Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 130-10086-100 - Provider product page
- Provider
- RayBiotech, Inc.
- Product name
- Mouse Anti-Human IGF
- Antibody type
- Monoclonal
- Antigen
- Recombinant protein derived from human IGF-1.
- Description
- Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein in humans encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by under-nutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen. The IgG fraction of tissue culture supernatant was purified by Protein G/A affinity chromatography.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
This antibody was produced from a h
ybridoma resulting from the fusion
of a mouse myeloma with B cells obt
ained from a mouse immunized with t
he immunogen. The IgG fraction of t
issue culture supernatant was purif
ied by Protein G/A affinity chromat
ography.- Isotype
- IgG
- Vial size
- 100 µg
- Handling
- Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1x PBS to a final concentration of 1 mg/ml.
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