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- Antibody Data
- Antigen structure
- References [408]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 14347-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14347-1-AP, RRID:AB_10638146
- Product name
- NOX4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NOX4 antibody (Cat. #14347-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis.
tFNA/GA@siRNOX4: A Multi-Mechanistic Nanodrug for the Amelioration of Cisplatin-Induced Acute Kidney Injury.
Pregnancy precipitates metabolic imbalance and accelerates death in an animal model of mitochondrial cardiomyopathy.
Diminazene attenuates astrocytic oxidative stress and neuronal ferroptosis via miR-10b-3p/NOX4 axis in Alzheimer's Disease Model.
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Exercise attenuates high-fat diet-induced liver injury in mice via PPARα pathway and reduction of oxidative stress and inflammation.
Shikonin alleviates high-fat diet-induced vascular aging and dysfunction by inhibiting oxidative stress and mitochondrial damage.
Teneligliptin and empagliflozin attenuate ferroptosis-mediated acute tubular injury.
Human Umbilical Cord Mesenchymal Stem Cells Protect Against Steroid-Induced Osteonecrosis of the Femoral Head Through Hippo Pathway.
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain.
Hyperoside impairs mitochondrial respiration in chronic myeloid leukemia by promoting STUB1-mediated ubiquitination and degradation of NOX4.
Inhibition of GRK2 mitigates cisplatin-induced acute and chronic nephrotoxicity by targeting the NADPH oxidase 4/oxidative stress axis.
ND-630, an acetyl-CoA carboxylase inhibitor, prevents renal fibrosis in adenine-induced CKD mice.
Macrophage migration inhibitory factor alleviates irradiation induced apoptosis of BMSCs through the LncRNA MEG3/NOX4 axis.
Nelumbinis Plumula attenuates high-fat-induced inflammation in non-alcoholic fatty liver through the NOX/NF-κB pathway.
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway.
[Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress].
Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance.
Urolithin A alleviates vascular remodeling through mitochondrial SIRT3-mediated SOD2 deacetylation and antioxidation in hypertensive rats.
Engineered exosomes mediated siNox4 delivery loaded polyzwitterionic hydrogel with electrophysiologic conductivity for synergistic treatment of spinal cord injury via suppressing neuronal ferroptosis.
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
Hydrogen decreases susceptibility to AngII-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways.
Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway.
Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice.
Intermedin(1-53) Improves Atherosclerosis by Reducing Local Endothelial Damage via AMPK Signaling Pathway in Obese apoE-Deficient Mice.
Catalpol Alleviates HFpEF via Inhibition of the S100A8-RAGE-NOX4 Inflammatory Axis in Murine Hearts.
Study of NOX4/ROS/NF-κB signaling pathway in anti-ischemia-reperfusion injury effect and mechanism of STQJD.
LncRNA C2orf27A Promotes Gastric Cancer by Sponging MiR-610 and Elevating NOX4 Expression.
Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway.
NOX4 modulates breast cancer progression through cancer cell metabolic reprogramming and CD8(+) T cell antitumor activity.
p22(phox) prevents the oxidation of SERCA2a and stabilizes it in the heart.
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
A potential role for NADPH oxidase (NOX1/2) in mutant huntingtin-induced anomalous neurite outgrowth.
Genetic and Pharmacological Inhibition of NOX4 Protects Against Rhabdomyolysis-Induced Acute Kidney Injury Through Suppression of Endoplasmic Reticulum Stress.
Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis.
NOX4 Regulates NLRP3 by Inhibiting the Ubiquitination of LRRC8A to Promote Ferroptosis in Nucleus Pulposus Cells.
Identification of key ferroptosis-related genes associated with the development of gastric cancer: Prognostic models, molecular mechanisms and potential treatment strategies.
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Curcumin modulates oxidative stress via NOX4 to ameliorate endometrial hyperplasia.
Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway.
Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence.
Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS.
Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ-ATF3-Gpx4 Signaling Pathway in Non-Small Cell Lung Cancer.
Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury.
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging.
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone.
Selective loss and transcriptional reprogramming of Nox4(+) GABAergic neurons in the trigeminal nucleus caudalis of NTG-induced chronic migraine model.
ELF3-regulated PES1 targets VEGFR2 to mediate angiogenesis and retinal inner barrier injury in diabetic retinopathy.
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
ECHS1-NOX4 interaction suppresses rotenone-induced dopaminergic neurotoxicity through inhibition of mitochondrial ROS production.
GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating ferroptosis.
Corynoxeine Supplementation Ameliorates Colistin-Induced Kidney Oxidative Stress and Inflammation in Mice.
Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid.
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease.
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4.
Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress.
Reduced glutathione enhances adipose tissue-derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway.
BRD4 Mediates Cadmium-Induced Oxidative Stress and Kidney Injury in Mice via Disruption of Redox Homeostasis.
SIRT6 attenuates calcium oxalate Nephrocalcinosis-induced renal inflammation and oxidative injury via activating NRF2 signaling.
Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways.
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome.
miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis.
Trigonelline attenuated sepsis-induced acute kidney injury by activating NAD+/SIRT1 Pathway.
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation.
Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.
Knockdown of Leucine-rich alpha-2-glycoprotein 1 alleviates renal ischemia-reperfusion injury by inhibiting NOX4-mediated apoptosis, inflammation, and oxidative stress.
Spinal AT1R contributes to neuroinflammation and neuropathic pain via NOX2-dependent redox signaling in microglia.
Unveiling a Doxorubicin-Cytochrome P450 Electron Transfer Pathway for Synergistic Multimodal Tumor Therapy.
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
Kirenol Ameliorates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation.
Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation.
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
Tumor redox heterogeneity-responsive nanoparticles for enhanced antitumor efficacy through combining chemo/chemodynamic therapy.
Targeting ER stress/ROS-driven VEGF signaling axis: AdipoRon as a multifunctional therapeutic agent for alkali burn-induced corneal neovascularization.
Cucurbitacin D Induces Apoptotic Cell Death via NOX4 and Overcomes Radioresistance in Colorectal Cancer.
Pioglitazone Modulates p65-Mediated Mitochondrial Bioenergetics: Implications for Acetaldehyde-Induced HIV Replication in Alveolar Macrophages.
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation.
Gnetupendin A attenuates ischemic stroke injury by modulating oxidative stress through AMPK/SIRT1 pathway.
Hyaluronic acid-functionalized nanoparticles enable enhanced chemo/chemodynamic therapy for the targeted treatment of colon cancer.
CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.
Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer's Disease Induced by Amyloid Beta 1-42 Peptide.
Pulsatilla Powder Ameliorates Damp-Heat Diarrhea in Piglets Through the Regulation of Intestinal Mucosal Barrier and the Pentose Phosphate Pathway Involving G6PD and NOX.
Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer's Disease by Regulating the NOX4/Nrf2 Signaling Pathway.
Microvesicles carrying EV71 virions cross BBB through endocytic pathway to induce brain injury.
Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes.
Krill Oil Ameliorates Liver Injury in Diabetic Mice by Activating Antioxidant Capacity and Inhibiting Ferroptosis.
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.
Annao Pingchong decoction attenuates oxidative stress and neuronal apoptosis following intracerebral hemorrhage via RAGE-NOX2/4 axis.
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein.
Intervention of Asprosin Attenuates Oxidative Stress and Neointima Formation in Vascular Injury.
Vitamin D(3) Attenuates Neuropathic Pain via Suppression of Mitochondria-Associated Ferroptosis by Inhibiting PKCα/NOX4 Signaling Pathway.
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice.
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Coexposure to microplastic and Bisphenol A exhacerbates damage to human kidney proximal tubular cells.
Searching for Hub Genes of Quince-Basil Co-Administration Against Atherosclerosis Using Bioinformatics Analysis and Experimental Validation.
Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress.
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
Cholecystokinin regulates atrial natriuretic peptide secretion through activation of NOX4-Sirt1-LEF1 signaling in beating rat hypoxic atria.
Involvement of spinal NADPH oxidase 4 and endoplasmic reticulum stress in morphine-tolerant rats.
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation.
cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy.
LRRC8A drives NADPH oxidase-mediated mitochondrial dysfunction and inflammation in allergic rhinitis.
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis.
High-intensity interval training and moderate-intensity continuous training alleviate vascular dysfunction in spontaneously hypertensive rats through the inhibition of pyroptosis.
Nintedanib-loaded exosomes from adipose-derived stem cells inhibit pulmonary fibrosis induced by bleomycin.
Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway.
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
C/EBPα aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells.
FGF21 Inhibits Hypoxia/Reoxygenation-induced Renal Tubular Epithelial Cell Injury by Regulating the PPARγ/NF-κB Signaling Pathway.
Collagen sponge scaffolds loaded with Trichostatin A pretreated BMSCs-derived exosomes regulate macrophage polarization to promote skin wound healing.
A novel Senescence-Based prognostic model unveils tumor interactions and drug resistance in colorectal cancer.
Type 2 diabetes aggravates periodontitis-induced pathological changes in the dental pulp.
Preventing loss of sirt1 lowers mitochondrial oxidative stress and preserves C2C12 myotube diameter in an in vitro model of cancer cachexia.
Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage.
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro.
Traditional Chinese medicine inspired dual-drugs loaded inhalable nano-therapeutics alleviated idiopathic pulmonary fibrosis by targeting early inflammation and late fibrosis.
Nicotinamide mononucleotide attenuates airway epithelial barrier dysfunction via inhibiting SIRT3 SUMOylation in asthma.
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Targeting CA9 restricts pancreatic cancer progression through pH regulation and ROS production.
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Obtusin ameliorates diabetic retinopathy by inhibiting oxidative stress and inflammation.
Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2.
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress.
Skeletal muscle-derived musclin attenuates glycolysis, oxidative stress, and pulmonary hypertension through the NPR3/AKT/mTORC1 pathway.
Anti-Inflammatory 8-Shogaol Mediates Apoptosis by Inducing Oxidative Stress and Sensitizes Radioresistance in Gastric Cancer.
Acetyl-11-keto-β-boswellia acid attenuates Ti particle-induced osteoblastic oxidative stress and osteolysis through the Foxo3 signaling pathway.
Anti-Inflammatory and Anticancer Effects of Kaurenoic Acid in Overcoming Radioresistance in Breast Cancer Radiotherapy.
A Novel PPARγ Modulator Falcarindiol Mediates ER Stress-Mediated Apoptosis by Regulating NOX4 and Overcomes Radioresistance in Breast Cancer.
Accumulation of Advanced Oxidation Protein Products Promotes Age-Related Decline of Type H Vessels in Bone.
Ablation of CCDC8 provides cardioprotection against cardiomyocyte apoptosis via TNF signaling pathway in myocardial ischemia reperfusion injury.
Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension.
Levosimendan Reverses Cardiac Malfunction and Cardiomyocyte Ferroptosis During Heart Failure with Preserved Ejection Fraction via Connexin 43 Signaling Activation.
Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes.
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Myricetin alleviates renal tubular epithelial-mesenchymal transition via NOX4/NF-κB/snail axis in diabetic nephropathy based on network pharmacology analysis.
Potential mechanism prediction of indole-3-propionic acid against diminished ovarian reserve via network pharmacology, molecular docking and experimental verification.
The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence.
Neutrophils meet their fate in endothelial adherens junctions.
Asprosin contributes to vascular remodeling in hypertensive rats via superoxide signaling.
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Cannabidiol regulates the activation of hepatic stellate cells by modulating the NOX4 and NF-κB pathways.
GKT137831 in combination with adipose-derived stem cells alleviates high glucose-induced inflammaging and improves diabetic wound healing.
Esculin targets TLR4 to protect against LPS-induced septic cardiomyopathy.
Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome.
Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis.
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia.
Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy.
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
Identifification and validation of ferroptosis signatures and immune infifiltration characteristics associated with intervertebral disc degeneration.
Involvement of NADPH oxidases in the Na/K‑ATPase/Src/ROS oxidant amplification loop in renal fibrosis.
The Chinese medicine Xin-tong-tai granule protects atherosclerosis by regulating oxidative stress through NOX/ROS/NF-κB signal pathway.
A Novel NOX Inhibitor Alleviates Parkinson's Disease Pathology in PFF-Injected Mice.
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder.
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Role and anti-inflammatory mechanisms of acupuncture and moxibustion therapy on pain relief through NOX-ROS-NLRP3 pathway in CCI rats models.
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Deciphering the anti-renal fibrosis mechanism of triptolide in diabetic nephropathy by the integrative approach of network pharmacology and experimental verification.
Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.
Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Targeting ER Stress with Saikosaponin A to Overcome Resistance under Radiation in Gastric Cancer Cells.
Hypoxia-Induced Kidney Injury in Newborn Rats.
Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms.
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Exercise reduces hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice via its effects against inflammation and oxidative stress.
2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats.
Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells.
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro.
Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation.
Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis.
S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression.
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis.
6-Shogaol Overcomes Gefitinib Resistance via ER Stress in Ovarian Cancer Cells.
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Functional Significance of Angiotensin Receptor Type 2 in the Neuroplasticity of Autonomic Ganglia in (mRen2)27 Transgenic Hypertensive Rats.
Effects of apocynin on ISO-induced delayed afterdepolarizations in rat atrial myocytes and the underlying mechanisms.
Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis.
Nootkatone Supplementation Attenuates Carbon Tetrachloride Exposure-Induced Nephrotoxicity in Mice.
Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis.
Adrenomedullin Improves Hypertension and Vascular Remodeling partly through the Receptor-Mediated AMPK Pathway in Rats with Obesity-Related Hypertension.
Nodakenin Induces ROS-Dependent Apoptotic Cell Death and ER Stress in Radioresistant Breast Cancer.
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Canagliflozin ameliorates high glucose-induced apoptosis in NRK-52E cells via inhibiting oxidative stress and activating AMPK/mTOR-mediated autophagy.
Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway.
Paeoniflorin Induces ER Stress-Mediated Apoptotic Cell Death by Generating Nox4-Derived ROS under Radiation in Gastric Cancer.
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4.
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1.
Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.
Lonicera caerulea Berry Polyphenols Extract Alleviates Exercise Fatigue in Mice by Reducing Oxidative Stress, Inflammation, Skeletal Muscle Cell Apoptosis, and by Increasing Cell Proliferation.
Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling.
Lycopene Ameliorates Hypoxic Pulmonary Hypertension via Suppression of Oxidative Stress.
Ageing Increases Cardiac Electrical Remodelling in Rats and Mice via NOX4/ROS/CaMKII-Mediated Calcium Signalling.
Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis.
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress.
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
The TBX1/miR-193a-3p/TGF-β2 Axis Mediates CHD by Promoting Ferroptosis.
Angiotensin II Induces Cardiac Edema and Hypertrophic Remodeling through Lymphatic-Dependent Mechanisms.
Soluble Epoxide Hydrolase Inhibition Protected against Diabetic Cardiomyopathy through Inducing Autophagy and Reducing Apoptosis Relying on Nrf2 Upregulation and Transcription Activation.
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Pyrrosia petiolosa Extract Ameliorates Ethylene Glycol-Induced Urolithiasis in Rats by Inhibiting Oxidative Stress and Inflammatory Response.
Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS.
Study on complications of osteoporosis based on network pharmacology.
Intimate intertwining of the pathogenesis of hypoxia and systemic sclerosis: A transcriptome integration analysis.
NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species.
Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.
A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway.
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation.
Tumor necrosis factor-α coordinates with transforming growth factor-β1 to induce epithelial-mesenchymal transition and migration via the NF-κB/NOX4 pathway in bronchial epithelial cells.
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
Suramin enhances chondrogenic properties by regulating the p67(phox)/PI3K/AKT/SOX9 signalling pathway.
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation.
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway.
Impact of Selective Renal Afferent Denervation on Oxidative Stress and Vascular Remodeling in Spontaneously Hypertensive Rats.
Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice.
MST1/2 inhibitor XMU-MP-1 alleviates the injury induced by ionizing radiation in haematopoietic and intestinal system.
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
MicroRNA 148a Suppresses Tuberculous Fibrosis by Targeting NOX4 and POLDIP2.
Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts.
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2.
Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis.
Accumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice.
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Sirtuin1 inhibitor attenuates hypertension in spontaneously hypertensive rats: role of Giα proteins and nitroxidative stress.
