Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [2]
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Validation data
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- Product number
- 10-3004 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-TLR3 Antibody
- Antibody type
- Monoclonal
- Description
- TLR3 (Toll-Like Receptor-3) acts as a major receptor in virus-mediated innate immune response. This protein belongs to TLR (Toll-like receptor) family which comprises of 10-12 type I integral membrane receptor paralogs that recognize pathogen associated molecular signatures and initiate inflammatory responses. TLR3 consist of pathogen-binding ECD (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 specifically senses dsRNA (Double-stranded RNA), an almost universal viral intermediate generated during most viral replications. TLR-3 activation induces multiple cellular antiviral responses, including production of IFN-alpha/beta and up-regulation of the anti-HIV cellular factor APOBEC3G. These are a family of pattern recognition receptors expressed by immune cells, including macrophages.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A partial length recombinant TLR3 p
rotein (amino acids 25-370) was use
d as the immunogen for this antibod
y.- Isotype
- IgG
- Antibody clone number
- ABM15D5
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Intracellular flow analysis of TLR3 in human PBMC (lymphocytes) using 2.0 µg/10^6 cells of TLR3antibody (Clone: ABM15D5). Green represents isotype control; red represents anti-TLR3 antibody. Goat anti-mouse PE conjugate was used as secondary.
- Protocol
- Protocol
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Intracellular flow analysis of TLR3 in human Jurkat using 0.5 µg/10^6 cells of TLR3 antibody (Clone: ABM15D5). Green represents isotype control; red represents anti-TLR3 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
- Protocol
- Protocol