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Learn10077-1-AP
antibody from Proteintech Group
Targeting: KPNB1
IMB1, Impnb, IPO1, IPOB, MGC2155, MGC2156, MGC2157, NTF97
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10077-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10077-1-AP, RRID:AB_2133977
- Product name
- Importin Beta antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Importin Beta antibody (Cat. #10077-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TRMT6-directed m(1)A modification initiates lung squamous cell carcinoma via YTHDF3-stabilized cell cycle genes.
CD276 promotes CD36-mediated lipid metabolism and confers resistance to tyrosine kinase inhibitors.
The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection.
ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis.
The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism.
ALFA nanobody-guided endogenous labeling.
Direct observation of importin α family member KPNA1 in axonal transport with or without a schizophrenia-related mutation.
TMX2 potentiates cell viability of hepatocellular carcinoma by promoting autophagy and mitophagy.
Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer.
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
Neddylation of PTEN regulates its nuclear import and promotes tumor development.
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Nuclear import of Nkx2-2 is mediated by multiple pathways.
Xue W, Zhu L, Wei X, Sun J, Lin W, Huang S, Wu L, Zhang D
NPJ precision oncology 2026 Mar 10;10(1)
NPJ precision oncology 2026 Mar 10;10(1)
CD276 promotes CD36-mediated lipid metabolism and confers resistance to tyrosine kinase inhibitors.
Huang X, Ma L, Lu Y, Cui J, Qi W, Song J, Guo J, Wang S, Fang J, Lu Z, Qiu W
Cancer letters 2026 Jul 10;650:218492
Cancer letters 2026 Jul 10;650:218492
The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection.
Woo TT, Takeo Y, Harwood MC, Houck ET, DiMaio D, Tsai B
Science advances 2025 Oct 24;11(43):eadz6792
Science advances 2025 Oct 24;11(43):eadz6792
ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis.
Zhu J, Ren S, Yi Y, Wu Z, Lin H, Shan G, Huang X, Pan B, Hu Z, Sui Q, Zhan C, Wang S, Liang J
Cell & bioscience 2025 Jun 28;15(1):94
Cell & bioscience 2025 Jun 28;15(1):94
The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism.
Shi S, Qin Z, Liu C, Zhao Y, Bai X, Sun C, Li X, Cong W, Yuan X, Sun L, Liu B, Li X
Scientific reports 2025 Jul 1;15(1):22067
Scientific reports 2025 Jul 1;15(1):22067
ALFA nanobody-guided endogenous labeling.
Wang Z, Hu F, Xue F, He W, Yuan L, Xu P
Nature chemical biology 2025 Dec;21(12):1992-2001
Nature chemical biology 2025 Dec;21(12):1992-2001
Direct observation of importin α family member KPNA1 in axonal transport with or without a schizophrenia-related mutation.
Mizuno K, Sugahara M, Kutomi O, Kato R, Itoh T, Fujita S, Yamada M
The Journal of biological chemistry 2025 Apr;301(4):108343
The Journal of biological chemistry 2025 Apr;301(4):108343
TMX2 potentiates cell viability of hepatocellular carcinoma by promoting autophagy and mitophagy.
Zhang W, Tang Y, Yang P, Chen Y, Xu Z, Qi C, Huang H, Liu R, Qin H, Ke H, Huang C, Xu F, Pang P, Zhao Z, Shan H, Xiao F
Autophagy 2024 Oct;20(10):2146-2163
Autophagy 2024 Oct;20(10):2146-2163
Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer.
Lu B, Qiu R, Wei J, Wang L, Zhang Q, Li M, Zhan X, Chen J, Hsieh IY, Yang C, Zhang J, Sun Z, Zhu Y, Jiang T, Zhu H, Li J, Zhao W
Nature cancer 2024 Nov;5(11):1622-1640
Nature cancer 2024 Nov;5(11):1622-1640
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF-κB/p65.