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Ferroptosis-related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma.
ZFP36 protects against oxygen-glucose deprivation/reoxygenation-induced mitochondrial fragmentation and neuronal apoptosis through inhibiting NOX4-DRP1 pathway.
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3.
The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells.
Bromelain Ameliorates Atherosclerosis by Activating the TFEB-Mediated Autophagy and Antioxidant Pathways.
Astragaloside IV ameliorates sepsis-induced myocardial dysfunction by regulating NOX4/JNK/BAX pathway.
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
SIRT7 Deficiency Protects against Aβ(42)-Induced Apoptosis through the Regulation of NOX4-Derived Reactive Oxygen Species Production in SH-SY5Y Cells.
Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation.
HPV(+) HNSCC-derived exosomal miR-9-5p inhibits TGF-β signaling-mediated fibroblast phenotypic transformation through NOX4.
PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells.
Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway.
17β-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression.
Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.
Knockdown of Salusin-β Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats.
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension.
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Effects of different intensities of continuous training on vascular inflammation and oxidative stress in spontaneously hypertensive rats.
The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model.
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
The protective effect of harpagoside on angiotensin II (Ang II)-induced blood-brain barrier leakage in vitro.
The Herbal Formula JI017 Induces ER Stress via Nox4 in Breast Cancer Cells.
JI017, a Complex Herbal Medication, Induces Apoptosis via the Nox4-PERK-CHOP Axis in Ovarian Cancer Cells.
Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy.
C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase.
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
LRRC8A contributes to angiotensin II-induced cardiac hypertrophy by interacting with NADPH oxidases via the C-terminal leucine-rich repeat domain.
NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium.
Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress.
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation.
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
IRE1α/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO(2) -induced liver fibrosis.
Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet.
RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling.
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves' Patients.
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats.
miR-31-5p Promotes Oxidative Stress and Vascular Smooth Muscle Cell Migration in Spontaneously Hypertensive Rats via Inhibiting FNDC5 Expression.
Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis.
Sitagliptin Mitigates Total Body Irradiation-Induced Hematopoietic Injury in Mice.
Effects of Saccharides from Arctium lappa L. Root on FeCl(3)-Induced Arterial Thrombosis via the ERK/NF-κB Signaling Pathway.
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway.
S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway.
Morroniside Inhibits H(2)O(2)-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro.
Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer.
Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs.
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
MiR155-5p Inhibits Cell Migration and Oxidative Stress in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats.
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
S-Allylmercaptocysteine attenuates Bleomycin-induced pulmonary fibrosis in mice via suppressing TGF-β1/Smad and oxidative stress pathways.
Cellular senescence and EMT crosstalk in bleomycin-induced pathogenesis of pulmonary fibrosis-an in vitro analysis.
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function.
BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension.
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Effects of Dexmedetomidine on the RhoA /ROCK/ Nox4 Signaling Pathway in Renal Fibrosis of Diabetic Rats.
Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats.
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.
Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.
Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress.
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β(1)/Smad(2)/Nrf(2)-NOX(4) signaling pathways.
Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease.
Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway.
Systemic Outcomes of (Pyr(1))-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features.
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice.
MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system.
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy.
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Calcium Release from Endoplasmic Reticulum Involves Calmodulin-Mediated NADPH Oxidase-Derived Reactive Oxygen Species Production in Endothelial Cells.
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
The Kidney Injury Induced by Short-Term PM(2.5) Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice.
Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress.
Sodium Citrate Increases Expression and Flux of Mg(2+) Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells.
BRG1 regulates NOX gene transcription in endothelial cells and contributes to cardiac ischemia-reperfusion injury.
Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity.
Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling.
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity.
Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration.
Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway.
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4.
Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury.
Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats.
Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension.
Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling.
ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress.
The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury.
Hydrogen sulfide improves the endothelial dysfunction in renovascular hypertensive rats.
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Luteolin inhibits smooth muscle cell migration and proliferation by attenuating the production of Nox4, p-Akt and VEGF in endothelial cells.
NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle.
Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS.
Li F, Li Y, Hao W, Zhang X, Shen X, Yang B, Zhang W, Fu L, Gu S
PloS one 2026;21(2):e0342649
PloS one 2026;21(2):e0342649
tFNA/GA@siRNOX4: A Multi-Mechanistic Nanodrug for the Amelioration of Cisplatin-Induced Acute Kidney Injury.
Xu J, Jiang F, Lu J, Huai L, Zhang Y, Zhu X, Wang J
Advanced healthcare materials 2026 May;15(18):e04036
Advanced healthcare materials 2026 May;15(18):e04036
Pregnancy precipitates metabolic imbalance and accelerates death in an animal model of mitochondrial cardiomyopathy.
Sayles NM, Casalena G, Zhao D, Dellinger RW, Holmes HE, Manzo O, Galkin A, Di Lorenzo A, Manfredi G
Molecular metabolism 2026 May;107:102352
Molecular metabolism 2026 May;107:102352
Diminazene attenuates astrocytic oxidative stress and neuronal ferroptosis via miR-10b-3p/NOX4 axis in Alzheimer's Disease Model.
Xu Z, Li X, Wang S, Lyu J, Zhu S, Chen S, Li Y, Zhang Y, Wang F, Duan R
Neuropharmacology 2026 May 15;289:110880
Neuropharmacology 2026 May 15;289:110880
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Ji K, Wei H, Wang R, Wu Y, Li C, Gao H, Zhao L
Aging cell 2026 Mar;25(3):e70423
Aging cell 2026 Mar;25(3):e70423
Exercise attenuates high-fat diet-induced liver injury in mice via PPARα pathway and reduction of oxidative stress and inflammation.
Yuan S, Liu J, Wu J, He J, Qiu L
Journal of physiology and biochemistry 2026 Mar 7;82(1)
Journal of physiology and biochemistry 2026 Mar 7;82(1)
Shikonin alleviates high-fat diet-induced vascular aging and dysfunction by inhibiting oxidative stress and mitochondrial damage.
Ren GQ, Liu HJ, Guo YQ, He ML, Li J, Li ZX, Jia CH, Liu T, Yang J
Molecular biology reports 2026 Mar 4;53(1)
Molecular biology reports 2026 Mar 4;53(1)
Teneligliptin and empagliflozin attenuate ferroptosis-mediated acute tubular injury.
Ema C, Iwakura T, Tsuji N, Nakayama Y, Tsuchida M, Kitamura A, Katahashi N, Ishigaki S, Isobe S, Fujikura T, Ohashi N, Kato A, Sugimoto K, Yasuda H
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Mar 31;41(4):750-765
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Mar 31;41(4):750-765
Human Umbilical Cord Mesenchymal Stem Cells Protect Against Steroid-Induced Osteonecrosis of the Femoral Head Through Hippo Pathway.
Xing H, Cai W, Chen J, Xu H, Zhang Y, Zhong C, Zhou J, Peng H
Biomedicines 2026 Mar 22;14(3)
Biomedicines 2026 Mar 22;14(3)
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis.
Hao R, Sun Y, Wang C, Wang Y, Li L, Sun H, Chen L
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
ACS applied materials & interfaces 2026 Mar 11;18(9):13384-13397
A spinal USP7-Bach1 positive feedback loop drives NOX4-mediated ferroptosis in neuropathic pain.
Jiao B, Liu S, Zhang K, Zhang W, Cao X, Zhang X, Sun J, Xu H
Redox biology 2026 Jun;93:104153
Redox biology 2026 Jun;93:104153
Hyperoside impairs mitochondrial respiration in chronic myeloid leukemia by promoting STUB1-mediated ubiquitination and degradation of NOX4.
Che H, Zhao B, Yi W, Liu P, Hu L
Toxicology and applied pharmacology 2026 Jun;511:117795
Toxicology and applied pharmacology 2026 Jun;511:117795
Inhibition of GRK2 mitigates cisplatin-induced acute and chronic nephrotoxicity by targeting the NADPH oxidase 4/oxidative stress axis.
Duan F, Ni L, Wang Q, Peng J, Wang X, Wang Y, Hu S, Kuai J, Jiang X, Wang Q, Xu B, Wei W, Wang C
British journal of pharmacology 2026 Jun;183(12):3149-3172
British journal of pharmacology 2026 Jun;183(12):3149-3172
ND-630, an acetyl-CoA carboxylase inhibitor, prevents renal fibrosis in adenine-induced CKD mice.
Liu X, Peng Y, Wu S, Xu Y, Ye X, Lu J
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2593-2605
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2593-2605
Macrophage migration inhibitory factor alleviates irradiation induced apoptosis of BMSCs through the LncRNA MEG3/NOX4 axis.
Hu K, Zhou H, Hu H, Bai Z, Mou L, Wu S, Shou Z, Liu C, Chen C
Open medicine (Warsaw, Poland) 2026 Jan;21(1):20251339
Open medicine (Warsaw, Poland) 2026 Jan;21(1):20251339
Nelumbinis Plumula attenuates high-fat-induced inflammation in non-alcoholic fatty liver through the NOX/NF-κB pathway.
Zhao X, Lin S, Wang J, Wu S, Ren C, Sun X, Lian D, Xu X, Wu J, Zhang S, Zeng J, Zhang Y, Tan C, Chen D
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120663
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120663
An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis.
Li Q, Chen L, Sun Y, Wang C, Sun Y, Lu K, Li L, Sun H, Liu M
Journal of nanobiotechnology 2026 Jan 29;24(1)
Journal of nanobiotechnology 2026 Jan 29;24(1)
Bu-Shen-Tian-Jing Formula alleviates oxidative-inflammatory stress in granulosa cells of polycystic ovary syndrome through AGEs-RAGE/NOX4/NF-κB pathway.
Zhang Q, Ren J, Ye J, Chen F, Xiang F, Shi B, Zhou Z, Zhou J, Wang F, Qu F
Chinese medicine 2026 Jan 23;21(1):50
Chinese medicine 2026 Jan 23;21(1):50
[Isovitexin alleviates myocardial oxidative stress injury in diabetic mice by enhancing myocardial SIRT3 expression and reducing oxidative stress].
Peng Y, Jiang Y, Ma D, He A, Lü D, Luo M, Luo S
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Feb 20;46(2):316-324
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Feb 20;46(2):316-324
Fusobacterium nucleatum drives endothelial cell senescence by disrupting NOX4/NRF2 balance.
Wu P, Zhou J, Wang J, Wu Y, Wang H, Zhao L
mBio 2026 Feb 11;17(2):e0344125
mBio 2026 Feb 11;17(2):e0344125
Urolithin A alleviates vascular remodeling through mitochondrial SIRT3-mediated SOD2 deacetylation and antioxidation in hypertensive rats.
Dai M, Wang YM, Dong HK, Xu XY, Wang JX, Zhu GQ, Zheng F
Redox report : communications in free radical research 2026 Dec;31(1):2622255
Redox report : communications in free radical research 2026 Dec;31(1):2622255
Engineered exosomes mediated siNox4 delivery loaded polyzwitterionic hydrogel with electrophysiologic conductivity for synergistic treatment of spinal cord injury via suppressing neuronal ferroptosis.
Wu C, Tang Y, Jiang Z, Hong C, Yang Q, Wu Z, Zhu J, Guo K, Liu J, Zheng SY, Guo L, Xu H, Ni W, Wang X, Sheng S, Xiao J, Wang C
Biomaterials 2026 Aug;331:124096
Biomaterials 2026 Aug;331:124096
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
Yu L, Zhai Z, Wang Y, Wang L, Li Q, Guo Y, Liang Y, Tang L
International immunopharmacology 2026 Apr 15;175:116448
International immunopharmacology 2026 Apr 15;175:116448
Hydrogen decreases susceptibility to AngII-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways.
Zhang B, Hou J, Liu J, He J, Gao Y, Li G, Ma T, Lv X, Dong L, Yang W
PloS one 2025;20(1):e0310852
PloS one 2025;20(1):e0310852
Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway.
Yuan X, Long L, Wang M, Chen W, Liang B, Xu L, Wang W, Li C
Drug design, development and therapy 2025;19:4641-4664
Drug design, development and therapy 2025;19:4641-4664
Ethyl Acetate Extract of Elsholtzia bodinieri Vaniot Attenuates Oxidative Stress in ALI Mice.
Yin H, Hu J, Li Y, Feng Y, Li Z, Sun R, Tian L, Li Y
Journal of inflammation research 2025;18:7323-7336
Journal of inflammation research 2025;18:7323-7336
Intermedin(1-53) Improves Atherosclerosis by Reducing Local Endothelial Damage via AMPK Signaling Pathway in Obese apoE-Deficient Mice.
Zhu HX, Ren JL, Cao WJ, Wang R, Chen LL, Gao Q, Zhou YB
Journal of inflammation research 2025;18:6583-6596
Journal of inflammation research 2025;18:6583-6596
Catalpol Alleviates HFpEF via Inhibition of the S100A8-RAGE-NOX4 Inflammatory Axis in Murine Hearts.
Cao Y, Li S, Zhang Y, He M, Shen Y
Journal of inflammation research 2025;18:17143-17161
Journal of inflammation research 2025;18:17143-17161
Study of NOX4/ROS/NF-κB signaling pathway in anti-ischemia-reperfusion injury effect and mechanism of STQJD.
Luo C, Zhang L, Wang A, Wang Y, Cai J, Ni R, Yang R, He S, Gu L, Chen P
American journal of translational research 2025;17(7):4894-4911
American journal of translational research 2025;17(7):4894-4911
LncRNA C2orf27A Promotes Gastric Cancer by Sponging MiR-610 and Elevating NOX4 Expression.
Zhuang M, Guo X, Lin D, Lin N, Wang X, Chen F
Journal of Cancer 2025;16(5):1504-1518
Journal of Cancer 2025;16(5):1504-1518
Pathological neutrophil extracellular traps hinder postoperative anal fistula wound healing and are attenuated by Zuoqing granule via suppression of the Nox4 pathway.
Fang X, Deng H, Li M, Gao X, He C, Liu H
Frontiers in immunology 2025;16:1730184
Frontiers in immunology 2025;16:1730184
NOX4 modulates breast cancer progression through cancer cell metabolic reprogramming and CD8(+) T cell antitumor activity.
Xiong Y, Weng Y, Zhu S, Qin J, Feng J, Jing X, Luo C, Gong W, Sun R, Peng M
Frontiers in immunology 2025;16:1534936
Frontiers in immunology 2025;16:1534936
p22(phox) prevents the oxidation of SERCA2a and stabilizes it in the heart.
Nakada Y, Titus AS, Mizushima W, Yang Y, Zhai P, Tian Y, Oka S, Kashihara T, Fefelova N, Pamarthi SH, Liu T, Li H, Xie LH, Takayama K, Ikeda S, Matsushita M, Huang CY, Hsu CP, Onoue K, Saito Y, Sadoshima J
Nature cardiovascular research 2025 Sep;4(9):1187-1205
Nature cardiovascular research 2025 Sep;4(9):1187-1205
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
Wang L, Lv W, Mao H, Chen Q, Ma Y, Zhang L, Ruan Y, Zhang C
Free radical biology & medicine 2025 Sep;237:251-269
Free radical biology & medicine 2025 Sep;237:251-269
A potential role for NADPH oxidase (NOX1/2) in mutant huntingtin-induced anomalous neurite outgrowth.
Villegas LD, Mathiesen AV, Rasmussen I, von Broich M, Qvist FL, Skotte N, Bardile CF, Budtz-Jørgensen E, Freude K, Schmid B, Pouladi MA, Nørremølle A, Vilhardt F
Molecular and cellular neurosciences 2025 Sep;134:104012
Molecular and cellular neurosciences 2025 Sep;134:104012
Genetic and Pharmacological Inhibition of NOX4 Protects Against Rhabdomyolysis-Induced Acute Kidney Injury Through Suppression of Endoplasmic Reticulum Stress.
Zhang Z, Li J, Chen S, Peng J, Luo X, Wang L, Liao R, Zhao Y, Zhang S, Su B
Antioxidants (Basel, Switzerland) 2025 Sep 25;14(10)
Antioxidants (Basel, Switzerland) 2025 Sep 25;14(10)
Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis.
