22242-1-AP

antibody from Proteintech Group

Targeting: REST DFNA27, NRSF, XBR

Provider product page for 22242-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [2]

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Product number: 22242-1-AP - Provider product page
Provider: Proteintech Group
Product name: REST antibody
Antibody type: Polyclonal
Description: KD/KO validated REST antibody (Cat. #22242-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

REST protein structure - 22242-1-AP shown in red.

Submitted references Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks.

Zhang M, Wang X, Yang N, Zhu X, Lu Z, Cai Y, Li B, Zhu Y, Li X, Wei Y, Zhang S, Tian J, Miao X
Science China. Life sciences 2024 Jan;67(1):132-148

Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells.

Panina SB, Schweer JV, Zhang Q, Raina G, Hardtke HA, Kim S, Yang W, Siegel D, Zhang YJ
BMC biology 2024 Apr 12;22(1):83

Epigenetic regulation of GABA catabolism in iPSC-derived neurons: The molecular links between FGF21 and histone methylation.

Ho MF, Zhang C, Moon I, Biernacka J, Coombes B, Ngo Q, Skillon C, Skime M, Oesterle T, Croarkin PE, Karpyak VM, Li H, Weinshilboum RM
Molecular metabolism 2023 Nov;77:101798

Systematic analysis identifies REST as an oncogenic and immunological biomarker in glioma.

Wang G, Yang X, Qi M, Li M, Dong M, Xu R, Zhang C
Scientific reports 2023 Feb 21;13(1):3023

Overexpression of REST Causes Neuronal Injury and Decreases Cofilin Phosphorylation in Mice.

Liu X, Yan J, Liu F, Zhou P, Lv X, Cheng N, Liu L
Journal of Alzheimer's disease : JAD 2022;87(2):873-886

Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through K(v)7.4 channel upsurge in auditory neurons and hair cells.

Zhang H, Li H, Lu M, Wang S, Ma X, Wang F, Liu J, Li X, Yang H, Zhang F, Shen H, Buckley NJ, Gamper N, Yamoah EN, Lv P
eLife 2022 Sep 20;11

Obata H, Naito K, Kikui A, Nakamura S, Suzuki K, Kawakita S, Suzuki T, Goto K, Nagura N, Sugiyama Y, Nagaoka I, Ishijima M
Experimental and therapeutic medicine 2022 Nov;24(5):682

NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice.

Zhang H, Yu S, Xia L, Peng X, Wang S, Yao B
Neurochemical research 2022 Mar;47(3):713-722

Comprehensive Analysis of REST/NRSF Gene in Glioma and Its ceRNA Network Identification.

Zhang Y, Wang Q, Wang Z, Zhang C, Xu X, Xu J, Ren H, Shao X, Zhen X, Zhang L, Yu Y
Frontiers in medicine 2021;8:739624

YAP drives fate conversion and chemoresistance of small cell lung cancer.

Wu Q, Guo J, Liu Y, Zheng Q, Li X, Wu C, Fang D, Chen X, Ma L, Xu P, Xu X, Liao C, Wu M, Shen L, Song H
Science advances 2021 Oct;7(40):eabg1850

Novel REST Truncation Mutations Causing Hereditary Gingival Fibromatosis.

Chen JT, Lin CH, Huang HW, Wang YP, Kao PC, Yang TP, Wang SK
Journal of dental research 2021 Jul;100(8):868-874

Remodeling of the m(6)A landscape in the heart reveals few conserved post-transcriptional events underlying cardiomyocyte hypertrophy.

Hinger SA, Wei J, Dorn LE, Whitson BA, Janssen PML, He C, Accornero F
Journal of molecular and cellular cardiology 2021 Feb;151:46-55

ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling.

He Y, Yue H, Cheng Y, Ding Z, Xu Z, Lv C, Wang Z, Wang J, Yin C, Hao H, Chen C
Cell death & disease 2021 Dec 1;12(12):1121

The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.

Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, Zhao Y
Cell death and differentiation 2020 Mar;27(3):1119-1133

Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury.

Bray JK, Elgamal OA, Jiang J, Wright LS, Sutaria DS, Badawi M, Borcyk MG, Liu X, Fredenburg KM, Campbell-Thompson ML, Schmittgen TD
Cell death & disease 2020 Feb 20;11(2):138

Inhibition of the Epigenetic Regulator REST Ameliorates Ischemic Brain Injury.

Morris-Blanco KC, Kim T, Bertogliat MJ, Mehta SL, Chokkalla AK, Vemuganti R
Molecular neurobiology 2019 Apr;56(4):2542-2550

Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.

Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D
Frontiers in molecular neuroscience 2017;10:128

Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling.

Song Z, Yang W, Zhou X, Yang L, Zhao D
Neuropharmacology 2017 Sep 1;123:332-348

REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.

Song Z, Zhu T, Zhou X, Barrow P, Yang W, Cui Y, Yang L, Zhao D
Oncotarget 2016 Mar 15;7(11):12035-52

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 22242-1-AP( REST Antibody) at dilution of 1:1500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The REST antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human REST. This antibody recognizes human antigen. The REST antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 22242-1-AP.pdf

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