Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [122]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 12482-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12482-1-AP, RRID:AB_2282876
- Product name
- NRF1/nuclear respiratory factor 1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NRF1/nuclear respiratory factor 1 antibody (Cat. #12482-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Puerarin Improves Glucose and Lipid Metabolism in Type 2 Diabetes by Regulating Gut Microbiota Homeostasis and Promoting Adipose Tissue Thermogenesis.
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer.
Yixin Yangshen Granules Target HIF-1 Signaling to Modulate the Neuroimmune Microenvironment in Alzheimer's Disease: Insights from Integrative Multi-Omics and Deep Learning.
PGC-1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti-Inflammatory Response.
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics.
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
Berberine Ameliorates Atherosclerosis by Promoting Mitochondrial Biogenesis via SIRT1/PGC-1α Signaling Pathway.
Human milk-derived 5'-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity.
Targeted energy metabolomics analysis-based mitochondrial restoration: Nutritional intervention of dairy-derived MFG-E8 synergistic with egg yolk phosphatidylcholine in skeletal muscle regeneration.
Reorganization of Mitochondrial Function and Architecture in Response to Plant-Derived Alkaloids: Anatabine, Anabasine, and Nicotine, Investigated in SH-SY5Y Cells and in a Cellular Model of Parkinson's Disease.
Protective effects of Ginkgolide B on myocardial ischemia reperfusion injury: role of the GAS6/Axl signaling pathway.
Non-esterified fatty acids disrupt hepatic lipid metabolism and mitochondrial function via TLR4/MyD88/IRAK2 signaling in bovine hepatocytes.
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the CK2/AKT pathway.
ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa.
A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.
Taurine ameliorates deoxynivalenol-induced intestinal injury in piglets: Restoration of mitochondrial function linked to the PGC1α-NRF1/2 axis.
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
METTL3-dependent m(6)A modification of GHR mRNA regulates mitochondrial function through mitochondrial biogenesis during myoblast differentiation.
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney.
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Canagliflozin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease via Mitochondrial Protection and Enhanced Mitophagy.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Analysis of the Protective Mechanism of PGC-1α/NRF1/2/TFAM Pathway in Cortical Neuron Injury Induced by Oxidative Stress.
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Urolithin A protects against domoic acid-induced cognitive deficits via promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice.
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Modular-Based Synergetic Mechanisms of Jasminoidin and Ursodeoxycholic Acid in Cerebral Ischemia Therapy.
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
A heterozygous SPRY4 variant identified in female infertility characterized by reduced oocyte potential and early embryonic arrest.
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
Pterostilbene protects against H(2) O(2) -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells.
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state.
Zearalenone modulates the function of goat endometrial cells via the mitochondrial quality control system.
Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury.
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Autoantibodies against the NineTeen complex and U5 RNP in systemic sclerosis.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts.
Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation.
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Non-Lethal Concentrations of CdCl(2) Cause Marked Alternations in Cellular Stress Responses within Exposed Sertoli Cell Line.
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease by Relieving Oxidative Stress through Activating the SIRT1/PGC-1α Pathway.
Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α.
Mitofusin 2 Integrates Mitochondrial Network Remodelling, Mitophagy and Renewal of Respiratory Chain Proteins in Neurons after Oxygen and Glucose Deprivation.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway.
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease.
A plant-derived natural photosynthetic system for improving cell anabolism.
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
Effects of Nrf1 in Hypothalamic Paraventricular Nucleus on Regulating the Blood Pressure During Hypertension.
Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis.
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3-dibromopropyl) phosphate in hepatocyte.
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover.
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration.
Nanoparticle-encapsulated antioxidant improves placental mitochondrial function in a sexually dimorphic manner in a rat model of prenatal hypoxia.
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.
AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle.
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
Long-isoform NRF1 protects against arsenic cytotoxicity in mouse bone marrow-derived mesenchymal stem cells by suppressing mitochondrial ROS and facilitating arsenic efflux.
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression.
Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.
(-)-Hydroxycitric acid regulates energy metabolism by activation of AMPK - PGC1α - NRF1 signal pathway in primary chicken hepatocytes.
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
(-)-Hydroxycitric Acid Suppresses Lipid Droplet Accumulation and Accelerates Energy Metabolism via Activation of the Adiponectin-AMPK Signaling Pathway in Broiler Chickens.