Yu BX, Long J, Liang YP, Zhang Q, Liu Y, Zeng GH, Liu YD, Sun XY
Communications biology 2025 Sep 2;8(1):1330
Communications biology 2025 Sep 2;8(1):1330
NOX4 Regulates NLRP3 by Inhibiting the Ubiquitination of LRRC8A to Promote Ferroptosis in Nucleus Pulposus Cells.
Zhang F, Cui D, Wang Z, Li Y, Wang K, Lu H, Yu H, Jiao W, Cui X
Inflammation 2025 Oct;48(5):3111-3129
Inflammation 2025 Oct;48(5):3111-3129
Identification of key ferroptosis-related genes associated with the development of gastric cancer: Prognostic models, molecular mechanisms and potential treatment strategies.
Wang H, Chen H, Liu J, Zhang D, Wang D, Huang M, Li M, He S, Ma L
Oncology letters 2025 Oct;30(4):450
Oncology letters 2025 Oct;30(4):450
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Yu C, Cai L, Zhuang L, Wu Y, Wu Q, Liang H, Shi M, Miao J, Song H, Jin H, Pan Y
Free radical biology & medicine 2025 Oct;238:206-219
Free radical biology & medicine 2025 Oct;238:206-219
Curcumin modulates oxidative stress via NOX4 to ameliorate endometrial hyperplasia.
Li W, Zheng C, Sun X, Lv W, Zhang X
International immunopharmacology 2025 Oct 30;164:115392
International immunopharmacology 2025 Oct 30;164:115392
Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway.
Li Q, Hong H, Xu G, Xia M, Wang T, Zhou Z, Huang J, Fu Q, Cui Z
Journal of integrative neuroscience 2025 Oct 29;24(10):43900
Journal of integrative neuroscience 2025 Oct 29;24(10):43900
Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence.
Fang L, Lyu L, Zhong H, Lin J, Ren P, Wang Y, Yin Y, Zhang M, Qu Y
European journal of pharmacology 2025 Oct 15;1005:178043
European journal of pharmacology 2025 Oct 15;1005:178043
Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS.
Wu HC, Huang TW, Weng EF, Lin CY, Su TP, Wu HE, Wang SM
Redox biology 2025 Nov;87:103875
Redox biology 2025 Nov;87:103875
Jujuboside B Induces Ferroptosis and Overcomes Radioresistance Through the PPARγ-ATF3-Gpx4 Signaling Pathway in Non-Small Cell Lung Cancer.
Kim TW, Ko SG
Phytotherapy research : PTR 2025 Nov;39(11):5345-5364
Phytotherapy research : PTR 2025 Nov;39(11):5345-5364
Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury.
Zhu T, Qian Z, Liu Z, Zhang Q, Li H
Brain research bulletin 2025 Nov;232:111618
Brain research bulletin 2025 Nov;232:111618
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging.
Wu D, Tan B, Cheng Z, Li H, Li H, Yin Y, Ma F, Chen T, Dong X, Wang W, Hu Q
Nature communications 2025 Nov 3;16(1):9667
Nature communications 2025 Nov 3;16(1):9667
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Bian WH, Wang SH, Kang ZC, Xu Y, Li YN, Yang MZ, Yang JH, Liu JY, Cheng YL, Chang D, Xie X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone.
Zheng R, He Y, Wang Y, Chen Y, Yang L, Wang R, Wu S, Xie H, Xie S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157327
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157327
Selective loss and transcriptional reprogramming of Nox4(+) GABAergic neurons in the trigeminal nucleus caudalis of NTG-induced chronic migraine model.
Xu Y, Deng Y, Wu P, Tian M, Liu C, Liu X, Liu D, Guo Y, Wang P, Xu Y, Wang Y, Li Y
The journal of headache and pain 2025 Nov 18;26(1):263
The journal of headache and pain 2025 Nov 18;26(1):263
ELF3-regulated PES1 targets VEGFR2 to mediate angiogenesis and retinal inner barrier injury in diabetic retinopathy.
Liu S, Hou J, Tao Y, Xu Y, Liu J, Lin S, Tao L, Jiang Z
Journal of translational medicine 2025 Nov 18;23(1):1309
Journal of translational medicine 2025 Nov 18;23(1):1309
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
Li F, Xie M, Zeng G, Zhu J, Zhou J, Tan S, Lin Q, Liu Q
International immunopharmacology 2025 Nov 14;165:115461
International immunopharmacology 2025 Nov 14;165:115461
ECHS1-NOX4 interaction suppresses rotenone-induced dopaminergic neurotoxicity through inhibition of mitochondrial ROS production.
Zhao Z, Wang R, Ge H, Hou L, Hatano T, Hattori N, Su H, Wang Q, Zhao J
Free radical biology & medicine 2025 May;232:56-71
Free radical biology & medicine 2025 May;232:56-71
GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating ferroptosis.
Li H, Feng Z, Li B, Bai J, Lin QY, Yu X, Zhang N, Xie Y, Yang X
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 May 7;27(5)
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2025 May 7;27(5)
Corynoxeine Supplementation Ameliorates Colistin-Induced Kidney Oxidative Stress and Inflammation in Mice.
Liu Y, Zhang R, Velkov T, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2025 May 15;14(5)
Antioxidants (Basel, Switzerland) 2025 May 15;14(5)
Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid.
Ivarsson J, Pecorelli A, Guiotto A, Souza MM, Choudhary H, Brieva P, Ferrara F, Valacchi G
Experimental dermatology 2025 Mar;34(3):e70069
Experimental dermatology 2025 Mar;34(3):e70069
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease.
Wang H, Zhao X, Wang X, Gong Y, Li S, Gu Y, He B, Wang J
Biochemical pharmacology 2025 Mar;233:116795
Biochemical pharmacology 2025 Mar;233:116795
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
Wang L, Song J, Yang Z, Zhang H, Wang Y, Liu J, Wang S, Shi J, Tong X
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4.
Guo Y, Wang J, Zhang D, Tang Y, Cheng Q, Li J, Gao T, Zhang X, Lu G, Liu M, Guan X, Tang X, Gu J
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1480-1496
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1480-1496
Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress.
Gu X, Lu S, Xu S, Li Y, Fan M, Lin G, Liu Y, Zhao Y, Zhao W, Liu X, Dong X, Zhang X
Genes & diseases 2025 Mar;12(2):101292
Genes & diseases 2025 Mar;12(2):101292
Reduced glutathione enhances adipose tissue-derived mesenchymal stem cell engraftment efficiency for liver fibrosis by targeting TGFβ1/SMAD3/NOX4 pathway.
Yu S, Wang Y, Shi Y, Yu S, Zhao B, Liao N, Liu X
Bioengineering & translational medicine 2025 Mar;10(2):e10735
Bioengineering & translational medicine 2025 Mar;10(2):e10735
BRD4 Mediates Cadmium-Induced Oxidative Stress and Kidney Injury in Mice via Disruption of Redox Homeostasis.
Chen J, Guo G, Wang X, Li Z, Ji T, Li Y, Dong H, Zhang H, Gao M
Toxics 2025 Mar 29;13(4)
Toxics 2025 Mar 29;13(4)
SIRT6 attenuates calcium oxalate Nephrocalcinosis-induced renal inflammation and oxidative injury via activating NRF2 signaling.
Zhang L, Song Z, Mao X, Yang Y, Hou B, Chen Y, Hao Z
International immunopharmacology 2025 Mar 26;150:114302
International immunopharmacology 2025 Mar 26;150:114302
Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways.
Wang Y, Su X, Wang Q, Zhang L, Yu Y, Zhao Y, Liu Z
Ecotoxicology and environmental safety 2025 Mar 1;292:117946
Ecotoxicology and environmental safety 2025 Mar 1;292:117946
Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming.
Liu J, Wang Y, Qiao P, Ying Y, Lin S, Lu F, Gao C, Li M, Yang B, Zhou H
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Antioxidants (Basel, Switzerland) 2025 Jun 24;14(7)
Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome.
Quan X, Yang Y, Liu X, Kaltwasser B, Pillath-Eilers M, Walkenfort B, Voortmann S, Mohamud Yusuf A, Hagemann N, Wang C, Hasenberg M, Hermann DM, Brockmeier U
Redox biology 2025 Jul;84:103700
Redox biology 2025 Jul;84:103700
miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis.
Huang SH, Liu ZM, Chen SJ, Tu PY, Tien YC, Lu CC, Wang CC, Chen LM, Shen PC
Cartilage 2025 Jul 30;:19476035251361679
Cartilage 2025 Jul 30;:19476035251361679
Trigonelline attenuated sepsis-induced acute kidney injury by activating NAD+/SIRT1 Pathway.
Lv W, Cao D, Yang F
Physiological research 2025 Jul 23;74(3):439-447
Physiological research 2025 Jul 23;74(3):439-447
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Huang S, Chen Z, Li H, Zou Y, Wang B, Zhao W, Zheng L, Zhou Z, Peng X, Tang C
Nutrients 2025 Jul 2;17(13)
Nutrients 2025 Jul 2;17(13)
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Zhong S, Su W, Wang Y, Liu D, Li X, Ma F, Xu L, Gao J, Wang H, Sun J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Xiao S, Wei T, Xiao M, Shan M, An Z, Li N, Zhou J, Zhao S, Lu X
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation.
Lin Z, Ying C, Si X, Xue N, Liu Y, Zheng R, Chen Y, Pu J, Zhang B
Neural regeneration research 2025 Jul 1;20(7):2038-2052
Neural regeneration research 2025 Jul 1;20(7):2038-2052
Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.
Gan Y, Wang K, Chen X, Li Y, He Y, Zhou Y, Zhang B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70362
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70362
Knockdown of Leucine-rich alpha-2-glycoprotein 1 alleviates renal ischemia-reperfusion injury by inhibiting NOX4-mediated apoptosis, inflammation, and oxidative stress.
Ye J, Qiu C, Zhang L
Experimental cell research 2025 Jan 1;444(1):114341
Experimental cell research 2025 Jan 1;444(1):114341
Spinal AT1R contributes to neuroinflammation and neuropathic pain via NOX2-dependent redox signaling in microglia.
Zhang W, Jiao B, Yu S, Zhang K, Sun J, Liu B, Zhang X
Free radical biology & medicine 2025 Feb 1;227:143-156
Free radical biology & medicine 2025 Feb 1;227:143-156
Unveiling a Doxorubicin-Cytochrome P450 Electron Transfer Pathway for Synergistic Multimodal Tumor Therapy.
Yin W, Liu Z, An S, Song T, Wang Y, Jiang X
Small methods 2025 Dec;9(12):e01358
Small methods 2025 Dec;9(12):e01358
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
Yang HX, Wang BX, Dong XL, Sun J, Miao ZL, Pan LL
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
Kirenol Ameliorates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation.
Pan L, Fu M, Tang XL, Ling Y, Su Y, Ge J
Cardiovascular drugs and therapy 2025 Dec;39(6):1259-1273
Cardiovascular drugs and therapy 2025 Dec;39(6):1259-1273
Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation.
Wang YM, Dong HK, Dai M, Wang JX, Xu XY, Zhu GQ, Li XZ
Redox report : communications in free radical research 2025 Dec;30(1):2494314
Redox report : communications in free radical research 2025 Dec;30(1):2494314
AMPK regulates the anti-pulmonary fibrosis effects of tracheloside.
Li S, Qian R, Xie W, Lin M, Huang X, Deng L, Xiong D, Liu W, Tang S
Chinese journal of natural medicines 2025 Dec;23(12):100005
Chinese journal of natural medicines 2025 Dec;23(12):100005
Tumor redox heterogeneity-responsive nanoparticles for enhanced antitumor efficacy through combining chemo/chemodynamic therapy.
Cui S, Yu L, Liu H, Liu W, Shi D
International journal of pharmaceutics: X 2025 Dec;10:100455
International journal of pharmaceutics: X 2025 Dec;10:100455
Targeting ER stress/ROS-driven VEGF signaling axis: AdipoRon as a multifunctional therapeutic agent for alkali burn-induced corneal neovascularization.
Wang C, Yuan K, Wu Y, Jiang T, Mou Y, Wang N, Chen X, Yu J, Yang S, Jin X
Free radical biology & medicine 2025 Dec 16;241:117-136
Free radical biology & medicine 2025 Dec 16;241:117-136
Cucurbitacin D Induces Apoptotic Cell Death via NOX4 and Overcomes Radioresistance in Colorectal Cancer.
Kim TW
International journal of molecular sciences 2025 Dec 13;26(24)
International journal of molecular sciences 2025 Dec 13;26(24)
Pioglitazone Modulates p65-Mediated Mitochondrial Bioenergetics: Implications for Acetaldehyde-Induced HIV Replication in Alveolar Macrophages.
New-Aaron M, Chang S, Fan X, Mehta A, Auld SC, Staitieh BS, Koval M, Yeligar SM
Biomolecules 2025 Dec 13;15(12)
Biomolecules 2025 Dec 13;15(12)
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation.
Song ML, Sun YY, Yin HJ, Li Y, Yang H
Acta pharmacologica Sinica 2025 Aug;46(8):2136-2150
Acta pharmacologica Sinica 2025 Aug;46(8):2136-2150
Gnetupendin A attenuates ischemic stroke injury by modulating oxidative stress through AMPK/SIRT1 pathway.
Wang D, Mu D, Mi Y, Zhang G, Meng Q, Yang Y, Liang D, Hou Y
Biochemical pharmacology 2025 Aug 29;242(Pt 1):117294
Biochemical pharmacology 2025 Aug 29;242(Pt 1):117294
Hyaluronic acid-functionalized nanoparticles enable enhanced chemo/chemodynamic therapy for the targeted treatment of colon cancer.
Liu S, Tong S, Liu G, Wang S, Zhang K, Qiu Z
International journal of biological macromolecules 2025 Apr;303:140553
International journal of biological macromolecules 2025 Apr;303:140553
CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.
Wu Q, Zhang Q, Jin C, Liu X, Yu H
Cellular signalling 2025 Apr;128:111638
Cellular signalling 2025 Apr;128:111638
Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer's Disease Induced by Amyloid Beta 1-42 Peptide.
Ateş Ş, Ülger H, Uçar S, Okan A, Ocak M, Güvenilir E, Şükranlı ZY, Kaymak E, Doğanyiğit Z, Taheri S, Yilmaz S
Biomolecules 2025 Apr 7;15(4)
Biomolecules 2025 Apr 7;15(4)
Pulsatilla Powder Ameliorates Damp-Heat Diarrhea in Piglets Through the Regulation of Intestinal Mucosal Barrier and the Pentose Phosphate Pathway Involving G6PD and NOX.
Qu Y, Ma Q, Wang C, Zhang L, Feng H, Lai S
Veterinary sciences 2025 Apr 25;12(5)
Veterinary sciences 2025 Apr 25;12(5)
Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer's Disease by Regulating the NOX4/Nrf2 Signaling Pathway.
Wang M, Li M, Jiang Y, Wang S, Yang X, Naseem A, Algradi AM, Hao Z, Guan W, Chen Q, Zhang L, Kuang H, Yang B, Liu Y
Journal of agricultural and food chemistry 2025 Apr 2;73(13):7725-7740
Journal of agricultural and food chemistry 2025 Apr 2;73(13):7725-7740
Microvesicles carrying EV71 virions cross BBB through endocytic pathway to induce brain injury.
Tian X, Liu B, Li L, Yuan M, You Q, Zhang R, Chen D, Cheng M, Zheng N, He M, Wu Z
Cell communication and signaling : CCS 2025 Apr 14;23(1):183
Cell communication and signaling : CCS 2025 Apr 14;23(1):183
Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes.
Yang WX, Su K, Liao MC, Zhou J, Peng J, Hébert MJ, Leal DN, Yamashita M, Miyata KN, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD
Diabetes 2025 Apr 1;74(4):554-568
Diabetes 2025 Apr 1;74(4):554-568
Krill Oil Ameliorates Liver Injury in Diabetic Mice by Activating Antioxidant Capacity and Inhibiting Ferroptosis.
Meng H, Li J, Yang Y, Zheng Y, Wang S, Guo X, Du L, Wu H
Journal of oleo science 2024;73(8):1069-1082
Journal of oleo science 2024;73(8):1069-1082
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.
Xiao Y, Zhang Y, Xie K, Huang X, Liu X, Luo J, Tan S
International journal of biological sciences 2024;20(7):2658-2685
International journal of biological sciences 2024;20(7):2658-2685
Annao Pingchong decoction attenuates oxidative stress and neuronal apoptosis following intracerebral hemorrhage via RAGE-NOX2/4 axis.
