HPA016811

antibody from Atlas Antibodies

Targeting: LRRC8A FLJ10337, KIAA1437, LRRC8, SWELL1

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA016811

Provider

Atlas Antibodies

Product name

Anti-LRRC8A

Antibody type

Polyclonal

Antigen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence

Description

Affinity purified using the PrEST antigen as affinity ligand

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Antigen sequence

ICLPCKWVTKDSCNDSFRGWAAPGPEPTYPNSTIL
PTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHWFA
K


Isotype

IgG

Vial size

100μl

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

References

Submitted references

Activation of osmo-sensitive LRRC8 anion channels in macrophages is important for micro-crystallin joint inflammation

Chirayath T, Ollivier M, Kayatekin M, Rubera I, Pham C, Friard J, Linck N, Hirbec H, Combes C, Zarka M, Lioté F, Richette P, Rassendren F, Compan V, Duranton C, Ea H
Nature Communications 2024;15(1)

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Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels

Centeio R, Ousingsawat J, Schreiber R, Kunzelmann K
Frontiers in Cell and Developmental Biology 2020;8

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Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells

Milenkovic A, Brandl C, Milenkovic V, Jendryke T, Sirianant L, Wanitchakool P, Zimmermann S, Reiff C, Horling F, Schrewe H, Schreiber R, Kunzelmann K, Wetzel C, Weber B
Proceedings of the National Academy of Sciences 2015;112(20)

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SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

Qiu Z, Dubin A, Mathur J, Tu B, Reddy K, Miraglia L, Reinhardt J, Orth A, Patapoutian A
Cell 2014;157(2):447-458