Antibody data
- Antibody Data
- Antigen structure
- References [121]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
Submit
Validation data
Reference
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- Product number
- 14347-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14347-1-AP, RRID:AB_10638146
- Product name
- NOX4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NOX4 antibody (Cat. #14347-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway.
Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension.
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice.
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
The protective effect of harpagoside on angiotensin II (Ang II)-induced blood-brain barrier leakage in vitro.
JI017, a Complex Herbal Medication, Induces Apoptosis via the Nox4-PERK-CHOP Axis in Ovarian Cancer Cells.
C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase.
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
LRRC8A contributes to angiotensin II-induced cardiac hypertrophy by interacting with NADPH oxidases via the C-terminal leucine-rich repeat domain.
NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium.
Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress.
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation.
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
IRE1α/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO2 -induced liver fibrosis.
Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet.
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling.
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats.
miR-31-5p Promotes Oxidative Stress and Vascular Smooth Muscle Cell Migration in Spontaneously Hypertensive Rats via Inhibiting FNDC5 Expression.
Sitagliptin Mitigates Total Body Irradiation-Induced Hematopoietic Injury in Mice.
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway.
S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway.
Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro.
Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer.
Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs.
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
MiR155-5p Inhibits Cell Migration and Oxidative Stress in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats.
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
S-Allylmercaptocysteine attenuates Bleomycin-induced pulmonary fibrosis in mice via suppressing TGF-β1/Smad and oxidative stress pathways.
Cellular senescence and EMT crosstalk in bleomycin-induced pathogenesis of pulmonary fibrosis-an in vitro analysis.
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function.
BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension.
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats.
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.
Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.
Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress.
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways.
Systemic Outcomes of (Pyr1)-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features.
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.
Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice.
MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system.
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Calcium Release from Endoplasmic Reticulum Involves Calmodulin-Mediated NADPH Oxidase-Derived Reactive Oxygen Species Production in Endothelial Cells.
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice.
Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress.
Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells.
BRG1 regulates NOX gene transcription in endothelial cells and contributes to cardiac ischemia-reperfusion injury.
Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity.
Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling.
CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity.
Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration.
Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway.
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4.
Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury.
Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats.
Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension.
Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling.
ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress.
The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury.
Hydrogen sulfide improves the endothelial dysfunction in renovascular hypertensive rats.
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Luteolin inhibits smooth muscle cell migration and proliferation by attenuating the production of Nox4, p-Akt and VEGF in endothelial cells.
NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle.
Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS.
Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Extracellular Vesicles Derived From Human Umbilical Cord Mesenchymal Stem Cells Protect Against DOX-Induced Heart Failure Through the miR-100-5p/NOX4 Pathway.
Zhong Z, Tian Y, Luo X, Zou J, Wu L, Tian J
Frontiers in bioengineering and biotechnology 2021;9:703241
Frontiers in bioengineering and biotechnology 2021;9:703241
Diabetes Promotes Retinal Vascular Endothelial Cell Injury by Inducing CCN1 Expression.
Li H, Li T, Wang H, He X, Li Y, Wen S, Peng R, Nie Y, Lu Y, Yang H, Ye Y, Shi G, Chen Y
Frontiers in cardiovascular medicine 2021;8:689318
Frontiers in cardiovascular medicine 2021;8:689318
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Zhang M, Luo C, Lin D, Cui K, Chen Z, Liu J
Oxidative medicine and cellular longevity 2021;2021:8877540
Oxidative medicine and cellular longevity 2021;2021:8877540
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Zhang C, Suo M, Liu L, Qi Y, Zhang C, Xie L, Zheng X, Ma C, Li J, Yang J, Bu P
Oxidative medicine and cellular longevity 2021;2021:6668887
Oxidative medicine and cellular longevity 2021;2021:6668887
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Fang L, Wang W, Chen J, Zuo A, Gao H, Yan T, Wang P, Lu Y, Lv R, Xu F, Chen Y, Lyu L
Oxidative medicine and cellular longevity 2021;2021:3309944
Oxidative medicine and cellular longevity 2021;2021:3309944
Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension.
