Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 315001 - Provider product page
- Provider
- BioLegend
- Product name
- Purified anti-human CD283 (TLR3)
- Antibody type
- Monoclonal
- Antigen
- Recombinant human Toll-like receptor 3 protein
- Description
- Toll-like receptor 3 (TLR3) is a 104 kD protein also known as CD283. It is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. TLR3 is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens. The ligands recognized by TLR3 are polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. TLR3 ligands induce NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. This antibody is useful for flow cytometry and Western blotting.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA.
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly.
Sadik CD, Bachmann M, Pfeilschifter J, Mühl H
Nucleic acids research 2009 Aug;37(15):5041-56
Nucleic acids research 2009 Aug;37(15):5041-56
Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly.
Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR
Journal of virology 2008 Aug;82(15):7613-23
Journal of virology 2008 Aug;82(15):7613-23
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Western blot analysis of extracts from 293T parent (lane 1) and 293T transfected with human TLR3 (lane 2) using anti-CD283 antibody(TLR-104).
- Conjugate
- Unconjugated