APR03580G

antibody from Leading Biology

Targeting: F11 FXI

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR03580G

Provider

Leading Biology

Product name

F11 Antibody (Center)

Antibody type

Polyclonal

Description

This gene encodes coagulation factor XI of the bloodcoagulation cascade. This protein is present in plasma as azymogen, which is a unique plasma coagulation enzyme because itexists as a homodimer consisting of two identical polypeptidechains linked by disulfide bonds. During activation of the plasmafactor XI, an internal peptide bond is cleaved by factor XIIa (orXII) in each of the two chains, resulting in activated factor XIa,a serine protease composed of two heavy and two light chains heldtogether by disulfide bonds. This activated plasma factor XItriggers the middle phase of the intrisic pathway of bloodcoagulation by activating factor IX. Defects in this factor lead toRosenthal syndrome, a blood coagulation abnormality. [provided byRefSeq].

Reactivity

Human

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.