67314-1-Ig

antibody from Proteintech Group

Targeting: TRIM25 EFP, RNF147, ZNF147

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67314-1-Ig

Provider

Proteintech Group

Product name

TRIM25 antibody

Antibody type

Monoclonal

Description

TRIM25 antibody (Cat. #67314-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1H6G1

Vial size

20ul, 150ul

References

Submitted references

Solasonine inhibits NSCLC malignant progression by regulating SLC7A11 ubiquitination degradation and inducing ferroptosis.

Wang Y, Li X, Zhou C, Qian M, Zou Z, Yang W, Wilfred NSJ, Huang G, Xu X, Xue F, Jin M
Respiratory research 2026 Jan 28;27(1):90

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Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC.

Lv S, Zhang J, Peng X, Liu H, Chu T, Liu Z, Duan K, Guo J, Wang J, Liu Y, Wei F
Theranostics 2025;15(18):9922-9943

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Acetylation-dependent USP7-TRIM25 axis drives oncogenic progression in non-small cell lung cancer.

Yang J, Chen Z, Hu W, Zeng W, Lei Z, Tong X, Li Q, Luo G, Hu K, Chen Z, Liu Z, Li C, Xu C, Ding C, Zhang HT, Zhao J
Cell death & disease 2025 Oct 6;16(1):695

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Obacunone ameliorates high-fat diet-induced MAFLD by regulating the PPARγ-FABP1/CD36 axis and the gut-liver crosstalk.

Wang X, Hong J, Liang R, Bao S, Li L, Wang J, Feng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157180

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TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis.

Xue C, Wei Q, Li M, Wei J, Zheng L, Wu Z, Xin H, Duan Y, Fan S, Xiong W, Li G, Tang F, Deng H, Zhou M
Cell death & disease 2025 Nov 28;16(1):872

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Destruction of VISTA by TRIM25 ablation in T cells potentiates cancer immunotherapy.

Sun Y, Zhang Z, Li H, Bu X, Chen L, Wang X, Fan L, Chen B, Kong L, Dai P, Song W, Xiao X, Shi J, Xiang B, He C, Yao Y, Xiong W, Yu H, Jiang C, Qian Q, Liu H, Tian S, Qing G, Yang Z, Wei W, Freeman GJ, Zhu H, Zhang J
Cell research 2025 Dec;35(12):1003-1020

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BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity.

Lai Y, Yang X, Wei D, Wang X, Sun R, Li Y, Ji P, Bao Y, Chu T, Zhang C, Liang Q, Xu J, Zhang X, Chen Y, Wang Y
Cell reports 2025 Apr 22;44(4):115493

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Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis.

Liu Z, Wang K, Jiang C, Chen Y, Liu F, Xie M, Yim WY, Yao D, Qian X, Chen S, Shi J, Xu K, Wang Y, Dong N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(20):e2307319

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Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis.

Yan Y, Zhou S, Chen X, Yi Q, Feng S, Zhao Z, Liu Y, Liang Q, Xu Z, Li Z, Sun L
Signal transduction and targeted therapy 2024 Mar 4;9(1):58

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Degradation of AZGP1 suppresses apoptosis and facilitates cholangiocarcinoma tumorigenesis via TRIM25.

Yun H, Jeong HR, Kim DY, You JE, Lee JU, Kang DH, Koh DI, Ryu YS, Bae S, Jin DH
Journal of cellular and molecular medicine 2024 Feb;28(3):e18104

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TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.

Wei J, Wang L, Zhang Y, Sun T, Zhang C, Hu Z, Zhou L, Liu X, Wan J, Ma L
Oncogene 2023 Jun;42(26):2103-2112

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Tripartite motif-containing 25 facilitates immunosuppression and inhibits apoptosis of glioma via activating NF-κB.

Ge MX, Shi YK, Liu D
Experimental biology and medicine (Maywood, N.J.) 2022 Sep;247(17):1529-1541

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TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability.

Zhou S, Peng J, Xiao L, Zhou C, Fang Y, Ou Q, Qin J, Liu M, Pan Z, Hou Z
Cell death & disease 2021 May 8;12(5):463

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RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination.

Yang Z, Wang J, He B, Zhang X, Li X, Kuang E
eLife 2021 Jul 27;10