Liu X, Wang X, Pan Y, Zhao L, Sun S, Luo A, Bao C, Tang H, Han Y
Drug design, development and therapy 2021;15:4489-4502
Drug design, development and therapy 2021;15:4489-4502
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Sun J, Chen W, Li S, Yang S, Zhang Y, Hu X, Qiu H, Wu J, Xu S, Chu T
Frontiers in pharmacology 2021;12:751845
Frontiers in pharmacology 2021;12:751845
Melatonin Alleviates Renal Injury in Mouse Model of Sepsis.
Chen L, Han Z, Shi Z, Liu C, Lu Q
Frontiers in pharmacology 2021;12:697643
Frontiers in pharmacology 2021;12:697643
Effects of β-glucan, probiotics, and synbiotics on obesity-associated colitis and hepatic manifestations in C57BL/6J mice.
Vu V, Muthuramalingam K, Singh V, Hyun C, Kim YM, Unno T, Cho M
European journal of nutrition 2021 Sep 24;
European journal of nutrition 2021 Sep 24;
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Hu S, Li S, Liu Y, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis.
Wang G, Huang W, Wang S, Wang J, Cui W, Zhang W, Lou A, Geng S, Li X
Journal of immunology (Baltimore, Md. : 1950) 2021 Oct 15;207(8):2118-2128
Journal of immunology (Baltimore, Md. : 1950) 2021 Oct 15;207(8):2118-2128
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
The protective effect of harpagoside on angiotensin II (Ang II)-induced blood-brain barrier leakage in vitro.
Lu YW, Hao RJ, Wei YY, Yu GR
Phytotherapy research : PTR 2021 Nov;35(11):6241-6254
Phytotherapy research : PTR 2021 Nov;35(11):6241-6254
JI017, a Complex Herbal Medication, Induces Apoptosis via the Nox4-PERK-CHOP Axis in Ovarian Cancer Cells.
Kim T, Ko SG
International journal of molecular sciences 2021 Nov 12;22(22)
International journal of molecular sciences 2021 Nov 12;22(22)
C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase.
Xue S, Tang H, Zhao G, Fang C, Shen Y, Yan D, Yuan Y, Fu W, Shi Z, Tang X, Guo D
Free radical biology & medicine 2021 May 1;167:181-192
Free radical biology & medicine 2021 May 1;167:181-192
Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress-induced premature senescence.
Luo X, Bai Y, He S, Sun S, Jiang X, Yang Z, Lu D, Wei P, Liang Y, Peng C, Wang Y, Sheng R, Han S, Li X, Zhang B
Cell proliferation 2021 Mar;54(3):e12991
Cell proliferation 2021 Mar;54(3):e12991
TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.
Ma M, Shi F, Zhai R, Wang H, Li K, Xu C, Yao W, Zhou F
Molecular biology reports 2021 Mar;48(3):2365-2375
Molecular biology reports 2021 Mar;48(3):2365-2375
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
Lyu L, Chen J, Wang W, Yan T, Lin J, Gao H, Li H, Lv R, Xu F, Fang L, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
LRRC8A contributes to angiotensin II-induced cardiac hypertrophy by interacting with NADPH oxidases via the C-terminal leucine-rich repeat domain.
Huo C, Liu Y, Li X, Xu R, Jia X, Hou L, Wang X
Free radical biology & medicine 2021 Mar;165:191-202
Free radical biology & medicine 2021 Mar;165:191-202
NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium.
Fu P, Ramchandran R, Sudhadevi T, Kumar PPK, Krishnan Y, Liu Y, Zhao Y, Parinandi NL, Harijith A, Sadoshima J, Natarajan V
Antioxidants (Basel, Switzerland) 2021 Mar 17;10(3)
Antioxidants (Basel, Switzerland) 2021 Mar 17;10(3)
Role of oncogene PIM-1 in the development and progression of papillary thyroid carcinoma: Involvement of oxidative stress.
Wen QL, Yi HQ, Yang K, Yin CT, Yin WJ, Xiang FY, Bao M, Shuai J, Song YW, Ge MH, Zhu X
Molecular and cellular endocrinology 2021 Mar 1;523:111144
Molecular and cellular endocrinology 2021 Mar 1;523:111144
Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.
