DCABH-4390

antibody from Creative Diagnostics

Targeting: TBX3 TBX3-ISO, UMS, XHL

No application information provided.

Antibody Data

Product number

DCABH-4390

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-4390, RRID:AB_2478167

Product name

Rabbit Anti-Human TBX3 monoclonal antibody, clone 33I34M32

Antibody type

Monoclonal

Description

T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms