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- Antibody Data
- Antigen structure
- References [15]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 13751-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13751-1-AP, RRID:AB_2266703
- Product name
- MYST2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MYST2 antibody (Cat. #13751-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references KAT7 enhances the proliferation and metastasis of head and neck squamous carcinoma by promoting the acetylation level of LDHA.
Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase.
The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma.
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.
A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia.
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7.
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells.
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).
Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells.
Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human.
Estrogen receptor α (ERα) mediates 17β-estradiol (E2)-activated expression of HBO1.
Lu Y, Wang Y, Zhang L, Ma Z, Yu K, Shu Y, Zou X, Yang J, Liu X, Wang C, Du Y, Li Q
Cancer letters 2024 May 28;590:216869
Cancer letters 2024 May 28;590:216869
Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase.
Zhang T, Zhao F, Li J, Sun X, Zhang X, Wang H, Fan P, Lai L, Li Z, Sui T
Nucleic acids research 2024 Apr 12;52(6):2776-2791
Nucleic acids research 2024 Apr 12;52(6):2776-2791
The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma.
Yang R, Peng W, Shi S, Peng X, Cai Q, Zhao Z, He B, Tu G, Yin W, Chen Y, Zhang Y, Liu F, Wang X, Xiao D, Tao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300971
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300971
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.
Liao L, He Y, Li SJ, Yu XM, Liu ZC, Liang YY, Yang H, Yang J, Zhang GG, Deng CM, Wei X, Zhu YD, Xu TY, Zheng CC, Cheng C, Li A, Li ZG, Liu JB, Li B
Cell research 2023 May;33(5):355-371
Cell research 2023 May;33(5):355-371
A Therapeutically Targetable NOTCH1-SIRT1-KAT7 Axis in T-cell Leukemia.
Lancho O, Singh A, da Silva-Diz V, Aleksandrova M, Khatun J, Tottone L, Nunes PR, Luo S, Zhao C, Zheng H, Chiles E, Zuo Z, Rocha PP, Su X, Khiabanian H, Herranz D
Blood cancer discovery 2023 Jan 6;4(1):12-33
Blood cancer discovery 2023 Jan 6;4(1):12-33
Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7.
Kueh AJ, Bergamasco MI, Quaglieri A, Phipson B, Li-Wai-Suen CSN, Lönnstedt IM, Hu Y, Feng ZP, Woodruff C, May RE, Wilcox S, Garnham AL, Snyder MP, Smyth GK, Speed TP, Thomas T, Voss AK
Cell reports 2023 Jan 31;42(1):111980
Cell reports 2023 Jan 31;42(1):111980
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Wang H, Qiu Y, Zhang H, Chang N, Hu Y, Chen J, Hu R, Liao P, Li Z, Yang Y, Cen Q, Ding X, Li M, Xie X, Li Y
Cell death & disease 2023 Aug 4;14(8):498
Cell death & disease 2023 Aug 4;14(8):498
SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing.
Liu W, Lu X, Zhao ZH, Su R, Li QL, Xue Y, Gao Z, Sun SS, Lei WL, Li L, An G, Liu H, Han Z, Ouyang YC, Hou Y, Wang ZB, Sun QY, Liu J
eLife 2022 Nov 10;11
eLife 2022 Nov 10;11
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Yan G, Li X, Zheng Z, Gao W, Chen C, Wang X, Cheng Z, Yu J, Zou G, Farooq MZ, Zhu X, Zhu W, Zhong Q, Yan X
Autophagy 2022 Dec;18(12):2799-2816
Autophagy 2022 Dec;18(12):2799-2816
HBO1 (KAT7) Does Not Have an Essential Role in Cell Proliferation, DNA Replication, or Histone 4 Acetylation in Human Cells.
Kueh AJ, Eccles S, Tang L, Garnham AL, May RE, Herold MJ, Smyth GK, Voss AK, Thomas T
Molecular and cellular biology 2020 Jan 30;40(4)
Molecular and cellular biology 2020 Jan 30;40(4)
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7
Cancer cell 2018 Mar 12;33(3):368-385.e7
Acetylproteomic analysis reveals functional implications of lysine acetylation in human spermatozoa (sperm).
Yu H, Diao H, Wang C, Lin Y, Yu F, Lu H, Xu W, Li Z, Shi H, Zhao S, Zhou Y, Zhang Y
Molecular & cellular proteomics : MCP 2015 Apr;14(4):1009-23
Molecular & cellular proteomics : MCP 2015 Apr;14(4):1009-23
Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells.
Duong MT, Akli S, Macalou S, Biernacka A, Debeb BG, Yi M, Hunt KK, Keyomarsi K
Cancer research 2013 Sep 1;73(17):5556-68
Cancer research 2013 Sep 1;73(17):5556-68
Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human.
Wang D, Fang C, Zong NC, Liem DA, Cadeiras M, Scruggs SB, Yu H, Kim AK, Yang P, Deng M, Lu H, Ping P
Molecular & cellular proteomics : MCP 2013 Dec;12(12):3793-802
Molecular & cellular proteomics : MCP 2013 Dec;12(12):3793-802
Estrogen receptor α (ERα) mediates 17β-estradiol (E2)-activated expression of HBO1.
Wang WZ, Liu HO, Wu YH, Hong Y, Yang JW, Liu YH, Wu WB, Zhou L, Sun LL, Xu JJ, Yun XJ, Gu JX
Journal of experimental & clinical cancer research : CR 2010 Nov 1;29(1):140
Journal of experimental & clinical cancer research : CR 2010 Nov 1;29(1):140
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 13751-1-AP(MYST2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 13751-1-AP(MYST2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MYST2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MYST2. This antibody recognizes human, mouse, rat antigen. The MYST2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