Gao X, Xuan Y, Zhou Z, Chen C, Wen Wang D, Wen Z
International immunopharmacology 2024 May 30;133:112073
International immunopharmacology 2024 May 30;133:112073
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
Xu F, Wang L
Cell reports 2024 Jun 25;43(6):114358
Cell reports 2024 Jun 25;43(6):114358
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
Sirois CL, Guo Y, Li M, Wolkoff NE, Korabelnikov T, Sandoval S, Lee J, Shen M, Contractor A, Sousa AMM, Bhattacharyya A, Zhao X
Cell reports 2024 Jun 25;43(6):114330
Cell reports 2024 Jun 25;43(6):114330
Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis.
Li J, Zhang B, Feng Z, An D, Zhou Z, Wan C, Hu Y, Sun Y, Wang Y, Liu X, Wei W, Yang X, Meng J, Che M, Sheng Y, Wu B, Wen L, Huang F, Li Y, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 23;43(1):28
Journal of experimental & clinical cancer research : CR 2024 Jan 23;43(1):28
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.
Yang C, Leifer C, Lammerding J, Hu F
The Journal of biological chemistry 2024 Dec;300(12):107999
The Journal of biological chemistry 2024 Dec;300(12):107999
Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.
Yao H, Li J, Liu Z, Ouyang C, Qiu Y, Zheng X, Mu J, Xie Z
Autophagy 2023 May;19(5):1491-1511
Autophagy 2023 May;19(5):1491-1511
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
Pan Z, Xu T, Bao L, Hu X, Jin T, Chen J, Chen J, Qian Y, Lu X, Li L, Zheng G, Zhang Y, Zou X, Song F, Zheng C, Jiang L, Wang J, Tan Z, Huang P, Ge M
Molecular cancer 2022 Oct 3;21(1):190
Molecular cancer 2022 Oct 3;21(1):190
Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
Nakanishi A, Okumura H, Hashita T, Yamashita A, Nishimura Y, Watanabe C, Kamimura S, Hayashi S, Murakami S, Ito K, Iwao T, Ikeda A, Hirose T, Sunazuka T, Tanaka Y, Matsunaga T
Viruses 2022 Nov 8;14(11)
Viruses 2022 Nov 8;14(11)
Neddylation of PTEN regulates its nuclear import and promotes tumor development.
Xie P, Peng Z, Chen Y, Li H, Du M, Tan Y, Zhang X, Lu Z, Cui CP, Liu CH, He F, Zhang L
Cell research 2021 Mar;31(3):291-311
Cell research 2021 Mar;31(3):291-311
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
Zhuo Y, Guo Z, Ba T, Zhang C, He L, Zeng C, Dai H
Virologica Sinica 2021 Apr;36(2):176-186
Virologica Sinica 2021 Apr;36(2):176-186
Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells.
Zhu ZC, Liu JW, Yang C, Li MJ, Wu RJ, Xiong ZQ
Cell death & disease 2019 Feb 11;10(2):118
Cell death & disease 2019 Feb 11;10(2):118
KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.
Zhu ZC, Liu JW, Li K, Zheng J, Xiong ZQ
Oncogene 2018 May;37(22):2936-2952
Oncogene 2018 May;37(22):2936-2952
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, Zhou Y, Li J, Zhao Y, Sun N, Huang S, Zhou C, Chang Y, Cui P, Chen P, Jiang Y, Deng G, Bu Z, Li C, Jiang L, Chen H
PLoS pathogens 2018 Jan;14(1):e1006851
PLoS pathogens 2018 Jan;14(1):e1006851
Nuclear import of Nkx2-2 is mediated by multiple pathways.
Lin W, Xu P, Guo Y, Jia Q, Tao T
Biochemical and biophysical research communications 2017 Jan 22;482(4):1511-1516
Biochemical and biophysical research communications 2017 Jan 22;482(4):1511-1516
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10077-1-AP( KPNB1 Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Importin beta antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Importin beta. This antibody recognizes human, mouse, rat antigen. The Importin beta antibody has been validated for the following applications: ELISA, IHC, WB analysis.
