25383-1-AP

antibody from Proteintech Group

Targeting: MTF1

Provider product page for 25383-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [37]
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Validations
Western blot [1]

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Product number: 25383-1-AP - Provider product page
Provider: Proteintech Group
Product name: MTF1 antibody
Antibody type: Polyclonal
Description: KD/KO validated MTF1 antibody (Cat. #25383-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MTF1 protein structure - 25383-1-AP shown in red.

Submitted references Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.

Li H, Zhang M, Ma J, Li W, Liu X, Li Y, Ma J, Yang D, Tie Y, Bai H, Wang S
Biological trace element research 2025 Sep;203(9):4659-4670

A CRISPR-Customizable Copper-Coordinated DNA Nanoplatform Potentiates Cuproptosis Through Circadian and Metabolic Pathway Manipulation.

Zhang W, Feng ZY, Feng Z, Lian R, Liu Z, Zhang J
ACS nano 2025 Oct 21;19(41):36701-36717

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis.

Yang Z, Su W, Wei X, Pan Y, Xing M, Niu L, Feng B, Kong W, Ren X, Huang F, Zhou J, Zhao W, Qiu Y, Liao T, Chen Q, Qu S, Wang Y, Guan Q, Li D, Zen K, Chen Y, Qin C, Wang Y, Zhou X, Xiang J, Yao B
Cancer cell 2025 May 12;43(5):937-954.e9

Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin-induced cardiotoxicity.

Wei J, Lan G, Zhang W, Ran W, Wei Y, Liu X, Zhang Y, Gong Q, Li H, Gao J
British journal of pharmacology 2025 Jun;182(11):2409-2425

Effects of Zinc Combined with Metformin on Zinc Homeostasis, Blood-Epididymal Barrier, and Epididymal Absorption in Male Diabetic Mice.

Zhang M, Li H, Ma J, Yang C, Yang Y, Zhao B, Tie Y, Wang S
Biological trace element research 2025 Jan;203(1):291-304

Biological characterization and clinical significance of cuproptosis-related genes in lung adenocarcinoma.

Li M, Tan Y, Li Z, Min L
BMC pulmonary medicine 2025 Jan 11;25(1):13

Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis.

Li Y, Li Y, Liu X, Bi J, Liu J, Li W, Li H, Wang S, Ma J
Biological trace element research 2025 Aug;203(8):4198-4210

Prognostic and Immunological Role of Cuproptosis-Related Gene MTF1 in Pan-Cancer.

Zhang C, Wang S, Tang H, Lai R, Cai Q, Su Y, Wu H, Huang Y
Journal of Cancer 2024;15(17):5786-5809

Transcriptional regulation of Znt family members znt4, znt5 and znt10 and their function in zinc transport in yellow catfish (Pelteobagrus fulvidraco).

Liu LL, Song CC, Abu-Elala N, Tan XY, Zhao T, Zheng H, Yang H, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2024 Sep;1867(3):195041

LATS1 inhibitor and zinc supplement synergistically ameliorates contrast-induced acute kidney injury: Induction of Metallothionein-1 and suppression of tubular ferroptosis.

Dai B, Liu X, Du M, Xie S, Dou L, Mi X, Zhou D, Su Y, Shen T, Zhang Y, Yue S, Wang D, Tan X
Free radical biology & medicine 2024 Oct;223:42-52

Palliative Effect of Combined Application of Zinc and Selenium on Reproductive Injury Induced by Tripterygium Glycosides in Male Rats.

Liu J, Zuo X, Bi J, Li H, Li Y, Ma J, Wang S
Biological trace element research 2024 Nov;202(11):5081-5093

Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy.

Hou G, Chen Y, Lei H, Lu Y, Liu L, Han Z, Sun S, Li J, Cheng L
Science advances 2024 Nov 8;10(45):eadp7160

MUC20 regulated by extrachromosomal circular DNA attenuates proteasome inhibitor resistance of multiple myeloma by modulating cuproptosis.

Wang X, Shi Y, Shi H, Liu X, Liao A, Liu Z, Orlowski RZ, Zhang R, Wang H
Journal of experimental & clinical cancer research : CR 2024 Mar 5;43(1):68

Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.

Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY
Acta pharmacologica Sinica 2024 Feb;45(2):391-404

Reduced Zn(2+) promotes retinal ganglion cells survival and optic nerve regeneration after injury through inhibiting autophagy mediated by ROS/Nrf2.

Wu C, Han J, Wu S, Liu C, Zhang Q, Tang J, Liu Z, Yang J, Chen Y, Zhuo Y, Li Y
Free radical biology & medicine 2024 Feb 20;212:415-432

Amplification of Metalloregulatory Proteins in Macrophages by Bioactive ZnMn@SF Hydrogels for Spinal Cord Injury Repair.

Cui X, Huang C, Huang Y, Zhang Y, Wu J, Wang G, Zhou XZ, Zhang J, Wang L, Cheng L, Zhang KQ
ACS nano 2024 Dec 10;18(49):33614-33628

Screening of miR-15a-5p as a potential biomarker for intervertebral disc degeneration through RNA-sequencing.

Li Y, Kong C, Wang W, Hu F, Chen X, Xu B, Lu S
International immunopharmacology 2023 Oct;123:110717

Bioinformatics-Based Analysis of Key Genes in Steroid-Induced Osteonecrosis of the Femoral Head That Are Associated with Copper Metabolism.