Wang X, Lin X, Chen Z, Long H, Zhou X, Lei S, Liu J, Dong H, Liu F, Hu H, Guo C
Frontiers in neuroscience 2024;18:1491343
Frontiers in neuroscience 2024;18:1491343
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
Zhou S, Zheng L, Zheng T, Zhan H, Lin Q, Wei J, Huang Y
Frontiers in pharmacology 2024;15:1447249
Frontiers in pharmacology 2024;15:1447249
Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein.
Yu W, Zhuang S, Zhan M, Chen Y, Zhang J, Chen L, Tu C, Zheng L, Chen S
Journal of Alzheimer's disease : JAD 2024;100(3):799-808
Journal of Alzheimer's disease : JAD 2024;100(3):799-808
Intervention of Asprosin Attenuates Oxidative Stress and Neointima Formation in Vascular Injury.
Zheng F, Ye C, Lei JZ, Ge R, Li N, Bo JH, Chen AD, Zhang F, Zhou H, Wang JJ, Chen Q, Li YH, Zhu GQ, Han Y
Antioxidants & redox signaling 2024 Sep;41(7-9):488-504
Antioxidants & redox signaling 2024 Sep;41(7-9):488-504
Vitamin D(3) Attenuates Neuropathic Pain via Suppression of Mitochondria-Associated Ferroptosis by Inhibiting PKCα/NOX4 Signaling Pathway.
Zhang W, Yu S, Jiao B, Zhang C, Zhang K, Liu B, Zhang X
CNS neuroscience & therapeutics 2024 Sep;30(9):e70067
CNS neuroscience & therapeutics 2024 Sep;30(9):e70067
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice.
Feng Z, Liu Y, Yang Y, Bai J, Lin QY, Xia YL, Xie Y
Heliyon 2024 Sep 30;10(18):e38098
Heliyon 2024 Sep 30;10(18):e38098
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Niu Q, Li D, Guo W, Feng Z, Han Z, Yang Y
BMC endocrine disorders 2024 Sep 10;24(1):184
BMC endocrine disorders 2024 Sep 10;24(1):184
Coexposure to microplastic and Bisphenol A exhacerbates damage to human kidney proximal tubular cells.
Verzola D, Rumeo N, Alberti S, Loiacono F, La Maestra S, Passalacqua M, Artini C, Russo E, Verrina E, Angeletti A, Matarese S, Mancianti N, Cravedi P, Gentile M, Viazzi F, Esposito P, La Porta E
Heliyon 2024 Oct 30;10(20):e39426
Heliyon 2024 Oct 30;10(20):e39426
Searching for Hub Genes of Quince-Basil Co-Administration Against Atherosclerosis Using Bioinformatics Analysis and Experimental Validation.
Hailati S, Han MY, Dilimulati D, Nueraihemaiti N, Baishan A, Aikebaier A, Zhou WT
Pharmaceuticals (Basel, Switzerland) 2024 Oct 25;17(11)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 25;17(11)
Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress.
Shen Z, Wang J, Chen Y, Fang P, Yuan A, Chen AF, Yan X, Lyu Y, Pu J
Redox biology 2024 Nov;77:103397
Redox biology 2024 Nov;77:103397
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
Du J, Zhou P, Zhao X, He YT, He CS, Wang RY
Toxicology and applied pharmacology 2024 Nov;492:117127
Toxicology and applied pharmacology 2024 Nov;492:117127
Cholecystokinin regulates atrial natriuretic peptide secretion through activation of NOX4-Sirt1-LEF1 signaling in beating rat hypoxic atria.
Xu LJ, Zhi MT, Lin XX, Li X, Li ZY, Cui X
Peptides 2024 Nov;181:171299
Peptides 2024 Nov;181:171299
Involvement of spinal NADPH oxidase 4 and endoplasmic reticulum stress in morphine-tolerant rats.
Xiao X, Yang J, Bai Q, Wang Z, Chen Y, Si Y, Xu Y, Li Z, Bu H
Journal of neurochemistry 2024 Nov;168(11):3745-3759
Journal of neurochemistry 2024 Nov;168(11):3745-3759
Copper-Based Composites Nanoparticles Improve Triple-Negative Breast Cancer Treatment with Induction of Apoptosis-Cuproptosis and Immune Activation.
Wang N, Liu Y, Peng D, Zhang Q, Zhang Z, Xu L, Yin L, Zhao X, Lu Z, Peng J
Advanced healthcare materials 2024 Nov;13(28):e2401646
Advanced healthcare materials 2024 Nov;13(28):e2401646
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation.
Chang CY, Wu CC, Tzeng CY, Li JR, Chen YF, Chen WY, Kuan YH, Liao SL, Chen CJ
Journal of neuroinflammation 2024 Nov 7;21(1):291
Journal of neuroinflammation 2024 Nov 7;21(1):291
cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy.
Huang Y, Wang L, Jin H
Investigative ophthalmology & visual science 2024 Nov 4;65(13):55
Investigative ophthalmology & visual science 2024 Nov 4;65(13):55
LRRC8A drives NADPH oxidase-mediated mitochondrial dysfunction and inflammation in allergic rhinitis.
Meng L, Hao D, Liu Y, Yu P, Luo J, Li C, Jiang T, Yu J, Zhang Q, Liu S, Shi L
Journal of translational medicine 2024 Nov 16;22(1):1034
Journal of translational medicine 2024 Nov 16;22(1):1034
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis.
Xu Z, Wang Y, Yang W, Han W, Ma B, Zhao Y, Bao T, Zhang Q, Lin X
Journal of ethnopharmacology 2024 Nov 15;334:118582
Journal of ethnopharmacology 2024 Nov 15;334:118582
High-intensity interval training and moderate-intensity continuous training alleviate vascular dysfunction in spontaneously hypertensive rats through the inhibition of pyroptosis.
Li Y, Luo M, Chang Q, Cao S, Wang Y, Chen Z, Yang J, Liu G
Heliyon 2024 Nov 15;10(21):e39505
Heliyon 2024 Nov 15;10(21):e39505
Nintedanib-loaded exosomes from adipose-derived stem cells inhibit pulmonary fibrosis induced by bleomycin.
Cai L, Wang J, Yi X, Yu S, Wang C, Zhang L, Zhang X, Cheng L, Ruan W, Dong F, Su P, Shi Y
Pediatric research 2024 May;95(6):1543-1552
Pediatric research 2024 May;95(6):1543-1552
Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.
Huang W, Wu D, Cai C, Yao H, Tian Z, Yang Y, Pang M, Rong L, Liu B
Redox biology 2024 May;71:103104
Redox biology 2024 May;71:103104
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Wang Y, Gu YH, Ren KW, Xie X, Wang SH, Zhu XX, Wang L, Yang XL, Bi HL
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Lan Y, Tian F, Tang H, Pu P, He Q, Duan L
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway.
Bo C, Liu F, Zhang Z, Du Z, Xiu H, Zhang Z, Li M, Zhang C, Jia Q
BMC pulmonary medicine 2024 May 8;24(1):224
BMC pulmonary medicine 2024 May 8;24(1):224
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Li Y, Xiao Y, Shang Y, Xu C, Han C, Hu D, Han J, Wang H
Cell biology and toxicology 2024 May 25;40(1):39
Cell biology and toxicology 2024 May 25;40(1):39
C/EBPα aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells.
Xia Z, Wei Z, Li X, Liu Y, Gu X, Huang S, Zhang X, Wang W
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167039
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167039
FGF21 Inhibits Hypoxia/Reoxygenation-induced Renal Tubular Epithelial Cell Injury by Regulating the PPARγ/NF-κB Signaling Pathway.
Li R, Liu X
Cell biochemistry and biophysics 2024 Jun;82(2):909-918
Cell biochemistry and biophysics 2024 Jun;82(2):909-918
Collagen sponge scaffolds loaded with Trichostatin A pretreated BMSCs-derived exosomes regulate macrophage polarization to promote skin wound healing.
Wang T, Xue Y, Zhang W, Zheng Z, Peng X, Zhou Y
International journal of biological macromolecules 2024 Jun;269(Pt 2):131948
International journal of biological macromolecules 2024 Jun;269(Pt 2):131948
A novel Senescence-Based prognostic model unveils tumor interactions and drug resistance in colorectal cancer.
Yue Y, She X, Ding W, Chen S, Xiao Q, Pan B, Zhou L, Yin Y, Li Y, Wang S, Xu M
International immunopharmacology 2024 Jun 15;134:112197
International immunopharmacology 2024 Jun 15;134:112197
Type 2 diabetes aggravates periodontitis-induced pathological changes in the dental pulp.
Yang T, Zhou B, Shan Z, Hu L
Oral diseases 2024 Jul;30(5):3250-3260
Oral diseases 2024 Jul;30(5):3250-3260
Preventing loss of sirt1 lowers mitochondrial oxidative stress and preserves C2C12 myotube diameter in an in vitro model of cancer cachexia.
Hain BA, Kimball SR, Waning DL
Physiological reports 2024 Jul;12(13):e16103
Physiological reports 2024 Jul;12(13):e16103
Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage.
Ivarsson J, Bennett A, Ferrara F, Strauch R, Vallase A, Iorizzo M, Pecorelli A, Lila MA, Valacchi G
Food & function 2024 Jul 29;15(15):7849-7864
Food & function 2024 Jul 29;15(15):7849-7864
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Hu M, Hu L, Yang T, Zhou B, Feng X, Fan Z, Shan Z
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Biochanin A inhibits cardiac hypertrophy and fibrosis in vivo and in vitro.
Feng Z, Zhang N, Bai J, Lin QY, Xie Y, Xia YL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116002
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116002
Traditional Chinese medicine inspired dual-drugs loaded inhalable nano-therapeutics alleviated idiopathic pulmonary fibrosis by targeting early inflammation and late fibrosis.
Zheng M, Liu K, Li L, Feng C, Wu G
Journal of nanobiotechnology 2024 Jan 3;22(1):14
Journal of nanobiotechnology 2024 Jan 3;22(1):14
Nicotinamide mononucleotide attenuates airway epithelial barrier dysfunction via inhibiting SIRT3 SUMOylation in asthma.
Liang J, Zhou C, Zhang C, Liang S, Zhou Z, Zhou Z, Wu C, Zhao H, Meng X, Zou F, Yu C, Cai S
International immunopharmacology 2024 Jan 25;127:111328
International immunopharmacology 2024 Jan 25;127:111328
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Ouyang Z, Ma M, Zhang Z, Wu H, Xue Y, Jian Y, Yin K, Yu S, Zhao C, Guo W, Gu X
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis.
Li S, Lyu Q, Shi Q, Bai Y, Ren X, Ma J
Clinical science (London, England : 1979) 2024 Feb 7;138(3):103-115
Clinical science (London, England : 1979) 2024 Feb 7;138(3):103-115
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294
Free radical biology & medicine 2024 Feb 20;212:284-294
Targeting CA9 restricts pancreatic cancer progression through pH regulation and ROS production.
Yang J, Tong X, Wang W, Yu X, Xu J, Shi S
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2367-2382
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2367-2382
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Li J, Nan W, Huang X, Meng H, Wang S, Zheng Y, Li Y, Li H, Zhang Z, Du L, Yin X, Wu H
EMBO reports 2024 Dec;25(12):5507-5536
EMBO reports 2024 Dec;25(12):5507-5536
Obtusin ameliorates diabetic retinopathy by inhibiting oxidative stress and inflammation.
Xu J, Shen R, Qian M, Ning L, Zhang X, Xie B, Jiang Y, Zhou Z, Dong W
Psychopharmacology 2024 Dec;241(12):2471-2484
Psychopharmacology 2024 Dec;241(12):2471-2484
Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2.
Pan GP, Liu YH, Qi MX, Guo YQ, Shao ZL, Liu HT, Qian YW, Guo S, Yin YL, Li P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156119
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156119
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Zhao LX, Ren H, Su JY, Zhang Q, He DL, Wu TY, Zhang YH, Wang ZY, Fan YG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress.
Guo X, Wang P, Wei H, Yan J, Zhang D, Qian Y, Guo B
International immunopharmacology 2024 Dec 5;142(Pt B):113134
International immunopharmacology 2024 Dec 5;142(Pt B):113134
Skeletal muscle-derived musclin attenuates glycolysis, oxidative stress, and pulmonary hypertension through the NPR3/AKT/mTORC1 pathway.
Sun X, Wang J, Xiao Y, Li D, Wang Q, Guo W, Yang Y
Acta biochimica et biophysica Sinica 2024 Dec 4;57(6):981-994
Acta biochimica et biophysica Sinica 2024 Dec 4;57(6):981-994
Anti-Inflammatory 8-Shogaol Mediates Apoptosis by Inducing Oxidative Stress and Sensitizes Radioresistance in Gastric Cancer.
Kim TW, Lee HG
International journal of molecular sciences 2024 Dec 28;26(1)
International journal of molecular sciences 2024 Dec 28;26(1)
Acetyl-11-keto-β-boswellia acid attenuates Ti particle-induced osteoblastic oxidative stress and osteolysis through the Foxo3 signaling pathway.
Gu Y, Wu Z, Xie H, Qian Z, Li Z, Tang Y, Wang Q, Fang T, Tao H, Chen K, Zhu P, Ding Y, Xu Y, Peng Y, Ye H, Guo X, Tao Y, Gu Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113547
International immunopharmacology 2024 Dec 25;143(Pt 3):113547
Anti-Inflammatory and Anticancer Effects of Kaurenoic Acid in Overcoming Radioresistance in Breast Cancer Radiotherapy.
Kim TW, Ko SG
Nutrients 2024 Dec 14;16(24)
Nutrients 2024 Dec 14;16(24)
A Novel PPARγ Modulator Falcarindiol Mediates ER Stress-Mediated Apoptosis by Regulating NOX4 and Overcomes Radioresistance in Breast Cancer.
Kim TW, Ko SG
Antioxidants (Basel, Switzerland) 2024 Dec 14;13(12)
Antioxidants (Basel, Switzerland) 2024 Dec 14;13(12)
Accumulation of Advanced Oxidation Protein Products Promotes Age-Related Decline of Type H Vessels in Bone.
Zhao K, Zhu GZ, Li HZ, Gao JW, Tu C, Wu DZ, Huang YS, Han D, Chen XY, Wu LY, Zhong ZM
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Dec 11;80(1)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Dec 11;80(1)
Ablation of CCDC8 provides cardioprotection against cardiomyocyte apoptosis via TNF signaling pathway in myocardial ischemia reperfusion injury.
Huang J, Li Z, Huang W, He J, Zheng J, Jiang S, Lin J, Xu M
Life sciences 2024 Dec 1;358:123151
Life sciences 2024 Dec 1;358:123151
Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension.
Liu SY, Wang Q, Zhou H, Tong N, Chang R, Wang FZ, Guo P, Li X, Zhou YB, Li ZZ
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Aug;47(8):2157-2171
Hypertension research : official journal of the Japanese Society of Hypertension 2024 Aug;47(8):2157-2171
Levosimendan Reverses Cardiac Malfunction and Cardiomyocyte Ferroptosis During Heart Failure with Preserved Ejection Fraction via Connexin 43 Signaling Activation.
Zhang LL, Chen GH, Tang RJ, Xiong YY, Pan Q, Jiang WY, Gong ZT, Chen C, Li XS, Yang YJ
Cardiovascular drugs and therapy 2024 Aug;38(4):705-718
Cardiovascular drugs and therapy 2024 Aug;38(4):705-718
Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiomyocytes.
Mohammed Abdul KS, Han K, Guerrero AB, Wilson CN, Kulkarni A, Purcell NH
Journal of molecular and cellular cardiology 2024 Aug;193:100-112
Journal of molecular and cellular cardiology 2024 Aug;193:100-112
CD9 Counteracts Liver Steatosis and Mediates GCGR Agonist Hepatic Effects.
Zheng Y, Wang Y, Xiong X, Zhang L, Zhu J, Huang B, Liu X, Liu J, Zhu Z, Yang G, Qu H, Zheng H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2400819
Myricetin alleviates renal tubular epithelial-mesenchymal transition via NOX4/NF-κB/snail axis in diabetic nephropathy based on network pharmacology analysis.
