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- Antigen structure
- References [136]
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- Product number
- 22803-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- IGF2BP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IGF2BP1 antibody (Cat. #22803-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Interferon regulatory factor 1 promotes pyroptosis and inflammation in mouse sepsis-induced cardiomyopathy.
MDM2-GPX4-ferroptosis regulatory axis exerts neurotoxic effects in intracerebral hemorrhage.
N(6)-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail.
The METTL3/IGF2BP1 axis-mediated m6 A modification of TRIM11 mRNA suppresses ferroptosis and accelerates malignant progression in non-small cell lung cancer cells by degrading ACSL4.
Targeted inhibition of IGF2BP1 effectively suppresses HBV replication via an m6A-dependent manner.
METTL3-mediated m(6)A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca(2+) signaling.
NRAV promotes HCC stemness via the m6A-regulated let-7c-5p/LIN28B axis.
An engineered linear cap-independent mRNA vaccine with intrinsic adjuvanticity induces potent anti-tumor immunity in mice.
IGF2BP1/HMOX1 Mediates Fate Determinations of Human Spermatogonial Stem Cells and Male Infertility via an m6A-Dependent Manner.
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.
circNRIP1 impairs tumorigenesis of colorectal cancer by sponging IGF2BP1 and decreasing NACC1 mRNA stability.
H3K36me3-Guided m(6)A Modification of Oncogenic L1CAM-AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma.
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma.
ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.
CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway.
METTL3-mediated modification of SIRT1 m6A methylation protects osteoblasts from TBHP-induced senescence and promotes osteoblast proliferation.
Lactylation-induced ALKBH5 targets RNF123 to worsen retinal Müller cell activation through PKM2-regulated Glycolysis in diabetic retinopathy.
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis.
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1.
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.
A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1.
Interaction of PHGDH with IGF2BP1 facilitates m6A-dependent stabilization of TCF7L2 mRNA to confer multidrug resistance in gastric cancer.
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent m(6)A regulation.
Estrogenic-like compounds severely disturb germ cell formation in Japanese quail.
IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1.
Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
Fuzheng Huayu recipe inhibits alveolar macrophage M2 polarization and oxidative phosphorylation via METTL3-mediated NDUFA2 m6A modification.
IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules.
Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity.
IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury by regulating neuronal ferroptosis and microglial polarization.
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.
IGF2BPs-regulated TIN2 confers the malignant biological behaviors of gastric cancer cells.
N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification.
Synonymous mutations promote tumorigenesis by disrupting m(6)A-dependent mRNA metabolism.
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.
Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1.
Curcumin chitosan microspheres regulate Th17/Treg balance via IGF2BP1- mediated m6A modification of LRP5 in ulcerative colitis.
IGF2BP1 Bolsters the Chondrocytes Ferroptosis of Osteoarthritis by Targeting m(6)A/MMP3 Axis.
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation.
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
N(6)-Methyladenosine (m(6)A) Reader IGF2BP1 Accelerates Gastric Cancer Development and Immune Escape by Targeting PD-L1.
RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism.
High-throughput tagging of endogenous loci for rapid characterization of protein function.
Divergent Regulatory Roles of Transcriptional Variants of the Chicken LDB3 Gene in Muscle Shaping.
Molecular characterization of m6A RNA methylation regulators with features of immune dysregulation in IgA nephropathy.
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
LncRNA linc01194 promotes the progress of endometrial carcinoma by up-regulating SOX2 through binding to IGF2BP1.
HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression.
METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging.
FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.
Oridonin represses lung cancer cell proliferation and migration by modulating AFAP1-AS1/IGF2BP1.
m6A-methylated Lonp1 drives mitochondrial proteostasis stress to induce testicular pyroptosis upon environmental cadmium exposure.
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.
Systematic analysis of IGF2BP family members in non-small-cell lung cancer.
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human.
FGF19/FGFR4 signaling contributes to hepatocellular carcinoma survival and immune escape by regulating IGF2BP1-mediated expression of PD-L1.
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
VIM-AS1, which is regulated by CpG methylation, cooperates with IGF2BP1 to inhibit tumor aggressiveness via EPHA3 degradation in hepatocellular carcinoma.
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1.
N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3.
Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.
N(6)-methyladenosine (m(6)A) reader IGF2BP1 facilitates clear-cell renal cell carcinoma aerobic glycolysis.
Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice.
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer.
Feedforward loop between IMP1 and YAP/TAZ promotes tumorigenesis and malignant progression in glioblastoma.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
CDCA4 interacts with IGF2BP1 to regulate lung adenocarcinoma proliferation via the PI3K/AKT pathway.
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
Atlas of interactions between SARS-CoV-2 macromolecules and host proteins.
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
IGF2BP1 enhances the stability of SIK2 mRNA through m(6)A modification to promote non-small cell lung cancer progression.
m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3.
ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy.
PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer.
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
RNA-Binding Protein IGF2BP1 Associated With Prognosis and Immunotherapy Response in Lung Adenocarcinoma.
APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly.
The "m6A writer" METTL3 and the "m6A reader" IGF2BP2 regulate cutaneous T-cell lymphomas progression via CDKN2A.
m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer.
Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation.
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference.
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Peptides from the croceine croaker (Larimichthys crocea) swim bladder attenuate busulfan-induced oligoasthenospermia in mice.
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.
Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment.
IGF2BP1-regulated expression of ERRα is involved in metabolic reprogramming of chemotherapy resistant osteosarcoma cells.
Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress.
Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma.
METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation.
An in vitro system to silence mitochondrial gene expression.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.
EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation.
A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA.
PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α.
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.
MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.
Pei MQ, Zeng YF, Yang YS, Fang YM, Lin S, Liang JW, He HF
Cellular signalling 2026 Mar;139:112332
Cellular signalling 2026 Mar;139:112332
MDM2-GPX4-ferroptosis regulatory axis exerts neurotoxic effects in intracerebral hemorrhage.
Yu Y, Liu T, Cai Y, Song Y, Zhou H, Cao F, Jiang R
Neural regeneration research 2026 Jul 1;21(7):3063-3072
Neural regeneration research 2026 Jul 1;21(7):3063-3072
N(6)-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail.
Tian Y, Peng J, Zhou J, Yang W, Peng Y, Li J, Rui Y, Zhang H, Xie G, Wang H, Wang J, Li J, Huang Z, Ma X, Wang H, He J
Science China. Life sciences 2026 Jan;69(1):119-135
Science China. Life sciences 2026 Jan;69(1):119-135
The METTL3/IGF2BP1 axis-mediated m6 A modification of TRIM11 mRNA suppresses ferroptosis and accelerates malignant progression in non-small cell lung cancer cells by degrading ACSL4.
Chen H, Wang C, Dai H, Shi J
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):665-681
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):665-681
Targeted inhibition of IGF2BP1 effectively suppresses HBV replication via an m6A-dependent manner.
Li D, Song Y, Lu D, Zhang Y, Qu C, Guan G, Ma Y, Mao T, Zheng L, Wang Y, Song W, Zhang T, Lu F, Ning J, Chen X
Antiviral research 2026 Jan;245:106310
Antiviral research 2026 Jan;245:106310
METTL3-mediated m(6)A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca(2+) signaling.
Chen C, Xiong K, Liang F, Zhong Y, Qin X, Huang N, Fang Y, Zhu B, Cheng J, Wei Q, Zheng L, Zhao J
Molecular cancer 2026 Jan 19;25(1)
Molecular cancer 2026 Jan 19;25(1)
NRAV promotes HCC stemness via the m6A-regulated let-7c-5p/LIN28B axis.
Chen Y, Dai S, Zhuang L, Cai W, Chen H, Zhao J, Zhang F, Chen L, Cheng CS
Cancer gene therapy 2026 Feb;33(2):171-185
Cancer gene therapy 2026 Feb;33(2):171-185
An engineered linear cap-independent mRNA vaccine with intrinsic adjuvanticity induces potent anti-tumor immunity in mice.
Yu H, Yang Y, Lin P, Liu C, Wen Y, Huang Z, Fang Z, Hu Z, Huang S
Nature communications 2026 Feb 26;17(1)
Nature communications 2026 Feb 26;17(1)
IGF2BP1/HMOX1 Mediates Fate Determinations of Human Spermatogonial Stem Cells and Male Infertility via an m6A-Dependent Manner.
Du L, Liu W, Cui Y, Chen W, He Z
Research (Washington, D.C.) 2025;8:1005
Research (Washington, D.C.) 2025;8:1005
WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.
Xu Q, Zhang J, Zou Y, Chen L, Sun F, Luo X, Wang T, Li Y, Zhang S, Xiong F, Yu Q, Yang P, Gong Q, Liu SW, Wang CY
International journal of biological sciences 2025;21(12):5428-5443
International journal of biological sciences 2025;21(12):5428-5443
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
Li J, Luo Q, Lu M, Lu C, Xu C, Ding J, Zhan T, Zhu J, Qian M, Lin S, Chang L, Li J, Wang K
International journal of biological sciences 2025;21(11):4782-4797
International journal of biological sciences 2025;21(11):4782-4797
Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.
Mi X, Ruan X, Lin R, Huang S, Cai P, Chen X, Liao J, Dai X
Frontiers in pharmacology 2025;16:1572771
Frontiers in pharmacology 2025;16:1572771
circNRIP1 impairs tumorigenesis of colorectal cancer by sponging IGF2BP1 and decreasing NACC1 mRNA stability.
Han K, Sui Q, Xu Y, Duan J, Peng J, Yu L, Li W, He J, Kong L, Tang J, Lin J, Ding P, Xie D, Pan Z
Gastroenterology report 2025;13:goaf041
Gastroenterology report 2025;13:goaf041
H3K36me3-Guided m(6)A Modification of Oncogenic L1CAM-AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma.
Wang T, Han L, Huo Y, Zhang L, Huang Y, Zhang N, Yang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e14909
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e14909
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma.
Huang T, You Q, Liu J, Shen X, Huang D, Tao X, He Z, Wu C, Xi X, Yu S, Liu F, Wu Z, Mao W, Zhu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e06529
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e06529
ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.
Dong A, Zhang P, Yang F, Wang Y, Liu H
Cell death & disease 2025 Oct 7;16(1):708
Cell death & disease 2025 Oct 7;16(1):708
CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway.