Effects of nitric oxide on steroidogenesis and apoptosis in goat luteinized granulosa cells.
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus.
A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Mitochondrial transcription factor A contributes to cisplatin resistance in patients with estrogen receptor‑positive breast cancer.
Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.
Cheng L, Gan M, Wang H, Song Y, Bai Y, Zhang D
Phytotherapy research : PTR 2026 May;40(5):2397-2416
Phytotherapy research : PTR 2026 May;40(5):2397-2416
Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer.
Yang F, Wang M, Hu S, Guan X, Zhao K, Zhou Y, Yao H, Zhang T, Li L, Gao Y, Zhao S, Liu N, Xiao W, Xiang Y, Miao H
Signal transduction and targeted therapy 2026 Mar 26;11(1)
Signal transduction and targeted therapy 2026 Mar 26;11(1)
Yixin Yangshen Granules Target HIF-1 Signaling to Modulate the Neuroimmune Microenvironment in Alzheimer's Disease: Insights from Integrative Multi-Omics and Deep Learning.
Wang Z, Wang L, Zhang Y, Yang S, Shi B, Liu D, Zhang H, Xiao W, Zhang J, Han X, Wei D
Pharmaceuticals (Basel, Switzerland) 2026 Mar 18;19(3)
Pharmaceuticals (Basel, Switzerland) 2026 Mar 18;19(3)
PGC-1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti-Inflammatory Response.
Hu Z, Pang J, Liu X, Zhao Y, Lu Y, Chen H, Zeng H, Yu Y, Zhao Y, Gao L, Zhang X, Jin J, Wang K, Shi Y, Zhan H, Wu W
CNS neuroscience & therapeutics 2026 Jan;32(1):e70744
CNS neuroscience & therapeutics 2026 Jan;32(1):e70744
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
Song Y, Lin W, Yuan H, Hu H, Wu S, Lu Y, Li D, Jing L, Tu S, Zhu W
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics.
Kumari B, Damodaran AP, Guiblet WM, Xiao MS, Behera AK, On TA, McIntosh CE, Teszler M, Holloway C, Le S, Parab N, Zhao Y, Aregger M, Gonatopoulos-Pournatzis T
Nature communications 2026 Feb 3;17(1):1218
Nature communications 2026 Feb 3;17(1):1218
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
Chuang YF, Wu CR, Chang WH, Su YJ, Hsu HT, Lin FL, Lo YC
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
Berberine Ameliorates Atherosclerosis by Promoting Mitochondrial Biogenesis via SIRT1/PGC-1α Signaling Pathway.
Wang SY, Zheng JM, Han XY, Jin BY, Hua CJ, Chen YS, Wang TT, Wang YH
Chinese journal of integrative medicine 2026 Apr 27;
Chinese journal of integrative medicine 2026 Apr 27;
Human milk-derived 5'-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity.
Zhang L, Peng Z, Lin C, Hu H, Du J, Huang S, Huang S, Gao J, Guo X
Frontiers in nutrition 2025;12:1661778
Frontiers in nutrition 2025;12:1661778
Targeted energy metabolomics analysis-based mitochondrial restoration: Nutritional intervention of dairy-derived MFG-E8 synergistic with egg yolk phosphatidylcholine in skeletal muscle regeneration.
Guan K, Liu X, Liu R, Xiao R, Lu W, Ma Y, Wang R, Niu T
International journal of biological macromolecules 2025 Sep;323(Pt 2):147215
International journal of biological macromolecules 2025 Sep;323(Pt 2):147215
Reorganization of Mitochondrial Function and Architecture in Response to Plant-Derived Alkaloids: Anatabine, Anabasine, and Nicotine, Investigated in SH-SY5Y Cells and in a Cellular Model of Parkinson's Disease.
Malińska D, Drabik K, Michalska B, Walczak J, Partyka M, Prill M, Szymański J, Patalas-Krawczyk P, Piecyk K, Duszyński J, Więckowski MR, Szczepanowska J
CNS neuroscience & therapeutics 2025 Sep;31(9):e70571
CNS neuroscience & therapeutics 2025 Sep;31(9):e70571
Protective effects of Ginkgolide B on myocardial ischemia reperfusion injury: role of the GAS6/Axl signaling pathway.