Yuan N, Chen Y, Yan Y, Wang F, Xu X, Wang M, Diao J, Xiao W
Heliyon 2024 Aug 30;10(16):e35234
Heliyon 2024 Aug 30;10(16):e35234
Potential mechanism prediction of indole-3-propionic acid against diminished ovarian reserve via network pharmacology, molecular docking and experimental verification.
Liu A, Liu Z, Shen H, Du W, Jiang Y, Wang L, Zhang R, Jin P, Zhang X
BMC complementary medicine and therapies 2024 Aug 27;24(1):316
BMC complementary medicine and therapies 2024 Aug 27;24(1):316
The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence.
Qian YW, Guo YQ, Li YL, Wang Y, Guo S, Niu QQ, Zhu ML, Li P
Life sciences 2024 Aug 15;351:122862
Life sciences 2024 Aug 15;351:122862
Neutrophils meet their fate in endothelial adherens junctions.
Mukhopadhyay A, Natarajan V, Komarova Y, Malik AB
Immunity 2024 Aug 13;57(8):1719-1720
Immunity 2024 Aug 13;57(8):1719-1720
Asprosin contributes to vascular remodeling in hypertensive rats via superoxide signaling.
Xu ZQ, Li XZ, Zhu R, Ge R, Wei H, Shi HW, Wang Z, Yang C, Yang YW, Lu XJ, Chen AD, Zhu GQ, Tan X
Journal of hypertension 2024 Aug 1;42(8):1427-1439
Journal of hypertension 2024 Aug 1;42(8):1427-1439
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Li Q, Kang J, Liu N, Huang J, Zhang X, Pang K, Zhang S, Wang M, Zhao Y, Dong S, Li H, Zhao D, Lu F, Zhang W
Free radical biology & medicine 2024 Apr;216:118-138
Free radical biology & medicine 2024 Apr;216:118-138
Cannabidiol regulates the activation of hepatic stellate cells by modulating the NOX4 and NF-κB pathways.
Xie N, Ma R, Wang L, Shu Y, He P, Zhou Y, Xiang Y, Wang Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114517
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114517
GKT137831 in combination with adipose-derived stem cells alleviates high glucose-induced inflammaging and improves diabetic wound healing.
Dong Y, Zhang Y, Li F, Tang B, Lv D, Wang H, Luo S
Journal of leukocyte biology 2024 Apr 29;115(5):882-892
Journal of leukocyte biology 2024 Apr 29;115(5):882-892
Esculin targets TLR4 to protect against LPS-induced septic cardiomyopathy.
Su Z, Gao M, Weng L, Xu T
International immunopharmacology 2024 Apr 20;131:111897
International immunopharmacology 2024 Apr 20;131:111897
Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome.
Zhang GL, Liu Y, Liu YF, Huang XT, Tao Y, Chen ZH, Lai HL
World journal of diabetes 2024 Apr 15;15(4):724-734
World journal of diabetes 2024 Apr 15;15(4):724-734
Dapagliflozin ameliorates myocardial infarction injury through AMPKα-dependent regulation of oxidative stress and apoptosis.
Peng Y, Guo M, Luo M, Lv D, Liao K, Luo S, Zhang B
Heliyon 2024 Apr 15;10(7):e29160
Heliyon 2024 Apr 15;10(7):e29160
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
Wang N, Zhang Q, Wang Z, Liu Y, Yang S, Zhao X, Peng J
Carbohydrate polymers 2024 Apr 1;329:121795
Carbohydrate polymers 2024 Apr 1;329:121795
Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia.
Gaston B, Smith LA, Davis MD, Saunders J, Daniels I, Horani A, Brody SL, Giddings O, Zhao Y, Marozkina N
American journal of physiology. Lung cellular and molecular physiology 2024 Apr 1;326(4):L468-L476
American journal of physiology. Lung cellular and molecular physiology 2024 Apr 1;326(4):L468-L476
Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy.
Tao Y, Chen W, Xu H, Xu J, Yang H, Luo X, Chen M, He J, Bai Y, Qi H
International journal of nanomedicine 2023;18:4705-4726
International journal of nanomedicine 2023;18:4705-4726
Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress.
An JR, Liu JT, Gao XM, Wang QF, Sun GY, Su JN, Zhang C, Yu JX, Yang YF, Shi Y
Frontiers in cellular neuroscience 2023;17:1136070
Frontiers in cellular neuroscience 2023;17:1136070
Identifification and validation of ferroptosis signatures and immune infifiltration characteristics associated with intervertebral disc degeneration.
Zhang F, Cui D, Wang K, Cheng H, Zhai Y, Jiao W, Wang Z, Cui X, Yu H
Frontiers in genetics 2023;14:1133615
Frontiers in genetics 2023;14:1133615
Involvement of NADPH oxidases in the Na/K‑ATPase/Src/ROS oxidant amplification loop in renal fibrosis.
Zhang H, Lai F, Cheng X, Wang Y
Molecular medicine reports 2023 Sep;28(3)
Molecular medicine reports 2023 Sep;28(3)
The Chinese medicine Xin-tong-tai granule protects atherosclerosis by regulating oxidative stress through NOX/ROS/NF-κB signal pathway.
Wei JM, Yuan H, Liu CX, Wang ZY, Shi M, Guo ZH, Li Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115200
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115200
A Novel NOX Inhibitor Alleviates Parkinson's Disease Pathology in PFF-Injected Mice.
Ofori K, Ghosh A, Verma DK, Wheeler D, Cabrera G, Seo JB, Kim YH
International journal of molecular sciences 2023 Sep 19;24(18)
International journal of molecular sciences 2023 Sep 19;24(18)
Aquaporin-7 Facilitates Proliferation and Adipogenic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Regulating Hydrogen Peroxide Transport.
Ma Y, Zhang J, Li Y, Hu H, Ye Q, Yang C, Yang L, Zhang B, Ma T
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Stem cell reviews and reports 2023 Oct;19(7):2378-2390
Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder.
Xiong F, Jiang K, Wu Y, Lou C, Ding C, Zhang W, Zhang X, Li C, Zheng H, Gao H
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166725
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166725
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.
Xie W, Deng L, Lin M, Huang X, Qian R, Xiong D, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)
The novel peptide athycaltide-1 attenuates Ang II-induced pathological myocardial hypertrophy by reducing ROS and inhibiting the activation of CaMKII and ERK1/2.
Zheng X, Su F, Lei M, Li J, Zhang C, Zhang Y, Wei M, Li W, Chen S, Liu Y, Gao Q, Hao L
European journal of pharmacology 2023 Oct 15;957:175969
European journal of pharmacology 2023 Oct 15;957:175969
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Zhao Y, Shen QR, Chen YX, Shi Y, Wu WB, Li Q, Li DJ, Shen FM, Fu H
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
Role and anti-inflammatory mechanisms of acupuncture and moxibustion therapy on pain relief through NOX-ROS-NLRP3 pathway in CCI rats models.
Jinying W, Keming L, Hanqing T, Xuqing Z, Muccee F, Xuan L, Yalin L, Meiye S, Shumin Z, Selvaraj C, Safi SZ
Molecular biology reports 2023 Nov;50(11):9367-9378
Molecular biology reports 2023 Nov;50(11):9367-9378
Compound 5 alleviated acute kidney injury without affecting the antitumor effect after cisplatin treatment.
Guo Y, Li X, Yuan R, Ren J, Huang Y, Tian H
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
Biochemical and biophysical research communications 2023 Nov 5;680:177-183
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P, Zhang Q, Ma W, Hu R, Gu Y, Bian Z, Yang D, Chen X, Wu H
European journal of pharmacology 2023 Nov 15;959:176085
European journal of pharmacology 2023 Nov 15;959:176085
Deciphering the anti-renal fibrosis mechanism of triptolide in diabetic nephropathy by the integrative approach of network pharmacology and experimental verification.
Fan D, Ying Z, Yang Y, Qian Q, Li Y, Wang P, An X, Yan M
Journal of ethnopharmacology 2023 Nov 15;316:116774
Journal of ethnopharmacology 2023 Nov 15;316:116774
Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.
Jeon J, Lee H, Jeon MS, Kim SJ, Choi C, Kim KW, Yang DJ, Lee S, Bae YS, Choi WI, Jung J, Eyun SI, Yang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2205161
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2205161
Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.
Zhong X, Li Z, Xu Q, Peng H, Su Y, Le K, Shu Z, Liao Y, Ma Z, Pan X, Xu S, Zhou S
Journal of hypertension 2023 May 1;41(5):775-793
Journal of hypertension 2023 May 1;41(5):775-793
Targeting ER Stress with Saikosaponin A to Overcome Resistance under Radiation in Gastric Cancer Cells.
Kim TW
International journal of molecular sciences 2023 Mar 16;24(6)
International journal of molecular sciences 2023 Mar 16;24(6)
Hypoxia-Induced Kidney Injury in Newborn Rats.
Chu YT, Chen BH, Chen HH, Lee JC, Kuo TJ, Chiu HC, Lu WH
Toxics 2023 Mar 11;11(3)
Toxics 2023 Mar 11;11(3)
Synergistic effects of combined treatment of 1,2-dichloroethane and high-dose ethanol on liver damage in mice and the related mechanisms.
Yang J, Zhang L, Wang T, Zhang J, Li M, Jin X, Tan X, Wang G, Zhao F, Jin Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113812
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113812
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Yu J, Zhao X, Yan X, Li W, Liu Y, Wang J, Wang J, Yang Y, Hao Y, Liang Z, Tao Y, Yuan Y, Du Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Exercise reduces hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice via its effects against inflammation and oxidative stress.
Pei Z, Ji J, Gao Y, Wang H, Wu Y, Yang J, Yang Q, Zhang L
Scientific reports 2023 Jun 5;13(1):9134
Scientific reports 2023 Jun 5;13(1):9134
2-phenylacetamide Separated from the seed of Lepidium apetalum Willd. inhibited renal fibrosis via MAPK pathway mediated RAAS and oxidative stress in SHR Rats.
Yuan PP, Li M, Zhang Q, Zeng MN, Ke YY, Wei YX, Fu Y, Zheng XK, Feng WS
BMC complementary medicine and therapies 2023 Jun 23;23(1):207
BMC complementary medicine and therapies 2023 Jun 23;23(1):207
Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells.
Zhang J, He L, Huang R, Alvarez JF, Yang DH, Sun Q, Wang F, Peng Z, Jiang N, Su L
Molecular biology reports 2023 Jul;50(7):6039-6047
Molecular biology reports 2023 Jul;50(7):6039-6047
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro.
Huang Q, Zhang Y, Jiang Y, Huang L, Liu Q, Ouyang D
Chinese journal of natural medicines 2023 Jul;21(7):516-526
Chinese journal of natural medicines 2023 Jul;21(7):516-526
Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
Mun SH, Lee CS, Kim HJ, Kim J, Lee H, Yang J, Im SH, Kim JH, Seong JK, Hwang CS
Cell reports 2023 Jul 25;42(7):112746
Cell reports 2023 Jul 25;42(7):112746
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
Pei Z, Zhou R, Yao W, Dong S, Liu Y, Gao Z
iScience 2023 Jul 21;26(7):107080
iScience 2023 Jul 21;26(7):107080
iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation.
Guo Y, Wen J, He A, Qu C, Peng Y, Luo S, Wang X
Journal of advanced research 2023 Jan;43:175-186
Journal of advanced research 2023 Jan;43:175-186
Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis.
Li RJ, Wu CY, Ke HL, Wang XP, Zhang YW
Iranian journal of basic medical sciences 2023 Jan;26(1):107-113
Iranian journal of basic medical sciences 2023 Jan;26(1):107-113
S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression.
Zhang Q, Ye W, Liu Y, Niu D, Zhao X, Li G, Qu Y, Zhao Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114018
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114018
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
Li H, Ren J, Cui H, Wang D, Zhao R, Liu X, Tian S, Wang J, Zhang J, Li P, Thorne RF, Duan S
Cell transplantation 2023 Jan-Dec;32:9636897231177356
Cell transplantation 2023 Jan-Dec;32:9636897231177356
Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis.
Li H, Cui H, Ren J, Wang D, Zhao R, Zhu S, Liu S, Liu X, Tian S, Zhang Y, Zhao P, Li P, Thorne RF, Duan S
Cell transplantation 2023 Jan-Dec;32:9636897231162526
Cell transplantation 2023 Jan-Dec;32:9636897231162526
6-Shogaol Overcomes Gefitinib Resistance via ER Stress in Ovarian Cancer Cells.
Kim TW, Lee HG
International journal of molecular sciences 2023 Jan 30;24(3)
International journal of molecular sciences 2023 Jan 30;24(3)
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Wu Y, Wu Y, Yu J, Zhang Y, Li Y, Fu R, Sun Y, Zhao K, Xiao Q
European journal of pharmacology 2023 Jan 15;939:175476
European journal of pharmacology 2023 Jan 15;939:175476
Functional Significance of Angiotensin Receptor Type 2 in the Neuroplasticity of Autonomic Ganglia in (mRen2)27 Transgenic Hypertensive Rats.
Swami Vetha BS, Byrum R, Peele K, Diz D, Aileru A
Journal of cardiovascular pharmacology 2023 Jan 1;81(1):76-84
Journal of cardiovascular pharmacology 2023 Jan 1;81(1):76-84
Effects of apocynin on ISO-induced delayed afterdepolarizations in rat atrial myocytes and the underlying mechanisms.
Zhang N, Dan Q, Dong Y, Liu Y, Zhuang W, Xie Z, Zhao Q, Lin K, Li Y
Biochemical and biophysical research communications 2023 Jan 1;638:36-42
Biochemical and biophysical research communications 2023 Jan 1;638:36-42
Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis.
Hu Y, Xu Y, Mintz RL, Luo X, Fang Y, Lao YH, Chan HF, Li K, Lv S, Chen G, Tao Y, Luo Y, Li M
Biomaterials 2023 Feb;293:121942
Biomaterials 2023 Feb;293:121942
Nootkatone Supplementation Attenuates Carbon Tetrachloride Exposure-Induced Nephrotoxicity in Mice.
Dai C, Liu M, Zhang Q, Das Gupta S, Tang S, Shen J
Antioxidants (Basel, Switzerland) 2023 Feb 3;12(2)
Antioxidants (Basel, Switzerland) 2023 Feb 3;12(2)
Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis.
Liu R, Duan T, Yu L, Tang Y, Liu S, Wang C, Fang WJ
Cardiovascular diabetology 2023 Feb 2;22(1):25
Cardiovascular diabetology 2023 Feb 2;22(1):25
Adrenomedullin Improves Hypertension and Vascular Remodeling partly through the Receptor-Mediated AMPK Pathway in Rats with Obesity-Related Hypertension.
Wang HY, Wang FZ, Chang R, Wang Q, Liu SY, Cheng ZX, Gao Q, Zhou H, Zhou YB
International journal of molecular sciences 2023 Feb 15;24(4)
International journal of molecular sciences 2023 Feb 15;24(4)
Nodakenin Induces ROS-Dependent Apoptotic Cell Death and ER Stress in Radioresistant Breast Cancer.
Kim TW
Antioxidants (Basel, Switzerland) 2023 Feb 15;12(2)
Antioxidants (Basel, Switzerland) 2023 Feb 15;12(2)
Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Zhang Y, Li JJ, Xu R, Wang XP, Zhao XY, Fang Y, Chen YP, Ma S, Di XH, Wu W, She G, Pang ZD, Wang YD, Zhang X, Xie W, Deng XL, Du XJ, Zhang Y
Redox biology 2023 Dec;68:102944
Redox biology 2023 Dec;68:102944
Canagliflozin ameliorates high glucose-induced apoptosis in NRK-52E cells via inhibiting oxidative stress and activating AMPK/mTOR-mediated autophagy.
Liu H, Chen W, Wan S, Chen Y, Fu M, Wang Z, Xiong F, Zhang Y
Molecular biology reports 2023 Dec;50(12):10325-10337
Molecular biology reports 2023 Dec;50(12):10325-10337
Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway.
Hong JR, Zhang CY, Zhong WJ, Yang HH, Xiong JB, Deng P, Yang NS, Chen H, Jin L, Guan CX, Duan JX, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115937
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115937
Paeoniflorin Induces ER Stress-Mediated Apoptotic Cell Death by Generating Nox4-Derived ROS under Radiation in Gastric Cancer.