Li BH, Liu L, Shi D, Wang XL, Meng TY, Xu XM, Zhai JL, He XJ, Wang GL, An TY, Jiang QL, Bi SX, Pan ZH, Zheng QS, Lu J, Li DF
Journal of translational medicine 2025 Oct 29;23(1):1186
Journal of translational medicine 2025 Oct 29;23(1):1186
METTL3-mediated modification of SIRT1 m6A methylation protects osteoblasts from TBHP-induced senescence and promotes osteoblast proliferation.
Chen Y, Wang Y, Xiao H, Teng F, Yang A, Liu J, Liu Z, Sheng X, Zhang C, Zhang S, Geng B, Xia Y
Chemico-biological interactions 2025 Oct 22;420:111672
Chemico-biological interactions 2025 Oct 22;420:111672
Lactylation-induced ALKBH5 targets RNF123 to worsen retinal Müller cell activation through PKM2-regulated Glycolysis in diabetic retinopathy.
Luo S, Sun Y, Hu Y, Xu Y
Journal of translational medicine 2025 Oct 15;23(1):1105
Journal of translational medicine 2025 Oct 15;23(1):1105
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024
Cellular signalling 2025 Nov;135:112024
SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis.
Sheng Z, Luo S, Huang L, Deng YN, Zhang N, Luo Y, Zhao X, Chen Y, Li Q, Dai R, Liang S
Oncogene 2025 May;44(19):1361-1374
Oncogene 2025 May;44(19):1361-1374
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
Miller C, Ealy A, Gregory A, Janarthanam C, Albers W, Richardson G, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Kanthasamy AG
Cell reports 2025 May 27;44(5):115618
Cell reports 2025 May 27;44(5):115618
Triple‑negative breast cancer cell‑derived piR‑31115 promotes the proliferation and migration of endothelial cells via METTL3‑mediated m6A modification of YAP1.
Du SM, Li N, Xu WJ, Liu K
Oncology reports 2025 Mar;53(3)
Oncology reports 2025 Mar;53(3)
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.
Guo D, Pang Y, Wang W, Feng Y, Wang L, Sun Y, Hao J, Li F, Zhao S
Cells 2025 Mar 1;14(5)
Cells 2025 Mar 1;14(5)
A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1.
Xu W, Yi J, Wei X, Wang M, Zhao M, Zhao M, Wang X, Shen Y, Wang Z, Jin S
Journal of translational medicine 2025 Jun 4;23(1):629
Journal of translational medicine 2025 Jun 4;23(1):629
Interaction of PHGDH with IGF2BP1 facilitates m6A-dependent stabilization of TCF7L2 mRNA to confer multidrug resistance in gastric cancer.
Chen S, Li T, Liu D, Liu Y, Long Z, Wu Y, Zhong Y, Zhao J, Wu T, He W, Cao T, Fan D, Wu K, Lu Y, Zhao X
Oncogene 2025 Jul;44(25):2064-2077
Oncogene 2025 Jul;44(25):2064-2077
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D
Clinical and translational medicine 2025 Jul;15(7):e70392
Clinical and translational medicine 2025 Jul;15(7):e70392
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
Luo X, Wei Q, Xie L, Chen N, Gu B, Xu J, Jiang X, Zuo X, Zhao H, Liu X, Yang Y, Liu T, Zhu Y, Yi P, Xu J
Clinical and translational medicine 2025 Jul;15(7):e70388
Clinical and translational medicine 2025 Jul;15(7):e70388
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
Liao X, Hu T
Mutation research 2025 Jul-Dec;831:111910
Mutation research 2025 Jul-Dec;831:111910
A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.
Guo J, Li K, Ming Y, Pan Y, Tan S, Ma H, Chen S, Duan Y, Peng Y
Proceedings of the National Academy of Sciences of the United States of America 2025 Jul 8;122(27):e2504320122
Proceedings of the National Academy of Sciences of the United States of America 2025 Jul 8;122(27):e2504320122
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
Li J, Bai R, Zhou Y, Song X, Li L
PLoS genetics 2025 Jan;21(1):e1011580
PLoS genetics 2025 Jan;21(1):e1011580
Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent m(6)A regulation.
Xu L, Zhang L, Sun Q, Zhang X, Zhang J, Zhao X, Hu Z, Zhang S, Shi F
Cellular and molecular life sciences : CMLS 2025 Jan 23;82(1):60
Cellular and molecular life sciences : CMLS 2025 Jan 23;82(1):60
Estrogenic-like compounds severely disturb germ cell formation in Japanese quail.
Ogawa Y, Mizushima S, Kuroiwa A
Biochemical and biophysical research communications 2025 Feb;746:151268
Biochemical and biophysical research communications 2025 Feb;746:151268
IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1.
Wei X, Su Y, Tian W, Cheng L, Yin L, He X
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16242
The journal of obstetrics and gynaecology research 2025 Feb;51(2):e16242
Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.