Liu H, Lei W, Ren Y, Tian J, Wang D, Tang Y, Zhou S, Huang C, Huang G, Yang Y, Liang Z
Chemico-biological interactions 2025 Sep 5;418:111607
Chemico-biological interactions 2025 Sep 5;418:111607
Non-esterified fatty acids disrupt hepatic lipid metabolism and mitochondrial function via TLR4/MyD88/IRAK2 signaling in bovine hepatocytes.
Wen Y, Wang Y, Loor JJ, Zhao C, Wang J
The Journal of steroid biochemistry and molecular biology 2025 Oct;253:106813
The Journal of steroid biochemistry and molecular biology 2025 Oct;253:106813
Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway.
Luo W, Bu W, Zhang G, Dong Y, Wang Y, Wang J, Liu C, Hu X, Jia Y, Ren H
Behavioural brain research 2025 Oct 18;495:115805
Behavioural brain research 2025 Oct 18;495:115805
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Chen L, Tang J, Zuo X, Li B, Liu C, Hong S, Min J, Hu M, Li S, Zhou M, Chen M, He Y, Xiao Y, Huang X, Hong L
Cell proliferation 2025 May;58(5):e70009
Cell proliferation 2025 May;58(5):e70009
Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the CK2/AKT pathway.
Zhang Y, Ye Y, Feng Y, Li X, Chen L, Zou X, Yan G, Chen Y, Nan L, Xu W, Chen L, Li H
Free radical biology & medicine 2025 May;232:353-366
Free radical biology & medicine 2025 May;232:353-366
ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa.
Hu C, Ren C, Wu Y, Lin R, Shen T, Li T, Yu D, Jiang L, Wan Z, Luo Y, Su T, Yu J, Qiu Y
Neuropharmacology 2025 May 15;269:110361
Neuropharmacology 2025 May 15;269:110361
A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans.
Ping J, Liu X, Lu Y, Quan C, Fan P, Lu H, Li Q, Wang C, Zhang Z, Liu M, Chen S, Chang L, Jiang Y, Huang Q, Liu J, Wuren T, Liu H, Hao Y, Kang L, Liu G, Lu H, Wei X, Wang Y, Li Y, Guo H, Cui Y, Zhang H, Zhang Y, Zhai Y, He Y, Zheng W, Qi X, Ouzhuluobu, Ma H, Yang L, Wang X, Jin W, Cui Y, Ge R, Wu S, Wei Y, Su B, He F, Zhang H, Zhou G
Cell genomics 2025 Mar 12;5(3):100782
Cell genomics 2025 Mar 12;5(3):100782
Taurine ameliorates deoxynivalenol-induced intestinal injury in piglets: Restoration of mitochondrial function linked to the PGC1α-NRF1/2 axis.
Ji X, Ding H, Zhou F, Zhang F, Wu D
Ecotoxicology and environmental safety 2025 Mar 1;292:117938
Ecotoxicology and environmental safety 2025 Mar 1;292:117938
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Song J, Luo X, Xiong L, Li S, Chen Y, Liu W, Yuan Y, Ma Y, Bian J, Liu Z, Zou H
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
Zhang Z, Yuan Y, Zhang X, Gu L, Tang Y, Zhao Y, Dai J, Tao Y, Xie Z
Translational stroke research 2025 Jun;16(3):625-644
Translational stroke research 2025 Jun;16(3):625-644
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function.
Zhao H, Zhang S, Gong Z, Chen T, Guo H, Yang M, Wang L, Zhou X, Xie J, Li H, Lu Y, Zhu Z
Journal of ethnopharmacology 2025 Jun 26;350:120036
Journal of ethnopharmacology 2025 Jun 26;350:120036
METTL3-dependent m(6)A modification of GHR mRNA regulates mitochondrial function through mitochondrial biogenesis during myoblast differentiation.
Zhao C, Hu B, Wang Z, Zhang Z, Luo W, Li H, Zhang X
Poultry science 2025 Jul;104(7):105216
Poultry science 2025 Jul;104(7):105216
Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney.
Zou H, Song J, Luo X, Ali W, Li S, Xiong L, Chen Y, Yuan Y, Ma Y, Tong X, Liu Z
Poultry science 2025 Jan;104(1):104490
Poultry science 2025 Jan;104(1):104490
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
Wu J, Chen L, Wen P
Scientific reports 2025 Feb 4;15(1):4298
Scientific reports 2025 Feb 4;15(1):4298
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Yang X, Wang S, Liu H, Zhang T, Cheng S, Du M
Journal of advanced research 2025 Dec;78:47-62
Journal of advanced research 2025 Dec;78:47-62
Canagliflozin Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease via Mitochondrial Protection and Enhanced Mitophagy.
Lu M, Zhao Y, Liu Z, Zhang Y, Liu J
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Dec;55(12):1598-1609
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Dec;55(12):1598-1609
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
Analysis of the Protective Mechanism of PGC-1α/NRF1/2/TFAM Pathway in Cortical Neuron Injury Induced by Oxidative Stress.
Li J, Zhang W, Hu W, Gao W, Wang J, Li J, Wang Y, Wang W, Gao H, Yi B
Bulletin of experimental biology and medicine 2025 Dec;180(2):259-266
Bulletin of experimental biology and medicine 2025 Dec;180(2):259-266
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Shen H, Lei Y, Xie W, Ma T, Bao L, Gao Q, Chen B, Dai B, Qin D
Adipocyte 2025 Dec;14(1):2278213
Adipocyte 2025 Dec;14(1):2278213
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Zhao Y, Hu W, Wang X, Ren Z, Gong Y, Liu L, Sun Y
International journal of molecular sciences 2025 Dec 12;26(24)
International journal of molecular sciences 2025 Dec 12;26(24)
Urolithin A protects against domoic acid-induced cognitive deficits via promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice.
Chen P, Lei J, Li R, Liu R, Zhou B
Free radical biology & medicine 2025 Dec 1;240:296-313
Free radical biology & medicine 2025 Dec 1;240:296-313
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Sun Y, Li L, Yang X, Yin S, Xiao Z
Translational psychiatry 2025 Aug 18;15(1):292
Translational psychiatry 2025 Aug 18;15(1):292
Modular-Based Synergetic Mechanisms of Jasminoidin and Ursodeoxycholic Acid in Cerebral Ischemia Therapy.
Wang J, Niu Q, Yu Y, Liu J, Zhang S, Zong W, Tian S, Wang Z, Li B
Biomedicines 2025 Apr 11;13(4)
Biomedicines 2025 Apr 11;13(4)
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders.
Wu X, Ding S, Wang G, Zhang W, He K
Journal of inflammation research 2024;17:8135-8146
Journal of inflammation research 2024;17:8135-8146
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Tao J, Rao Y, Wang J, Tan S, Zhao J, Cao Z, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Xu Z, Li M, Lyu D, Xiao H, Li S, Li Z, Li M, Xiao J, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Lan X, Wang Q, Liu Y, You Q, Wei W, Zhu C, Hai D, Cai Z, Yu J, Zhang J, Liu N
Redox biology 2024 Nov;77:103406
Redox biology 2024 Nov;77:103406
A heterozygous SPRY4 variant identified in female infertility characterized by reduced oocyte potential and early embryonic arrest.
Xia L, Huang J, Che Q, Zhang J, Zhang Z, Shen Y, Wang D, Zhong Y, Liu S, Du J
Human reproduction (Oxford, England) 2024 Nov 1;39(11):2618-2629
Human reproduction (Oxford, England) 2024 Nov 1;39(11):2618-2629
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
Yin H, Li X, Wang C, Li X, Liu J
Chemico-biological interactions 2024 May 1;394:110975
Chemico-biological interactions 2024 May 1;394:110975
Pterostilbene protects against H(2) O(2) -induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells.
Di W, Zhao A, Li X, Chen J, Dai Y, Li J, Lei W, Yang Y, Lu H
Cell biochemistry and function 2024 Mar;42(2):e3956
Cell biochemistry and function 2024 Mar;42(2):e3956
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
Pan L, Xu Z, Wen M, Li M, Lyu D, Xiao H, Li Z, Xiao J, Cheng Y, Huang H
Chinese medicine 2024 Jun 11;19(1):82
Chinese medicine 2024 Jun 11;19(1):82
Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state.
Gao Q, Jiang Y, Song Z, Ren H, Kong Y, Wang C, Zheng M, Shan C, Yang Y
Scientific reports 2024 Jul 23;14(1):16878
Scientific reports 2024 Jul 23;14(1):16878
Zearalenone modulates the function of goat endometrial cells via the mitochondrial quality control system.
Zhang G, Zeng C, Sun X, Zhang Q, Wang Y, Xia R, Mai Q, Xue G, Huang H, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23701
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23701
Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance.
Yang J, Zou Y, Lv X, Chen J, Cui C, Song J, Yang M, Hu H, Gao J, Xia L, Wang L, Chen L, Hou X
Diabetology & metabolic syndrome 2024 Jan 3;16(1):7
Diabetology & metabolic syndrome 2024 Jan 3;16(1):7
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury.
Shi J, Piao M, Liu C, Yang J, Guan X, Liu H, Li Q, Zhang Y, Yu J
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167480
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167480
Qianyang yuyin granule ameliorates mitochondrial dysfunction of hypertensive myocardial remodeling.
Zheng Y, Fang Y, Luo Y, Fan Y, Fang Z
Journal of ethnopharmacology 2024 Dec 5;335:118610
Journal of ethnopharmacology 2024 Dec 5;335:118610
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
Li L, Zou J, Zhou M, Li H, Zhou T, Liu X, Huang Q, Yang S, Xiang Q, Yu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Xie B, Chen Q, Dai Z, Jiang C, Chen X
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway.
Zou R, Wang S, Cai H, Wang Y, Wang C
Cardiovascular therapeutics 2023;2023:2108584
Cardiovascular therapeutics 2023;2023:2108584
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Zou YY, Tang XB, Chen ZL, Liu B, Zheng L, Song MY, Xiao Q, Zhou ZQ, Peng XY, Tang CF
Frontiers in endocrinology 2023;14:1162485
Frontiers in endocrinology 2023;14:1162485
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Song X, Leonhard WN, Kanhai AA, Steinberg GR, Pei Y, Peters DJM
Frontiers in molecular biosciences 2023;10:1058825
Frontiers in molecular biosciences 2023;10:1058825
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Chen ZL, Guo C, Zou YY, Feng C, Yang DX, Sun CC, Wen W, Jian ZJ, Zhao Z, Xiao Q, Zheng L, Peng XY, Zhou ZQ, Tang CF
Experimental gerontology 2023 Sep;180:112265
Experimental gerontology 2023 Sep;180:112265
Autoantibodies against the NineTeen complex and U5 RNP in systemic sclerosis.
Vulsteke JB, Smith V, Bonroy C, Lenaerts JL, Derua R, Wuyts WA, Blockmans D, De Haes P, Piette Y, De Langhe E, Bossuyt X
Journal of autoimmunity 2023 Sep;139:103056
Journal of autoimmunity 2023 Sep;139:103056
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts.
Kamienieva I, Charzyńska A, Duszyński J, Malińska D, Szczepanowska J
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166787
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166787
Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Duan Y, Dai H, Zhang H, Huang Y, Fu W, Sun W, Zhao B
Chinese journal of natural medicines 2023 Nov;21(11):812-829
Chinese journal of natural medicines 2023 Nov;21(11):812-829
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C
Nature communications 2023 Nov 18;14(1):7527
Nature communications 2023 Nov 18;14(1):7527
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Hong JR, Jin L, Zhang CY, Zhong WJ, Yang HH, Wang GM, Ma SC, Guan CX, Li Q, Zhou Y
Heliyon 2023 Jun;9(6):e17361
Heliyon 2023 Jun;9(6):e17361
Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation.
Hu B, Zhao C, Pan X, Wei H, Mo G, Xian M, Luo W, Nie Q, Li H, Zhang X
Cell communication and signaling : CCS 2023 Jun 19;21(1):148
Cell communication and signaling : CCS 2023 Jun 19;21(1):148
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Koh YC, Chok D, Chang CH, Wei CC, Wu CT, Cheng KC, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Non-Lethal Concentrations of CdCl(2) Cause Marked Alternations in Cellular Stress Responses within Exposed Sertoli Cell Line.
Man Y, Liu Y, Xiong C, Zhang Y, Zhang L
Toxics 2023 Feb 9;11(2)
Toxics 2023 Feb 9;11(2)
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154
Cell & bioscience 2023 Aug 21;13(1):154
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Liang Z, Yang Y, Wu X, Lu C, Zhao H, Chen K, Zhao A, Li X, Xu J
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Glucose Starvation Inhibits Ferroptosis by Activating the LKB1/AMPK Signaling Pathway and Promotes the High Speed Linear Motility of Dairy Goat Sperm.
