14805-1-AP

antibody from Proteintech Group

Targeting: EXOSC2 hRrp4p, p7, RRP4, Rrp4p

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

14805-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14805-1-AP, RRID:AB_2101837

Product name

EXOSC2 antibody

Antibody type

Polyclonal

Description

KD/KO validated EXOSC2 antibody (Cat. #14805-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Humanized Saccharomyces cerevisiae provides a facile and effective tool to identify damaging human variants that cause exosomopathies.

Ahammed KS, Fasken MB, Corbett AH, van Hoof A
G3 (Bethesda, Md.) 2025 Apr 17;15(4)

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EXOSC2 Mediates the Pro-tumor Role of WTAP in Breast Cancer Cells via Activating the Wnt/β-Catenin Signal.

Lv CG, Cheng Y, Zhang L, Wu GG, Liang CY, Tao Z, Chen B
Molecular biotechnology 2024 Sep;66(9):2569-2582

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Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting.

Fan J, Wang Y, Wen M, Tong D, Wu K, Yan K, Jia P, Zhu Y, Liu Q, Zou H, Zhao P, Lu F, Yun C, Xue Y, Zhou Y, Cheng H
Molecular cell 2024 Nov 21;84(22):4297-4313.e7

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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex.

Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Büchel G, Vos SM, Eilers M
Molecular cell 2024 Jun 6;84(11):2070-2086.e20

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Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Moll T, Odon V, Harvey C, Collins MO, Peden A, Franklin J, Graves E, Marshall JN, Dos Santos Souza C, Zhang S, Castelli L, Hautbergue G, Azzouz M, Gordon D, Krogan N, Ferraiuolo L, Snyder MP, Shaw PJ, Rehwinkel J, Cooper-Knock J
Life science alliance 2023 Jan;6(1)

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The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest.

Trendel J, Schwarzl T, Horos R, Prakash A, Bateman A, Hentze MW, Krijgsveld J
Cell 2019 Jan 10;176(1-2):391-403.e19

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Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression.

Goodarzi H, Nguyen HCB, Zhang S, Dill BD, Molina H, Tavazoie SF
Cell 2016 Jun 2;165(6):1416-1427

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 14805-1-AP(EXOSC2 antibody) at dilution of 1:500

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of MCF-7 cells, using EXOSC2 antibody 14805-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human skin cancer using 14805-1-AP(EXOSC2 antibody) at dilution of 1:100 (under 40x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human skin cancer using 14805-1-AP(EXOSC2 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue