Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 12573-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12573-1-AP, RRID:AB_2209732
- Product name
- TRIM25 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM25 antibody (Cat. #12573-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability.
Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy.
JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis.
Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha.
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.
USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.
Disturbed P53-MDM2 Feedback Loop Contributes to Thoracic Aortic Dissection Formation and May be a Result of TRIM25 Overexpression.
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Zhou S, Peng J, Xiao L, Zhou C, Fang Y, Ou Q, Qin J, Liu M, Pan Z, Hou Z
Cell death & disease 2021 May 8;12(5):463
Cell death & disease 2021 May 8;12(5):463
Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy.
Tong J, Xu X, Zhang Z, Ma C, Xiang R, Liu J, Xu W, Wu C, Li J, Zhan F, Wu Y, Yan H
Haematologica 2020 Jun;105(6):1630-1640
Haematologica 2020 Jun;105(6):1630-1640
JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis.
Chen JJ, Ren YL, Shu CJ, Zhang Y, Chen MJ, Xu J, Li J, Li AP, Chen DY, He JD, Shu YQ, Zhou JW
Journal of experimental & clinical cancer research : CR 2020 Jun 23;39(1):118
Journal of experimental & clinical cancer research : CR 2020 Jun 23;39(1):118
Knockdown of ZBTB7A inhibits cell proliferation of breast cancer through regulating the ubiquitination of estrogen receptor alpha.
Xiao X, Shen Y, Yin L, He J, Ni X, Luo G, Chen X, Zhu W, Zhong J, Liu J, Peng X, Zu X
Life sciences 2019 Dec 15;239:117042
Life sciences 2019 Dec 15;239:117042
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C
mBio 2019 Aug 27;10(4)
mBio 2019 Aug 27;10(4)
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS
Structure (London, England : 1993) 2019 Apr 2;27(4):590-605.e5
Structure (London, England : 1993) 2019 Apr 2;27(4):590-605.e5
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.
Liu W, Li J, Zheng W, Shang Y, Zhao Z, Wang S, Bi Y, Zhang S, Xu C, Duan Z, Zhang L, Wang YL, Jiang Z, Liu W, Sun L
eLife 2017 Jun 8;6
eLife 2017 Jun 8;6
USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.
Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P
Nature immunology 2017 Jan;18(1):54-63
Nature immunology 2017 Jan;18(1):54-63
Disturbed P53-MDM2 Feedback Loop Contributes to Thoracic Aortic Dissection Formation and May be a Result of TRIM25 Overexpression.
Gong B, Wang Z, Zhang M, Hu Z, Ren Z, Tang Z, Jiang W, Cheng L, Huang J, Ren W, Wang Q
Annals of vascular surgery 2017 Apr;40:243-251
Annals of vascular surgery 2017 Apr;40:243-251
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Jiang J, Li J, Fan W, Zheng W, Yu M, Chen C, Sun L, Bi Y, Ding C, Gao GF, Liu W
Journal of virology 2016 Jul 15;90(14):6263-6275
Journal of virology 2016 Jul 15;90(14):6263-6275
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E
Nature immunology 2010 Oct;11(10):912-9
Nature immunology 2010 Oct;11(10):912-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 12573-1-AP(TRIM25 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TRIM25 antibody 12573-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line