CABT-B9228
antibody from Creative Diagnostics
Targeting: KPNB1
IMB1, Impnb, IPO1, IPOB, MGC2155, MGC2156, MGC2157, NTF97
Antibody data
- Antibody Data
- Antigen structure
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- Comments [0]
- Validations [0]
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- Product number
- CABT-B9228 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Rat Karyopherin beta monoclonal antibody, clone 34
- Antibody type
- Monoclonal
- Description
- Using nuclear import assays, several cytosolic proteins that form a multi-protein complex have been identified. These proteins of 54 kDa, 56 kDa, and 97 kDa stimulate the nuclear transport of proteins containing a nuclear localization signal (NLS). The 97 kDa protein has been named karyopherin ÉÇ. The NLS binds to karyopherin Ï«. Binding is enhanced by karyopherin ÉÇ. The NLS substrate also binds to the N-terminal region of karyopherin ÉÇ. Both karyopherins bind to repeat sequences of nucleoporins at the nuclear envelope. Once the substrate is docked to the nuclear envelope, Ran hydrolyzes GTP and translocation occurs. Karyopherin ÉÇ also binds to and inhibits the Ran GTPase protein, thus providing a mechanism of nuclear transport termination.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 34
- Vial size
- 50ug, 150ug
- Concentration
- 250 Ã×g/ml
- Storage
- Store undiluted at -20°C.
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