Kim TW
Nutrients 2023 Dec 13;15(24)
Nutrients 2023 Dec 13;15(24)
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, Duan H, Shi Y
Cellular signalling 2023 Aug;108:110712
Cellular signalling 2023 Aug;108:110712
Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4.
Zhou D, Liu W, Zhang J, Dong Y, Wu J, Zhang Y, Dai C, Zhang T, Yang G, Zhang Y, Li A
Cell death discovery 2023 Aug 1;9(1):279
Cell death discovery 2023 Aug 1;9(1):279
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Zhong Y, Wang L, Jin R, Liu J, Luo R, Zhang Y, Zhu L, Peng X
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1.
Tao W, Ouyang Z, Liao Z, Li L, Zhang Y, Gao J, Ma L, Yu S
Cancers 2023 Apr 20;15(8)
Cancers 2023 Apr 20;15(8)
Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.
Luo M, Cao S, Lv D, He L, He Z, Li L, Li Y, Luo S, Chang Q
Frontiers in cardiovascular medicine 2022;9:922705
Frontiers in cardiovascular medicine 2022;9:922705
Lonicera caerulea Berry Polyphenols Extract Alleviates Exercise Fatigue in Mice by Reducing Oxidative Stress, Inflammation, Skeletal Muscle Cell Apoptosis, and by Increasing Cell Proliferation.
Liu S, Meng F, Zhang D, Shi D, Zhou J, Guo S, Chang X
Frontiers in nutrition 2022;9:853225
Frontiers in nutrition 2022;9:853225
Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling.
Wang R, Pan J, Han J, Gong M, Liu L, Zhang Y, Liu Y, Wang D, Tang Q, Wu N, Wang L, Yan J, Li H, Yuan Y
Frontiers in cardiovascular medicine 2022;9:790921
Frontiers in cardiovascular medicine 2022;9:790921
Lycopene Ameliorates Hypoxic Pulmonary Hypertension via Suppression of Oxidative Stress.
Wang D, Ji Y, Wang R, Cheng K, Liu L, Wu N, Tang Q, Zheng X, Li J, Zhu Z, Wang Q, Zhang X, Li R, Pan J, Sui Z, Yuan Y
Oxidative medicine and cellular longevity 2022;2022:9179427
Oxidative medicine and cellular longevity 2022;2022:9179427
Ageing Increases Cardiac Electrical Remodelling in Rats and Mice via NOX4/ROS/CaMKII-Mediated Calcium Signalling.
Luo X, Yu W, Liu Z, Pu Z, Liu T, Li Y, Liu W, Lei M, Tan X, Chen T
Oxidative medicine and cellular longevity 2022;2022:8538296
Oxidative medicine and cellular longevity 2022;2022:8538296
Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis.
Luo M, Hu Y, Lv D, Xie L, Yang S, Zuo D, Xue Y, He A
Oxidative medicine and cellular longevity 2022;2022:7812407
Oxidative medicine and cellular longevity 2022;2022:7812407
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Li W, Zhang H, Zhang L, Zhang T, Ding H
BioMed research international 2022;2022:7709926
BioMed research international 2022;2022:7709926
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress.
Mu L, Chen N, Chen Y, Yang Z, Zhou H, Song S, Shi Y
International journal of endocrinology 2022;2022:6073911
International journal of endocrinology 2022;2022:6073911
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
Shi H, Yan Y, Yang H, Pu P, Tang H
BioMed research international 2022;2022:5623555
BioMed research international 2022;2022:5623555
The TBX1/miR-193a-3p/TGF-β2 Axis Mediates CHD by Promoting Ferroptosis.
Zhong L, Yang H, Zhu B, Zhao X, Xie M, Cao M, Liu C, Zhao D, Lyu Y, Shang W, Wang B, Wu Y, Sun X, Qiu G, Fu W, Jiang H
Oxidative medicine and cellular longevity 2022;2022:5130546
Oxidative medicine and cellular longevity 2022;2022:5130546
Angiotensin II Induces Cardiac Edema and Hypertrophic Remodeling through Lymphatic-Dependent Mechanisms.
Bai J, Yin L, Yu WJ, Zhang YL, Lin QY, Li HH
Oxidative medicine and cellular longevity 2022;2022:5044046
Oxidative medicine and cellular longevity 2022;2022:5044046
Soluble Epoxide Hydrolase Inhibition Protected against Diabetic Cardiomyopathy through Inducing Autophagy and Reducing Apoptosis Relying on Nrf2 Upregulation and Transcription Activation.
Fang Q, Liu X, Ding J, Zhang Z, Chen G, Du T, Wang Y, Xu R
Oxidative medicine and cellular longevity 2022;2022:3773415
Oxidative medicine and cellular longevity 2022;2022:3773415
Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Liao X, Lv X, Zhang Y, Han Y, Li J, Zeng J, Tang D, Meng J, Yuan X, Peng Z, Tao L, Xie Y
Oxidative medicine and cellular longevity 2022;2022:2453617
Oxidative medicine and cellular longevity 2022;2022:2453617
Pyrrosia petiolosa Extract Ameliorates Ethylene Glycol-Induced Urolithiasis in Rats by Inhibiting Oxidative Stress and Inflammatory Response.
Zhou F, Wang X
Disease markers 2022;2022:1913067
Disease markers 2022;2022:1913067
Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS.
Yuan Y, Wang W, Zhang Y, Hong Q, Huang W, Li L, Xie Z, Chen Y, Li X, Meng Y
Journal of inflammation research 2022;15:2121-2139
Journal of inflammation research 2022;15:2121-2139
Study on complications of osteoporosis based on network pharmacology.
Song Z, Zhang H, Jiang Y, Zhao R, Pei X, Ning H, Chen H, Pan J, Gong Y, Song M, Wang W
Frontiers in genetics 2022;13:941098
Frontiers in genetics 2022;13:941098
Intimate intertwining of the pathogenesis of hypoxia and systemic sclerosis: A transcriptome integration analysis.
He X, Shi Y, Zeng Z, Tang B, Xiao X, Yu J, Zou P, Liu J, Xiao Y, Luo Y, Xiao R
Frontiers in immunology 2022;13:929289
Frontiers in immunology 2022;13:929289
NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species.
Harijith A, Basa P, Ha A, Thomas J, Jafri A, Fu P, MacFarlane PM, Raffay TM, Natarajan V, Sudhadevi T
Frontiers in pharmacology 2022;13:880878
Frontiers in pharmacology 2022;13:880878
Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.
Luo W, Tao Y, Chen S, Luo H, Li X, Qu S, Chen K, Zeng C
Frontiers in pharmacology 2022;13:860944
Frontiers in pharmacology 2022;13:860944
A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway.
Han D, Wang F, Wang B, Qiao Z, Cui X, Zhang Y, Jiang Q, Liu M, Shangguan J, Zheng X, Bai Y, Du C, Shen D
Frontiers in pharmacology 2022;13:830763
Frontiers in pharmacology 2022;13:830763
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Gu YH, Ren KW, Wang Y, Wang SH, Yu XH, Xu LW, Li HH, Bi HL
Frontiers in pharmacology 2022;13:1021361
Frontiers in pharmacology 2022;13:1021361
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Guo W, Long X, Lv M, Deng S, Liu D, Yang Q
The Journal of international medical research 2022 Sep;50(9):3000605221118680
The Journal of international medical research 2022 Sep;50(9):3000605221118680
Boosting cisplatin chemotherapy by nanomotor-enhanced tumor penetration and DNA adducts formation.
Xu L, Zhang K, Ma X, Li Y, Jin Y, Liang C, Wang Y, Duan W, Zhang H, Zhang Z, Shi J, Liu J, Wang Y, Li W
Journal of nanobiotechnology 2022 Sep 29;20(1):429
Journal of nanobiotechnology 2022 Sep 29;20(1):429
Tumor necrosis factor-α coordinates with transforming growth factor-β1 to induce epithelial-mesenchymal transition and migration via the NF-κB/NOX4 pathway in bronchial epithelial cells.
Li K, Zhou R, Ma M, Jin C, Jiao L, Zhang S, Tian M, Zhou F
Molecular biology reports 2022 Oct;49(10):9325-9333
Molecular biology reports 2022 Oct;49(10):9325-9333
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
Bian Y, Shi C, Song S, Mu L, Wu M, Qiu D, Dong J, Zhang W, Yuan C, Wang D, Zhou Z, Dong X, Shi Y
Cell and tissue research 2022 Oct;390(1):93-112
Cell and tissue research 2022 Oct;390(1):93-112
Suramin enhances chondrogenic properties by regulating the p67(phox)/PI3K/AKT/SOX9 signalling pathway.
Liu ZM, Shen PC, Lu CC, Chou SH, Tien YC
Bone & joint research 2022 Oct;11(10):723-738
Bone & joint research 2022 Oct;11(10):723-738
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
Yang T, Zhao Q, Hu M, Pan S, Zhang L, Zhu R, Zhou B, Feng X, Gao Z, Zhu Z, Zhang Y, Hu L, Liu F, Shan Z
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
Liang P, Wang L, Yang S, Pan X, Li J, Zhang Y, Liang Y, Li J, Zhou B
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation.
Hu J, Deng Y, Ding T, Dong J, Liang Y, Lou B
Acta biochimica et biophysica Sinica 2022 Nov 25;55(1):117-130
Acta biochimica et biophysica Sinica 2022 Nov 25;55(1):117-130
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Li XT, Song JW, Zhang ZZ, Zhang MW, Liang LR, Miao R, Liu Y, Chen YH, Liu XY, Zhong JC
Free radical biology & medicine 2022 Nov 20;193(Pt 1):459-473
Free radical biology & medicine 2022 Nov 20;193(Pt 1):459-473
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension.
Wang R, Guo Y, Li L, Luo M, Peng L, Lv D, Cheng Z, Xue Q, Wang L, Huang J
Genes & diseases 2022 May;9(3):753-765
Genes & diseases 2022 May;9(3):753-765
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Zhang L, Zhang H, Ma J, Wang Y, Pei Z, Ding H
International journal of molecular medicine 2022 May;49(5)
International journal of molecular medicine 2022 May;49(5)
Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway.
Dai C, Li M, Sun T, Zhang Y, Wang Y, Shen Z, Velkov T, Tang S, Shen J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 May;163:112966
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 May;163:112966
Impact of Selective Renal Afferent Denervation on Oxidative Stress and Vascular Remodeling in Spontaneously Hypertensive Rats.
Wu LL, Zhang Y, Li XZ, Du XL, Gao Y, Wang JX, Wang XL, Chen Q, Li YH, Zhu GQ, Tan X
Antioxidants (Basel, Switzerland) 2022 May 20;11(5)
Antioxidants (Basel, Switzerland) 2022 May 20;11(5)
Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.
Ren J, Huang R, Li Y, Chen R, Tian H, Liu C
Scientific reports 2022 May 19;12(1):8419
Scientific reports 2022 May 19;12(1):8419
Pu-erh Tea Restored Circadian Rhythm Disruption by Regulating Tryptophan Metabolism.
Hu S, Luo L, Bian X, Liu RH, Zhao S, Chen Y, Sun K, Jiang J, Liu Z, Zeng L
Journal of agricultural and food chemistry 2022 May 11;70(18):5610-5623
Journal of agricultural and food chemistry 2022 May 11;70(18):5610-5623
Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice.
Vu V, Muthuramalingam K, Singh V, Hyun C, Kim YM, Unno T, Cho M
European journal of nutrition 2022 Mar;61(2):793-807
European journal of nutrition 2022 Mar;61(2):793-807
MST1/2 inhibitor XMU-MP-1 alleviates the injury induced by ionizing radiation in haematopoietic and intestinal system.
Zhou X, Wang H, Li D, Song N, Yang F, Xu W
Journal of cellular and molecular medicine 2022 Mar;26(5):1621-1628
Journal of cellular and molecular medicine 2022 Mar;26(5):1621-1628
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
Zhong Y, Liu J, Sun D, Guo T, Yao Y, Xia X, Shi C, Peng X
Food & function 2022 Mar 21;13(6):3660-3673
Food & function 2022 Mar 21;13(6):3660-3673
MicroRNA 148a Suppresses Tuberculous Fibrosis by Targeting NOX4 and POLDIP2.
Woo SJ, Kim Y, Jung H, Lee JJ, Hong JY
International journal of molecular sciences 2022 Mar 10;23(6)
International journal of molecular sciences 2022 Mar 10;23(6)
Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts.
Weng L, Li L, Zhao K, Xu T, Mao Y, Shu H, Chen X, Chen J, Wu J, Guo X, Tu J, Zhang D, Sun W, Kong X
Cardiovascular drugs and therapy 2022 Jun;36(3):413-424
Cardiovascular drugs and therapy 2022 Jun;36(3):413-424
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
Li SN, Yu YL, Wang BY, Qiao SY, Hu MM, Wang H, Fu CN, Dong B
Human gene therapy 2022 Jun;33(11-12):598-613
Human gene therapy 2022 Jun;33(11-12):598-613
In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2.
He Y, Su H, Li N, Zhang Y, Zhang P, Zhang Y, Ye Y, Zhang Y, Tang J, Xu Z
Hypertension research : official journal of the Japanese Society of Hypertension 2022 Jul;45(7):1168-1182
Hypertension research : official journal of the Japanese Society of Hypertension 2022 Jul;45(7):1168-1182
Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis.
Wu Y, Wu Y, Yang Y, Yu J, Wu J, Liao Z, Guo A, Sun Y, Zhao Y, Chen J, Xiao Q
Aging cell 2022 Jul;21(7):e13659
Aging cell 2022 Jul;21(7):e13659
Accumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice.
Tu C, Lai S, Huang Z, Cai G, Zhao K, Gao J, Wu Z, Zhong Z
Bone & joint research 2022 Jul;11(7):413-425
Bone & joint research 2022 Jul;11(7):413-425
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Song S, Shi C, Bian Y, Yang Z, Mu L, Wu H, Duan H, Shi Y
Cell death & disease 2022 Jul 30;13(7):663
Cell death & disease 2022 Jul 30;13(7):663
Sirtuin1 inhibitor attenuates hypertension in spontaneously hypertensive rats: role of Giα proteins and nitroxidative stress.
Arifen N, Li Y, Srivastava AK, Anand-Srivastava MB
Journal of hypertension 2022 Jul 1;40(7):1314-1326
Journal of hypertension 2022 Jul 1;40(7):1314-1326
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Qiu D, Song S, Wang Y, Bian Y, Wu M, Wu H, Shi Y, Duan H
Journal of translational medicine 2022 Jan 28;20(1):44
Journal of translational medicine 2022 Jan 28;20(1):44
Ferroptosis-related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma.
Xiao R, Wang S, Guo J, Liu S, Ding A, Wang G, Li W, Zhang Y, Bian X, Zhao S, Qiu W
Journal of cellular and molecular medicine 2022 Feb;26(4):1183-1193
Journal of cellular and molecular medicine 2022 Feb;26(4):1183-1193
ZFP36 protects against oxygen-glucose deprivation/reoxygenation-induced mitochondrial fragmentation and neuronal apoptosis through inhibiting NOX4-DRP1 pathway.
Guo H, Jiang Y, Gu Z, Ren L, Zhu C, Yu S, Wei R
Brain research bulletin 2022 Feb;179:57-67
Brain research bulletin 2022 Feb;179:57-67
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
Sun X, Xiao H, Li S, Chen R, Lin Z, Yang Y, Chen Z, Deng L, Huang H
Pharmacological research 2022 Feb;176:106084
Pharmacological research 2022 Feb;176:106084
MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3.
Liu Y, Dong ZJ, Song JW, Liang LR, Sun LL, Liu XY, Miao R, Xu YL, Li XT, Zhang MW, Zhang ZZ, Zhong JC
Experimental cell research 2022 Feb 15;411(2):113017
Experimental cell research 2022 Feb 15;411(2):113017
The BCL2/BAX/ROS pathway is involved in the inhibitory effect of astragaloside IV on pyroptosis in human umbilical vein endothelial cells.
