BS8539

antibody from Bioworld Technology, Inc
Targeting: NPHP1 JBTS4, NPH1, SLSN1
Provider product page for BS8539
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8539 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Nephrocystin 1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Nephrocystin1; Nephrocystin 1; Juvenile nephronophthisis 1 protein; NPHP1; NPH1
Description
Juvenile nephronophthisis type 1 is caused by mutations of NPHP1, the gene encoding for nephrocystin. Nephrocystin interacts with p130Cas (BCAR1), proline-rich tyrosine kinase-2 (PTK2B or Pyk2), and tensin in embryonic kidney and testis, indicating that these proteins participate in a common signaling pathway. Nephrocystin and p130Cas interact in mammalian cells and both proteins prominently localize at or near sites of cell-cell contact in polarized Madin-Darby canine kidney epithelial cells. Expression of nephrocystin results in phosphorylation of Pyk2 on Tyrosine 402 as well as activation of downstream mitogen-activated protein kinases, such as ERK1 and ERK2. Nephrocystin contains a src-homology 3 (SH3) domain, which is highly conserved throughout evolution.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NPHP1 protein structure - BS8539 shown in red.