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- Antibody Data
- Antigen structure
- References [119]
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- Product number
- 25055-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- NR1H4 antibody
- Antibody type
- Polyclonal
- Description
- NR1H4 antibody (Cat. #25055-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways.
Metabolomics identifies chenodeoxycholic acid as a protective factor in diabetic foot ulcers.
Fermented grape pomace alleviates Salmonella typhimurium-induced Hepatointestinal inflammation: FXR mediates protection by orchestrating bile acid homeostasis and suppressing the colonic NLRP3 Inflammasome.
Microcystin-LR Disrupts Bile Acid Homeostasis, Driving Cholestatic Liver Injury and Gallstones via FXR/SHP Antagonism.
FXR overexpression promotes liver regeneration through inducing FGF2 activation in APAP-induced acute liver injury.
Hexafluoropropylene oxide trimer acid (HFPO-TA) exposure predisposes to MASLD through reprogramming hepatic epigenome and transcriptome.
Taurochenodeoxycholic Acid Activates Calcium Signaling to Protect Against Fuchs' Endothelial Corneal Dystrophy.
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
Compound probiotics alleviate Escherichia coli-induced diarrhea in calves by modulating tryptophan and bile acid metabolism of the fecal microbiota.
Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling.
FXR overexpression restores NLRP3-mediated mitophagy and improves mitochondrial dysfunction in alcoholic liver disease.
Cordyceps cicadae polysaccharides ameliorate ulcerative colitis by modulating the gut microbiota and regulating the bile acid/FXR/NF-κB signaling pathway.
Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2-NETs-Mediated Liver-Bile Barrier Damage.
Vitamin D(3) Metabolite-Enhanced Hepatic VDR-FXR Binding Attenuates Bile Acid Dysregulation-Induced Diarrhea in Weaned Piglets.
Effects and mechanisms of nobiletin on gut motility by coordinating bile acid signaling via dual ileal-colonic axes in STC model mice.
Deficiency of Epithelial PIEZO1 Alleviates Liver Steatosis Induced by High-Fat Diet in Mice.
Unveiling the Therapeutic Potential of Suyin Detoxification Prescription in Diabetic Nephropathy: A Comprehensive Study Integrating Clinical Efficacy, Network Pharmacology, and Molecular Mechanisms.
Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model.
L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
Natural small molecule hinokitone mitigates NASH fibrosis by targeting regulation of FXR-mediated hepatocyte apoptosis.
Disruption of Bile Acid Metabolism in the Gut-Liver Axis Predisposes Mice to Inflammatory Bowel Disease.
FXR overexpression alleviates cholestasis via NLRC4 inflammasome suppression and bile acid homeostasis regulation.
Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis.
TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.
Microbiota-derived secondary bile acids promote STING activation and antitumor activity.
Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by attenuating the malignancy of cancer stem cells via the gut microbiota-bile acid-FXR axis.
3-O-Acetyloleanolic acid alleviates autoimmune liver injury by targeting FXR.
Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe.
Salidroside attenuates NASH through regulating bile acid-FXR/TGR5 signaling pathway via targeting gut microbiota.
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Schisandra chinensis lignans ameliorate hepatic inflammation and steatosis in methionine choline-deficient diet-fed mice by modulating the gut-liver axis.
Gut microbiota-mediated bile acid transformations regulate the transport of aflatoxin B1 from the intestine to the liver in piglets.
Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism.
Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway.
Psoraleae Fructus affects the livers of normal and ulcerative colitis rats differently by altering bile acid metabolism.
Nuclear receptor FXR inhibits ferroptosis to alleviate hepatic ischemia-reperfusion injury by targeting GPX4 in a mouse model.
IGFBP1 orchestrates metabolic reprogramming to drive clear cell renal cell carcinoma progression through NR1H4-mediated lipid homeostasis disruption.
FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis.
Salvianolic acid B attenuates hypercholesterolemia via modulating the gut microbiota and bile acid metabolism.
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress.
Uncovering the pharmacological mechanism and the main herbal medicine contributing to the efficacy of Xiaoyanlidan Tablet (XYLDT) in treating cholestatic liver injury.
Simiao Wan attenuates high-fat diet-induced hyperlipidemia in mice by modulating the gut microbiota-bile acid axis.
Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers.
Dual GIP and GLP-1 receptor agonist tirzepatide alleviates hepatic steatosis and modulates gut microbiota and bile acid metabolism in diabetic mice.
Discovery of Fluorescent Probe ABDS-2 for Farnesoid X Receptor Modulator Characterization and Cell-Based Imaging.
Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1/FXR and Keap1/Nrf2 signaling pathways.
7-Ketolithocholic Acid Exerts Anti-Renal Fibrotic Effects Through FXR-Mediated Inhibition of TGF-β/Smad and Wnt/β-Catenin Pathways.
Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota.
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Age-Independent Hypocholesterolemic Effects of Rice Protein via FXR-Mediated Stimulation of Cholesterol Elimination.
Hepatocyte-Enriched miRNA-193b-3p Promotes Hepatitis B Virus Replication by Dual Activation of Viral Core Promoter Activity and Autophagy Induction by Targeting IGF-1R.
Multiomics combined analysis reveals protective effect of 7-O-α-L-rhamnopyranosyl-kaempferol-3-O-β-D-glucopyranoside on autoimmune hepatitis.
Activation of gut FXR improves the metabolism of bile acids, intestinal barrier, and microbiota under cholestatic condition caused by GCDCA in mice.
Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to Upregulate CYPs and miR-19a-3p to Ameliorate Drug-Induced Liver Injury.
Nobiletin Enhances Skeletal Muscle Mass and Modulates Bile Acid Composition in Diet-Induced Obese Mice.
Ramulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism.
Lingguizhugan oral solution alleviates MASLD by regulating bile acids metabolism and the gut microbiota through activating FXR/TGR5 signaling pathways.
Hyodeoxycholic acid inhibits colorectal cancer proliferation through the FXR/EREG/EGFR axis.
Protective effects and mechanism of Sangyu granule on acetaminophen-induced liver injury in mice.
Abelmoschi Corolla polysaccharides and related metabolite ameliorates colitis via modulating gut microbiota and regulating the FXR/STAT3 signaling pathway.
A Mix of Probiotic Strains Prevents Hepatic Steatosis, and Improves Oxidative Stress Status and Gut Microbiota Composition in Obese Mice.
VSV infection and LPS treatment alter serum bile acid profiles, bile acid biosynthesis, and bile acid receptors in mice.
FXR deficiency induced ferroptosis via modulation of the CBP-dependent p53 acetylation to suppress breast cancer growth and metastasis.
Identification of 18β-glycyrrhetinic acid as an AGT inhibitor against LPS-induced myocardial dysfunction via high throughput screening.
Neoagarotetraose Alleviates Atherosclerosis via Modulating Cholesterol and Bile Acid Metabolism in ApoE(-/-) Mice.
Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes.
Lactiplantibacillus plantarum ATCC8014 Alleviates Postmenopausal Hypercholesterolemia in Mice by Remodeling Intestinal Microbiota to Increase Secondary Bile Acid Excretion.
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis.
Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats.
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling.
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells.
Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis.
A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage.
New finding based on Comparative Toxicogenomics Database: Hepatic YY1 mediates drug-induced liver injury.
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification.
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity.
Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner.
Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway.
Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis.
Fucogalactan Sulfate (FS) from Laminaria japonica Regulates Lipid Metabolism in Diet-Induced Humanized Dyslipidemia Mice via an Intestinal FXR-FGF19-CYP7A1/CYP8B1 Pathway.
Bisphenol A induced hepatic steatosis by disturbing bile acid metabolism and FXR/TGR5 signaling pathways via remodeling the gut microbiota in CD-1 mice.
HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis.
Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia.
Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice.
Jiang-Tang-San-Huang pill alleviates type 2 diabetes mellitus through modulating the gut microbiota and bile acids metabolism.
Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling.
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.
Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.
The choleretic role of tauroursodeoxycholic acid exacerbates alpha-naphthylisothiocyanate induced cholestatic liver injury through the FXR/BSEP pathway.
Hepatic Clstn3 Ameliorates Lipid Metabolism Disorders in High Fat Diet-Induced NAFLD through Activation of FXR.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Impaired FXR-CPT1a signaling contributes to parenteral nutrition-induced villus atrophy in short-bowel syndrome.
Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.
Taurocholic Acid and Glycocholic Acid Inhibit Inflammation and Activate Farnesoid X Receptor Expression in LPS-Stimulated Zebrafish and Macrophages.
Sodium cholate ameliorates nonalcoholic steatohepatitis by activation of FXR signaling.
Restraint stress promotes nonalcoholic steatohepatitis by regulating the farnesoid X receptor/NLRP3 signaling pathway.
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Hepatoprotective Effects of Glycyrrhetinic Acid on Lithocholic Acid-Induced Cholestatic Liver Injury Through Choleretic and Anti-Inflammatory Mechanisms.
Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress.
Theacrine ameliorates experimental liver fibrosis in rats by lowering cholesterol storage via activation of the Sirtuin 3-farnesoid X receptor signaling pathway.
Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics.
Lignans from the seeds of Herpetospermum pedunculosum and their farnesoid X receptor-activating effect.
The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice via mediating the FXR/LXRα pathway.
Gut microbiota mediates methamphetamine-induced hepatic inflammation via the impairment of bile acid homeostasis.
FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice.
Mesenchymal stem cell-derived exosome mitigates colitis via the modulation of the gut metagenomics-metabolomics-farnesoid X receptor axis.
Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway.
DMRT2 Interacts With FXR and Improves Insulin Resistance in Adipocytes and a Mouse Model.
Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism.
Probiotic-fermented black tartary buckwheat alleviates hyperlipidemia and gut microbiota dysbiosis in rats fed with a high-fat diet.
The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines.
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zhang Y, Lan H, Yu X, Zhuo L, Zhao B, Liu F, An L, Zhang F, Liu Z, Wang C
International journal of biological sciences 2026;22(1):387-409
International journal of biological sciences 2026;22(1):387-409
Metabolomics identifies chenodeoxycholic acid as a protective factor in diabetic foot ulcers.
Li Y, Guo R, Lv L, Jiang T, Zhang C, Chang J, Hu K, Peng H, Chen L, Chen R, Chen H, Ma Y
Frontiers in endocrinology 2026;17:1754743
Frontiers in endocrinology 2026;17:1754743
Fermented grape pomace alleviates Salmonella typhimurium-induced Hepatointestinal inflammation: FXR mediates protection by orchestrating bile acid homeostasis and suppressing the colonic NLRP3 Inflammasome.
Zhang J, Jiang D, Zhang X, Yang Y, Wu Z
Food research international (Ottawa, Ont.) 2026 May 1;231(Pt 2):118797
Food research international (Ottawa, Ont.) 2026 May 1;231(Pt 2):118797
Microcystin-LR Disrupts Bile Acid Homeostasis, Driving Cholestatic Liver Injury and Gallstones via FXR/SHP Antagonism.
He J, Xu WL, Chen F, Chen J, Xie P
Environmental science & technology 2026 Mar 31;60(12):8958-8970
Environmental science & technology 2026 Mar 31;60(12):8958-8970
FXR overexpression promotes liver regeneration through inducing FGF2 activation in APAP-induced acute liver injury.
Wang R, Chen J, Wang W, Li X, Xiao Y, Shi Y, Qv Y, Wang C, Fu T, Meng Q
Hepatology international 2026 Mar 29;
Hepatology international 2026 Mar 29;
Hexafluoropropylene oxide trimer acid (HFPO-TA) exposure predisposes to MASLD through reprogramming hepatic epigenome and transcriptome.
Yu J, Guo M, Zhou Q, Xue L, Wang W, Wu X, Qin Y, Gu W, Du G
Ecotoxicology and environmental safety 2026 Mar 1;312:119940
Ecotoxicology and environmental safety 2026 Mar 1;312:119940
Taurochenodeoxycholic Acid Activates Calcium Signaling to Protect Against Fuchs' Endothelial Corneal Dystrophy.
Qiao Y, Zhao C, Yao S, Dou S, Li X, Wang Q, Zhou Q
Investigative ophthalmology & visual science 2026 Feb 2;67(2):16
Investigative ophthalmology & visual science 2026 Feb 2;67(2):16
Metagenomics and Machine Learning Identify TMA-Producing Serratia Induced by High-Fat/Choline Diet: A Novel Obesity Target for TMA.
Wang Z, Wei J, Huang Z, Liu X, Li S, Fang Z, Hu L, Li R, Tao L, Li C, Chen H
Nutrients 2026 Feb 17;18(4)
Nutrients 2026 Feb 17;18(4)
Compound probiotics alleviate Escherichia coli-induced diarrhea in calves by modulating tryptophan and bile acid metabolism of the fecal microbiota.
Zhong J, Tang J, Han L, Wang W, Zhang X, Zhang S
Virulence 2026 Dec;17(1):2629106
Virulence 2026 Dec;17(1):2629106
Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling.
Lin J, Zeng X, Su Z, Li X, Yu Y, Qian S, Hou Q, Duan W, Wang Z, Liu C, Zhang J, Huang C, Liao L
Journal of advanced research 2026 Apr;82:881-900
Journal of advanced research 2026 Apr;82:881-900
FXR overexpression restores NLRP3-mediated mitophagy and improves mitochondrial dysfunction in alcoholic liver disease.
Chen J, Wang W, Li X, Wang R, Xiao Y, Wang C, Wang C, Dong R, Hao L, Meng Q
Free radical biology & medicine 2026 Apr;247:173-186
Free radical biology & medicine 2026 Apr;247:173-186
Cordyceps cicadae polysaccharides ameliorate ulcerative colitis by modulating the gut microbiota and regulating the bile acid/FXR/NF-κB signaling pathway.
Zhou S, Su F, Gao Q, Wang M, Duan J, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158007
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158007
Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2-NETs-Mediated Liver-Bile Barrier Damage.
Shi C, Feng S, Liu T, Meng Z, Zheng Y, Huang Z, Wang T, Zhang B, Xue D, Ma B, Meng X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(24):e19500
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(24):e19500
Vitamin D(3) Metabolite-Enhanced Hepatic VDR-FXR Binding Attenuates Bile Acid Dysregulation-Induced Diarrhea in Weaned Piglets.
He L, Wu J, Wang Y, Jiao Y, Zhang F, Lin Z, Liu Q, Feng Y
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12069-12086
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12069-12086
Effects and mechanisms of nobiletin on gut motility by coordinating bile acid signaling via dual ileal-colonic axes in STC model mice.
Wang D, Zhu H, Zhou H, Li X, Zhao B, Zhu Y, Chu Y, Han Q
The Journal of nutritional biochemistry 2026 Apr 15;155:110385
The Journal of nutritional biochemistry 2026 Apr 15;155:110385
Deficiency of Epithelial PIEZO1 Alleviates Liver Steatosis Induced by High-Fat Diet in Mice.
Xu Z, Xu S, Liu X, Cheng L, Liu X, Xie X, Zhou D, Wang D, Chen J, Deng X, Zhang L, He R, Li Y, Cheng M, Yang L, Hou X, Bai T
International journal of biological sciences 2025;21(2):745-757
International journal of biological sciences 2025;21(2):745-757
Unveiling the Therapeutic Potential of Suyin Detoxification Prescription in Diabetic Nephropathy: A Comprehensive Study Integrating Clinical Efficacy, Network Pharmacology, and Molecular Mechanisms.
Wei T, Huang J, Wan B, Huang B, Cheng J, Shi C, Yong C, Li Y, Zhou E
Journal of diabetes research 2025;2025:e4566357
Journal of diabetes research 2025;2025:e4566357
Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model.
Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z
Drug design, development and therapy 2025;19:3611-3630
Drug design, development and therapy 2025;19:3611-3630
L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
Huang L, Li H, Yang W, Huang L, Chen Q, Li S, Zou Z, Zhao L, Zeng Z
Journal of microbiology and biotechnology 2025 Sep 22;35:e2504017
Journal of microbiology and biotechnology 2025 Sep 22;35:e2504017
Natural small molecule hinokitone mitigates NASH fibrosis by targeting regulation of FXR-mediated hepatocyte apoptosis.
Ma ZJ, Qiu YK, Yu ZW, Song TT, Hu YT, Peng AK, Qi R
Journal of advanced research 2025 Oct;76:553-568
Journal of advanced research 2025 Oct;76:553-568
Disruption of Bile Acid Metabolism in the Gut-Liver Axis Predisposes Mice to Inflammatory Bowel Disease.
Chang H, Jiang Y, Zhao Q, Su Z, Chen M, He Q, Lai J, Jiang Y, Zheng J, Pan R, Shao J, Zhao RC, Chen Y
MedComm 2025 Oct;6(10):e70429
MedComm 2025 Oct;6(10):e70429
FXR overexpression alleviates cholestasis via NLRC4 inflammasome suppression and bile acid homeostasis regulation.
Wang W, Li L, Li X, Chen J, Wang R, Yang Q, Qu Y, Wang C, Fu T, Meng Q
Free radical biology & medicine 2025 Oct;238:152-168
Free radical biology & medicine 2025 Oct;238:152-168
Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis.
Chen J, Zhang L, Chen Y, Yan Y, Lu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157108
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157108
TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.
Chen X, Zhou Q, He Y, Wang Y, Jiang Y, Ren Y, Ren Y, Cai J, Yu H, Chen C, Cheng K, Xie P
Translational psychiatry 2025 Oct 6;15(1):366
Translational psychiatry 2025 Oct 6;15(1):366
Microbiota-derived secondary bile acids promote STING activation and antitumor activity.
Yang X, Zhang X, Li W, Gharpure A, Hansel-Harris A, Tillack AF, Wu C, Hsieh YZ, Sulpizio A, Fam KT, Dikiy S, Zhao X, Forli S, Lairson LL, Ward A, Parker CG, Hang HC
bioRxiv : the preprint server for biology 2025 Oct 23;
bioRxiv : the preprint server for biology 2025 Oct 23;
Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by attenuating the malignancy of cancer stem cells via the gut microbiota-bile acid-FXR axis.
Zhang Y, Shen M, Baokan J, Xu L, Ni M, Jin J, Shen W, Sun D, Li L, Lai Y, Yan Q, Yu C, Tan J, Xu C, Tao L, Fan M, Cheng H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157366
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157366
3-O-Acetyloleanolic acid alleviates autoimmune liver injury by targeting FXR.
Wang Y, Li Z, Xiao W, Yongbo X, Li Y, Li Z, Chen D, Feng Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157273
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157273
Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe.
Niu D, Wu X, Zhang Y, Wang X, Shiu-Hin Chan D, Jing S, Wong CY, Wang W, Leung CH
Journal of advanced research 2025 May;71:307-316
Journal of advanced research 2025 May;71:307-316
Salidroside attenuates NASH through regulating bile acid-FXR/TGR5 signaling pathway via targeting gut microbiota.
Zhang J, Zhou J, He Z, Xia Z, Liu H, Wu Y, Chen S, Wu B, Li H
International journal of biological macromolecules 2025 May;307(Pt 4):142276
International journal of biological macromolecules 2025 May;307(Pt 4):142276
Human umbilical cord mesenchymal stem cell-derived exosomes repair IBD by activating the SIRT1-FXR pathway in macrophages.
Zhou M, Pei B, Cai P, Yi C, Akanyibah FA, Lyu C, Mao F
Stem cell research & therapy 2025 May 9;16(1):233
Stem cell research & therapy 2025 May 9;16(1):233
Schisandra chinensis lignans ameliorate hepatic inflammation and steatosis in methionine choline-deficient diet-fed mice by modulating the gut-liver axis.
Yan LS, Kang JY, Gu CY, Qiu XY, Li JJ, Cheng BC, Wang YW, Luo G, Zhang Y
Journal of ethnopharmacology 2025 May 28;348:119801
Journal of ethnopharmacology 2025 May 28;348:119801
Gut microbiota-mediated bile acid transformations regulate the transport of aflatoxin B1 from the intestine to the liver in piglets.
Mao J, Wei Y, Ni Z, Zhang J, Zhu J, Wang H
Journal of animal science and biotechnology 2025 Mar 8;16(1):38
Journal of animal science and biotechnology 2025 Mar 8;16(1):38
Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism.
Bai X, Duan Z, Deng J, Zhang Z, Fu R, Zhu C, Fan D
Journal of advanced research 2025 Jun;72:37-52
Journal of advanced research 2025 Jun;72:37-52
Yinchenhao Decoction Mitigates Cholestatic Liver Injury in Mice via Gut Microbiota Regulation and Activation of FXR-FGF15 Pathway.
Li W, Huang D, Luo Z, Zhou T, Jin Z
Pharmaceuticals (Basel, Switzerland) 2025 Jun 20;18(7)
Pharmaceuticals (Basel, Switzerland) 2025 Jun 20;18(7)
Psoraleae Fructus affects the livers of normal and ulcerative colitis rats differently by altering bile acid metabolism.
Liu X, Zhao Y, Liu C, Li C, Yi Y, Liu S, Tang X, Pan C, Zhang Y, Tian J, Han J, Yue X, Liang A
Journal of ethnopharmacology 2025 Jun 12;349:119849
Journal of ethnopharmacology 2025 Jun 12;349:119849
Nuclear receptor FXR inhibits ferroptosis to alleviate hepatic ischemia-reperfusion injury by targeting GPX4 in a mouse model.
Chen M, Guo S, Huang X, Mo Q, Chen Q, Zhang S, Zhang Y, Liu C
Journal of molecular histology 2025 Jul 31;56(4):243
Journal of molecular histology 2025 Jul 31;56(4):243
IGFBP1 orchestrates metabolic reprogramming to drive clear cell renal cell carcinoma progression through NR1H4-mediated lipid homeostasis disruption.
Sun Y, Hao Y, Peng F, Ling H, Sun K, Qiu J, Yang T, Zhao L, Xia Q
Cancer cell international 2025 Jul 28;25(1):284
Cancer cell international 2025 Jul 28;25(1):284
FXR acts as a therapeutic target for ulcerative colitis via suppressing ferroptosis.
Zhao C, Li X, Mu M, Quan L, Yuan H, Zheng J, Zhao W, Sun X, Yu J
Molecular medicine (Cambridge, Mass.) 2025 Jul 18;31(1):258
Molecular medicine (Cambridge, Mass.) 2025 Jul 18;31(1):258
Salvianolic acid B attenuates hypercholesterolemia via modulating the gut microbiota and bile acid metabolism.
Meng X, Chen Y, Zhao B, Liu Q, Zhao L, Zheng X, Feng W
European journal of pharmacology 2025 Jul 15;999:177701
European journal of pharmacology 2025 Jul 15;999:177701
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress.
Song L, Hou Y, Xu D, Dai X, Luo J, Liu Y, Huang Z, Yang M, Chen J, Hu Y, Chen C, Tang Y, Rao Z, Ma J, Zheng M, Shi K, Cai C, Lu M, Tang R, Ma X, Xie C, Luo Y, Li X, Huang Z
Cell metabolism 2025 Jan 7;37(1):104-120.e9
Cell metabolism 2025 Jan 7;37(1):104-120.e9
Uncovering the pharmacological mechanism and the main herbal medicine contributing to the efficacy of Xiaoyanlidan Tablet (XYLDT) in treating cholestatic liver injury.
Wu Z, Shi J, Zhang Y, Shi R, Guo Q, Zhang J, Lu B, Huang Z, Ji L
Journal of ethnopharmacology 2025 Jan 31;340:119163
Journal of ethnopharmacology 2025 Jan 31;340:119163
Simiao Wan attenuates high-fat diet-induced hyperlipidemia in mice by modulating the gut microbiota-bile acid axis.
Wang K, Xu W, He W, Ding M, Xia T, Tan X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118868
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118868
Targeting UGT2B15 and NR1H4 interaction: a novel therapeutic strategy for polycystic ovary syndrome using naftopidil enantiomers.
Zheng X, Chen Z, Liang M, Zhou L, Wang M, Zhang S, Zhang S, Ma L, Yi W, Liu X
Journal of ovarian research 2025 Jan 24;18(1):13
Journal of ovarian research 2025 Jan 24;18(1):13
Dual GIP and GLP-1 receptor agonist tirzepatide alleviates hepatic steatosis and modulates gut microbiota and bile acid metabolism in diabetic mice.
Hu W, Gong W, Yang F, Cheng R, Zhang G, Gan L, Zhu Y, Qin W, Gao Y, Li X, Liu J
International immunopharmacology 2025 Feb 6;147:113937
International immunopharmacology 2025 Feb 6;147:113937
Discovery of Fluorescent Probe ABDS-2 for Farnesoid X Receptor Modulator Characterization and Cell-Based Imaging.
Qiu X, Li W, Li X, Wu B, Dai M, Xia Y, Zhang G, Bian Y, Chen J, Wu K, Lu Y, Tang M, Lin H, Shang J
Analytical chemistry 2025 Feb 4;97(4):2019-2027
Analytical chemistry 2025 Feb 4;97(4):2019-2027
Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1/FXR and Keap1/Nrf2 signaling pathways.
Bayoude A, Zhang J, Shen Y, Tilyek A, Chai C
Journal of ethnopharmacology 2025 Feb 27;342:119400
Journal of ethnopharmacology 2025 Feb 27;342:119400
7-Ketolithocholic Acid Exerts Anti-Renal Fibrotic Effects Through FXR-Mediated Inhibition of TGF-β/Smad and Wnt/β-Catenin Pathways.
Guo Q, Peng L, Zhang J, Hu J, Wang Y, Wei J, Zhang Z
Pharmaceuticals (Basel, Switzerland) 2025 Dec 21;19(1)
Pharmaceuticals (Basel, Switzerland) 2025 Dec 21;19(1)
Ileal FXR Knockdown Ameliorates MASLD Progression in Rats via Modulating Bile Acid Metabolism Mediated by Gut Microbiota.
Wang J, Gao J, Zhang Q, Lu J, Yang Y, Cai X, Dong H, Lu L
Journal of gastroenterology and hepatology 2025 Aug;40(8):2091-2103
Journal of gastroenterology and hepatology 2025 Aug;40(8):2091-2103
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.
Li J, Wang M, Qu K, Sun Y, Yin Z, Dong N, Sun X, Xu Y, Chen L, Zhang S, Xian X, Xu S, Ma L, Duan Y, Zhu H
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063
Age-Independent Hypocholesterolemic Effects of Rice Protein via FXR-Mediated Stimulation of Cholesterol Elimination.
Liu B, Wang Z, Liang M, Yang L
Food science & nutrition 2025 Aug;13(8):e70687
Food science & nutrition 2025 Aug;13(8):e70687
Hepatocyte-Enriched miRNA-193b-3p Promotes Hepatitis B Virus Replication by Dual Activation of Viral Core Promoter Activity and Autophagy Induction by Targeting IGF-1R.
Deng Y, Zheng J, Li F, Zou H, Tian S, Zhao Z, Zeng H, Zhai Y, Deng W, Zhang J, Lu M, Jia B, Lin Y
Journal of medical virology 2025 Apr;97(4):e70330
Journal of medical virology 2025 Apr;97(4):e70330
Multiomics combined analysis reveals protective effect of 7-O-α-L-rhamnopyranosyl-kaempferol-3-O-β-D-glucopyranoside on autoimmune hepatitis.
Xiao W, Li Z, Wang Y, Yongbo X, Li W, Li J, He M, Feng Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156460
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156460
Activation of gut FXR improves the metabolism of bile acids, intestinal barrier, and microbiota under cholestatic condition caused by GCDCA in mice.
Xie X-M, Zhang B-Y, Feng S, Fan Z-J, Wang G-Y
Microbiology spectrum 2025 Apr;13(4):e0315024
Microbiology spectrum 2025 Apr;13(4):e0315024
Geniposidic Acid Targeting FXR "S332 and H447" Mediated Conformational Change to Upregulate CYPs and miR-19a-3p to Ameliorate Drug-Induced Liver Injury.
Fan M, Xu Y, Wu B, Long J, Liu C, Liang Z, Zhang R, Liu Z, Wang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2409107
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2409107
Nobiletin Enhances Skeletal Muscle Mass and Modulates Bile Acid Composition in Diet-Induced Obese Mice.
Koh YC, Liu CP, Leung SY, Lin WS, Ho PY, Ho CT, Pan MH
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9076-9087
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9076-9087
Ramulus Mori (Sangzhi) alkaloids ameliorate high-fat diet induced obesity in rats by modulating gut microbiota and bile acid metabolism.
Shang X, Fu Y, Wang Y, Yan S
Frontiers in endocrinology 2024;15:1506430
Frontiers in endocrinology 2024;15:1506430
Lingguizhugan oral solution alleviates MASLD by regulating bile acids metabolism and the gut microbiota through activating FXR/TGR5 signaling pathways.
Wang J, Zang J, Yu Y, Liu Y, Cao H, Guo R, Zhang L, Liu M, Zhang Z, Li X, Kong L
Frontiers in pharmacology 2024;15:1426049
Frontiers in pharmacology 2024;15:1426049
Hyodeoxycholic acid inhibits colorectal cancer proliferation through the FXR/EREG/EGFR axis.
Pang Q, Huang S, Li X, Cao J
Frontiers in cell and developmental biology 2024;12:1480998
Frontiers in cell and developmental biology 2024;12:1480998
Protective effects and mechanism of Sangyu granule on acetaminophen-induced liver injury in mice.
Xiao K, Li H, Li Y, Zhan B, Fang X, Zhao B, Zhang X, Wu Y, Wang F, Jia Y
Journal of ethnopharmacology 2024 Sep 15;331:118282
Journal of ethnopharmacology 2024 Sep 15;331:118282
Abelmoschi Corolla polysaccharides and related metabolite ameliorates colitis via modulating gut microbiota and regulating the FXR/STAT3 signaling pathway.
He L, Chen K, Chen Z, Chen C, Zhou J, Shao Y, Ma J, Qiu Z, Chen Y, Zhang W
International journal of biological macromolecules 2024 Oct;277(Pt 3):134370
International journal of biological macromolecules 2024 Oct;277(Pt 3):134370
A Mix of Probiotic Strains Prevents Hepatic Steatosis, and Improves Oxidative Stress Status and Gut Microbiota Composition in Obese Mice.
Guo C, He S, Le Barz M, Binda S, Wang H
Molecular nutrition & food research 2024 Nov;68(21):e2300672
Molecular nutrition & food research 2024 Nov;68(21):e2300672
VSV infection and LPS treatment alter serum bile acid profiles, bile acid biosynthesis, and bile acid receptors in mice.
Li Y, Luo Y, Wang C, Xu L, Dai X, An Y, He L, Zeng D, Bai Y, Zhang H
Microbiology spectrum 2024 Nov 5;12(11):e0083624
Microbiology spectrum 2024 Nov 5;12(11):e0083624
FXR deficiency induced ferroptosis via modulation of the CBP-dependent p53 acetylation to suppress breast cancer growth and metastasis.
Huang P, Zhao H, Dai H, Li J, Pan X, Pan W, Xia C, Liu F
Cell death & disease 2024 Nov 14;15(11):826
Cell death & disease 2024 Nov 14;15(11):826
Identification of 18β-glycyrrhetinic acid as an AGT inhibitor against LPS-induced myocardial dysfunction via high throughput screening.
Shi M, Zhang S, Rong J, Heng Z, Xu Y, Wang Y, Zhang Z
Biochemical pharmacology 2024 May;223:116127
Biochemical pharmacology 2024 May;223:116127
Neoagarotetraose Alleviates Atherosclerosis via Modulating Cholesterol and Bile Acid Metabolism in ApoE(-/-) Mice.
Li J, Yang S, Liu D, Yan Q, Guo H, Jiang Z
Nutrients 2024 May 16;16(10)
Nutrients 2024 May 16;16(10)
Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes.
Sun L, Wen L, Li Q, Chen R, Wen S, Lai X, Lai Z, Cao J, Zhang Z, Hao M, Cao F, Sun S
Nutrients 2024 Mar 28;16(7)
Nutrients 2024 Mar 28;16(7)
Lactiplantibacillus plantarum ATCC8014 Alleviates Postmenopausal Hypercholesterolemia in Mice by Remodeling Intestinal Microbiota to Increase Secondary Bile Acid Excretion.
Zhang S, Liu R, Ma Y, Ma Y, Feng H, Ding X, Zhang Q, Li Y, Shan J, Bian H, Zhu R, Meng Q
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6236-6249
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6236-6249
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Feng S, Xie X, Li J, Xu X, Chen C, Zou G, Lin G, Huang T, Hu R, Ran T, Han L, Zhang Q, Li Y, Zhao X
Hepatology international 2024 Jun;18(3):1040-1052
Hepatology international 2024 Jun;18(3):1040-1052
Postbiotics Prepared Using Lactobacillus reuteri Ameliorates Ethanol-Induced Liver Injury by Regulating the FXR/SHP/SREBP-1c Axis.
Liu C, Cai T, Cheng Y, Bai J, Li M, Gu B, Huang M, Fu W
Molecular nutrition & food research 2024 Jul;68(14):e2300927
Molecular nutrition & food research 2024 Jul;68(14):e2300927
Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats.
Guan L, Zhang L, Gong D, Li P, Zhu S, Tang J, Du M, Zhang M, Zou Y
The Journal of pharmacy and pharmacology 2024 Jul 5;76(7):897-907
The Journal of pharmacy and pharmacology 2024 Jul 5;76(7):897-907
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.
Li L, Xu S, Wang W, Li X, Wang H, Yang Q, Wang C, Gu J, Luo H, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693
Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling.
Sun DQ, Yuan F, Fu MZ, Zhong MY, Zhang SL, Lu Y, Targher G, Byrne CD, Zheng MH, Yuan WJ
Molecular metabolism 2024 Jan;79:101841
Molecular metabolism 2024 Jan;79:101841
Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.
Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930
FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.
Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205
Hepatology international 2024 Feb;18(1):188-205
Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells.
Liu CX, Gao Y, Xu XF, Jin X, Zhang Y, Xu Q, Ding HX, Li BJ, Du FK, Li LC, Zhong MW, Zhu JK, Zhang GY
World journal of gastroenterology 2024 Feb 7;30(5):485-498
World journal of gastroenterology 2024 Feb 7;30(5):485-498
Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis.
Lai J, Li F, Li H, Huang R, Ma F, Gu X, Cai Y, Huang D, Li S, Xiao S, Hao H
International immunopharmacology 2024 Feb 15;128:111360
International immunopharmacology 2024 Feb 15;128:111360
A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage.
Li T, Ding N, Guo H, Hua R, Lin Z, Tian H, Yu Y, Fan D, Yuan Z, Gonzalez FJ, Wu Y
Cell host & microbe 2024 Feb 14;32(2):191-208.e9
Cell host & microbe 2024 Feb 14;32(2):191-208.e9
New finding based on Comparative Toxicogenomics Database: Hepatic YY1 mediates drug-induced liver injury.
Zhao JQ, Sun Y, Yang LL, Long J, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156102
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156102
Jianwei Shoutai Pills alleviates miscarriage by modulating gut microbial production of BAs and NLRP3-inflammasome at the maternal-fetal interface of rats.
Chen S, Xue X, Zhang H, Huang X, Lin X, He J, Chen L, Luo S, Gao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156000
Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification.
Shen H, Zhou L, Zhang H, Yang Y, Jiang L, Wu D, Shu H, Zhang H, Xie L, Zhou K, Cheng C, Yang L, Jiang J, Wang S, Han Y, Zhu J, Xu L, Liu Z, Wang H, Yin S
Cell host & microbe 2024 Aug 14;32(8):1331-1346.e6
Cell host & microbe 2024 Aug 14;32(8):1331-1346.e6
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity.
Chen X, Wang L, Denning KL, Mazur A, Xu Y, Wang K, Lawrence LM, Wang X, Lu Y
Biomedicines 2024 Apr 30;12(5)
Biomedicines 2024 Apr 30;12(5)
Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner.
Huang W, Qian Y, Lin J, Wang F, Kong X, Tan W
Biochemical and biophysical research communications 2024 Apr 23;705:149670
Biochemical and biophysical research communications 2024 Apr 23;705:149670
Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway.
Sun X, Chen Z, Yu L, Zeng W, Sun B, Fan H, Bai Y
Frontiers in pharmacology 2023;14:1205323
Frontiers in pharmacology 2023;14:1205323
Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis.
Dai Y, Jia Z, Fang C, Zhu M, Yan X, Zhang Y, Wu H, Feng M, Liu L, Huang B, Li Y, Liu J, Xiao H
Frontiers in pharmacology 2023;14:1099935
Frontiers in pharmacology 2023;14:1099935
Fucogalactan Sulfate (FS) from Laminaria japonica Regulates Lipid Metabolism in Diet-Induced Humanized Dyslipidemia Mice via an Intestinal FXR-FGF19-CYP7A1/CYP8B1 Pathway.
Song J, Lu X, Liu D, Zhang Y, Zhai X, Zhou L, Gao J
Journal of agricultural and food chemistry 2023 Sep 27;71(38):14027-14037
Journal of agricultural and food chemistry 2023 Sep 27;71(38):14027-14037
Bisphenol A induced hepatic steatosis by disturbing bile acid metabolism and FXR/TGR5 signaling pathways via remodeling the gut microbiota in CD-1 mice.
Hong T, Zou J, He Y, Zhang H, Liu H, Mai H, Yang J, Cao Z, Chen X, Yao J, Feng D
The Science of the total environment 2023 Sep 1;889:164307
The Science of the total environment 2023 Sep 1;889:164307
HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis.
Fu J, Liang Y, Shi Y, Yu D, Wang Y, Chen P, Liu S, Lu F
Heliyon 2023 Nov;9(11):e21935
Heliyon 2023 Nov;9(11):e21935
Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia.
Xu H, Fang F, Wu K, Song J, Li Y, Lu X, Liu J, Zhou L, Yu W, Yu F, Gao J
Microbiome 2023 Nov 25;11(1):262
Microbiome 2023 Nov 25;11(1):262
Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice.
Xu Z, Tang W, Xie Q, Cao X, Zhang M, Zhang X, Chai J
Experimental cell research 2023 Nov 15;432(2):113781
Experimental cell research 2023 Nov 15;432(2):113781
Jiang-Tang-San-Huang pill alleviates type 2 diabetes mellitus through modulating the gut microbiota and bile acids metabolism.
Tawulie D, Jin L, Shang X, Li Y, Sun L, Xie H, Zhao J, Liao J, Zhu Z, Cui H, Wen W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154733
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154733
Dietary Isoquercetin Reduces Hepatic Cholesterol and Triglyceride in NAFLD Mice by Modulating Bile Acid Metabolism via Intestinal FXR-FGF15 Signaling.
Zhang C, Shi Z, Lei H, Wu F, Chen C, Cao Z, Song Y, Zhang C, Zhou J, Lu Y, Zhang L
Journal of agricultural and food chemistry 2023 May 24;71(20):7723-7733
Journal of agricultural and food chemistry 2023 May 24;71(20):7723-7733
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling.
Xie Y, Shen F, He Y, Guo C, Yang R, Cao H, Pan Q, Fan J
Nutrients 2023 Mar 2;15(5)
Nutrients 2023 Mar 2;15(5)
Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.
Zhang X, Yun Y, Lai Z, Ji S, Yu G, Xie Z, Zhang H, Zhong X, Wang T, Zhang L
Journal of animal science and biotechnology 2023 Mar 13;14(1):36
Journal of animal science and biotechnology 2023 Mar 13;14(1):36
Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.
Shi W, Le W, Tang Q, Shi S, Shi J
BMC nephrology 2023 Jun 19;24(1):180
BMC nephrology 2023 Jun 19;24(1):180
The choleretic role of tauroursodeoxycholic acid exacerbates alpha-naphthylisothiocyanate induced cholestatic liver injury through the FXR/BSEP pathway.
Zhao J, Song G, Weng F, Li Y, Zou B, Jin J, Yan D, Sun X, Liu C, Qiu FR
Journal of applied toxicology : JAT 2023 Jul;43(7):1095-1103
Journal of applied toxicology : JAT 2023 Jul;43(7):1095-1103
Hepatic Clstn3 Ameliorates Lipid Metabolism Disorders in High Fat Diet-Induced NAFLD through Activation of FXR.
Guo J, Huang S, Yi Q, Liu N, Cui T, Duan S, Chen J, Li J, Li J, Wang L, Gao Y, Nie G
ACS omega 2023 Jul 25;8(29):26158-26169
ACS omega 2023 Jul 25;8(29):26158-26169
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Impaired FXR-CPT1a signaling contributes to parenteral nutrition-induced villus atrophy in short-bowel syndrome.
Zhao Y, Feng H, Wang Y, Jiang L, Yan J, Cai W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22713
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jan;37(1):e22713
Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet.
Ge Y, Zhang L, Chen W, Sun M, Liu W, Li X
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)
Antioxidants (Basel, Switzerland) 2023 Jan 3;12(1)
Taurocholic Acid and Glycocholic Acid Inhibit Inflammation and Activate Farnesoid X Receptor Expression in LPS-Stimulated Zebrafish and Macrophages.
Ge X, Huang S, Ren C, Zhao L
Molecules (Basel, Switzerland) 2023 Feb 21;28(5)
Molecules (Basel, Switzerland) 2023 Feb 21;28(5)
Sodium cholate ameliorates nonalcoholic steatohepatitis by activation of FXR signaling.
Pan L, Yu Z, Liang X, Yao J, Fu Y, He X, Ren X, Chen J, Li X, Lu M, Lan T
Hepatology communications 2023 Feb 1;7(2):e0039
Hepatology communications 2023 Feb 1;7(2):e0039
Restraint stress promotes nonalcoholic steatohepatitis by regulating the farnesoid X receptor/NLRP3 signaling pathway.
Yang F, Lv XT, Lin XL, Wang RH, Wang SM, Wang GE
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1961-1971
Acta biochimica et biophysica Sinica 2023 Dec 25;55(12):1961-1971
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.
Chen Z, Tang Z, Kong J, Chen L, Liu J, Li Y, Huang W, Li W, Wu J, Zhao W, Meng X, Fan H
Frontiers in nutrition 2022;9:914323
Frontiers in nutrition 2022;9:914323
Hepatoprotective Effects of Glycyrrhetinic Acid on Lithocholic Acid-Induced Cholestatic Liver Injury Through Choleretic and Anti-Inflammatory Mechanisms.
Wang Q, Song GC, Weng FY, Zou B, Jin JY, Yan DM, Tan B, Zhao J, Li Y, Qiu FR
Frontiers in pharmacology 2022;13:881231
Frontiers in pharmacology 2022;13:881231
Ginsenoside Rc, as an FXR activator, alleviates acetaminophen-induced hepatotoxicity via relieving inflammation and oxidative stress.
Zhong Y, Chen Y, Pan Z, Tang K, Zhong G, Guo J, Cui T, Li T, Duan S, Yang X, Gao Y, Wang Q, Zhang D
Frontiers in pharmacology 2022;13:1027731
Frontiers in pharmacology 2022;13:1027731
Theacrine ameliorates experimental liver fibrosis in rats by lowering cholesterol storage via activation of the Sirtuin 3-farnesoid X receptor signaling pathway.
Lv XT, Wang RH, Liu XT, Ye YJ, Liu XY, Qiao JD, Wang GE
Chemico-biological interactions 2022 Sep 1;364:110051
Chemico-biological interactions 2022 Sep 1;364:110051
Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics.
Wang J, Wen J, Ma X, Yang J, Zhang Z, Xie S, Wei S, Jing M, Li H, Lang L, Zhou X, Zhao Y
European journal of pharmacology 2022 Nov 15;935:175331
European journal of pharmacology 2022 Nov 15;935:175331
Lignans from the seeds of Herpetospermum pedunculosum and their farnesoid X receptor-activating effect.
Meng F, Ma Y, Zhan H, Zong W, Linghu L, Wang Z, Lan X, Liao Z, Chen M
Phytochemistry 2022 Jan;193:113010
Phytochemistry 2022 Jan;193:113010
The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice via mediating the FXR/LXRα pathway.
Ma S, Pang X, Tian S, Sun J, Hu Q, Li X, Lu Y
Food & function 2022 Dec 13;13(24):12966-12982
Food & function 2022 Dec 13;13(24):12966-12982
Gut microbiota mediates methamphetamine-induced hepatic inflammation via the impairment of bile acid homeostasis.
Zhang KK, Liu JL, Chen LJ, Li JH, Yang JZ, Xu LL, Chen YK, Zhang QY, Li XW, Liu Y, Zhao D, Xie XL, Wang Q
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Aug;166:113208
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Aug;166:113208
FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice.
Zhang B, Li J, Zong X, Wang J, Xin L, Song H, Zhang W, Koda S, Hua H, Zhang B, Yu Q, Zheng KY, Yan C
PLoS neglected tropical diseases 2022 Aug;16(8):e0010651
PLoS neglected tropical diseases 2022 Aug;16(8):e0010651
Mesenchymal stem cell-derived exosome mitigates colitis via the modulation of the gut metagenomics-metabolomics-farnesoid X receptor axis.
Ocansey DKW, Zhang Z, Xu X, Liu L, Amoah S, Chen X, Wang B, Zhang X, Mao F
Biomaterials science 2022 Aug 24;10(17):4822-4836
Biomaterials science 2022 Aug 24;10(17):4822-4836
Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway.
Feng S, Xie X, Chen C, Zuo S, Zhao X, Li H
Nutrition & metabolism 2022 Aug 23;19(1):57
Nutrition & metabolism 2022 Aug 23;19(1):57
DMRT2 Interacts With FXR and Improves Insulin Resistance in Adipocytes and a Mouse Model.
Tao J, Yu XL, Yuan YJ, Shen X, Liu J, Gu PP, Wang Z, Ma YT, Li GQ
Frontiers in endocrinology 2021;12:723623
Frontiers in endocrinology 2021;12:723623
Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism.
Meng F, Zong W, Wei X, Tao Y, Wang G, Liao Z, Chen M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153588
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153588
Probiotic-fermented black tartary buckwheat alleviates hyperlipidemia and gut microbiota dysbiosis in rats fed with a high-fat diet.
Ren Y, Wu S, Xia Y, Huang J, Ye J, Xuan Z, Li P, Du B
Food & function 2021 Jul 5;12(13):6045-6057
Food & function 2021 Jul 5;12(13):6045-6057
The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines.
Li M, Zhang X, Lu Y, Meng S, Quan H, Hou P, Tong P, Chai D, Gao X, Zheng J, Tong X, Bai J
Cell death & disease 2020 Jan 16;11(1):31
Cell death & disease 2020 Jan 16;11(1):31
Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway.
Li T, Zheng R, Xu L, Zhou M, Wang X, Guo Q, Ji H, Li L
Toxicology and applied pharmacology 2020 Dec 1;408:115248
Toxicology and applied pharmacology 2020 Dec 1;408:115248
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
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