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- Antibody Data
- Antigen structure
- References [19]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 20214-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20214-1-AP, RRID:AB_10666736
- Product name
- IGF1A-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IGF1A-Specific antibody (Cat. #20214-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Detection of multiple biomarkers associated with satellite cell fate in the contused skeletal muscle of rats for wound age estimation.
Icing after skeletal muscle injury decreases M1 macrophage accumulation and TNF-α expression during the early phase of muscle regeneration in rats.
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Icing after eccentric contraction-induced muscle damage perturbs the disappearance of necrotic muscle fibers and phenotypic dynamics of macrophages in mice.
BMSC-derived leptin and IGFBP2 promote erlotinib resistance in lung adenocarcinoma cells through IGF-1R activation in hypoxic environment.
The role of insulin-like growth factor 1 in ALS cell and mouse models: A mitochondrial protector.
The Dipeptide Pro-Gly Promotes IGF-1 Expression and Secretion in HepG2 and Female Mice via PepT1-JAK2/STAT5 Pathway.
Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1(G93A) ALS Mouse Model via Upregulation of D-Amino Acid Oxidase.
Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation.
Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1.
Plumbagin suppresses the migration and invasion of glioma cells via downregulation of MMP-2/9 expression and inaction of PI3K/Akt signaling pathway in vitro.
The energy sensing LKB1-AMPKα1 pathway regulates IGF1 secretion and consequent activation of the IGF1R-PKB pathway in primary hepatocytes.
AAV9-IGF1 protects TDP-25 cells from apoptosis and oxidative stress partly via up-regulating the expression of VEGF in vitro.
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Receptor activator of nuclear factor-kappa ligand, OPG, and IGF-I expression during orthodontically induced inflammatory root resorption in the recombinant human growth hormone-treated rats.
IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1.
Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.
Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice.
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Tian ZL, Wang RL, Yang QF, Qin ZQ, Dong HW, Zou DH, Li ZD, Wang JM, Guan DW, Zhang JH, Liu NG
International journal of legal medicine 2023 May;137(3):875-886
International journal of legal medicine 2023 May;137(3):875-886
Icing after skeletal muscle injury decreases M1 macrophage accumulation and TNF-α expression during the early phase of muscle regeneration in rats.
Miyazaki A, Kawashima M, Nagata I, Miyoshi M, Miyakawa M, Sugiyama M, Sakuraya T, Sonomura T, Arakawa T
Histochemistry and cell biology 2023 Jan;159(1):77-89
Histochemistry and cell biology 2023 Jan;159(1):77-89
MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.
Xu Y, Tang Z, Dai H, Hou J, Li F, Tang Z, Zhang D
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Obesity (Silver Spring, Md.) 2022 Feb;30(2):447-459
Icing after eccentric contraction-induced muscle damage perturbs the disappearance of necrotic muscle fibers and phenotypic dynamics of macrophages in mice.
Kawashima M, Kawanishi N, Tominaga T, Suzuki K, Miyazaki A, Nagata I, Miyoshi M, Miyakawa M, Sakuraya T, Sonomura T, Arakawa T
Journal of applied physiology (Bethesda, Md. : 1985) 2021 May 1;130(5):1410-1420
Journal of applied physiology (Bethesda, Md. : 1985) 2021 May 1;130(5):1410-1420
BMSC-derived leptin and IGFBP2 promote erlotinib resistance in lung adenocarcinoma cells through IGF-1R activation in hypoxic environment.
Wang F, Zhang L, Sai B, Wang L, Zhang X, Zheng L, Tang J, Li G, Xiang J
Cancer biology & therapy 2020;21(1):61-71
Cancer biology & therapy 2020;21(1):61-71
The role of insulin-like growth factor 1 in ALS cell and mouse models: A mitochondrial protector.
Wen D, Cui C, Duan W, Wang W, Wang Y, Liu Y, Li Z, Li C
Brain research bulletin 2019 Jan;144:1-13
Brain research bulletin 2019 Jan;144:1-13
The Dipeptide Pro-Gly Promotes IGF-1 Expression and Secretion in HepG2 and Female Mice via PepT1-JAK2/STAT5 Pathway.
Zhang M, Xu J, Wang T, Wan X, Zhang F, Wang L, Zhu X, Gao P, Shu G, Jiang Q, Wang S
Frontiers in endocrinology 2018;9:424
Frontiers in endocrinology 2018;9:424
Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1(G93A) ALS Mouse Model via Upregulation of D-Amino Acid Oxidase.
Lin H, Hu H, Duan W, Liu Y, Tan G, Li Z, Liu Y, Deng B, Song X, Wang W, Wen D, Wang Y, Li C
Molecular neurobiology 2018 Jan;55(1):682-695
Molecular neurobiology 2018 Jan;55(1):682-695
Dietary protein-induced hepatic IGF-1 secretion mediated by PPARγ activation.
Wan X, Wang S, Xu J, Zhuang L, Xing K, Zhang M, Zhu X, Wang L, Gao P, Xi Q, Sun J, Zhang Y, Li T, Shu G, Jiang Q
PloS one 2017;12(3):e0173174
PloS one 2017;12(3):e0173174
Regulator of Calcineurin 1 Gene Isoform 4, Down-regulated in Hepatocellular Carcinoma, Prevents Proliferation, Migration, and Invasive Activity of Cancer Cells and Metastasis of Orthotopic Tumors by Inhibiting Nuclear Translocation of NFAT1.
Jin H, Wang C, Jin G, Ruan H, Gu D, Wei L, Wang H, Wang N, Arunachalam E, Zhang Y, Deng X, Yang C, Xiong Y, Feng H, Yao M, Fang J, Gu J, Cong W, Qin W
Gastroenterology 2017 Sep;153(3):799-811.e33
Gastroenterology 2017 Sep;153(3):799-811.e33
Plumbagin suppresses the migration and invasion of glioma cells via downregulation of MMP-2/9 expression and inaction of PI3K/Akt signaling pathway in vitro.
Chen G, Yue Y, Qin J, Xiao X, Ren Q, Xiao B
Journal of pharmacological sciences 2017 May;134(1):59-67
Journal of pharmacological sciences 2017 May;134(1):59-67
The energy sensing LKB1-AMPKα1 pathway regulates IGF1 secretion and consequent activation of the IGF1R-PKB pathway in primary hepatocytes.
Chen L, Chen Q, Rong P, Wang HY, Chen S
The FEBS journal 2017 Jul;284(13):2096-2109
The FEBS journal 2017 Jul;284(13):2096-2109
AAV9-IGF1 protects TDP-25 cells from apoptosis and oxidative stress partly via up-regulating the expression of VEGF in vitro.
Li Z, Duan W, Cui C, Liu Y, Li C, Liu Y
Neuroscience letters 2017 Feb 15;640:123-129
Neuroscience letters 2017 Feb 15;640:123-129
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
Receptor activator of nuclear factor-kappa ligand, OPG, and IGF-I expression during orthodontically induced inflammatory root resorption in the recombinant human growth hormone-treated rats.
Hu Y, Liu W, Liu Z, Kuang W, He H
The Angle orthodontist 2015 Jul;85(4):562-9
The Angle orthodontist 2015 Jul;85(4):562-9
IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1.
Yuan L, Zhou C, Lu Y, Hong M, Zhang Z, Zhang Z, Chang Y, Zhang C, Li X
Cancer letters 2015 Apr 1;359(1):136-47
Cancer letters 2015 Apr 1;359(1):136-47
Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.
Wen Y, Li J, Tan Y, Qin J, Xie X, Wang L, Mei Q, Wang H, Magdalou J, Chen L
PloS one 2014;9(9):e107024
PloS one 2014;9(9):e107024
Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice.
Tang H, Liao Y, Xu L, Zhang C, Liu Z, Deng Y, Jiang Z, Fu S, Chen Z, Zhou S
International journal of cancer 2013 Nov 15;133(10):2473-82
International journal of cancer 2013 Nov 15;133(10):2473-82
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Xu X, Hueckstaedt LK, Ren J
Journal of hepatology 2013 Aug;59(2):308-17
Journal of hepatology 2013 Aug;59(2):308-17
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 20214-1-AP(IGF1A-Specific antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IGF1A-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human IGF1A-Specific. This antibody recognizes human,mouse,rat antigen. The IGF1A-Specific antibody has been validated for the following applications: ELISA, WB, IHC, IF, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 20214-1-AP(IGF1A-Specific antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 20214-1-AP(IGF1A-Specific antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