Wang T, Wang J, Sun T, Li Y
Inflammation 2021 Jun;44(3):1119-1129
Inflammation 2021 Jun;44(3):1119-1129
Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR.
He M, Yan G, Wang Y, Gong R, Lei H, Yu S, He X, Li G, Du W, Ma T, Gao M, Yu M, Liu S, Xu Z, Idiiatullina E, Zagidullin N, Pavlov V, Cai B, Yuan Y, Yang L
Journal of cellular and molecular medicine 2021 Jun;25(11):4962-4973
Journal of cellular and molecular medicine 2021 Jun;25(11):4962-4973
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation.
Matsuura T, Soeki T, Fukuda D, Uematsu E, Tobiume T, Hara T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Yamada H, Wakatsuki T, Sata M
Circulation journal : official journal of the Japanese Circulation Society 2021 Jul 21;85(8):1383-1391
Circulation journal : official journal of the Japanese Circulation Society 2021 Jul 21;85(8):1383-1391
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Chen H, Qian Z, Zhang S, Tang J, Fang L, Jiang F, Ge D, Chang J, Cao J, Yang L, Cao X
Redox biology 2021 Jan;38:101774
Redox biology 2021 Jan;38:101774
Carbohydrate response element-binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy.
Chen N, Mu L, Yang Z, Du C, Wu M, Song S, Yuan C, Shi Y
Journal of cellular physiology 2021 Jan;236(1):625-640
Journal of cellular physiology 2021 Jan;236(1):625-640
IRE1α/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO2 -induced liver fibrosis.
Tao Y, Qiu T, Yao X, Jiang L, Wang N, Jiang J, Jia X, Wei S, Zhang J, Zhu Y, Tian W, Yang G, Liu X, Liu S, Ding Y, Sun X
Journal of cellular physiology 2021 Feb;236(2):1469-1480
Journal of cellular physiology 2021 Feb;236(2):1469-1480
Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet.
Oe Y, Mitsui S, Sato E, Shibata N, Kisu K, Sekimoto A, Miyazaki M, Sato H, Ito S, Takahashi N
The American journal of pathology 2021 Feb;191(2):283-293
The American journal of pathology 2021 Feb;191(2):283-293
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Chen N, Song S, Yang Z, Wu M, Mu L, Zhou T, Shi Y
Journal of diabetes and its complications 2021 Dec;35(12):108050
Journal of diabetes and its complications 2021 Dec;35(12):108050
RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling.
Wu N, Zheng F, Li N, Han Y, Xiong XQ, Wang JJ, Chen Q, Li YH, Zhu GQ, Zhou YB
Redox biology 2021 Dec 6;48:102204
Redox biology 2021 Dec 6;48:102204
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats.
Tian J, Zhang M, Suo M, Liu D, Wang X, Liu M, Pan J, Jin T, An F
Journal of cellular and molecular medicine 2021 Aug;25(16):7642-7659
Journal of cellular and molecular medicine 2021 Aug;25(16):7642-7659
miR-31-5p Promotes Oxidative Stress and Vascular Smooth Muscle Cell Migration in Spontaneously Hypertensive Rats via Inhibiting FNDC5 Expression.
Zhou B, Wu LL, Zheng F, Wu N, Chen AD, Zhou H, Chen JY, Chen Q, Li YH, Kang YM, Zhu GQ
Biomedicines 2021 Aug 13;9(8)
Biomedicines 2021 Aug 13;9(8)
Sitagliptin Mitigates Total Body Irradiation-Induced Hematopoietic Injury in Mice.
Wang M, Dong Y, Wu J, Li H, Zhang J, Lu L, Zhang Y, Zhou Z, Fan S, Li D, Meng A
Oxidative medicine and cellular longevity 2020;2020:8308616
Oxidative medicine and cellular longevity 2020;2020:8308616
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Zhou B, Qiu Y, Wu N, Chen AD, Zhou H, Chen Q, Kang YM, Li YH, Zhu GQ
Oxidative medicine and cellular longevity 2020;2020:6384803
Oxidative medicine and cellular longevity 2020;2020:6384803
Ginkgetin Alleviates Inflammation, Oxidative Stress, and Apoptosis Induced by Hypoxia/Reoxygenation in H9C2 Cells via Caspase-3 Dependent Pathway.
