15552-1-AP

antibody from Proteintech Group

Targeting: PNPO PDXPO

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

15552-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#15552-1-AP, RRID:AB_2165814

Product name

PNPO antibody

Antibody type

Polyclonal

Description

PNPO antibody (Cat. #15552-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol-Inspired Approach.

Yu T, Wang C, Xie J, Wei Y, Cui H, Zhang H, Zhou F, Deng Z, Yang Y, Gu C
Basic & clinical pharmacology & toxicology 2026 May;138(5):e70227

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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8(+) T cells.

Wu J, Li G, Zhou J, Sun X, Wang H, Gong H, Jiang P
Developmental cell 2026 Mar 11;61(3):589-604.e7

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Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states.

Okada J, Landgraf A, Xiaoli AM, Liu L, Horton M, Schuster VL, Yang F, Sidoli S, Qiu Y, Kurland IJ, Eliscovich C, Shinoda K, Pessin JE
Nature metabolism 2025 May;7(5):1073-1091

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PNPO-Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β-Catenin Pathway.

Deng Z, Sun S, Zhou N, Peng Y, Cheng L, Yu X, Yuan Y, Guo M, Xu M, Cheng Y, Zhou F, Li N, Yang Y, Gu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407681

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Targeting PNPO to suppress tumor growth via inhibiting autophagic flux and to reverse paclitaxel resistance in ovarian cancer.

Li X, Guan W, Liu H, Yuan J, Wang F, Guan B, Chen J, Lu Q, Zhang L, Xu G
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1546-1563

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PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity.

Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H
Nature metabolism 2024 Jun;6(6):1108-1127

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Patient mutations in DRP1 perturb synaptic maturation of cortical neurons.

Baum TB, Bodnya C, Costanzo J, Gama V
bioRxiv : the preprint server for biology 2024 Aug 26;

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Prognostic Implication and Oncogenic Role of PNPO in Pan-Cancer.

Zhang L, Li X, Zhang J, Xu G
Frontiers in cell and developmental biology 2021;9:763674

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

MCF7 cells were subjected to SDS PAGE followed by western blot with 15552-1-AP(PNPO antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using PNPO antibody 15552-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver using 15552-1-AP(PNPO antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver using 15552-1-AP(PNPO antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue