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- Antibody Data
- Antigen structure
- References [26]
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- Validations
- Western blot [2]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 12229-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12229-1-AP, RRID:AB_11182600
- Product name
- NDP52 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NDP52 antibody (Cat. #12229-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy.
Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
PINK1-mediated mitophagy maintains pluripotency through optineurin.
TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization.
GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon.
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury.
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.
Activation of PINK1-Parkin-dependent mitophagy in Tri-ortho-cresyl phosphate-treated Neuro2a cells.
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.
Jiang Y, Li H, Huang P, Li S, Li B, Huo L, Zhong J, Pan Z, Li Y, Xia X
Journal of ethnopharmacology 2022 Mar 1;285:114859
Journal of ethnopharmacology 2022 Mar 1;285:114859
Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.
Xie W, Jin S, Zhang C, Yang S, Wu Y, Zhao Y, Songyang Z, Cui J
Cell death and differentiation 2022 Jan;29(1):40-53
Cell death and differentiation 2022 Jan;29(1):40-53
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
Liu ZZ, Hong CG, Hu WB, Chen ML, Duan R, Li HM, Yue T, Cao J, Wang ZX, Chen CY, Hu XK, Wu B, Liu HM, Tan YJ, Liu JH, Luo ZW, Zhang Y, Rao SS, Luo MJ, Yin H, Wang YY, Xia K, Xu L, Tang SY, Hu RG, Xie H
Autophagy 2021 Oct;17(10):2766-2782
Autophagy 2021 Oct;17(10):2766-2782
PINK1-mediated mitophagy maintains pluripotency through optineurin.
Wang C, Liu K, Cao J, Wang L, Zhao Q, Li Z, Zhang H, Chen Q, Zhao T
Cell proliferation 2021 May;54(5):e13034
Cell proliferation 2021 May;54(5):e13034
TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.
Baek M, Choe YJ, Bannwarth S, Kim J, Maitra S, Dorn GW 2nd, Taylor JP, Paquis-Flucklinger V, Kim NC
Nature communications 2021 Mar 26;12(1):1924
Nature communications 2021 Mar 26;12(1):1924
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
Wang W, Qin Y, Song H, Wang L, Jia M, Zhao C, Gong M, Zhao W
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2692-2699
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2692-2699
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B
Scientific reports 2021 Jul 5;11(1):13863
Scientific reports 2021 Jul 5;11(1):13863
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.
Zhang C, Nie P, Zhou C, Hu Y, Duan S, Gu M, Jiang D, Wang Y, Deng Z, Chen J, Chen S, Wang L
Cell death & disease 2021 Feb 24;12(2):209
Cell death & disease 2021 Feb 24;12(2):209
Nitazoxanide impairs mitophagy flux through ROS-mediated mitophagy initiation and lysosomal dysfunction in bladder cancer.
Sun H, Ou T, Hu J, Yang Z, Lei Q, Li Y, Wang G, Li Y, Wu K, Wang S, Wu S
Biochemical pharmacology 2021 Aug;190:114588
Biochemical pharmacology 2021 Aug;190:114588
METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Yang Z, Yang S, Cui YH, Wei J, Shah P, Park G, Cui X, He C, He YY
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 31;118(35)
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 31;118(35)
CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
Zhang W, Zhou M, Lu W, Gong J, Gao F, Li Y, Xu X, Lin Y, Zhang X, Ding L, Zhang Z, Li G, Chen X, Sun X, Zhu X, Xu P, Zhang Y
Theranostics 2020;10(7):3000-3021
Theranostics 2020;10(7):3000-3021
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.
Bhushan J, Radke JB, Perng YC, Mcallaster M, Lenschow DJ, Virgin HW, Sibley LD
mBio 2020 Oct 6;11(5)
mBio 2020 Oct 6;11(5)
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo GM, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S, Yue Z
Autophagy 2020 May;16(5):917-931
Autophagy 2020 May;16(5):917-931
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.
Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z
Nature communications 2020 Mar 13;11(1):1386
Nature communications 2020 Mar 13;11(1):1386
Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization.
Ogawa M, Takada N, Shizukuishi S, Tomokiyo M, Chang B, Yoshida M, Kakuta S, Tanida I, Ryo A, Guan JL, Takeyama H, Ohnishi M
Communications biology 2020 Jan 13;3(1):25
Communications biology 2020 Jan 13;3(1):25
GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon.
Zhang Z, Gu H, Li Q, Zheng J, Cao S, Weng C, Jia H
Infection and immunity 2020 Apr 20;88(5)
Infection and immunity 2020 Apr 20;88(5)
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab.
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, Zhang J, Young CY, Yuan H
Oncogene 2019 May;38(18):3458-3474
Oncogene 2019 May;38(18):3458-3474
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW
Molecular cell 2019 Jun 6;74(5):891-908.e10
Molecular cell 2019 Jun 6;74(5):891-908.e10
Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury.
Marek-Iannucci S, Thomas A, Hou J, Crupi A, Sin J, Taylor DJ, Czer LS, Esmailian F, Mentzer RM Jr, Andres AM, Gottlieb RA
Scientific reports 2019 Jul 10;9(1):10001
Scientific reports 2019 Jul 10;9(1):10001
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats.
Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D
Nature communications 2019 Jan 18;10(1):329
Nature communications 2019 Jan 18;10(1):329
Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.
Houtman J, Freitag K, Gimber N, Schmoranzer J, Heppner FL, Jendrach M
The EMBO journal 2019 Feb 15;38(4)
The EMBO journal 2019 Feb 15;38(4)
Activation of PINK1-Parkin-dependent mitophagy in Tri-ortho-cresyl phosphate-treated Neuro2a cells.
Wang Y, Zhang C, Shen Z, Kou R, Xie K, Song F
Chemico-biological interactions 2019 Aug 1;308:70-79
Chemico-biological interactions 2019 Aug 1;308:70-79
Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.
Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J
Molecular cell 2017 Oct 19;68(2):308-322.e4
Molecular cell 2017 Oct 19;68(2):308-322.e4
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M
Cell 2016 Feb 25;164(5):896-910
Cell 2016 Feb 25;164(5):896-910
Phosphatase and tensin homologue (PTEN)-induced putative kinase 1 reduces pancreatic β-cells apoptosis in glucotoxicity through activation of autophagy.
Zhang J, Chen K, Wang L, Wan X, Shrestha C, Zhou J, Mo Z
Biochemical and biophysical research communications 2016 Aug 5;476(4):299-305
Biochemical and biophysical research communications 2016 Aug 5;476(4):299-305
A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.
Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD
mBio 2015 Sep 8;6(5):e01157-15
mBio 2015 Sep 8;6(5):e01157-15
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12229-1-AP(CALCOCO2 antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12229-1-AP( CALCOCO2 Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CALCOCO2 (IP:12229-1-AP, 3ug; Detection:12229-1-AP 1:1000) with HeLa cells lysate 2150ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CALCOCO2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CALCOCO2. This antibody recognizes human, mouse, rat antigen. The CALCOCO2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