Li Y, Zhang G, Wen F, Xian M, Guo S, Zhang X, Feng X, Hu Z, Hu J
Animals : an open access journal from MDPI 2023 Apr 23;13(9)
Animals : an open access journal from MDPI 2023 Apr 23;13(9)
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Ma Z, Liu Z, Li X, Zhang H, Han D, Xiong W, Zhou H, Yang X, Zeng Q, Ren H, Xu D
Biology 2023 Apr 11;12(4)
Biology 2023 Apr 11;12(4)
Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer's Disease by Relieving Oxidative Stress through Activating the SIRT1/PGC-1α Pathway.
Yin Z, Gao D, Du K, Han C, Liu Y, Wang Y, Gao X
Oxidative medicine and cellular longevity 2022;2022:2524832
Oxidative medicine and cellular longevity 2022;2022:2524832
Hippocampus-Based Mitochondrial Respiratory Function Decline Is Responsible for Perioperative Neurocognitive Disorders.
He K, Zhang J, Zhang W, Wang S, Li D, Ma X, Wu X, Chai X, Liu Q
Frontiers in aging neuroscience 2022;14:772066
Frontiers in aging neuroscience 2022;14:772066
Yangjing Zhongyu decoction facilitates mitochondrial activity, estrogenesis, and energy metabolism in H(2)O(2)-induced human granulosa cell line KGN.
Liu J, Shi D, Ma Q, Zhao P
Journal of ethnopharmacology 2022 Sep 15;295:115398
Journal of ethnopharmacology 2022 Sep 15;295:115398
miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α.
Zhou H, Gan M, Jin X, Dai M, Wang Y, Lei Y, Lin Z, Ming J
International journal of oncology 2022 Oct;61(4)
International journal of oncology 2022 Oct;61(4)
Mitofusin 2 Integrates Mitochondrial Network Remodelling, Mitophagy and Renewal of Respiratory Chain Proteins in Neurons after Oxygen and Glucose Deprivation.
Wojtyniak P, Boratynska-Jasinska A, Serwach K, Gruszczynska-Biegala J, Zablocka B, Jaworski J, Kawalec M
Molecular neurobiology 2022 Oct;59(10):6502-6518
Molecular neurobiology 2022 Oct;59(10):6502-6518
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Tai H, Cui XZ, He J, Lan ZM, Li SM, Li LB, Yao SC, Jiang XL, Meng XS, Kuang JS
Aging 2022 Oct 20;14(20):8302-8320
Aging 2022 Oct 20;14(20):8302-8320
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Lv Q, Han X, Ni J, Ma Q, Dai R, Liu J, Liu J, Zhai Y, Shen Q, Sun L, Liu H, Rao J, Xu H
Cell death & disease 2022 Oct 13;13(10):867
Cell death & disease 2022 Oct 13;13(10):867
Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway.
Chen H, Zhu J, Le Y, Pan J, Liu Y, Liu Z, Wang C, Dou X, Lu D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153964
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153964
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Dai H, Duan Y, Zhang H, Huang Y, Fu W, Meng Y, Zhao B
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Tai H, Tong YJ, Yu R, Yu Y, Yao SC, Li LB, Liu Y, Cui XZ, Kuang JS, Meng XS, Jiang XL
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease.
Li X, Pan J, Li H, Li G, Liu B, Tang X, Liu X, He Z, Peng Z, Zhang H, Wang L, Li Y, Xiang X, Chai X, Yuan Y, Zheng P, Zhang D
EBioMedicine 2022 Feb;76:103859
EBioMedicine 2022 Feb;76:103859
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Chai X, Pan M, Wang J, Feng M, Wang Y, Zhang Q, Sun Y
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis.
Ye P, Li W, Huang X, Zhao S, Chen W, Xia Y, Yu W, Rao T, Ning J, Zhou X, Ruan Y, Cheng F
Journal of cellular and molecular medicine 2022 Apr;26(7):1994-2009
Journal of cellular and molecular medicine 2022 Apr;26(7):1994-2009
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
He H, Li C, Lu X, Li Y, Li X, Sun X, Tang B, Wu Y, Li C
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Effects of Nrf1 in Hypothalamic Paraventricular Nucleus on Regulating the Blood Pressure During Hypertension.
Yu XJ, Xiao T, Liu XJ, Li Y, Qi J, Zhang N, Fu LY, Liu KL, Li Y, Kang YM
Frontiers in neuroscience 2021;15:805070
Frontiers in neuroscience 2021;15:805070
Rhein Relieves Oxidative Stress in an Aβ(1-42) Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis.
