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- Antibody Data
- Antigen structure
- References [32]
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- Product number
- 66070-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#66070-1-Ig, RRID:AB_11042765
- Product name
- Integrin Alpha 3 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Integrin Alpha 3 antibody (Cat. #66070-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, mouse and has been validated for the following applications: FC, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3F9G4
- Vial size
- 20ul, 150ul
Submitted references Pan-cancer analysis of integrin alpha family and prognosis validation in head and neck squamous cell carcinoma.
The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level.
Oligomeric Proanthocyanidins Reverse Lenvatinib Resistance in Hepatocellular Carcinoma Through ITGA3-Mediated Pathway.
Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis.
Angiopoietin-2 regulates the phenotypic switch of vascular smooth muscle cells.
ITGA3 participates in the pathogenesis of recurrent spontaneous abortion by downregulating ULK1-mediated autophagy to inhibiting trophoblast function.
Prognostic analysis and mechanistic exploration of the autophagy-related exosome genes ITGA3, ITGB4, and PTK6 in pancreatic ductal adenocarcinoma.
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Inhibition of integrin α3 suppresses gastric cancer progression via STAT3-mediated regulation of SLC1A5-dependent glutamine uptake.
Pathology-oriented multiplexing enables integrative disease mapping.
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.
Immunological role and prognostic value of ITGA3 and ITGA5 in oral squamous cell carcinoma.
3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation.
Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis.
A biomimetic targeted nanosystem delivering synergistic inhibitors for glioblastoma immune microenvironment reprogramming and treatment.
Characterization of glomerular basement membrane components within pediatric glomerular diseases.
Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma.
Biodegradable Cardiac Occluder with Surface Modification by Gelatin-Peptide Conjugate to Promote Endogenous Tissue Regeneration.
Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.
Hyaluronic acid-g-lipoic acid granular gel for promoting diabetic wound healing.
Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity.
Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways.
An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family.
TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
Swine acute diarrhea syndrome coronavirus induces autophagy to promote its replication via the Akt/mTOR pathway.
Clinical and Molecular Characterizations of Papillary Thyroid Cancer in Children and Young Adults: A Multicenter Retrospective Study.
Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling.
Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.
Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy.
Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis.
FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.
Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.
Ji S, Hao F, Zhang C, Hu C, Ren H, Huang Q, Gu J
Frontiers in oncology 2025;15:1556226
Frontiers in oncology 2025;15:1556226
The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level.
Liu B, Wu Y, Xiang A, Yu Y, Song S, Zhang Y, Gu J, Lu H, Xu P, Liu F, Ruan Y
Cell reports 2025 Sep 23;44(9):116249
Cell reports 2025 Sep 23;44(9):116249
Oligomeric Proanthocyanidins Reverse Lenvatinib Resistance in Hepatocellular Carcinoma Through ITGA3-Mediated Pathway.
Noma T, Li Y, Wada Y, Morine Y, Ikemoto T, Saito Y, Yamada S, Teraoku H, Shimada M, Goel A
Pharmaceuticals (Basel, Switzerland) 2025 Sep 12;18(9)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 12;18(9)
Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis.
MacDonald E, Forrester A, Valades-Cruz CA, Madsen TD, Hetmanski JHR, Dransart E, Ng Y, Godbole R, Shp AA, Leconte L, Chambon V, Ghosh D, Pinet A, Bhatia D, Lombard B, Loew D, Larsen MR, Leffler H, Lefeber DJ, Clausen H, Blangy A, Caswell P, Shafaq-Zadah M, Mayor S, Weigert R, Wunder C, Johannes L
Nature cell biology 2025 Mar;27(3):449-463
Nature cell biology 2025 Mar;27(3):449-463
Angiopoietin-2 regulates the phenotypic switch of vascular smooth muscle cells.
Gan X, Lu S, Ning F, Ye Y, Guo K, Chen M, Ou D, Lu Q, Lash GE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70434
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70434
ITGA3 participates in the pathogenesis of recurrent spontaneous abortion by downregulating ULK1-mediated autophagy to inhibiting trophoblast function.
Wang R, Dai F, Deng Z, Tang L, Liu H, Xia L, Cheng Y
American journal of physiology. Cell physiology 2025 Jun 1;328(6):C1941-C1956
American journal of physiology. Cell physiology 2025 Jun 1;328(6):C1941-C1956
Prognostic analysis and mechanistic exploration of the autophagy-related exosome genes ITGA3, ITGB4, and PTK6 in pancreatic ductal adenocarcinoma.
Liang L, Guo P, Xiao M, Zu F, Hao G, Zhang C, Liu Q
Discover oncology 2025 Jul 1;16(1):1204
Discover oncology 2025 Jul 1;16(1):1204
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253
Cancer gene therapy 2025 Feb;32(2):240-253
Inhibition of integrin α3 suppresses gastric cancer progression via STAT3-mediated regulation of SLC1A5-dependent glutamine uptake.