Su Y, Yin X, Huang X, Guo Q, Ma M, Guo L
Pharmaceutical biology 2022 Dec;60(1):1812-1818
Pharmaceutical biology 2022 Dec;60(1):1812-1818
Bromelain Ameliorates Atherosclerosis by Activating the TFEB-Mediated Autophagy and Antioxidant Pathways.
Chen CH, Hsia CC, Hu PA, Yeh CH, Chen CT, Peng CL, Wang CH, Lee TS
Antioxidants (Basel, Switzerland) 2022 Dec 29;12(1)
Antioxidants (Basel, Switzerland) 2022 Dec 29;12(1)
Astragaloside IV ameliorates sepsis-induced myocardial dysfunction by regulating NOX4/JNK/BAX pathway.
Su Y, Yin X, Huang X, Guo Q, Ma M, Guo L
Life sciences 2022 Dec 1;310:121123
Life sciences 2022 Dec 1;310:121123
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.
Fang Y, Fang D
Gene 2022 Aug 5;834:146594
Gene 2022 Aug 5;834:146594
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
SIRT7 Deficiency Protects against Aβ(42)-Induced Apoptosis through the Regulation of NOX4-Derived Reactive Oxygen Species Production in SH-SY5Y Cells.
Mizutani H, Sato Y, Yamazaki M, Yoshizawa T, Ando Y, Ueda M, Yamagata K
International journal of molecular sciences 2022 Aug 12;23(16)
International journal of molecular sciences 2022 Aug 12;23(16)
Hypobaric hypoxia triggers pyroptosis in the retina via NLRP3 inflammasome activation.
Xin X, Yang K, Liu H, Li Y
Apoptosis : an international journal on programmed cell death 2022 Apr;27(3-4):222-232
Apoptosis : an international journal on programmed cell death 2022 Apr;27(3-4):222-232
HPV(+) HNSCC-derived exosomal miR-9-5p inhibits TGF-β signaling-mediated fibroblast phenotypic transformation through NOX4.
Wang B, Zhang S, Tong F, Wang Y, Wei L
Cancer science 2022 Apr;113(4):1475-1487
Cancer science 2022 Apr;113(4):1475-1487
PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells.
Liu H, Jia K, Ren Z, Sun J, Pan LL
Cell death & disease 2022 Apr 4;13(4):299
Cell death & disease 2022 Apr 4;13(4):299
Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway.
Zhong Z, Tian Y, Luo X, Zou J, Wu L, Tian J
Frontiers in bioengineering and biotechnology 2021;9:703241
Frontiers in bioengineering and biotechnology 2021;9:703241
17β-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression.
Feng DD, Zheng B, Yu J, Zhang ML, Ma Y, Hao X, Wen JK, Zhang XH
Frontiers in cardiovascular medicine 2021;8:768662
Frontiers in cardiovascular medicine 2021;8:768662
Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.
Li H, Li T, Wang H, He X, Li Y, Wen S, Peng R, Nie Y, Lu Y, Yang H, Ye Y, Shi G, Chen Y
Frontiers in cardiovascular medicine 2021;8:689318
Frontiers in cardiovascular medicine 2021;8:689318
Knockdown of Salusin-β Improves Cardiovascular Function in Myocardial Infarction-Induced Chronic Heart Failure Rats.
Xu Y, Pan Y, Wang X, Chen A, Tang X, Liu X, Han Y
Oxidative medicine and cellular longevity 2021;2021:8896226
Oxidative medicine and cellular longevity 2021;2021:8896226
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Zhang M, Luo C, Lin D, Cui K, Chen Z, Liu J
Oxidative medicine and cellular longevity 2021;2021:8877540
Oxidative medicine and cellular longevity 2021;2021:8877540
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Zhang C, Suo M, Liu L, Qi Y, Zhang C, Xie L, Zheng X, Ma C, Li J, Yang J, Bu P
Oxidative medicine and cellular longevity 2021;2021:6668887
Oxidative medicine and cellular longevity 2021;2021:6668887
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Pei Z, Wang X, Yang C, Dong M, Wang F
Oxidative medicine and cellular longevity 2021;2021:3899356
Oxidative medicine and cellular longevity 2021;2021:3899356
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Fang L, Wang W, Chen J, Zuo A, Gao H, Yan T, Wang P, Lu Y, Lv R, Xu F, Chen Y, Lyu L
Oxidative medicine and cellular longevity 2021;2021:3309944
Oxidative medicine and cellular longevity 2021;2021:3309944
Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension.
Liu X, Wang X, Pan Y, Zhao L, Sun S, Luo A, Bao C, Tang H, Han Y
Drug design, development and therapy 2021;15:4489-4502
Drug design, development and therapy 2021;15:4489-4502
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Sun J, Chen W, Li S, Yang S, Zhang Y, Hu X, Qiu H, Wu J, Xu S, Chu T
Frontiers in pharmacology 2021;12:751845
Frontiers in pharmacology 2021;12:751845
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Chen L, Han Z, Shi Z, Liu C, Lu Q
Frontiers in pharmacology 2021;12:697643
Frontiers in pharmacology 2021;12:697643
Effects of different intensities of continuous training on vascular inflammation and oxidative stress in spontaneously hypertensive rats.
Luo M, Cao C, Niebauer J, Yan J, Ma X, Chang Q, Zhang T, Huang X, Liu G
Journal of cellular and molecular medicine 2021 Sep;25(17):8522-8536
Journal of cellular and molecular medicine 2021 Sep;25(17):8522-8536
The effects of compound centella formula on OxInflammation and silent information regulator 1 in a high-fat diet/streptozotocin-induced diabetic kidney disease rat model.
Zhu Q, Li XH, Chen HY, Jin QY
Experimental and therapeutic medicine 2021 Sep;22(3):962
Experimental and therapeutic medicine 2021 Sep;22(3):962
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Hu S, Li S, Liu Y, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis.
Wang G, Huang W, Wang S, Wang J, Cui W, Zhang W, Lou A, Geng S, Li X
Journal of immunology (Baltimore, Md. : 1950) 2021 Oct 15;207(8):2118-2128
Journal of immunology (Baltimore, Md. : 1950) 2021 Oct 15;207(8):2118-2128
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
The protective effect of harpagoside on angiotensin II (Ang II)-induced blood-brain barrier leakage in vitro.
Lu YW, Hao RJ, Wei YY, Yu GR
Phytotherapy research : PTR 2021 Nov;35(11):6241-6254
Phytotherapy research : PTR 2021 Nov;35(11):6241-6254
The Herbal Formula JI017 Induces ER Stress via Nox4 in Breast Cancer Cells.
Kim TW, Ko SG
Antioxidants (Basel, Switzerland) 2021 Nov 25;10(12)
Antioxidants (Basel, Switzerland) 2021 Nov 25;10(12)
JI017, a Complex Herbal Medication, Induces Apoptosis via the Nox4-PERK-CHOP Axis in Ovarian Cancer Cells.
Kim T, Ko SG
International journal of molecular sciences 2021 Nov 12;22(22)
International journal of molecular sciences 2021 Nov 12;22(22)
Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy.
Wu M, Yang Z, Zhang C, Shi Y, Han W, Song S, Mu L, Du C, Shi Y
Metabolism: clinical and experimental 2021 May;118:154748
Metabolism: clinical and experimental 2021 May;118:154748
C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase.
Xue S, Tang H, Zhao G, Fang C, Shen Y, Yan D, Yuan Y, Fu W, Shi Z, Tang X, Guo D
Free radical biology & medicine 2021 May 1;167:181-192
Free radical biology & medicine 2021 May 1;167:181-192
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Luo X, Bai Y, He S, Sun S, Jiang X, Yang Z, Lu D, Wei P, Liang Y, Peng C, Wang Y, Sheng R, Han S, Li X, Zhang B
Cell proliferation 2021 Mar;54(3):e12991
Cell proliferation 2021 Mar;54(3):e12991
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Ma M, Shi F, Zhai R, Wang H, Li K, Xu C, Yao W, Zhou F
Molecular biology reports 2021 Mar;48(3):2365-2375
Molecular biology reports 2021 Mar;48(3):2365-2375
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
Lyu L, Chen J, Wang W, Yan T, Lin J, Gao H, Li H, Lv R, Xu F, Fang L, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
LRRC8A contributes to angiotensin II-induced cardiac hypertrophy by interacting with NADPH oxidases via the C-terminal leucine-rich repeat domain.
Huo C, Liu Y, Li X, Xu R, Jia X, Hou L, Wang X
Free radical biology & medicine 2021 Mar;165:191-202
Free radical biology & medicine 2021 Mar;165:191-202
NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium.
Fu P, Ramchandran R, Sudhadevi T, Kumar PPK, Krishnan Y, Liu Y, Zhao Y, Parinandi NL, Harijith A, Sadoshima J, Natarajan V
Antioxidants (Basel, Switzerland) 2021 Mar 17;10(3)
Antioxidants (Basel, Switzerland) 2021 Mar 17;10(3)
Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress.
Wen QL, Yi HQ, Yang K, Yin CT, Yin WJ, Xiang FY, Bao M, Shuai J, Song YW, Ge MH, Zhu X
Molecular and cellular endocrinology 2021 Mar 1;523:111144
Molecular and cellular endocrinology 2021 Mar 1;523:111144
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Wang T, Wang J, Sun T, Li Y
Inflammation 2021 Jun;44(3):1119-1129
Inflammation 2021 Jun;44(3):1119-1129
Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR.
He M, Yan G, Wang Y, Gong R, Lei H, Yu S, He X, Li G, Du W, Ma T, Gao M, Yu M, Liu S, Xu Z, Idiiatullina E, Zagidullin N, Pavlov V, Cai B, Yuan Y, Yang L
Journal of cellular and molecular medicine 2021 Jun;25(11):4962-4973
Journal of cellular and molecular medicine 2021 Jun;25(11):4962-4973
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation.
Matsuura T, Soeki T, Fukuda D, Uematsu E, Tobiume T, Hara T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Yamada H, Wakatsuki T, Sata M
Circulation journal : official journal of the Japanese Circulation Society 2021 Jul 21;85(8):1383-1391
Circulation journal : official journal of the Japanese Circulation Society 2021 Jul 21;85(8):1383-1391
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Chen H, Qian Z, Zhang S, Tang J, Fang L, Jiang F, Ge D, Chang J, Cao J, Yang L, Cao X
Redox biology 2021 Jan;38:101774
Redox biology 2021 Jan;38:101774
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Chen N, Mu L, Yang Z, Du C, Wu M, Song S, Yuan C, Shi Y
Journal of cellular physiology 2021 Jan;236(1):625-640
Journal of cellular physiology 2021 Jan;236(1):625-640
IRE1α/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO(2) -induced liver fibrosis.
Tao Y, Qiu T, Yao X, Jiang L, Wang N, Jiang J, Jia X, Wei S, Zhang J, Zhu Y, Tian W, Yang G, Liu X, Liu S, Ding Y, Sun X
Journal of cellular physiology 2021 Feb;236(2):1469-1480
Journal of cellular physiology 2021 Feb;236(2):1469-1480
Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet.
Oe Y, Mitsui S, Sato E, Shibata N, Kisu K, Sekimoto A, Miyazaki M, Sato H, Ito S, Takahashi N
The American journal of pathology 2021 Feb;191(2):283-293
The American journal of pathology 2021 Feb;191(2):283-293
RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling.
Wu N, Zheng F, Li N, Han Y, Xiong XQ, Wang JJ, Chen Q, Li YH, Zhu GQ, Zhou YB
Redox biology 2021 Dec;48:102204
Redox biology 2021 Dec;48:102204
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Chen N, Song S, Yang Z, Wu M, Mu L, Zhou T, Shi Y
Journal of diabetes and its complications 2021 Dec;35(12):108050
Journal of diabetes and its complications 2021 Dec;35(12):108050
miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves' Patients.
Craps J, Joris V, Baldeschi L, Daumerie C, Camboni A, Buemi A, Lengelé B, Behets C, Boschi A, Mourad M, Many MC, Dessy C
International journal of molecular sciences 2021 Dec 23;23(1)
International journal of molecular sciences 2021 Dec 23;23(1)
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats.
Tian J, Zhang M, Suo M, Liu D, Wang X, Liu M, Pan J, Jin T, An F
Journal of cellular and molecular medicine 2021 Aug;25(16):7642-7659
Journal of cellular and molecular medicine 2021 Aug;25(16):7642-7659
miR-31-5p Promotes Oxidative Stress and Vascular Smooth Muscle Cell Migration in Spontaneously Hypertensive Rats via Inhibiting FNDC5 Expression.
Zhou B, Wu LL, Zheng F, Wu N, Chen AD, Zhou H, Chen JY, Chen Q, Li YH, Kang YM, Zhu GQ
Biomedicines 2021 Aug 13;9(8)
Biomedicines 2021 Aug 13;9(8)
Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis.
Hepp M, Werion A, De Greef A, de Ville de Goyet C, de Bournonville M, Behets C, Lengelé B, Daumerie C, Mourad M, Ludgate M, Many MC, Joris V, Craps J
International journal of molecular sciences 2021 Apr 7;22(8)
International journal of molecular sciences 2021 Apr 7;22(8)
Sitagliptin Mitigates Total Body Irradiation-Induced Hematopoietic Injury in Mice.
Wang M, Dong Y, Wu J, Li H, Zhang J, Lu L, Zhang Y, Zhou Z, Fan S, Li D, Meng A
Oxidative medicine and cellular longevity 2020;2020:8308616
Oxidative medicine and cellular longevity 2020;2020:8308616
Effects of Saccharides from Arctium lappa L. Root on FeCl(3)-Induced Arterial Thrombosis via the ERK/NF-κB Signaling Pathway.
Qiu T, Zhou H, Li S, Tian N, Li Z, Wang R, Sun P, Peng J, Du J, Ma X, Diao Y, Lv L, Wang L, Li H
Oxidative medicine and cellular longevity 2020;2020:7691352
Oxidative medicine and cellular longevity 2020;2020:7691352
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Zhou B, Qiu Y, Wu N, Chen AD, Zhou H, Chen Q, Kang YM, Li YH, Zhu GQ
Oxidative medicine and cellular longevity 2020;2020:6384803
Oxidative medicine and cellular longevity 2020;2020:6384803
Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway.
Liu X, Bian H, Dou QL, Huang XW, Tao WY, Liu WH, Li N, Zhang WW
BioMed research international 2020;2020:1928410
BioMed research international 2020;2020:1928410
S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway.
Yang G, Sun S, Wang J, Li W, Wang X, Yuan L, Li S
Drug design, development and therapy 2020;14:4533-4546
Drug design, development and therapy 2020;14:4533-4546
Morroniside Inhibits H(2)O(2)-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro.
Gao X, Liu Y, Wang L, Sai N, Liu Y, Ni J
Frontiers in pharmacology 2020;11:533809
Frontiers in pharmacology 2020;11:533809
Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer.
Owada S, Endo H, Okada C, Yoshida K, Shida Y, Tatemichi M
Anticancer research 2020 Sep;40(9):5071-5079
Anticancer research 2020 Sep;40(9):5071-5079
Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs.
Yang YZ, Liu ZH, Wang SC, Zhang XQ, Xu HJ, Yang L, Kong LD
European journal of pharmacology 2020 Sep 15;883:173314
European journal of pharmacology 2020 Sep 15;883:173314
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Kim TW, Hong DW, Kang CM, Hong SH
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Tan X, Li T, Zhu S, Zhong W, Li F, Wang Y
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Xu Q, Xiong H, Zhu W, Liu Y, Du Y
Life sciences 2020 Nov 1;260:118315
Life sciences 2020 Nov 1;260:118315
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746
Pharmacological research 2020 May;155:104746
Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway.
An X, Zhang Y, Cao Y, Chen J, Qin H, Yang L
Nutrients 2020 May 22;12(5)
Nutrients 2020 May 22;12(5)
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Song S, Qiu D, Wang Y, Wei J, Wu H, Wu M, Wang S, Zhou X, Shi Y, Duan H
Experimental cell research 2020 Mar 15;388(2):111862
Experimental cell research 2020 Mar 15;388(2):111862
MiR155-5p Inhibits Cell Migration and Oxidative Stress in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats.