Yin Z, Geng X, Zhang Z, Wang Y, Gao X
Frontiers in pharmacology 2021;12:746711
Frontiers in pharmacology 2021;12:746711
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Yang Y, Wu Y, Zou J, Wang YH, Xu MX, Huang W, Yu DJ, Zhang L, Zhang YY, Sun XD
Frontiers in pharmacology 2021;12:687095
Frontiers in pharmacology 2021;12:687095
Multiplexed quantitative evaluation on mitochondrial toxicity of tris (2,3-dibromopropyl) phosphate in hepatocyte.
Ma X, Lu D, Liu Y, Le Y, Chen H, Li X, Wang C
Ecotoxicology and environmental safety 2021 Sep 15;221:112425
Ecotoxicology and environmental safety 2021 Sep 15;221:112425
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Yang C, Luo P, Chen SJ, Deng ZC, Fu XL, Xu DN, Tian YB, Huang YM, Liu WJ
Poultry science 2021 Nov;100(11):101459
Poultry science 2021 Nov;100(11):101459
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Yang M, Cui Y, Song J, Cui C, Wang L, Liang K, Wang C, Sha S, He Q, Hu H, Guo X, Zang N, Sun L, Chen L
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
Nrf1 Knock-Down in the Hypothalamic Paraventricular Nucleus Alleviates Hypertension Through Intervention of Superoxide Production-Removal Balance and Mitochondrial Function.
Li Y, Yu XJ, Xiao T, Chi HL, Zhu GQ, Kang YM
Cardiovascular toxicology 2021 Jun;21(6):472-489
Cardiovascular toxicology 2021 Jun;21(6):472-489
Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover.
Drabik K, Malińska D, Piecyk K, Dębska-Vielhaber G, Vielhaber S, Duszyński J, Szczepanowska J
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 10;10(6)
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
Harper SA, Bassler JR, Peramsetty S, Yang Y, Roberts LM, Drummer D, Mankowski RT, Leeuwenburgh C, Ricart K, Patel RP, Bamman MM, Anton SD, Jaeger BC, Buford TW
Experimental gerontology 2021 Jan;143:111111
Experimental gerontology 2021 Jan;143:111111
Upregulation of silent information regulator 1 alleviates mitochondrial dysfunction in the trigeminal nucleus caudalis in a rat model of chronic migraine.
Liang J, Zhou X, Wang J, Fei ZY, Qin GC, Zhang DK, Zhou JY, Chen LX
Neuroreport 2021 Jan 13;32(2):144-156
Neuroreport 2021 Jan 13;32(2):144-156
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration.
Sivalingam K, Cirino TJ, McLaughlin JP, Samikkannu T
Molecular neurobiology 2021 Feb;58(2):490-504
Molecular neurobiology 2021 Feb;58(2):490-504
Nanoparticle-encapsulated antioxidant improves placental mitochondrial function in a sexually dimorphic manner in a rat model of prenatal hypoxia.
Ganguly E, Kirschenman R, Spaans F, Holody CD, Phillips TEJ, Case CP, Cooke CM, Murphy MP, Lemieux H, Davidge ST
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21338
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21338
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
Zhang Q, Guo D, Wang Y, Wang X, Wang Q, Wu Y, Li C, Wang W, Wang Y
Frontiers in pharmacology 2020;11:458
Frontiers in pharmacology 2020;11:458
Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.
Wu H, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X, Qin Y, Liu L, Chen Q
Redox biology 2020 Sep;36:101661
Redox biology 2020 Sep;36:101661
AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle.
Chen M, Ji C, Yang Q, Gao S, Peng Y, Li Z, Gao X, Li Y, Jiang N, Zhang Y, Bian X, Chen C, Zhang K, Sanchis D, Yan F, Ye J
Clinical science (London, England : 1979) 2020 Sep 18;134(17):2381-2398
Clinical science (London, England : 1979) 2020 Sep 18;134(17):2381-2398
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
Li L, Chu X, Yao Y, Cao J, Li Q, Ma H
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
Long-isoform NRF1 protects against arsenic cytotoxicity in mouse bone marrow-derived mesenchymal stem cells by suppressing mitochondrial ROS and facilitating arsenic efflux.
Lou B, Hu Y, Lu X, Zhang X, Li Y, Pi J, Xu Y
Toxicology and applied pharmacology 2020 Nov 15;407:115251
Toxicology and applied pharmacology 2020 Nov 15;407:115251
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression.