Liu X, Bian H, Dou QL, Huang XW, Tao WY, Liu WH, Li N, Zhang WW
BioMed research international 2020;2020:1928410
BioMed research international 2020;2020:1928410
S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway.
Yang G, Sun S, Wang J, Li W, Wang X, Yuan L, Li S
Drug design, development and therapy 2020;14:4533-4546
Drug design, development and therapy 2020;14:4533-4546
Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro.
Gao X, Liu Y, Wang L, Sai N, Liu Y, Ni J
Frontiers in pharmacology 2020;11:533809
Frontiers in pharmacology 2020;11:533809
Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer.
Owada S, Endo H, Okada C, Yoshida K, Shida Y, Tatemichi M
Anticancer research 2020 Sep;40(9):5071-5079
Anticancer research 2020 Sep;40(9):5071-5079
Magnesium isoglycyrrhizinate alleviates fructose-induced liver oxidative stress and inflammatory injury through suppressing NOXs.
Yang YZ, Liu ZH, Wang SC, Zhang XQ, Xu HJ, Yang L, Kong LD
European journal of pharmacology 2020 Sep 15;883:173314
European journal of pharmacology 2020 Sep 15;883:173314
A novel PPARɣ ligand, PPZ023, overcomes radioresistance via ER stress and cell death in human non-small-cell lung cancer cells.
Kim TW, Hong DW, Kang CM, Hong SH
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Experimental & molecular medicine 2020 Oct;52(10):1730-1743
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Tan X, Li T, Zhu S, Zhong W, Li F, Wang Y
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice.
Xu Q, Xiong H, Zhu W, Liu Y, Du Y
Life sciences 2020 Nov 1;260:118315
Life sciences 2020 Nov 1;260:118315
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
Zhu Y, Zhu C, Yang H, Deng J, Fan D
Pharmacological research 2020 May;155:104746
Pharmacological research 2020 May;155:104746
Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway.
An X, Zhang Y, Cao Y, Chen J, Qin H, Yang L
Nutrients 2020 May 22;12(5)
Nutrients 2020 May 22;12(5)
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Song S, Qiu D, Wang Y, Wei J, Wu H, Wu M, Wang S, Zhou X, Shi Y, Duan H
Experimental cell research 2020 Mar 15;388(2):111862
Experimental cell research 2020 Mar 15;388(2):111862
MiR155-5p Inhibits Cell Migration and Oxidative Stress in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats.
Wu N, Ye C, Zheng F, Wan GW, Wu LL, Chen Q, Li YH, Kang YM, Zhu GQ
Antioxidants (Basel, Switzerland) 2020 Mar 1;9(3)
Antioxidants (Basel, Switzerland) 2020 Mar 1;9(3)
Cathelicidin Modulates Vascular Smooth Muscle Cell Phenotypic Switching through ROS/IL-6 Pathway.
Dong X, Wu D, Zhang Y, Jia L, Pan X, Sun J, Pan LL
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 5;9(6)
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress- and indomethacin- induced gastric mucosal damage.
Cao L, Li X, Xu R, Yao K, Yang W, Zhu H, Wang G, Zhang J
European journal of pharmacology 2020 Jun 5;876:173058
European journal of pharmacology 2020 Jun 5;876:173058
Plumbagin attenuated oxygen-glucose deprivation/reoxygenation-induced injury in human SH-SY5Y cells by inhibiting NOX4-derived ROS-activated NLRP3 inflammasome.
Zhang Q, Zhao S, Zheng W, Fu H, Wu T, Hu F
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Bioscience, biotechnology, and biochemistry 2020 Jan;84(1):134-142
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H
British journal of pharmacology 2020 Jan;177(1):145-160
British journal of pharmacology 2020 Jan;177(1):145-160
S-Allylmercaptocysteine attenuates Bleomycin-induced pulmonary fibrosis in mice via suppressing TGF-β1/Smad and oxidative stress pathways.
Li C, Sun X, Li A, Mo M, Zhao Z
International immunopharmacology 2020 Feb;79:106110
International immunopharmacology 2020 Feb;79:106110
Cellular senescence and EMT crosstalk in bleomycin-induced pathogenesis of pulmonary fibrosis-an in vitro analysis.
Muthuramalingam K, Cho M, Kim Y
Cell biology international 2020 Feb;44(2):477-487
Cell biology international 2020 Feb;44(2):477-487
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Chen ZQ, Sun XH, Li XJ, Xu ZC, Yang Y, Lin ZY, Xiao HM, Zhang M, Quan SJ, Huang HQ
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function.
Zhang QY, Wang ZJ, Miao L, Wang Y, Chang LL, Guo W, Zhu YZ
Oxidative medicine and cellular longevity 2019;2019:7850154
Oxidative medicine and cellular longevity 2019;2019:7850154
BCL6 Attenuates Proliferation and Oxidative Stress of Vascular Smooth Muscle Cells in Hypertension.
Chen D, Zang YH, Qiu Y, Zhang F, Chen AD, Wang JJ, Chen Q, Li YH, Kang YM, Zhu GQ
Oxidative medicine and cellular longevity 2019;2019:5018410
Oxidative medicine and cellular longevity 2019;2019:5018410
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Zhang HF, Wang JH, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Zhang Z
Oxidative medicine and cellular longevity 2019;2019:2853534
Oxidative medicine and cellular longevity 2019;2019:2853534
Protective Effects of 18β-Glycyrrhetinic Acid on Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats.
Zhang M, Chang Z, Zhao F, Zhang P, Hao YJ, Yan L, Liu N, Wang JL, Bo L, Ma P, Zhou W, Ma X, Xu QB, Zhou R
Frontiers in pharmacology 2019;10:13
Frontiers in pharmacology 2019;10:13
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.
Choi SA, Kim YH, Park YH, Yang HJ, Jeong PS, Cha JJ, Yoon SB, Kim JS, Song BS, Lee JH, Sim BW, Huh JW, Song IS, Lee SR, Kim MK, Kim JM, Bae YS, Imakawa K, Kim SU, Chang KT
Cell death and differentiation 2019 Sep;26(9):1582-1599
Cell death and differentiation 2019 Sep;26(9):1582-1599
Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, Liao D, Yang M, Chen D, Jiang P
Redox biology 2019 Sep;26:101295
Redox biology 2019 Sep;26:101295
Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells.
Balta E, Hardt R, Liang J, Kirchgessner H, Orlik C, Jahraus B, Hillmer S, Meuer S, Hübner K, Wabnitz GH, Samstag Y
Nature communications 2019 Sep 9;10(1):4073
Nature communications 2019 Sep 9;10(1):4073
Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress.
Lin J, Fang L, Li H, Li Z, Lyu L, Wang H, Xiao J
European journal of pharmacology 2019 Sep 15;859:172490
European journal of pharmacology 2019 Sep 15;859:172490
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Gao W, Wang W, Zhang J, Deng P, Hu J, Yang J, Deng Z
Metabolic brain disease 2019 Oct;34(5):1267-1280
Metabolic brain disease 2019 Oct;34(5):1267-1280
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Yang Q, Wang C, Jin Y, Ma X, Xie T, Wang J, Liu K, Sun H
Pharmacological research 2019 Oct;148:104414
Pharmacological research 2019 Oct;148:104414
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, Ma C, Yang J
Atherosclerosis 2019 Nov;290:9-18
Atherosclerosis 2019 Nov;290:9-18
Growth differentiation factor 11 is involved in isoproterenol‑induced heart failure.
Zhang XJ, Tan H, Shi ZF, Li N, Jia Y, Hao Z
Molecular medicine reports 2019 May;19(5):4109-4118
Molecular medicine reports 2019 May;19(5):4109-4118
Costunolide inhibits pulmonary fibrosis via regulating NF-kB and TGF-β1/Smad2/Nrf2-NOX4 signaling pathways.
