GRM8

gene product
GLUR8, GPRC1H, mGlu8, MGLUR8
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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Invitrogen Antibodies
10 antibodies
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antibodies-online
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GeneTex
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NovoPro Bioscience Inc.
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St John's Laboratory
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1 antibody
Boster Biological Technology
1 antibody
Proteintech Group
1 antibody
Abgent
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Atlas Antibodies
1 antibody
RabMAbs
1 antibody
RayBiotech, Inc.
5 antibodies
Creative Biolabs
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
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MyBioSource
6 antibodies
Creative Diagnostics
5 antibodies
Leading Biology
5 antibodies
ProSci
2 antibodies
GenWay
3 antibodies
EMD Millipore
2 antibodies
Sigma-Aldrich
2 antibodies