Shanley KL, Hu CL, Bizzozero OA
Journal of neurochemistry 2020 Mar;152(5):585-601
Journal of neurochemistry 2020 Mar;152(5):585-601
Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin.
Yao L, Zhang JW, Chen B, Cai MM, Feng D, Wang QZ, Wang XY, Sun JG, Zheng YW, Wang GJ, Zhou F
Acta pharmacologica Sinica 2020 Jun;41(6):866-878
Acta pharmacologica Sinica 2020 Jun;41(6):866-878
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.
Meng Q, Qi X, Fu Y, Chen Q, Cheng P, Yu X, Sun X, Wu J, Li W, Zhang Q, Li Y, Wang A, Bian H
Journal of ethnopharmacology 2020 Feb 10;248:112326
Journal of ethnopharmacology 2020 Feb 10;248:112326
(-)-Hydroxycitric acid regulates energy metabolism by activation of AMPK - PGC1α - NRF1 signal pathway in primary chicken hepatocytes.
Li L, Jiang Z, Yao Y, Yang Z, Ma H
Life sciences 2020 Aug 1;254:117785
Life sciences 2020 Aug 1;254:117785
l-Arginine Inhibits Apoptosis of Ovine Intestinal Epithelial Cells through the l-Arginine-Nitric Oxide Pathway.
Zhang H, Zhao F, Peng A, Guo S, Wang M, Elsabagh M, Loor JJ, Wang H
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
The Journal of nutrition 2020 Aug 1;150(8):2051-2060
Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes.
Wang X, Li S, Liu L, Jian Z, Cui T, Yang Y, Guo S, Yi X, Wang G, Li C, Gao T, Li K
Journal of dermatological science 2019 Oct;96(1):33-41
Journal of dermatological science 2019 Oct;96(1):33-41
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G
Aging 2019 Nov 22;11(22):10356-10373
Aging 2019 Nov 22;11(22):10356-10373
(-)-Hydroxycitric Acid Suppresses Lipid Droplet Accumulation and Accelerates Energy Metabolism via Activation of the Adiponectin-AMPK Signaling Pathway in Broiler Chickens.
Li L, Zhang H, Yao Y, Yang Z, Ma H
Journal of agricultural and food chemistry 2019 Mar 20;67(11):3188-3197
Journal of agricultural and food chemistry 2019 Mar 20;67(11):3188-3197
Effects of nitric oxide on steroidogenesis and apoptosis in goat luteinized granulosa cells.
Guo YX, Zhang GM, Yao XL, Tong R, Cheng CY, Zhang TT, Wang ST, Yang H, Wang F
Theriogenology 2019 Mar 1;126:55-62
Theriogenology 2019 Mar 1;126:55-62
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Molecular nutrition & food research 2019 Feb;63(4):e1800795
Modified Si-Ni-San Decoction Ameliorates Central Fatigue by Improving Mitochondrial Biogenesis in the Rat Hippocampus.
Han C, Li F, Liu Y, Ma J, Yu X, Wu X, Zhang W, Li D, Chen D, Dai N, Lin B, Wu F, Mao M
Evidence-based complementary and alternative medicine : eCAM 2018;2018:9452127
Evidence-based complementary and alternative medicine : eCAM 2018;2018:9452127
A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.
Kim JS, Ha JY, Yang SJ, Son JH
Journal of cellular biochemistry 2018 Jan;119(1):347-357
Journal of cellular biochemistry 2018 Jan;119(1):347-357
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, Guan Z
PPAR research 2017;2017:4089214
PPAR research 2017;2017:4089214
Mitochondrial transcription factor A contributes to cisplatin resistance in patients with estrogen receptor‑positive breast cancer.
Gao W, Wu MH, Wang N, Ying MZ, Zhang YY, Hua J, Chuan L, Wang YJ
Molecular medicine reports 2016 Dec;14(6):5304-5310
Molecular medicine reports 2016 Dec;14(6):5304-5310
Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.
Yu H, Wark L, Ji H, Willard L, Jaing Y, Han J, He H, Ortiz E, Zhang Y, Medeiros DM, Lin D
Molecular nutrition & food research 2013 Jul;57(7):1158-69
Molecular nutrition & food research 2013 Jul;57(7):1158-69
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12482-1-AP(NRF1 antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NRF1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NRF1. This antibody recognizes human,mouse,rat antigen. The NRF1 antibody has been validated for the following applications: ELISA, WB, IP analysis.