Liu B, Rong Y, Sun D, Li W, Chen H, Cao B, Wang T
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Biochemical and biophysical research communications 2019 Mar 5;510(2):329-333
Systemic Outcomes of (Pyr1)-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features.
Yamaleyeva LM, Brosnihan KB, Elsangeedy E, McGee C, Shi S, Caudell D, Miller C, Varagic J, Bader M, Dechend R, Shaltout HA
Scientific reports 2019 Jun 12;9(1):8579
Scientific reports 2019 Jun 12;9(1):8579
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Song Q, Zhang Y, Han X, Zhang Y, Zhang X, Gao Y, Zhang J, Chu L, Zhao S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:945-956
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Song S, Qiu D, Shi Y, Wang S, Zhou X, Chen N, Wei J, Wu M, Wu H, Duan H
Journal of cellular physiology 2019 Feb 11;
Journal of cellular physiology 2019 Feb 11;
SRT1720 retards renal fibrosis via inhibition of HIF1α /GLUT1 in diabetic nephropathy.
Han W, Wang C, Yang Z, Mu L, Wu M, Chen N, Du C, Duan H, Shi Y
The Journal of endocrinology 2019 Feb 1;
The Journal of endocrinology 2019 Feb 1;
Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice.
Guo Y, You Y, Lv D, Yan J, Shang FF, Wang X, Zhang C, Fan Q, Luo S
Life sciences 2019 Dec 15;239:116912
Life sciences 2019 Dec 15;239:116912
MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system.
Zhang C, Han F, Shi M, Sun H, Li Y, Ci Y, Yao Y, Dou P, Akhtar ML, Nie H, He J, Li Y
Molecular carcinogenesis 2019 Aug;58(8):1410-1426
Molecular carcinogenesis 2019 Aug;58(8):1410-1426
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Liu P, Zhang HM, Hu K, Zhou XF, Tang S
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
Xue M, Li T, Wang Y, Chang Y, Cheng Y, Lu Y, Liu X, Xu L, Li X, Yu X, Sun B, Chen L
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Liu L, Hong W, Li M, Ren H, Wang J, Xu H, Shi X, Xu Y
Antioxidants & redox signaling 2019 Apr 20;30(12):1539-1552
Antioxidants & redox signaling 2019 Apr 20;30(12):1539-1552
Calcium Release from Endoplasmic Reticulum Involves Calmodulin-Mediated NADPH Oxidase-Derived Reactive Oxygen Species Production in Endothelial Cells.
Sakurada R, Odagiri K, Hakamata A, Kamiya C, Wei J, Watanabe H
International journal of molecular sciences 2019 Apr 2;20(7)
International journal of molecular sciences 2019 Apr 2;20(7)
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure.
Zhang J, An H, Ni K, Chen B, Li H, Li Y, Sheng G, Zhou C, Xie M, Chen S, Zhou T, Yang G, Chen X, Wu G, Jin S, Li M
Cell death & disease 2019 Apr 11;10(4):321
Cell death & disease 2019 Apr 11;10(4):321
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Shen D, Tian L, Shen T, Sun H, Liu P
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
The Kidney Injury Induced by Short-Term PM2.5 Exposure and the Prophylactic Treatment of Essential Oils in BALB/c Mice.
Zhang Y, Li Q, Fang M, Ma Y, Liu N, Yan X, Zhou J, Li F
Oxidative medicine and cellular longevity 2018;2018:9098627
Oxidative medicine and cellular longevity 2018;2018:9098627
Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress.
Jiang H, Gao X, Gong J, Yang Q, Lan R, Wang T, Liu J, Yin C, Wang S, Liu Z
Oxidative medicine and cellular longevity 2018;2018:1724648
Oxidative medicine and cellular longevity 2018;2018:1724648
Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells.
Takashina Y, Manabe A, Hasegawa H, Matsunaga T, Endo S, Ikari A
Nutrients 2018 Sep 20;10(10)
Nutrients 2018 Sep 20;10(10)
BRG1 regulates NOX gene transcription in endothelial cells and contributes to cardiac ischemia-reperfusion injury.