Wu N, Ye C, Zheng F, Wan GW, Wu LL, Chen Q, Li YH, Kang YM, Zhu GQ
Antioxidants (Basel, Switzerland) 2020 Mar 1;9(3)
Antioxidants (Basel, Switzerland) 2020 Mar 1;9(3)
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
Cao L, Li X, Xu R, Yao K, Yang W, Zhu H, Wang G, Zhang J
European journal of pharmacology 2020 Jun 5;876:173058
European journal of pharmacology 2020 Jun 5;876:173058
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H
British journal of pharmacology 2020 Jan;177(1):145-160
British journal of pharmacology 2020 Jan;177(1):145-160
S-Allylmercaptocysteine attenuates Bleomycin-induced pulmonary fibrosis in mice via suppressing TGF-β1/Smad and oxidative stress pathways.
Li C, Sun X, Li A, Mo M, Zhao Z
International immunopharmacology 2020 Feb;79:106110
International immunopharmacology 2020 Feb;79:106110
Cellular senescence and EMT crosstalk in bleomycin-induced pathogenesis of pulmonary fibrosis-an in vitro analysis.
Muthuramalingam K, Cho M, Kim Y
Cell biology international 2020 Feb;44(2):477-487
Cell biology international 2020 Feb;44(2):477-487
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Chen ZQ, Sun XH, Li XJ, Xu ZC, Yang Y, Lin ZY, Xiao HM, Zhang M, Quan SJ, Huang HQ
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function.
Zhang QY, Wang ZJ, Miao L, Wang Y, Chang LL, Guo W, Zhu YZ
Oxidative medicine and cellular longevity 2019;2019:7850154
Oxidative medicine and cellular longevity 2019;2019:7850154
BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension.
Chen D, Zang YH, Qiu Y, Zhang F, Chen AD, Wang JJ, Chen Q, Li YH, Kang YM, Zhu GQ
Oxidative medicine and cellular longevity 2019;2019:5018410
Oxidative medicine and cellular longevity 2019;2019:5018410
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Zhang HF, Wang JH, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Zhang Z
Oxidative medicine and cellular longevity 2019;2019:2853534
Oxidative medicine and cellular longevity 2019;2019:2853534
Effects of Dexmedetomidine on the RhoA /ROCK/ Nox4 Signaling Pathway in Renal Fibrosis of Diabetic Rats.
Jihua C, Cai C, Xubin B, Yue Y
Open medicine (Warsaw, Poland) 2019;14:890-898
Open medicine (Warsaw, Poland) 2019;14:890-898
Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats.
Zhang M, Chang Z, Zhao F, Zhang P, Hao YJ, Yan L, Liu N, Wang JL, Bo L, Ma P, Zhou W, Ma X, Xu QB, Zhou R
Frontiers in pharmacology 2019;10:13
Frontiers in pharmacology 2019;10:13
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.
Choi SA, Kim YH, Park YH, Yang HJ, Jeong PS, Cha JJ, Yoon SB, Kim JS, Song BS, Lee JH, Sim BW, Huh JW, Song IS, Lee SR, Kim MK, Kim JM, Bae YS, Imakawa K, Kim SU, Chang KT
Cell death and differentiation 2019 Sep;26(9):1582-1599
Cell death and differentiation 2019 Sep;26(9):1582-1599
Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, Liao D, Yang M, Chen D, Jiang P
Redox biology 2019 Sep;26:101295
Redox biology 2019 Sep;26:101295
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Song S, Qiu D, Shi Y, Wang S, Zhou X, Chen N, Wei J, Wu M, Wu H, Duan H
Journal of cellular physiology 2019 Sep;234(9):16485-16502
Journal of cellular physiology 2019 Sep;234(9):16485-16502
Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.
Balta E, Hardt R, Liang J, Kirchgessner H, Orlik C, Jahraus B, Hillmer S, Meuer S, Hübner K, Wabnitz GH, Samstag Y
Nature communications 2019 Sep 9;10(1):4073
Nature communications 2019 Sep 9;10(1):4073
Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress.
Lin J, Fang L, Li H, Li Z, Lyu L, Wang H, Xiao J
European journal of pharmacology 2019 Sep 15;859:172490
European journal of pharmacology 2019 Sep 15;859:172490
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Gao W, Wang W, Zhang J, Deng P, Hu J, Yang J, Deng Z
Metabolic brain disease 2019 Oct;34(5):1267-1280
Metabolic brain disease 2019 Oct;34(5):1267-1280
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Yang Q, Wang C, Jin Y, Ma X, Xie T, Wang J, Liu K, Sun H
Pharmacological research 2019 Oct;148:104414
Pharmacological research 2019 Oct;148:104414
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, Ma C, Yang J
Atherosclerosis 2019 Nov;290:9-18
Atherosclerosis 2019 Nov;290:9-18
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
Zhang XJ, Tan H, Shi ZF, Li N, Jia Y, Hao Z
Molecular medicine reports 2019 May;19(5):4109-4118
Molecular medicine reports 2019 May;19(5):4109-4118
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β(1)/Smad(2)/Nrf(2)-NOX(4) signaling pathways.
Liu B, Rong Y, Sun D, Li W, Chen H, Cao B, Wang T
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease.
Li YJ, Luo LJ, Harroun SG, Wei SC, Unnikrishnan B, Chang HT, Huang YF, Lai JY, Huang CC
Nanoscale 2019 Mar 21;11(12):5580-5594
Nanoscale 2019 Mar 21;11(12):5580-5594
Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway.
Zeng SY, Yang L, Lu HQ, Yan QJ, Gao L, Qin XP
Journal of cellular and molecular medicine 2019 Jun;23(6):4196-4207
Journal of cellular and molecular medicine 2019 Jun;23(6):4196-4207
Systemic Outcomes of (Pyr(1))-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features.
Yamaleyeva LM, Brosnihan KB, Elsangeedy E, McGee C, Shi S, Caudell D, Miller C, Varagic J, Bader M, Dechend R, Shaltout HA
Scientific reports 2019 Jun 12;9(1):8579
Scientific reports 2019 Jun 12;9(1):8579
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, Zhang J, Chu L, Zhao S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice.
Guo Y, You Y, Lv D, Yan J, Shang FF, Wang X, Zhang C, Fan Q, Luo S
Life sciences 2019 Dec 15;239:116912
Life sciences 2019 Dec 15;239:116912
MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system.
Zhang C, Han F, Shi M, Sun H, Li Y, Ci Y, Yao Y, Dou P, Akhtar ML, Nie H, He J, Li Y
Molecular carcinogenesis 2019 Aug;58(8):1410-1426
Molecular carcinogenesis 2019 Aug;58(8):1410-1426
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Liu P, Zhang HM, Hu K, Zhou XF, Tang S
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
Xue M, Li T, Wang Y, Chang Y, Cheng Y, Lu Y, Liu X, Xu L, Li X, Yu X, Sun B, Chen L
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy.
Han W, Wang C, Yang Z, Mu L, Wu M, Chen N, Du C, Duan H, Shi Y
The Journal of endocrinology 2019 Apr;241(1):85-98
The Journal of endocrinology 2019 Apr;241(1):85-98
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Liu L, Hong W, Li M, Ren H, Wang J, Xu H, Shi X, Xu Y
Antioxidants & redox signaling 2019 Apr 20;30(12):1539-1552
Antioxidants & redox signaling 2019 Apr 20;30(12):1539-1552
Calcium Release from Endoplasmic Reticulum Involves Calmodulin-Mediated NADPH Oxidase-Derived Reactive Oxygen Species Production in Endothelial Cells.
Sakurada R, Odagiri K, Hakamata A, Kamiya C, Wei J, Watanabe H
International journal of molecular sciences 2019 Apr 2;20(7)
International journal of molecular sciences 2019 Apr 2;20(7)
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
Zhang J, An H, Ni K, Chen B, Li H, Li Y, Sheng G, Zhou C, Xie M, Chen S, Zhou T, Yang G, Chen X, Wu G, Jin S, Li M
Cell death & disease 2019 Apr 11;10(4):321
Cell death & disease 2019 Apr 11;10(4):321
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Shen D, Tian L, Shen T, Sun H, Liu P
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
The Kidney Injury Induced by Short-Term PM(2.5) Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice.
Zhang Y, Li Q, Fang M, Ma Y, Liu N, Yan X, Zhou J, Li F
Oxidative medicine and cellular longevity 2018;2018:9098627
Oxidative medicine and cellular longevity 2018;2018:9098627
Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress.
Jiang H, Gao X, Gong J, Yang Q, Lan R, Wang T, Liu J, Yin C, Wang S, Liu Z
Oxidative medicine and cellular longevity 2018;2018:1724648
Oxidative medicine and cellular longevity 2018;2018:1724648
Sodium Citrate Increases Expression and Flux of Mg(2+) Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells.
Takashina Y, Manabe A, Hasegawa H, Matsunaga T, Endo S, Ikari A
Nutrients 2018 Sep 20;10(10)
Nutrients 2018 Sep 20;10(10)
BRG1 regulates NOX gene transcription in endothelial cells and contributes to cardiac ischemia-reperfusion injury.
Li Z, Zhang X, Liu S, Zeng S, Yu L, Yang G, Guo J, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3477-3486
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3477-3486
Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.
Liu L, Wu X, Xu H, Yu L, Zhang X, Li L, Jin J, Zhang T, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3109-3121
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3109-3121
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Rong Y, Cao B, Liu B, Li W, Chen Y, Chen H, Liu Y, Liu T
International immunopharmacology 2018 Nov;64:183-191
International immunopharmacology 2018 Nov;64:183-191
Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity.
Long W, Zhang G, Dong Y, Li D
Journal of radiation research 2018 Jul 1;59(4):387-394
Journal of radiation research 2018 Jul 1;59(4):387-394
Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling.
Almajdoob S, Hossain E, Anand-Srivastava MB
Vascular pharmacology 2018 Feb;101:48-56
Vascular pharmacology 2018 Feb;101:48-56
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Fan L, Xiao Q, Zhang L, Wang X, Huang Q, Li S, Zhao X, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury.
Yu L, Yang G, Zhang X, Wang P, Weng X, Yang Y, Li Z, Fang M, Xu Y, Sun A, Ge J
Circulation 2018 Dec 11;138(24):2820-2836
Circulation 2018 Dec 11;138(24):2820-2836
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity.
Zhang QY, Wang ZJ, Sun DM, Wang Y, Xu P, Wu WJ, Liu XH, Zhu YZ
Oxidative medicine and cellular longevity 2017;2017:7150376
Oxidative medicine and cellular longevity 2017;2017:7150376
Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration.
Lajko M, Cardona HJ, Taylor JM, Farrow KN, Fawzi AA
PloS one 2017;12(7):e0180384
PloS one 2017;12(7):e0180384
Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway.
Yao M, Gao F, Wang X, Shi Y, Liu S, Duan H
Molecular medicine reports 2017 Jun;15(6):4319-4325
Molecular medicine reports 2017 Jun;15(6):4319-4325
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Lu SY, Wang CY, Jin Y, Meng Q, Liu Q, Liu ZH, Liu KX, Sun HJ, Liu MZ
Scientific reports 2017 Jun 13;7(1):3331
Scientific reports 2017 Jun 13;7(1):3331
Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4.
Zhang D, Liu B, Cao B, Wei F, Yu X, Li GF, Chen H, Wei LQ, Wang PL
International immunopharmacology 2017 Jul;48:67-75
International immunopharmacology 2017 Jul;48:67-75
Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury.
Ma ZN, Li YZ, Li W, Yan XT, Yang G, Zhang J, Zhao LC, Yang LM
International journal of molecular sciences 2017 Jul 13;18(7)
International journal of molecular sciences 2017 Jul 13;18(7)
Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.
Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Sato N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Nakanishi Y, Kuwano K
Autophagy 2017 Aug 3;13(8):1420-1434
Autophagy 2017 Aug 3;13(8):1420-1434
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, Sun B, Song Y, Lin Y, Peng J, Tang Z
Vascular pharmacology 2017 Apr;91:26-35
Vascular pharmacology 2017 Apr;91:26-35
Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats.
Zhang J, An SJ, Fu JQ, Liu P, Shao TM, Li M, Li X, Jiao Z, Chai XQ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(1-2):347-360
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(1-2):347-360
Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension.
Xiao L, Dong JH, Jin S, Xue HM, Guo Q, Teng X, Wu YM
Oxidative medicine and cellular longevity 2016;2016:8128957
Oxidative medicine and cellular longevity 2016;2016:8128957
Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling.
Liu B, Cao B, Zhang D, Xiao N, Chen H, Li GQ, Peng SC, Wei LQ
Toxicology and applied pharmacology 2016 Oct 15;309:111-20
Toxicology and applied pharmacology 2016 Oct 15;309:111-20
ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress.
Zhou J, Ge L, Jia C, Zheng X, Cui H, Zong R, Bao X, Yin Y, Ma JX, Li W, Liu Z, Zhou Y
Scientific reports 2016 Nov 2;6:36481
Scientific reports 2016 Nov 2;6:36481
The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury.
Li D, Tian Z, Tang W, Zhang J, Lu L, Sun Z, Zhou Z, Fan F
International journal of molecular sciences 2016 Jun 14;17(6)
International journal of molecular sciences 2016 Jun 14;17(6)
Hydrogen sulfide improves the endothelial dysfunction in renovascular hypertensive rats.
Xue H, Zhou S, Xiao L, Guo Q, Liu S, Wu Y
Physiological research 2015;64(5):663-72
Physiological research 2015;64(5):663-72
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Li Y, Wang W, Xu X, Sun S, Xu X, Qu XJ
BioMed research international 2015;2015:491205
BioMed research international 2015;2015:491205
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Fu C, Xu D, Wang CY, Jin Y, Liu Q, Meng Q, Liu KX, Sun HJ, Liu MZ
Journal of cellular physiology 2015 Sep;230(9):2184-201
Journal of cellular physiology 2015 Sep;230(9):2184-201
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Xu G, Wu H, Zhang J, Li D, Wang Y, Wang Y, Zhang H, Lu L, Li C, Huang S, Xing Y, Zhou D, Meng A
Free radical biology & medicine 2015 Oct;87:15-25
Free radical biology & medicine 2015 Oct;87:15-25
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Kim HJ, Magesh V, Lee JJ, Kim S, Knaus UG, Lee KJ
Oncotarget 2015 Jun 30;6(18):16287-303
Oncotarget 2015 Jun 30;6(18):16287-303
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
Jin Y, Liu K, Peng J, Wang C, Kang L, Chang N, Sun H
Toxicology letters 2015 Jan 5;232(1):149-58
Toxicology letters 2015 Jan 5;232(1):149-58
PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.
Wang J, Shao M, Liu M, Peng P, Li L, Wu W, Wang L, Duan F, Zhang M, Song S, Jia D, Ruan Y, Gu J
Biochemical and biophysical research communications 2015 Aug 7;463(4):839-45
Biochemical and biophysical research communications 2015 Aug 7;463(4):839-45
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Li W, Wang C, Peng J, Liang J, Jin Y, Liu Q, Meng Q, Liu K, Sun H
Current pharmaceutical biotechnology 2014;15(12):1173-82
Current pharmaceutical biotechnology 2014;15(12):1173-82
Luteolin inhibits smooth muscle cell migration and proliferation by attenuating the production of Nox4, p-Akt and VEGF in endothelial cells.
Ding H, Li D, Zhang Y, Zhang T, Zhu H, Xu T, Luo Y, Wang C
Current pharmaceutical biotechnology 2014;14(12):1009-15
Current pharmaceutical biotechnology 2014;14(12):1009-15
NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle.
Ginnan R, Jourd'heuil FL, Guikema B, Simons M, Singer HA, Jourd'heuil D
Free radical biology & medicine 2013 Jan;54:125-34
Free radical biology & medicine 2013 Jan;54:125-34
Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS.
Yang LL, Li DY, Zhang YB, Zhu MY, Chen D, Xu TD
Acta pharmacologica Sinica 2012 Jan;33(1):41-8
Acta pharmacologica Sinica 2012 Jan;33(1):41-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14347-1-AP(NOX4 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NOX4 (IP:14347-1-AP, 3ug; Detection:14347-1-AP 1:1000) with HEK-293 cells lysate 1700ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 14347-1-AP(NOX4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 14347-1-AP(NOX4 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NOX4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NOX4. This antibody recognizes human, mouse antigen. The NOX4 antibody has been validated for the following applications: ELISA, WB, IHC, IP, FC analysis.