Zhu W, Pan S, Xu J, Wang Y, Fu Z, Han X, Zhang Y, Zhao Q, Zhang R, Hu C, Xu Z
Journal of gastroenterology 2025 Dec;60(12):1496-1512
Journal of gastroenterology 2025 Dec;60(12):1496-1512
Pathology-oriented multiplexing enables integrative disease mapping.
Kuehl M, Okabayashi Y, Wong MN, Gernhold L, Gut G, Kaiser N, Schwerk M, Gräfe SK, Ma FY, Tanevski J, Schäfer PSL, Mezher S, Sarabia Del Castillo J, Goldbeck-Strieder T, Zolotareva O, Hartung M, Delgado Chaves FM, Klinkert L, Gnirck AC, Spehr M, Fleck D, Joodaki M, Parra V, Shaigan M, Diebold M, Prinz M, Kranz J, Kux JM, Braun F, Kretz O, Wu H, Grahammer F, Heins S, Zimmermann M, Haas F, Kylies D, Wanner N, Czogalla J, Dumoulin B, Zolotarev N, Lindenmeyer M, Karlson P, Nyengaard JR, Sebode M, Weidemann S, Wiech T, Groene HJ, Tomas NM, Meyer-Schwesinger C, Kuppe C, Kramann R, Karras A, Bruneval P, Tharaux PL, Pastene D, Yard B, Schaub JA, McCown PJ, Pyle L, Choi YJ, Yokoo T, Baumbach J, Sáez PJ, Costa I, Turner JE, Hodgin JB, Saez-Rodriguez J, Huber TB, Bjornstad P, Kretzler M, Lenoir O, Nikolic-Paterson DJ, Pelkmans L, Bonn S, Puelles VG
Nature 2025 Aug;644(8076):516-526
Nature 2025 Aug;644(8076):516-526
Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.
Zhang Z, Zhao Z, Huang X, Zhou L, Jiang X, Wu H, Liu C, Huang K, Wen J, Liu Y, Miller MC, Zhao Z, He Z, Wang Y, Liu S, Huang L, Yuan L, Zeng R, Cen Z, Chen A, Chen Y, Zeng G, Liu W, Hong X, Ren M, Yan L, Zhang Y, Guan D, Tian X, Cai W, Tai G, Mayo KH, Zhou Y, Li Z, Chen S
Nature communications 2025 Aug 7;16(1):7287
Nature communications 2025 Aug 7;16(1):7287
Immunological role and prognostic value of ITGA3 and ITGA5 in oral squamous cell carcinoma.
Wang L, Xu X, Zeng D, Peng Q
Scientific reports 2025 Aug 17;15(1):30046
Scientific reports 2025 Aug 17;15(1):30046
3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation.
Yan J, Ye Z, Lu Y, Yuan Y, Wang X, Yan T, Yin J, Wang Y
Materials today. Bio 2025 Apr;31:101515
Materials today. Bio 2025 Apr;31:101515
Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis.
White MJV, Ozkan M, Gomez-Medellin JE, Rączy MM, Koss KM, Solanki A, Zhang ZJ, Alpar AT, Naved BA, Wertheim J, Hubbell JA
Scientific reports 2024 Sep 16;14(1):21623
Scientific reports 2024 Sep 16;14(1):21623
A biomimetic targeted nanosystem delivering synergistic inhibitors for glioblastoma immune microenvironment reprogramming and treatment.
Mu Y, Zhang Z, Zhou H, Jin M, Ma L, Liu B, Ma C, Hu X, Zhang Y, Wang DA
Materials today. Bio 2024 Oct;28:101222
Materials today. Bio 2024 Oct;28:101222
Characterization of glomerular basement membrane components within pediatric glomerular diseases.
Chen D, Zhou X, Gan C, Yang Q, Chen W, Feng X, Zhang T, Zhang L, Dai L, Chen Y, Yang H, Wang M, Jiang W, Li Q
Clinical kidney journal 2024 Mar;17(3):sfae037
Clinical kidney journal 2024 Mar;17(3):sfae037
Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma.
Kantheti HS, Hale MA, Pal Choudhuri S, Huang H, Wang XD, Zolghadri Y, Innamorati G, Manikonda SPR, Reddy N, Reddy S, Kollipara RK, Lumani V, Girard L, Bezrukov Y, Demenkov P, MacDonald RJ, Brekken RA, Yu Y, Wilkie TM
International journal of molecular sciences 2024 Jun 16;25(12)
International journal of molecular sciences 2024 Jun 16;25(12)
Biodegradable Cardiac Occluder with Surface Modification by Gelatin-Peptide Conjugate to Promote Endogenous Tissue Regeneration.
