315002

antibody from BioLegend

Targeting: TLR3 CD283

Western blot

Antibody data

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Validation data

Product number: 315002 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#315002, RRID:AB_2303470
Product name: Purified anti-human CD283 (TLR3)
Antibody type: Monoclonal
Antigen: Recombinant human Toll-like receptor 3 protein
Description: Toll-like receptor 3 (TLR3) is a 104 kD protein also known as CD283. It is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. TLR3 is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens. The ligands recognized by TLR3 are polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. TLR3 ligands induce NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. This antibody is useful for flow cytometry and Western blotting.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C.

TLR3 protein structure - 315002 shown in red.