67681-1-Ig

antibody from Proteintech Group

Targeting: NOX4 KOX, KOX-1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67681-1-Ig

Provider

Proteintech Group

Product name

NOX4 antibody

Antibody type

Monoclonal

Description

NOX4 antibody (Cat. #67681-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

4E5F1

Vial size

20ul, 150ul

References

Submitted references

Anjiang formula inhibits PVN microglial activation and lowers blood pressure by targeting RhoA/ROCK2 pathway: a retrospective clinical and experimental study.

Chen X, Chen J, Chen Z, Lian D, Wang J, Wu M, Luo J, Shen A, Chen L
Frontiers in pharmacology 2026;17:1795297

---

Chronic hypoxia induces skeletal muscle atrophy in mice: Potential roles of antioxidant imbalance and FOXO1.

Luo X, Tang S, Luo X, Wangmo S, Xia R, Wang X
Biochimica et biophysica acta. General subjects 2026 May;1870(5):130922

---

Hyperoside impairs mitochondrial respiration in chronic myeloid leukemia by promoting STUB1-mediated ubiquitination and degradation of NOX4.

Che H, Zhao B, Yi W, Liu P, Hu L
Toxicology and applied pharmacology 2026 Jun;511:117795

---

Inhibition of GRK2 mitigates cisplatin-induced acute and chronic nephrotoxicity by targeting the NADPH oxidase 4/oxidative stress axis.

Duan F, Ni L, Wang Q, Peng J, Wang X, Wang Y, Hu S, Kuai J, Jiang X, Wang Q, Xu B, Wei W, Wang C
British journal of pharmacology 2026 Jun;183(12):3149-3172

---

Gastrin releasing peptide receptor antagonism in the paraventricular nucleus exerts antihypertensive effects in 2K1C rats.

Wang XM, Liu JJ, Wang YP, Bai C, Issotina Zibrila A, Xia WJ, Yang RN, Kang YM, Yu XJ
Toxicology and applied pharmacology 2026 Jan;506:117620

---

Liver-Targeting Nanoparticles GA-MSe@AR Treat NAFLD Through Dual Lipid-Lowering and Antioxidant Efficacy.

Lei S, Wu Q, Zhang B, Lu M, Xia Y, Li N
International journal of nanomedicine 2025;20:5017-5037

---

Chaihushugan powder regulates the gut microbiota to alleviate mitochondrial oxidative stress in the gastric tissues of rats with functional dyspepsia.

Liu X, Yang K, Jia Y, Yeertai Y, Wu C, Wang X, Jia Q, Gu Z, Cong J, Ling J
Frontiers in immunology 2025;16:1549554

---

Gastrin-releasing peptide in the paraventricular nucleus exerts hypertensive effects in preeclampsia.

Wang X, Ali MA, Liu X, Zeng M, Zeng Z, Yuan M, Issotina Zibrila A, Liu S, Ping N, Kang Y, Li X, Liu J
Neurochemistry international 2025 Sep;188:106004

---

SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.

Li Y, Zhang Y, Chen Y, Qiao Z, Wang D, Yang Y, Huang W, Yan J
European journal of pharmacology 2025 Oct 5;1004:177938

---

Xiasangju alleviates hepatic insulin resistance in db/db mice via AMPK pathway: Mechanisms and active components study.

An Y, Zhao H, He C, Shi L, Su X, Zhang H, Huang Y, Shan Z, Wang M, Du Y, Xie J, Zhao Y, Yang Y, Huang Z, Wan A, Zhao Y, Zhao B
International immunopharmacology 2025 May 27;156:114675

---

Dual-responsive nanoscale ultrasound contrast agent as an oxidative stress amplifier for enhanced DNA damage in BRCA-proficient ovarian cancer.

Zhang J, Wang X, Guo L, Xiao S, Meng D, Shang M, Sun X, Shi D, Zhao Y, Liu R, Huang S, Zeng X, Li J
Materials today. Bio 2025 Jun;32:101761

---

Down-regulation of E2F1 attenuates UVB-induced human lens epithelial cell oxidative stress and pyroptosis through inhibiting NLRP3.

Wang F, Yang F, Yang G, Zhou Q, Lv H
Human & experimental toxicology 2025 Jan-Dec;44:9603271241309258

---

Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E(2)-Induced Oxidative Stress in Hypertension.

Fan JF, Tan X, Wang W, Li JK, Xiao YC, Wang WZ, Wang YK
Journal of the American Heart Association 2025 Jan 21;14(2):e036762

---

L-arginine ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in male metabolic syndrome rats.

Tagami K, Okuzawa T, Yoshida K, Mishima R, Obara N, Kunimatsu A, Koide M, Teranishi T, Itakura K, Ikeda K, Murohara T, Nagata K
Physiological reports 2025 Feb;13(4):e70183

---

CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury.

Fu J, Du M, Wu B, Wu C, Li X, Tan W, Huang X, Zhu Z, Zhang J, Liao ZB
Cell & bioscience 2025 Feb 17;15(1):21

---

Pyridostigmine attenuates placental-ischemia-upregulated placental angiotensin II type 1 receptor in rats.

Issotina Zibrila A, Alkuhali AA, Yuan M, Zeng Z, Ali MA, Zeng M, Elenany AM, Manzoor M, Wang X, Zhao M, Jin L, Liu J
Peptides 2025 Dec;194:171450

---

Triptolide decreases podocytes permeability by regulating TET2-mediated hydroxymethylation of ZO-1.

Tang YW, Jiang MY, Cao JW, Wan F
Experimental biology and medicine (Maywood, N.J.) 2024;249:10051

---

Melatonin Alleviates Osteoarthritis by Regulating NADPH Oxidase 4-Induced Ferroptosis and Mitigating Mitochondrial Dysfunction.

Wang Q, Qi B, Shi S, Jiang W, Li D, Jiang X, Yi C
Journal of pineal research 2024 Sep;76(6):e12992

---

Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat.

Issotina Zibrila A, Zhou J, Wang X, Zeng M, Ali MA, Liu X, Alkuhali AA, Zeng Z, Meng Y, Wang Z, Li X, Liu J
Pflugers Archiv : European journal of physiology 2024 Nov;476(11):1677-1691

---

PLC-CN-NFAT1 signaling-mediated Aβ and IL-1β crosstalk synergistically promotes hippocampal neuronal damage.

Shi Q, Sun X, Zhang H, Yang L, Fu Y, Wang G, Su Y, Li W, Li W
International immunopharmacology 2024 Jun 15;134:112259

---

Deletion of stimulator of interferons genes aggravated cardiac dysfunction in physiological aged mice.

Gao D, Zhao B, Yu J, Li X, Yang D, Luo Y, Xia Y, Cai X, Guo Y
Mechanisms of ageing and development 2024 Dec;222:111978

---

Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis.

Xie W, Deng L, Lin M, Huang X, Qian R, Xiong D, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2023 Oct 29;12(11)

---

Identification of NOX4 as a New Biomarker in Hepatocellular Carcinoma and Its Effect on Sorafenib Therapy.

Li HZ, Liu QQ, Chang DH, Li SX, Yang LT, Zhou P, Deng JB, Huang CH, Xiao YD
Biomedicines 2023 Aug 4;11(8)

---

The Effect of Tauroursodeoxycholic Acid (TUDCA) Treatment on Pregnancy Outcomes and Vascular Function in a Rat Model of Advanced Maternal Age.

Pasha M, Kirschenman R, Wooldridge A, Spaans F, Cooke CM, Davidge ST
Antioxidants (Basel, Switzerland) 2022 Jun 28;11(7)