Kong P, Liu X, Li Z, Wang J, Gao R, Feng S, Li H, Zhang F, Feng Z, Huang P, Wang S, Zhuang D, Ouyang W, Wang W, Pan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2305967
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2305967
Integrin α3 is required for high-frequency repetitive transcranial magnetic stimulation-induced glutamatergic synaptic transmission in mice with ischemia.
Liu L, Hu H, Wu J, Koleske AJ, Chen H, Wang N, Yu K, Wu Y, Xiao X, Zhang Q
CNS neuroscience & therapeutics 2024 Apr;30(4):e14498
CNS neuroscience & therapeutics 2024 Apr;30(4):e14498
Hyaluronic acid-g-lipoic acid granular gel for promoting diabetic wound healing.
Zhang S, Pan Y, Mao Z, Zhang J, Zhang K, Yin J, Wang C
Bioengineering & translational medicine 2023 Mar;8(2):e10402
Bioengineering & translational medicine 2023 Mar;8(2):e10402
Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity.
Mayner JM, Masutani EM, Demeester E, Kumar A, Macapugay G, Beri P, Lo Sardo V, Engler AJ
Proceedings of the National Academy of Sciences of the United States of America 2023 Jun 13;120(24):e2217122120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jun 13;120(24):e2217122120
Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways.
Huang A, Wang R, Cui J, Gao Y, Yin Z, Chen L, He M, Li W
Frontiers in molecular biosciences 2022;9:808152
Frontiers in molecular biosciences 2022;9:808152
An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family.
Cegarra C, Cameron B, Chaves C, Dabdoubi T, Do TM, Genêt B, Roudières V, Shi Y, Tchepikoff P, Lesuisse D
PloS one 2022;17(9):e0274667
PloS one 2022;17(9):e0274667
TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration.
Li B, Brusman L, Dahlka J, Niswander LA
Development (Cambridge, England) 2022 Sep 1;149(17)
Development (Cambridge, England) 2022 Sep 1;149(17)
Swine acute diarrhea syndrome coronavirus induces autophagy to promote its replication via the Akt/mTOR pathway.
Zeng S, Zhao Y, Peng O, Xia Y, Xu Q, Li H, Xue C, Cao Y, Zhang H
iScience 2022 Nov 18;25(11):105394
iScience 2022 Nov 18;25(11):105394
Clinical and Molecular Characterizations of Papillary Thyroid Cancer in Children and Young Adults: A Multicenter Retrospective Study.
Guo K, Qian K, Shi Y, Sun T, Chen L, Mei D, Dong K, Gu S, Liu J, Lv Z, Wang Z
Thyroid : official journal of the American Thyroid Association 2021 Nov;31(11):1693-1706
Thyroid : official journal of the American Thyroid Association 2021 Nov;31(11):1693-1706
Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling.
Hou H, Ning F, Zhang JY, Lu Q, Zhang M, Wu P, Chen M, Lash GE
Molecular human reproduction 2021 Feb 27;27(3)
Molecular human reproduction 2021 Feb 27;27(3)
Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.
Jin Y, Liu W, Wang F, Wang M, Xu K, Yang A, Wang C, Zhang L, Zhang F, Li M
Cell adhesion & migration 2021 Dec;15(1):74-83
Cell adhesion & migration 2021 Dec;15(1):74-83
Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy.
Tang Z, Lu Y, Zhang S, Wang J, Wang Q, Xiao Y, Zhang X
Journal of materials chemistry. B 2021 Dec 15;9(48):9989-10002
Journal of materials chemistry. B 2021 Dec 15;9(48):9989-10002
Exosome-derived ENO1 regulates integrin α6β4 expression and promotes hepatocellular carcinoma growth and metastasis.
Jiang K, Dong C, Yin Z, Li R, Mao J, Wang C, Zhang J, Gao Z, Liang R, Wang Q, Wang L
Cell death & disease 2020 Nov 12;11(11):972
Cell death & disease 2020 Nov 12;11(11):972
FAM83A exerts tumor‑suppressive roles in cervical cancer by regulating integrins.
Xu J, Lu W
International journal of oncology 2020 Aug;57(2):509-521
International journal of oncology 2020 Aug;57(2):509-521
Hypoxia-induced changes to integrin α 3 glycosylation facilitate invasion in epidermoid carcinoma cell line A431.
Ren Y, Hao P, Law SK, Sze SK
Molecular & cellular proteomics : MCP 2014 Nov;13(11):3126-37
Molecular & cellular proteomics : MCP 2014 Nov;13(11):3126-37
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Integrin alpha-3 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human Integrin alpha-3. This antibody recognizes human antigen. The Integrin alpha-3 antibody has been validated for the following applications: ELISA, WB analysis.