Yan S, Fu P, Zhu Y, Li H, Shan R, Gong B
Microbial pathogenesis 2025 Feb;199:107248
Microbial pathogenesis 2025 Feb;199:107248
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
Liu Z, Sun T, Zhang Z, Piao C, Kong C, Zhang X
Clinical and translational medicine 2025 Feb;15(2):e70232
Clinical and translational medicine 2025 Feb;15(2):e70232
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Xin W, Zhou J, Peng Y, Gong S, Liao W, Wang Y, Huang X, Mao Y, Yao M, Qin S, Xiong J, Li Y, Lan Q, Huang Y, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
Sheng Q, Yu Q, Lu S, Yang M, Fan X, Su H, Kong Z, Gao Y, Wang R, Lv Z
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
Fuzheng Huayu recipe inhibits alveolar macrophage M2 polarization and oxidative phosphorylation via METTL3-mediated NDUFA2 m6A modification.
Sun Y, Yuan X, Huang W, Li Q, Zhang S, Hang Y, Huang J, Li J, Qian Y, Zhang W, Li L
Journal of bioenergetics and biomembranes 2025 Dec;57(6):453-467
Journal of bioenergetics and biomembranes 2025 Dec;57(6):453-467
IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules.
Su X, Zang J, Wang Y, Zhang S, Wu P, Chen W, Shi L, Wu Y, Deng D, Cai K, Mai H, Xu A, Lu D
Acta pharmaceutica Sinica. B 2025 Dec;15(12):6478-6494
Acta pharmaceutica Sinica. B 2025 Dec;15(12):6478-6494
Phosphorylation of Shiftless by casein kinase 1 δ/ε is required for its antiviral activity.
Wang Y, Fu S, Wang X, Gao G
Journal of virology 2025 Dec 23;99(12):e0186425
Journal of virology 2025 Dec 23;99(12):e0186425
IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury by regulating neuronal ferroptosis and microglial polarization.
Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y, Yu Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167877
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167877
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.
Xie X, Zhao Y, Liu J, Li H, Zhu X, Liu Y, Sang Y, Xu K, Du F, Ren H, Cui X, Cai B, Chen H, Wu N, Hou G, Jing C, Chong W, Li L, Shang L
Cell death & disease 2025 Aug 7;16(1):596
Cell death & disease 2025 Aug 7;16(1):596
IGF2BPs-regulated TIN2 confers the malignant biological behaviors of gastric cancer cells.
Li F, Zhou Y, Liao Z, Huang D, Zhang Z, Chen G
Tissue & cell 2025 Apr;93:102716
Tissue & cell 2025 Apr;93:102716
N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification.
Li H, Tang Y, Hu S, Ruan X, Zhang J, Shi Y, Qiu L, Yang H, Zhang K, Chen H, Chen K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413970
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413970
Synonymous mutations promote tumorigenesis by disrupting m(6)A-dependent mRNA metabolism.
Lan Y, Xia Z, Shao Q, Lin P, Lu J, Xiao X, Zheng M, Chen D, Dou Y, Xie Q
Cell 2025 Apr 3;188(7):1828-1841.e15
Cell 2025 Apr 3;188(7):1828-1841.e15
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis.
Hu Y, Yang L, Huang L, Zeng C, Ren S
Cellular and molecular life sciences : CMLS 2025 Apr 12;82(1):157
Cellular and molecular life sciences : CMLS 2025 Apr 12;82(1):157
Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1.
Su Y, Tian W, Cheng L, Yin L, He X, Wei X
Folia histochemica et cytobiologica 2024;62(1):25-36
Folia histochemica et cytobiologica 2024;62(1):25-36
Curcumin chitosan microspheres regulate Th17/Treg balance via IGF2BP1- mediated m6A modification of LRP5 in ulcerative colitis.
Chen L, Xiang Y, Zhong S, Wu Y, Liu J, Wu Y, Wang Z, Huang G
Iranian journal of basic medical sciences 2024;27(10):1276-1283
Iranian journal of basic medical sciences 2024;27(10):1276-1283
IGF2BP1 Bolsters the Chondrocytes Ferroptosis of Osteoarthritis by Targeting m(6)A/MMP3 Axis.
Zhao Z, Dong S, Yang Y, Yin H, Xiong G, Ma J
International journal of general medicine 2024;17:2433-2443
International journal of general medicine 2024;17:2433-2443
Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.
Liu J, Wang S, Zhang C, Wei Z, Han D, Song Y, Song X, Chao F, Wu Z, Xu G, Chen G
American journal of cancer research 2024;14(2):490-506
American journal of cancer research 2024;14(2):490-506
ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation.
Zhang Q, Du Z, Zhou W, Li W, Yang Q, Yu H, Liu T
Cancer gene therapy 2024 Sep;31(9):1427-1437
Cancer gene therapy 2024 Sep;31(9):1427-1437
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Cai Y, Zhou J, Xu A, Huang J, Zhang H, Xie G, Zhong K, Wu Y, Ye P, Wang H, Niu H
The Journal of biological chemistry 2024 Sep;300(9):107598
The Journal of biological chemistry 2024 Sep;300(9):107598
N(6)-Methyladenosine (m(6)A) Reader IGF2BP1 Accelerates Gastric Cancer Development and Immune Escape by Targeting PD-L1.
Tang B, Bi L, Xu Y, Cao L, Li X
Molecular biotechnology 2024 Oct;66(10):2850-2859
Molecular biotechnology 2024 Oct;66(10):2850-2859
RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner.
Luo J, Yang C, Xu S, Ji Z, Zhang Y, Bai H, Deng Z, Liang J, Huang Y, Zhi E, Tian R, Li P, Zhao F, Zhou Z, Li Z, Yao C
Communications biology 2024 Oct 21;7(1):1362
Communications biology 2024 Oct 21;7(1):1362
IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism.
Hornegger H, Anisimova AS, Muratovic A, Bourgeois B, Spinetti E, Niedermoser I, Covino R, Madl T, Karagöz GE
Nature communications 2024 Oct 20;15(1):9054
Nature communications 2024 Oct 20;15(1):9054
High-throughput tagging of endogenous loci for rapid characterization of protein function.
Kim J, Kratz AF, Chen S, Sheng J, Kim HK, Zhang L, Singh BK, Chavez A
Science advances 2024 May 3;10(18):eadg8771
Science advances 2024 May 3;10(18):eadg8771
Divergent Regulatory Roles of Transcriptional Variants of the Chicken LDB3 Gene in Muscle Shaping.
Wei C, Niu Y, Chen B, Wang Y, Cai H, Han R, Tian Y, Liu X, Guo W, Kang X, Li Z
Journal of agricultural and food chemistry 2024 May 29;72(21):12240-12250
Journal of agricultural and food chemistry 2024 May 29;72(21):12240-12250
Molecular characterization of m6A RNA methylation regulators with features of immune dysregulation in IgA nephropathy.
Wang Y, Sun N, He R, Wang Z, Jin J, Gao T, Qu J
Clinical and experimental medicine 2024 May 2;24(1):92
Clinical and experimental medicine 2024 May 2;24(1):92
XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression.
Wang K, Bhattacharya A, Haratake N, Daimon T, Nakashoji A, Ozawa H, Peng B, Li W, Kufe D
Cell death & disease 2024 May 13;15(5):330
Cell death & disease 2024 May 13;15(5):330
LncRNA linc01194 promotes the progress of endometrial carcinoma by up-regulating SOX2 through binding to IGF2BP1.
Huang Z, Shen F, Chen J, Xie B, Chen X, Zhao Y, Chen S
Journal of gynecologic oncology 2024 Mar;35(2):e21
Journal of gynecologic oncology 2024 Mar;35(2):e21
HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression.
Hu T, Zeng C, Song Z, Liu Q, Chen S, Huang W, Ma Q, Li H
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167050
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167050
METTL3-mediated m6A modification increases Hspa1a stability to inhibit osteoblast aging.
Wang Y, Chen Y, Xiao H, Liu Z, Liu X, Feng Z, Sheng X, Peng B, Ren X, Xu L, Teng F, Yi Z, Niu Y, Xiang D, Xia Y, Geng B
Cell death discovery 2024 Mar 27;10(1):155
Cell death discovery 2024 Mar 27;10(1):155
FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.
Wang K, Mei Z, Zheng M, Liu X, Li D, Wang H
Heliyon 2024 Mar 15;10(5):e27571
Heliyon 2024 Mar 15;10(5):e27571
Oridonin represses lung cancer cell proliferation and migration by modulating AFAP1-AS1/IGF2BP1.
Chen M, Shen Y
Cellular and molecular biology (Noisy-le-Grand, France) 2024 Jun 5;70(6):108-113
Cellular and molecular biology (Noisy-le-Grand, France) 2024 Jun 5;70(6):108-113
m6A-methylated Lonp1 drives mitochondrial proteostasis stress to induce testicular pyroptosis upon environmental cadmium exposure.
Ouyang KW, Wang TT, Wang H, Luo YX, Hu YF, Zheng XM, Ling Q, Wang KW, Xiong YW, Zhang J, Chang W, Zhang YF, Yuan Z, Li H, Gao L, Xu DX, Zhu HL, Yang L, Wang H
The Science of the total environment 2024 Jun 25;931:172938
The Science of the total environment 2024 Jun 25;931:172938
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
m6A Modification Promotes EMT and Metastasis of Castration-Resistant Prostate Cancer by Upregulating NFIB.
Shu F, Liu H, Chen X, Liu Y, Zhou J, Tang L, Cao W, Yang S, Long Y, Li R, Wang H, Wang H, Jiang G
Cancer research 2024 Jun 14;84(12):1947-1962
Cancer research 2024 Jun 14;84(12):1947-1962
Systematic analysis of IGF2BP family members in non-small-cell lung cancer.
Gong L, Liu Q, Jia M, Sun X
Human genomics 2024 Jun 12;18(1):63
Human genomics 2024 Jun 12;18(1):63
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human.
Huang W, Xiong T, Zhao Y, Heng J, Han G, Wang P, Zhao Z, Shi M, Li J, Wang J, Wu Y, Liu F, Xi JJ, Wang Y, Zhang QC
Nature genetics 2024 Jan;56(1):124-135
Nature genetics 2024 Jan;56(1):124-135
FGF19/FGFR4 signaling contributes to hepatocellular carcinoma survival and immune escape by regulating IGF2BP1-mediated expression of PD-L1.
Guo C, Zhou N, Lu Y, Mu M, Li Z, Zhang X, Tu L, Du J, Li X, Huang D, Xu Q, Zheng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115955
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115955
Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification.
Xiong YW, Zhu HL, Zhang J, Geng H, Tan LL, Zheng XM, Li H, Fan LL, Wang XR, Zhang XD, Wang KW, Chang W, Zhang YF, Yuan Z, Duan ZL, Cao YX, He XJ, Xu DX, Wang H
Nature communications 2024 Feb 14;15(1):1353
Nature communications 2024 Feb 14;15(1):1353
VIM-AS1, which is regulated by CpG methylation, cooperates with IGF2BP1 to inhibit tumor aggressiveness via EPHA3 degradation in hepatocellular carcinoma.
Han SH, Ko JY, Jung S, Oh S, Kim DY, Kang E, Kim MS, Chun KH, Yoo KH, Park JH
Experimental & molecular medicine 2024 Dec;56(12):2617-2630
Experimental & molecular medicine 2024 Dec;56(12):2617-2630
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Li F, Wang F, Wang L, Wang J, Wei S, Meng J, Li Y, Feng L, Jiang P
Epigenetics 2024 Dec;19(1):2326868
Epigenetics 2024 Dec;19(1):2326868
Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1.
Meng Q, Xiang H, Wang Y, Hu K, Luo X, Wang J, Chen E, Zhang W, Chen J, Chen X, Wang H, Ju Z, Song Z
Biology direct 2024 Dec 20;19(1):130
Biology direct 2024 Dec 20;19(1):130
N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer.
Ding P, Wu H, Wu J, Li T, He J, Ju Y, Liu Y, Li F, Deng H, Gu R, Zhang L, Guo H, Tian Y, Yang P, Meng N, Li X, Guo Z, Meng L, Zhao Q
Oncogene 2024 Aug;43(34):2548-2563
Oncogene 2024 Aug;43(34):2548-2563
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3.
Wu J, Li X, Nie H, Shen Y, Guo Z, Huihan Chu C, Cai K, Tang C
Biochemical pharmacology 2024 Apr;222:116118
Biochemical pharmacology 2024 Apr;222:116118
Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.
Mao Y, Jiang F, Xu XJ, Zhou LB, Jin R, Zhuang LL, Juan CX, Zhou GP
International journal of biological sciences 2023;19(2):593-609
International journal of biological sciences 2023;19(2):593-609
N(6)-methyladenosine (m(6)A) reader IGF2BP1 facilitates clear-cell renal cell carcinoma aerobic glycolysis.
Yuan B, Zhou J
PeerJ 2023;11:e14591
PeerJ 2023;11:e14591
Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice.
Zhang J, Xiong YW, Tan LL, Zheng XM, Zhang YF, Ling Q, Zhang C, Zhu HL, Chang W, Wang H
Journal of hazardous materials 2023 Sep 15;458:131891
Journal of hazardous materials 2023 Sep 15;458:131891
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer.
Sun X, Ye G, Li J, Shou H, Bai G, Zhang J
Clinical and translational medicine 2023 Oct;13(10):e1457
Clinical and translational medicine 2023 Oct;13(10):e1457
Feedforward loop between IMP1 and YAP/TAZ promotes tumorigenesis and malignant progression in glioblastoma.
Yang J, Wu X, Wang J, Guo X, Chen J, Yang X, Zhong J, Li X, Deng Z
Cancer science 2023 May;114(5):2053-2062
Cancer science 2023 May;114(5):2053-2062
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, Martin JM, Biagini JC, Mena D, Ching JKT, Malolepsza E, Li T, Singh T, Ge T, Egri SB, Tanenbaum B, Stanclift CR, Apffel AM, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Carr SA, Schenone M, Jaffe J, Fornelos N, Huang H, Eggan KC, Lage K
iScience 2023 May 19;26(5):106701
iScience 2023 May 19;26(5):106701
CDCA4 interacts with IGF2BP1 to regulate lung adenocarcinoma proliferation via the PI3K/AKT pathway.
Feng S, Cao H, Sui Y, Shen Z, Wu J, Ma R, Feng J
Thoracic cancer 2023 Mar;14(8):724-735
Thoracic cancer 2023 Mar;14(8):724-735
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.
Pintacuda G, Hsu YH, Tsafou K, Li KW, Martín JM, Riseman J, Biagini JC, Ching JKT, Mena D, Gonzalez-Lozano MA, Egri SB, Jaffe J, Smit AB, Fornelos N, Eggan KC, Lage K
Cell genomics 2023 Mar 8;3(3):100250
Cell genomics 2023 Mar 8;3(3):100250
A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.
Hao R, Zhang L, Si Y, Zhang P, Wang Y, Li B, Hu J, Qi Y
Cancer cell international 2023 Mar 25;23(1):54
Cancer cell international 2023 Mar 25;23(1):54
The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.
Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822
METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression.
Wei W, Zhang ZY, Shi B, Cai Y, Zhang HS, Sun CL, Fei YF, Zhong W, Zhang S, Wang C, He B, Jiang GM, Wang H
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Journal of experimental & clinical cancer research : CR 2023 Jun 20;42(1):151
Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Jiang WJ, Sun MH, Li XH, Lee SH, Heo G, Zhou D, Cui XS
Journal of cellular physiology 2023 Jul;238(7):1592-1604
Journal of cellular physiology 2023 Jul;238(7):1592-1604
LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.
Chen QW, Cai QQ, Yang Y, Dong S, Liu YY, Chen ZY, Kang CL, Qi B, Dong YW, Wu W, Zhuang LP, Shen YH, Meng ZQ, Wu XZ
Clinical and translational medicine 2023 Jan;13(1):e1129
Clinical and translational medicine 2023 Jan;13(1):e1129
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
Atlas of interactions between SARS-CoV-2 macromolecules and host proteins.
Li G, Tang Z, Fan W, Wang X, Huang L, Jia Y, Wang M, Hu Z, Zhou Y
Cell insight 2023 Feb;2(1):100068
Cell insight 2023 Feb;2(1):100068
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.
Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503
Nature chemical biology 2023 Dec;19(12):1492-1503
IGF2BP1 enhances the stability of SIK2 mRNA through m(6)A modification to promote non-small cell lung cancer progression.
Xu Y, Xu L, Kong Y, Li K, Li J, Xu F, Liang S, Chen B
Biochemical and biophysical research communications 2023 Dec 3;684:149113
Biochemical and biophysical research communications 2023 Dec 3;684:149113
m(6)A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3.
Shan T, Liu F, Wen M, Chen Z, Li S, Wang Y, Cheng H, Zhou Y
Molecular cell 2023 Dec 21;83(24):4494-4508.e6
Molecular cell 2023 Dec 21;83(24):4494-4508.e6
ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy.
Zhai J, Chen H, Wong CC, Peng Y, Gou H, Zhang J, Pan Y, Chen D, Lin Y, Wang S, Kang W, To KF, Chen Z, Nie Y, He HH, Sung JJ, Yu J
Gastroenterology 2023 Aug;165(2):445-462
Gastroenterology 2023 Aug;165(2):445-462
PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer.
Shi Y, Niu Y, Yuan Y, Li K, Zhong C, Qiu Z, Li K, Lin Z, Yang Z, Zuo D, Qiu J, He W, Wang C, Liao Y, Wang G, Yuan Y, Li B
Nature communications 2023 Apr 6;14(1):1932
Nature communications 2023 Apr 6;14(1):1932
Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.
Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120
RNA-Binding Protein IGF2BP1 Associated With Prognosis and Immunotherapy Response in Lung Adenocarcinoma.
Liu J, Li Z, Cheang I, Li J, Zhou C
Frontiers in genetics 2022;13:777399
Frontiers in genetics 2022;13:777399
APAF1-Binding Long Noncoding RNA Promotes Tumor Growth and Multidrug Resistance in Gastric Cancer by Blocking Apoptosome Assembly.
Wang Q, Chen C, Xu X, Shu C, Cao C, Wang Z, Fu Y, Xu L, Xu K, Xu J, Xia A, Wang B, Xu G, Zou X, Su R, Kang W, Xue Y, Mo R, Sun B, Wang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(28):e2201889
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(28):e2201889
The "m6A writer" METTL3 and the "m6A reader" IGF2BP2 regulate cutaneous T-cell lymphomas progression via CDKN2A.
Wang X, Hu M, Yu L, Wang X, Jiang X, Zhang G, Ding K
Hematological oncology 2022 Oct;40(4):567-576
Hematological oncology 2022 Oct;40(4):567-576
m(6)A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer.
Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H
Cancer gene therapy 2022 Oct;29(10):1355-1372
Cancer gene therapy 2022 Oct;29(10):1355-1372
Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation.
Ou B, Liu Y, Gao Z, Xu J, Yan Y, Li Y, Zhang J
Cell death & disease 2022 Oct 27;13(10):905
Cell death & disease 2022 Oct 27;13(10):905
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
Jiang T, He X, Zhao Z, Zhang X, Wang T, Jia L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.
Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554
The Journal of biological chemistry 2022 Nov;298(11):102554
CRISPR-iPAS: a novel dCAS13-based method for alternative polyadenylation interference.
Tian S, Zhang B, He Y, Sun Z, Li J, Li Y, Yi H, Zhao Y, Zou X, Li Y, Cui H, Fang L, Gao X, Hu Y, Chen W
Nucleic acids research 2022 Mar 21;50(5):e26
Nucleic acids research 2022 Mar 21;50(5):e26
Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.
Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
Matkovic R, Morel M, Lanciano S, Larrous P, Martin B, Bejjani F, Vauthier V, Hansen MMK, Emiliani S, Cristofari G, Gallois-Montbrun S, Margottin-Goguet F
Nature communications 2022 Jan 10;13(1):66
Nature communications 2022 Jan 10;13(1):66
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
Biology 2022 Feb 11;11(2)
Biology 2022 Feb 11;11(2)
Peptides from the croceine croaker (Larimichthys crocea) swim bladder attenuate busulfan-induced oligoasthenospermia in mice.
Zhao X, Sang M, Han P, Gao J, Liu Z, Li H, Gu Y, Wang C, Sun F
Pharmaceutical biology 2022 Dec;60(1):319-325
Pharmaceutical biology 2022 Dec;60(1):319-325
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
Sun Z, Chen W, Wang Z, Wang S, Zan J, Zheng L, Zhao W
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
Clinical immunology (Orlando, Fla.) 2022 Dec;245:109176
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
Li Y, Miao H, Wei W, Tian J, Chen J
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.
Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB
EBioMedicine 2022 Aug;82:104142
EBioMedicine 2022 Aug;82:104142
Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment.
Liu Y, Guo Q, Yang H, Zhang XW, Feng N, Wang JK, Liu TT, Zeng KW, Tu PF
ACS central science 2022 Aug 24;8(8):1102-1115
ACS central science 2022 Aug 24;8(8):1102-1115
IGF2BP1-regulated expression of ERRα is involved in metabolic reprogramming of chemotherapy resistant osteosarcoma cells.
He Q, Hao P, He G, Mai H, Liu W, Zhang W, Zhang K, Zhong G, Guo R, Yu C, Li Y, Wong C, Chen Q, Chen Y
Journal of translational medicine 2022 Aug 2;20(1):348
Journal of translational medicine 2022 Aug 2;20(1):348
Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress.
Zaepfel BL, Rothstein JD
Frontiers in cell and developmental biology 2021;9:809859
Frontiers in cell and developmental biology 2021;9:809859
Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma.
Takada T
Case reports in dermatology 2021 Sep-Dec;13(3):506-512
Case reports in dermatology 2021 Sep-Dec;13(3):506-512
METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.
He B, Wang J
Aging 2021 Oct 5;13(19):23108-23118
Aging 2021 Oct 5;13(19):23108-23118
Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.
He RZ, Jiang J, Hu X, Lei M, Li J, Luo W, Duan L, Hu Z, Mo YY, Luo DX, Peng WX
Cancer cell international 2021 Nov 22;21(1):616
Cancer cell international 2021 Nov 22;21(1):616
Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation.
Lin XT, Yu HQ, Fang L, Tan Y, Liu ZY, Wu D, Zhang J, Xiong HJ, Xie CM
eLife 2021 Nov 15;10
eLife 2021 Nov 15;10
An in vitro system to silence mitochondrial gene expression.
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P
Cell 2021 Nov 11;184(23):5824-5837.e15
Cell 2021 Nov 11;184(23):5824-5837.e15
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients.
Wu X, Sheng H, Wang L, Xia P, Wang Y, Yu L, Lv W, Hu J
Aging 2021 Mar 26;13(7):10034-10057
Aging 2021 Mar 26;13(7):10034-10057
EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization.
Ying Y, Ma X, Fang J, Chen S, Wang W, Li J, Xie H, Wu J, Xie B, Liu B, Wang X, Zheng X, Xie L
Cell death & disease 2021 Jul 29;12(8):750
Cell death & disease 2021 Jul 29;12(8):750
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Wang H, Wei W, Zhang ZY, Liu Y, Shi B, Zhong W, Zhang HS, Fang X, Sun CL, Wang JB, Liu LX
Cell death & disease 2021 Dec 17;13(1):3
Cell death & disease 2021 Dec 17;13(1):3
In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.
Sun L, Li P, Ju X, Rao J, Huang W, Ren L, Zhang S, Xiong T, Xu K, Zhou X, Gong M, Miska E, Ding Q, Wang J, Zhang QC
Cell 2021 Apr 1;184(7):1865-1883.e20
Cell 2021 Apr 1;184(7):1865-1883.e20
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Zhu MJ, Liu BY, Shi L, Wang X, Wang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation.
Wang LJ, Xue Y, Li H, Huo R, Yan Z, Wang J, Xu H, Wang J, Cao Y, Zhao JZ
Journal of cellular and molecular medicine 2020 May;24(9):4981-4991
Journal of cellular and molecular medicine 2020 May;24(9):4981-4991
A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA.
He J, Zuo Q, Hu B, Jin H, Wang C, Cheng Z, Deng X, Yang C, Ruan H, Yu C, Zhao F, Yao M, Fang J, Gu J, Zhou J, Fan J, Qin W, Yang XR, Wang H
Cancer letters 2019 May 28;450:98-109
Cancer letters 2019 May 28;450:98-109
PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α.
Hou P, Chen F, Yong H, Lin T, Li J, Pan Y, Jiang T, Li M, Chen Y, Song J, Zheng J, Bai J
Journal of experimental & clinical cancer research : CR 2019 Jul 10;38(1):301
Journal of experimental & clinical cancer research : CR 2019 Jul 10;38(1):301
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma.
Li Z, Zhang J, Liu X, Li S, Wang Q, Di Chen, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X
Nature communications 2018 Apr 20;9(1):1572
Nature communications 2018 Apr 20;9(1):1572
Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.
Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, Yang X, Abdelmohsen K, Gorospe M
Nucleic acids research 2017 Apr 20;45(7):4021-4035
Nucleic acids research 2017 Apr 20;45(7):4021-4035
MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1.
Wang RJ, Li JW, Bao BH, Wu HC, Du ZH, Su JL, Zhang MH, Liang HQ
The Journal of biological chemistry 2015 Apr 3;290(14):8938-48
The Journal of biological chemistry 2015 Apr 3;290(14):8938-48
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IGF2BP1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IGF2BP1. This antibody recognizes human, mouse, rat antigen. The IGF2BP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