Li Z, Zhang X, Liu S, Zeng S, Yu L, Yang G, Guo J, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3477-3486
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3477-3486
Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.
Liu L, Wu X, Xu H, Yu L, Zhang X, Li L, Jin J, Zhang T, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3109-3121
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3109-3121
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
Rong Y, Cao B, Liu B, Li W, Chen Y, Chen H, Liu Y, Liu T
International immunopharmacology 2018 Nov;64:183-191
International immunopharmacology 2018 Nov;64:183-191
Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity.
Long W, Zhang G, Dong Y, Li D
Journal of radiation research 2018 Jul 1;59(4):387-394
Journal of radiation research 2018 Jul 1;59(4):387-394
Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling.
Almajdoob S, Hossain E, Anand-Srivastava MB
Vascular pharmacology 2018 Feb;101:48-56
Vascular pharmacology 2018 Feb;101:48-56
CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Fan L, Xiao Q, Zhang L, Wang X, Huang Q, Li S, Zhao X, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury.
Yu L, Yang G, Zhang X, Wang P, Weng X, Yang Y, Li Z, Fang M, Xu Y, Sun A, Ge J
Circulation 2018 Dec 11;138(24):2820-2836
Circulation 2018 Dec 11;138(24):2820-2836
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Novel Therapeutic Effects of Leonurine On Ischemic Stroke: New Mechanisms of BBB Integrity.
Zhang QY, Wang ZJ, Sun DM, Wang Y, Xu P, Wu WJ, Liu XH, Zhu YZ
Oxidative medicine and cellular longevity 2017;2017:7150376
Oxidative medicine and cellular longevity 2017;2017:7150376
Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration.
Lajko M, Cardona HJ, Taylor JM, Farrow KN, Fawzi AA
PloS one 2017;12(7):e0180384
PloS one 2017;12(7):e0180384
Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway.
Yao M, Gao F, Wang X, Shi Y, Liu S, Duan H
Molecular medicine reports 2017 Jun;15(6):4319-4325
Molecular medicine reports 2017 Jun;15(6):4319-4325
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Lu SY, Wang CY, Jin Y, Meng Q, Liu Q, Liu ZH, Liu KX, Sun HJ, Liu MZ
Scientific reports 2017 Jun 13;7(1):3331
Scientific reports 2017 Jun 13;7(1):3331
Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-β1/Smad2 pathways and overexpression of NOX4.
Zhang D, Liu B, Cao B, Wei F, Yu X, Li GF, Chen H, Wei LQ, Wang PL
International immunopharmacology 2017 Jul;48:67-75
International immunopharmacology 2017 Jul;48:67-75
Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury.
Ma ZN, Li YZ, Li W, Yan XT, Yang G, Zhang J, Zhao LC, Yang LM
International journal of molecular sciences 2017 Jul 13;18(7)
International journal of molecular sciences 2017 Jul 13;18(7)
Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.
Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, Kadota T, Sato N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Yoshii Y, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Nakanishi Y, Kuwano K
Autophagy 2017 Aug 3;13(8):1420-1434
Autophagy 2017 Aug 3;13(8):1420-1434
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, Sun B, Song Y, Lin Y, Peng J, Tang Z
Vascular pharmacology 2017 Apr;91:26-35
Vascular pharmacology 2017 Apr;91:26-35
Mixed Aqueous Extract of Salvia Miltiorrhiza Reduces Blood Pressure through Inhibition of Vascular Remodelling and Oxidative Stress in Spontaneously Hypertensive Rats.
Zhang J, An SJ, Fu JQ, Liu P, Shao TM, Li M, Li X, Jiao Z, Chai XQ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(1-2):347-360
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(1-2):347-360
Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension.
Xiao L, Dong JH, Jin S, Xue HM, Guo Q, Teng X, Wu YM
Oxidative medicine and cellular longevity 2016;2016:8128957
Oxidative medicine and cellular longevity 2016;2016:8128957
Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling.
Liu B, Cao B, Zhang D, Xiao N, Chen H, Li GQ, Peng SC, Wei LQ
Toxicology and applied pharmacology 2016 Oct 15;309:111-20
Toxicology and applied pharmacology 2016 Oct 15;309:111-20
ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress.
