Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7878 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- HTATIP2 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human HTATIP2.
- Description
- TIP30 (30 kDa HIV-1 TAT-interacting protein), also known as HTATIP2 (HIV-1 TAT-interactive protein 2) or CC3, is a ubiquitously expressed protein that functions as an oxidoreductase. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induction of apoptosis. TIP30 interacts with the ERÏ«-interacting coactivator NCoA-5 and functions to regulate liganded and unliganded ERÏ«-mediated c-Myc transcription. More specifically, when overexpressed TIP30 represses c-Myc transcription mediated by ERÏ«, while the deficiency of TIP30 leads to an increase in c-Myc transcription. In addition, TIP30 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in TIP30 are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for TIP30 in antitumor therapy.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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