PABL-103

antibody from Creative Biolabs

Targeting: GIPR

No application information provided.

Antibody Data

Product number

PABL-103

Provider

Creative Biolabs

Product name

Human Anti-GIPR Recombinant Antibody (clone Gipg013)

Antibody type

Monoclonal

Description

Recombinant Human Antibody (Gipg013) is capable of binding to GIPR, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-GIPR mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-GIPR mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody is a specific competitive antagonist with equally high potencies to mouse, rat, dog, and human GIP receptors with a Ki of 7 nm for the human GIPr. Gipg013 antagonizes the GIP receptor and inhibits GIP-induced insulin secretion in vitro and in vivo.

Reactivity

Human

Antibody clone number

Gipg013

Storage

Centrifuge briefly prior to opening vial. Store at +4¡ãC short term (1-2 weeks). Aliquot and store at -20¡ãC long term. Avoid repeated freeze/thaw cycles.