Qi B, Li C, Cai X, Pu L, Guo M, Tang Z, Bu P, Xu Y
Biomedicines 2023 Mar 13;11(3)

The biological significance of cuproptosis-key gene MTF1 in pan-cancer and its inhibitory effects on ROS-mediated cell death of liver hepatocellular carcinoma.

Song L, Zeng R, Yang K, Liu W, Xu Z, Kang F
Discover oncology 2023 Jun 28;14(1):113

Regulatory effects mediated by ulvan oligosaccharide and its zinc complex on lipid metabolism in high-fat diet-fed mice.

Chi Y, Wu Z, Du C, Zhang M, Wang X, Xie A, Wang P, Li R
Carbohydrate polymers 2023 Jan 15;300:120249

lncRNA SND1-IT1 delivered via intracerebral hemorrhage-derived exosomes affect the growth of human microglia by regulating the miR-124-3p/MTF1 axis.

Wang J, Teng F, Liu S, Pan X, Yang B, Wu W
Journal of cellular physiology 2023 Feb;238(2):366-378

Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.

Lv WH, Zhao T, Pantopoulos K, Chen GH, Wei XL, Zhang DG, Luo Z
Antioxidants & redox signaling 2022 Sep;37(7-9):417-436

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333

Loss of MBD2 ameliorates LPS-induced alveolar epithelial cell apoptosis and ALI in mice via modulating intracellular zinc homeostasis.

Liu J, Yao S, Jia J, Chen Z, Yuan Y, He Y, Wasti B, Duan W, Li D, Wang G, Jia A, Sun W, Qiu S, Ma L, Li J, Liu Y, Zheng J, Xiang X, Zhang X, Liu S, He Z, Peng Z, Zhang H, Zhang D, Xiao B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Feb;36(2):e22162

Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.

Chen GH, Song CC, Zhao T, Hogstrand C, Wei XL, Lv WH, Song YF, Luo Z
Environmental science & technology 2022 Feb 15;56(4):2407-2420

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.

Lu S, Song Y, Luo R, Li S, Li G, Wang K, Liao Z, Wang B, Ke W, Xiang Q, Chen C, Wu X, Zhang Y, Ling L, Yang C
Oxidative medicine and cellular longevity 2021;2021:6670497

Dietary Nano-ZnO Is Absorbed via Endocytosis and ZIP Pathways, Upregulates Lipogenesis, and Induces Lipotoxicity in the Intestine of Yellow Catfish.

Chen SW, Lv WH, Wu K, Chen GH, Chen F, Song CC, Luo Z
International journal of molecular sciences 2021 Nov 7;22(21)

A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h.

Jing W, Zhang T, Liu J, Huang X, Yu Q, Yu H, Zhang Q, Li H, Deng M, Zhu LQ, Du H, Lu Y
Cell reports 2021 Dec 28;37(13):110177

Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.

Song CC, Chen GH, Zhong CC, Chen F, Chen SW, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2021 Aug;1864(8):194723

Zn Induces Lipophagy via the Deacetylation of Beclin1 and Alleviates Cu-Induced Lipotoxicity at Their Environmentally Relevant Concentrations.

Wei X, Hogstrand C, Chen G, Lv W, Song Y, Xu Y, Luo Z
Environmental science & technology 2021 Apr 20;55(8):4943-4953

Autophagy of the m(6)A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.

Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, He YY
Nature communications 2021 Apr 12;12(1):2183

lncRNA LINC00665 Stabilized by TAF15 Impeded the Malignant Biological Behaviors of Glioma Cells via STAU1-Mediated mRNA Degradation.

Ruan X, Zheng J, Liu X, Liu Y, Liu L, Ma J, He Q, Yang C, Wang D, Cai H, Li Z, Liu J, Xue Y
Molecular therapy. Nucleic acids 2020 Jun 5;20:823-840

Nano-Zn Increased Zn Accumulation and Triglyceride Content by Up-Regulating Lipogenesis in Freshwater Teleost, Yellow Catfish Pelteobagrus fulvidraco.

Ling SC, Zhuo MQ, Zhang DG, Cui HY, Luo Z
International journal of molecular sciences 2020 Feb 27;21(5)

Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2.

Yang S, Deng Q, Sun L, Dong K, Li Y, Wu S, Huang R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):13450-13464

Zinc reduces hepatic lipid deposition and activates lipophagy via Zn(2+)/MTF-1/PPARα and Ca(2+)/CaMKKβ/AMPK pathways.

Wei CC, Luo Z, Hogstrand C, Xu YH, Wu LX, Chen GH, Pan YX, Song YF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 18;:fj201800463

LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.

Gao M, Li C, Xu M, Liu Y, Cong M, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018 Jul;5(7):1800087

An MTF1 binding site disrupted by a homozygous variant in the promoter of ATP7B likely causes Wilson Disease.

Chen HI, Jagadeesh KA, Birgmeier J, Wenger AM, Guturu H, Schelley S, Bernstein JA, Bejerano G
European journal of human genetics : EJHG 2018 Dec;26(12):1810-1818

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MTF1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human MTF1. This antibody recognizes human, mouse antigen. The MTF1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 25383-1-AP.pdf

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