Heart and circulatory physiology 2006 Nov;291(5):H2334-43
American journal of physiology. Heart and circulatory physiology 2006 Nov;291(5):H2334-43
Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labéta MO
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3742-52
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3742-52
Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labéta MO
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3742-52
Journal of immunology (Baltimore, Md. : 1950) 2006 Mar 15;176(6):3742-52
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.
Johnsen IB, Nguyen TT, Ringdal M, Tryggestad AM, Bakke O, Lien E, Espevik T, Anthonsen MW
The EMBO journal 2006 Jul 26;25(14):3335-46
The EMBO journal 2006 Jul 26;25(14):3335-46
Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis.
Mansson A, Adner M, Cardell LO
Respiratory research 2006 Feb 27;7:36
Respiratory research 2006 Feb 27;7:36
Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells.
Groskreutz DJ, Monick MM, Powers LS, Yarovinsky TO, Look DC, Hunninghake GW
Journal of immunology (Baltimore, Md. : 1950) 2006 Feb 1;176(3):1733-40
Journal of immunology (Baltimore, Md. : 1950) 2006 Feb 1;176(3):1733-40
High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production.
Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, Koski G, Czerniecki BJ
Surgery 2006 Aug;140(2):170-8
Surgery 2006 Aug;140(2):170-8
Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation.
Sun J, Duffy KE, Ranjith-Kumar CT, Xiong J, Lamb RJ, Santos J, Masarapu H, Cunningham M, Holzenburg A, Sarisky RT, Mbow ML, Kao C
The Journal of biological chemistry 2006 Apr 21;281(16):11144-51
The Journal of biological chemistry 2006 Apr 21;281(16):11144-51
Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages.
Qi HY, Shelhamer JH
The Journal of biological chemistry 2005 Nov 25;280(47):38969-75
The Journal of biological chemistry 2005 Nov 25;280(47):38969-75
Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.
de Bouteiller O, Merck E, Hasan UA, Hubac S, Benguigui B, Trinchieri G, Bates EE, Caux C
The Journal of biological chemistry 2005 Nov 18;280(46):38133-45
The Journal of biological chemistry 2005 Nov 18;280(46):38133-45
Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.
Harii N, Lewis CJ, Vasko V, McCall K, Benavides-Peralta U, Sun X, Ringel MD, Saji M, Giuliani C, Napolitano G, Goetz DJ, Kohn LD
Molecular endocrinology (Baltimore, Md.) 2005 May;19(5):1231-50
Molecular endocrinology (Baltimore, Md.) 2005 May;19(5):1231-50
Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines.
Ueta M, Hamuro J, Kiyono H, Kinoshita S
Biochemical and biophysical research communications 2005 May 27;331(1):285-94
Biochemical and biophysical research communications 2005 May 27;331(1):285-94
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
François S, El Benna J, Dang PM, Pedruzzi E, Gougerot-Pocidalo MA, Elbim C
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
François S, El Benna J, Dang PM, Pedruzzi E, Gougerot-Pocidalo MA, Elbim C
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
Journal of immunology (Baltimore, Md. : 1950) 2005 Mar 15;174(6):3633-42
Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.
Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):376-84
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):376-84
Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses.
Schneeman TA, Bruno ME, Schjerven H, Johansen FE, Chady L, Kaetzel CS
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):376-84
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 1;175(1):376-84
Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria.
Furrie E, Macfarlane S, Thomson G, Macfarlane GT, Microbiology & Gut Biology Group., Tayside Tissue & Tumour Bank.
Immunology 2005 Aug;115(4):565-74
Immunology 2005 Aug;115(4):565-74
Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
Li K, Chen Z, Kato N, Gale M Jr, Lemon SM
The Journal of biological chemistry 2005 Apr 29;280(17):16739-47
The Journal of biological chemistry 2005 Apr 29;280(17):16739-47
The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.
Wen L, Peng J, Li Z, Wong FS
Journal of immunology (Baltimore, Md. : 1950) 2004 Mar 1;172(5):3173-80
Journal of immunology (Baltimore, Md. : 1950) 2004 Mar 1;172(5):3173-80
The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets.
Wen L, Peng J, Li Z, Wong FS
Journal of immunology (Baltimore, Md. : 1950) 2004 Mar 1;172(5):3173-80
Journal of immunology (Baltimore, Md. : 1950) 2004 Mar 1;172(5):3173-80
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.
Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T
International immunology 2004 Aug;16(8):1143-54
International immunology 2004 Aug;16(8):1143-54
Subcellular localization of Toll-like receptor 3 in human dendritic cells.
Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, Yamamoto A, Seya T
Journal of immunology (Baltimore, Md. : 1950) 2003 Sep 15;171(6):3154-62
Journal of immunology (Baltimore, Md. : 1950) 2003 Sep 15;171(6):3154-62
Subcellular localization of Toll-like receptor 3 in human dendritic cells.
Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, Yamamoto A, Seya T
Journal of immunology (Baltimore, Md. : 1950) 2003 Sep 15;171(6):3154-62
Journal of immunology (Baltimore, Md. : 1950) 2003 Sep 15;171(6):3154-62
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Supportive validation
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- Novus Biologicals (provider)
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- Western Blot: TLR3 Antibody (40C1285.6) [NBP2-24875] - Analysis of TLR3 in lysates from A) untransfected 293, B) 293 cells transfected with human TLR3 cDNA, C) human intestine, D) placenta, E) heart and F) ovary using TLR3 antibody at 3 ug/ml. Goat anti-mouse HRP conjugate was used as secondary.
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- Western Blot: TLR3 Antibody (40C1285.6) [NBP2-24875] - Analysis of TLR3 in lysates from A) human intestine and F) ovary using TLR3 antibody at 3 ug/ml. Goat anti-mouse HRP conjugate was used as secondary.
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- Western Blot: TLR3 Antibody (40C1285.6) [NBP2-24875] - HEK293T cells were transfected with TLR3, TLR3-9-3 and TLR3-3-9. Western blot was performed using anti-TLR3 or anti-HA antibodies. Anti-Beta-actin antibodies were used as a loading control. The representative data from three experiments are shown. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0092391) licensed under a CC-BY licence.
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- Western Blot: TLR3 Antibody (40C1285.6) [NBP2-24875] - All the cell lines displayed a strong expression of TLR3 protein. Cell lysates were electrophoresed and blotted to PVDF membrane, which was probed with TLR3-specific antibody. To confirm the immunoreactivity of the antibody, different positive controls were included. Beta-actin was served as loading control and was used to normalize expression levels between cells. Data are representative for analysis of >=2 independent experiments. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0060671) licensed under a CC-BY licence.
Supportive validation
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- Novus Biologicals (provider)
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- Immunohistochemistry-Paraffin: TLR3 Antibody (40C1285.6) [NBP2-24875] - Analysis of TLR3 in (A) human gut lumen (longitudinal section, transverse region) using this antibody at 10 ug/ml (Data courtesy Dr. Elizabeth Furrie, University of Dundee) and mouse spleen tissue using isotype control (B) and this antibody (C) at 5 mg/ml.
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- Immunohistochemistry-Paraffin: TLR3 Antibody (40C1285.6) [NBP2-24875] - Tissue section of mouse intestine using TLR3 antibody (clone 40C1285.6) at 1:500 dilution with HRP-DAB detection and hematoxylin counterstaining. The representative image shows a punctate staining of the ER and endosomes in a subset of cells in Peyer's patches (organized lymphoid nodules) in the tested section.
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- Immunohistochemistry-Paraffin: TLR3 Antibody (40C1285.6) [NBP2-24875] - Mouse colon using TLR3 antibody (clone 40C1285.6) at 1:500 dilution with HRP-DAB detection and hematoxylin counterstaining. Intense signal was found in subset of cells at the bases of the crypts.
Supportive validation
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- Novus Biologicals (provider)
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- Flow Cytometry: TLR3 Antibody (40C1285.6) [NBP2-24875] - Intracellular flow analysis of TLR3 in human monocytes using 0.5 ug of the antibody. Shaded histogram represents monocytes without antibody; green represents isotype control (Novus, 20109); red represents anti-TLR3 antibody. Goat anti-mouse IgG1 PE conjugate (BD) was used as secondary
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- Flow Cytometry: TLR3 Antibody (40C1285.6) [NBP2-24875] - Analysis using the FITC conjugate of NBP2-24875. Staining of TLR3 in human B cells using 1ug/10^6 cells of this antibody. Green represents isotype control; red represents anti-TLR3 antibody.
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- Flow (Intracellular): TLR3 Antibody (40C1285.6) [NBP2-24875] - Analysis using the PE conjugate of NBP2-24875. Staining of TLR3 in human monocytes using 0.5 ug/10^6 cells of this antibody. Shaded histogram represents cells without antibody; green represents isotype control ; red represents anti-TLR3 antibody.
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- Flow Cytometry: TLR3 Antibody (40C1285.6) [NBP2-24875] - Expression of TLR3 protein on epithelial cells. HNEC (A), Detroit-562 (B) and FaDu (C) were stained intracellularly with FITC-Abs against TLR3 (open histograms) or appropriate isotype control (shaded histograms) and analyzed by flow cytometry. Representative pictures from one out of three independent experiments are shown. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0098239), licensed under a CC-BY licence.
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- Flow Cytometry: TLR3 Antibody (40C1285.6) [NBP2-24875] - Expression of TLR3 in Fravel, L363, OPM1, RPMI8226, XG1, and NCI-H929 as determined by flow cytometry. HCMLs were stained using an intracellular staining protocol with TLR3 antibodies followed by relevant secondary fluorescent-conjugated antibodies. Filled histograms (purple) represent the isotype controls and the open histograms (red) indicate TLR3. Data are representative for analysis of >=2 independent experiments. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0060671) licensed under a CC-BY licence.