Zhou J, Ge L, Jia C, Zheng X, Cui H, Zong R, Bao X, Yin Y, Ma JX, Li W, Liu Z, Zhou Y
Scientific reports 2016 Nov 2;6:36481
Scientific reports 2016 Nov 2;6:36481
The Protective Effects of 5-Methoxytryptamine-α-lipoic Acid on Ionizing Radiation-Induced Hematopoietic Injury.
Li D, Tian Z, Tang W, Zhang J, Lu L, Sun Z, Zhou Z, Fan F
International journal of molecular sciences 2016 Jun 14;17(6)
International journal of molecular sciences 2016 Jun 14;17(6)
Hydrogen sulfide improves the endothelial dysfunction in renovascular hypertensive rats.
Xue H, Zhou S, Xiao L, Guo Q, Liu S, Wu Y
Physiological research 2015;64(5):663-72
Physiological research 2015;64(5):663-72
{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3.
Li Y, Wang W, Xu X, Sun S, Xu X, Qu XJ
BioMed research international 2015;2015:491205
BioMed research international 2015;2015:491205
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Fu C, Xu D, Wang CY, Jin Y, Liu Q, Meng Q, Liu KX, Sun HJ, Liu MZ
Journal of cellular physiology 2015 Sep;230(9):2184-201
Journal of cellular physiology 2015 Sep;230(9):2184-201
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Xu G, Wu H, Zhang J, Li D, Wang Y, Wang Y, Zhang H, Lu L, Li C, Huang S, Xing Y, Zhou D, Meng A
Free radical biology & medicine 2015 Oct;87:15-25
Free radical biology & medicine 2015 Oct;87:15-25
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Kim HJ, Magesh V, Lee JJ, Kim S, Knaus UG, Lee KJ
Oncotarget 2015 Jun 30;6(18):16287-303
Oncotarget 2015 Jun 30;6(18):16287-303
Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway.
Jin Y, Liu K, Peng J, Wang C, Kang L, Chang N, Sun H
Toxicology letters 2015 Jan 5;232(1):149-58
Toxicology letters 2015 Jan 5;232(1):149-58
PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.
Wang J, Shao M, Liu M, Peng P, Li L, Wu W, Wang L, Duan F, Zhang M, Song S, Jia D, Ruan Y, Gu J
Biochemical and biophysical research communications 2015 Aug 7;463(4):839-45
Biochemical and biophysical research communications 2015 Aug 7;463(4):839-45
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Li W, Wang C, Peng J, Liang J, Jin Y, Liu Q, Meng Q, Liu K, Sun H
Current pharmaceutical biotechnology 2014;15(12):1173-82
Current pharmaceutical biotechnology 2014;15(12):1173-82
Luteolin inhibits smooth muscle cell migration and proliferation by attenuating the production of Nox4, p-Akt and VEGF in endothelial cells.
Ding H, Li D, Zhang Y, Zhang T, Zhu H, Xu T, Luo Y, Wang C
Current pharmaceutical biotechnology 2014;14(12):1009-15
Current pharmaceutical biotechnology 2014;14(12):1009-15
NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle.
Ginnan R, Jourd'heuil FL, Guikema B, Simons M, Singer HA, Jourd'heuil D
Free radical biology & medicine 2013 Jan;54:125-34
Free radical biology & medicine 2013 Jan;54:125-34
Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS.
Yang LL, Li DY, Zhang YB, Zhu MY, Chen D, Xu TD
Acta pharmacologica Sinica 2012 Jan;33(1):41-8
Acta pharmacologica Sinica 2012 Jan;33(1):41-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14347-1-AP(NOX4 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NOX4 (IP:14347-1-AP, 3ug; Detection:14347-1-AP 1:1000) with HEK-293 cells lysate 1700ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 14347-1-AP(NOX4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 14347-1-AP(NOX4 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NOX4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NOX4. This antibody recognizes human, mouse antigen. The NOX4 antibody has been validated for the following applications: ELISA, WB, IHC, IP, FC analysis.